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alanine and Motor Neuron Disease

alanine has been researched along with Motor Neuron Disease in 5 studies

Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.

Motor Neuron Disease: Diseases characterized by a selective degeneration of the motor neurons of the spinal cord, brainstem, or motor cortex. Clinical subtypes are distinguished by the major site of degeneration. In AMYOTROPHIC LATERAL SCLEROSIS there is involvement of upper, lower, and brainstem motor neurons. In progressive muscular atrophy and related syndromes (see MUSCULAR ATROPHY, SPINAL) the motor neurons in the spinal cord are primarily affected. With progressive bulbar palsy (BULBAR PALSY, PROGRESSIVE), the initial degeneration occurs in the brainstem. In primary lateral sclerosis, the cortical neurons are affected in isolation. (Adams et al., Principles of Neurology, 6th ed, p1089)

Research Excerpts

ExcerptRelevanceReference
"Amyotrophic lateral sclerosis (ALS), a multifactorial disease characterized by diffuse motor neuron degeneration, has proven to be a difficult target for stem cell therapy."1.32Intravenous administration of human umbilical cord blood cells in a mouse model of amyotrophic lateral sclerosis: distribution, migration, and differentiation. ( Chen, N; Davis, CD; Garbuzova-Davis, S; Hudson, JE; Justen, EB; Lane, JC; Sanberg, PR; Saporta, S; Willing, AE; Zigova, T, 2003)
"In classical amyotrophic lateral sclerosis, the odds ratio was 3."1.30Manganese-containing superoxide dismutase signal sequence polymorphism associated with sporadic motor neuron disease. ( Andersen, PM; Beckman, G; Beckman, L; Tabatabaie, P; Van Landeghem, GF, 1999)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (40.00)18.2507
2000's3 (60.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Garbuzova-Davis, S1
Willing, AE1
Zigova, T1
Saporta, S1
Justen, EB1
Lane, JC1
Hudson, JE1
Chen, N1
Davis, CD1
Sanberg, PR1
Cheroni, C1
Peviani, M1
Cascio, P1
Debiasi, S1
Monti, C1
Bendotti, C1
Gitcho, MA1
Baloh, RH1
Chakraverty, S1
Mayo, K1
Norton, JB1
Levitch, D1
Hatanpaa, KJ1
White, CL1
Bigio, EH1
Caselli, R1
Baker, M1
Al-Lozi, MT1
Morris, JC1
Pestronk, A1
Rademakers, R1
Goate, AM1
Cairns, NJ1
Khan, JK1
Kuo, YH1
Haque, A1
Lambein, F1
Van Landeghem, GF1
Tabatabaie, P1
Beckman, G1
Beckman, L1
Andersen, PM1

Other Studies

5 other studies available for alanine and Motor Neuron Disease

ArticleYear
Intravenous administration of human umbilical cord blood cells in a mouse model of amyotrophic lateral sclerosis: distribution, migration, and differentiation.
    Journal of hematotherapy & stem cell research, 2003, Volume: 12, Issue:3

    Topics: Alanine; Animals; Cord Blood Stem Cell Transplantation; Disease Models, Animal; Disease Progression;

2003
Accumulation of human SOD1 and ubiquitinated deposits in the spinal cord of SOD1G93A mice during motor neuron disease progression correlates with a decrease of proteasome.
    Neurobiology of disease, 2005, Volume: 18, Issue:3

    Topics: Alanine; Amino Acid Substitution; Animals; Female; Glycine; Humans; Mice; Mice, Inbred C57BL; Mice,

2005
TDP-43 A315T mutation in familial motor neuron disease.
    Annals of neurology, 2008, Volume: 63, Issue:4

    Topics: Aged; Aged, 80 and over; Alanine; Amino Acid Sequence; Amino Acid Substitution; DNA Mutational Analy

2008
Inhibitory and excitatory amino acids in cerebrospinal fluid of neurolathyrism patients, a highly prevalent motorneurone disease.
    Acta neurologica Scandinavica, 1995, Volume: 91, Issue:6

    Topics: Adolescent; Adult; Aged; Alanine; Aspartic Acid; Eating; Excitatory Amino Acids; Fabaceae; Glutamic

1995
Manganese-containing superoxide dismutase signal sequence polymorphism associated with sporadic motor neuron disease.
    European journal of neurology, 1999, Volume: 6, Issue:6

    Topics: Alanine; Alleles; DNA Mutational Analysis; Female; Humans; Infant, Newborn; Male; Motor Neuron Disea

1999