alanine has been researched along with Multiple Sclerosis in 11 studies
Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.
Multiple Sclerosis: An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Myelin basic protein (MBP)-reactive T cells may play an important role in the pathogenesis of multiple sclerosis (MS)." | 7.70 | T cell recognition motifs of an immunodominant peptide of myelin basic protein in patients with multiple sclerosis: structural requirements and clinical implications. ( Aebischer, I; Boehme, SA; Crowe, PD; Kozovska, M; Lnu, S; Rivera, VM; Zang, YC; Zhang, JZ, 1998) |
| "Flecainide was also potent in suppressing microglial activation in experimental autoimmune encephalomyelitis." | 5.39 | Safinamide and flecainide protect axons and reduce microglial activation in models of multiple sclerosis. ( Bechtold, D; Chauhdry, S; Hassoon, P; Lee, W; Malpass, K; Morsali, D; Palchaudhuri, U; Piers, T; Pocock, J; Roach, A; Smith, KJ; Snell, DM, 2013) |
| "Myelin basic protein (MBP)-reactive T cells may play an important role in the pathogenesis of multiple sclerosis (MS)." | 3.70 | T cell recognition motifs of an immunodominant peptide of myelin basic protein in patients with multiple sclerosis: structural requirements and clinical implications. ( Aebischer, I; Boehme, SA; Crowe, PD; Kozovska, M; Lnu, S; Rivera, VM; Zang, YC; Zhang, JZ, 1998) |
| "Choline was significantly elevated in acute lesions compared with controls (P < 0." | 2.70 | Proton MR spectroscopy with metabolite-nulling reveals elevated macromolecules in acute multiple sclerosis. ( Grodd, W; Klose, U; Mader, I; Melms, A; Naegele, T; Seeger, U; Weissert, R, 2001) |
| "Flecainide was also potent in suppressing microglial activation in experimental autoimmune encephalomyelitis." | 1.39 | Safinamide and flecainide protect axons and reduce microglial activation in models of multiple sclerosis. ( Bechtold, D; Chauhdry, S; Hassoon, P; Lee, W; Malpass, K; Morsali, D; Palchaudhuri, U; Piers, T; Pocock, J; Roach, A; Smith, KJ; Snell, DM, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 4 (36.36) | 29.6817 |
| 2010's | 4 (36.36) | 24.3611 |
| 2020's | 2 (18.18) | 2.80 |
| Authors | Studies |
|---|---|
| Cinkir, U | 1 |
| Bir, LS | 1 |
| Tekin, S | 1 |
| Karagulmez, AM | 1 |
| Avci Cicek, E | 1 |
| Senol, H | 1 |
| Li, J | 1 |
| Liu, HH | 1 |
| Yin, XD | 1 |
| Li, CC | 1 |
| Wang, J | 1 |
| Morsali, D | 1 |
| Bechtold, D | 1 |
| Lee, W | 1 |
| Chauhdry, S | 1 |
| Palchaudhuri, U | 1 |
| Hassoon, P | 1 |
| Snell, DM | 1 |
| Malpass, K | 1 |
| Piers, T | 1 |
| Pocock, J | 1 |
| Roach, A | 1 |
| Smith, KJ | 1 |
| Ruprecht, K | 1 |
| Wunderlich, B | 1 |
| Gieß, R | 1 |
| Meyer, P | 1 |
| Loebel, M | 1 |
| Lenz, K | 1 |
| Hofmann, J | 1 |
| Rosche, B | 1 |
| Wengert, O | 1 |
| Paul, F | 1 |
| Reimer, U | 1 |
| Scheibenbogen, C | 1 |
| Stojković, L | 1 |
| Stanković, A | 1 |
| Djurić, T | 1 |
| Dinčić, E | 1 |
| Alavantić, D | 1 |
| Zivković, M | 1 |
| Lorefice, L | 1 |
| Murru, MR | 1 |
| Fenu, G | 1 |
| Corongiu, D | 1 |
| Frau, J | 1 |
| Cuccu, S | 1 |
| Coghe, GC | 1 |
| Tranquilli, S | 1 |
| Cocco, E | 1 |
| Marrosu, MG | 1 |
| Klotz, L | 1 |
| Schmidt, S | 1 |
| Heun, R | 1 |
| Klockgether, T | 1 |
| Kölsch, H | 1 |
| Zhou, Q | 1 |
| Rammohan, K | 1 |
| Lin, S | 1 |
| Robinson, N | 1 |
| Li, O | 1 |
| Liu, X | 1 |
| Bai, XF | 1 |
| Yin, L | 1 |
| Scarberry, B | 1 |
| Du, P | 1 |
| You, M | 1 |
| Guan, K | 1 |
| Zheng, P | 1 |
| Liu, Y | 1 |
| Singh, RA | 1 |
| Zhang, JZ | 2 |
| Kozovska, M | 1 |
| Zang, YC | 1 |
| Aebischer, I | 1 |
| Lnu, S | 1 |
| Rivera, VM | 1 |
| Crowe, PD | 1 |
| Boehme, SA | 1 |
| Mader, I | 1 |
| Seeger, U | 1 |
| Weissert, R | 1 |
| Klose, U | 1 |
| Naegele, T | 1 |
| Melms, A | 1 |
| Grodd, W | 1 |
1 review available for alanine and Multiple Sclerosis
| Article | Year |
|---|---|
COVID-19 illness and autoimmune diseases: recent insights.
Topics: Adenosine Monophosphate; Alanine; Angiotensin-Converting Enzyme 2; Arthritis, Rheumatoid; Autoimmune | 2021 |
1 trial available for alanine and Multiple Sclerosis
| Article | Year |
|---|---|
Proton MR spectroscopy with metabolite-nulling reveals elevated macromolecules in acute multiple sclerosis.
Topics: Acute Disease; Adrenal Cortex Hormones; Adult; Alanine; Amino Acids; Aspartic Acid; Biomarkers; Chol | 2001 |
9 other studies available for alanine and Multiple Sclerosis
| Article | Year |
|---|---|
Investigation of anti-galectin-8 levels in patients with multiple sclerosis: A consort-clinical study.
Topics: Alanine; Biomarkers; Galectin 3; Humans; Mammals; Multiple Sclerosis; Transaminases | 2023 |
Safinamide and flecainide protect axons and reduce microglial activation in models of multiple sclerosis.
Topics: Alanine; Animals; Benzylamines; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; | 2013 |
Multiple sclerosis: the elevated antibody response to Epstein-Barr virus primarily targets, but is not confined to, the glycine-alanine repeat of Epstein-Barr nuclear antigen-1.
Topics: Adult; Alanine; Antibody Formation; Antigens, Viral; Epitopes; Epstein-Barr Virus Infections; Epstei | 2014 |
The gender-specific association of CXCL16 A181V gene polymorphism with susceptibility to multiple sclerosis, and its effects on PBMC mRNA and plasma soluble CXCL16 levels: preliminary findings.
Topics: Adult; Alanine; Analysis of Variance; Case-Control Studies; Chemokine CXCL16; Chemokines, CXC; Disab | 2014 |
A genetic association study of two genes linked to neurodegeneration in a Sardinian multiple sclerosis population: the TARDBP Ala382Thr mutation and C9orf72 expansion.
Topics: Adult; Aged; Aged, 80 and over; Alanine; C9orf72 Protein; Cohort Studies; DNA Repeat Expansion; DNA- | 2015 |
Association of the PPARgamma gene polymorphism Pro12Ala with delayed onset of multiple sclerosis.
Topics: Adolescent; Adult; Age of Onset; Aged; Alanine; Case-Control Studies; Community Health Planning; Fem | 2009 |
CD24 is a genetic modifier for risk and progression of multiple sclerosis.
Topics: Alanine; Alleles; Animals; Antigens, CD; CD24 Antigen; CD3 Complex; Cell Membrane; Cloning, Molecula | 2003 |
Differential activation of ERK, p38, and JNK required for Th1 and Th2 deviation in myelin-reactive T cells induced by altered peptide ligand.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Cell Differentiation; Clone Cells; Cytokines; | 2004 |
T cell recognition motifs of an immunodominant peptide of myelin basic protein in patients with multiple sclerosis: structural requirements and clinical implications.
Topics: Alanine; Cells, Cultured; Cross Reactions; Epitopes, T-Lymphocyte; Herpesvirus 2, Human; Humans; Imm | 1998 |