alanine has been researched along with Motor Neuron Disease in 5 studies
Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.
Motor Neuron Disease: Diseases characterized by a selective degeneration of the motor neurons of the spinal cord, brainstem, or motor cortex. Clinical subtypes are distinguished by the major site of degeneration. In AMYOTROPHIC LATERAL SCLEROSIS there is involvement of upper, lower, and brainstem motor neurons. In progressive muscular atrophy and related syndromes (see MUSCULAR ATROPHY, SPINAL) the motor neurons in the spinal cord are primarily affected. With progressive bulbar palsy (BULBAR PALSY, PROGRESSIVE), the initial degeneration occurs in the brainstem. In primary lateral sclerosis, the cortical neurons are affected in isolation. (Adams et al., Principles of Neurology, 6th ed, p1089)
Excerpt | Relevance | Reference |
---|---|---|
"Amyotrophic lateral sclerosis (ALS), a multifactorial disease characterized by diffuse motor neuron degeneration, has proven to be a difficult target for stem cell therapy." | 1.32 | Intravenous administration of human umbilical cord blood cells in a mouse model of amyotrophic lateral sclerosis: distribution, migration, and differentiation. ( Chen, N; Davis, CD; Garbuzova-Davis, S; Hudson, JE; Justen, EB; Lane, JC; Sanberg, PR; Saporta, S; Willing, AE; Zigova, T, 2003) |
"In classical amyotrophic lateral sclerosis, the odds ratio was 3." | 1.30 | Manganese-containing superoxide dismutase signal sequence polymorphism associated with sporadic motor neuron disease. ( Andersen, PM; Beckman, G; Beckman, L; Tabatabaie, P; Van Landeghem, GF, 1999) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 2 (40.00) | 18.2507 |
2000's | 3 (60.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Garbuzova-Davis, S | 1 |
Willing, AE | 1 |
Zigova, T | 1 |
Saporta, S | 1 |
Justen, EB | 1 |
Lane, JC | 1 |
Hudson, JE | 1 |
Chen, N | 1 |
Davis, CD | 1 |
Sanberg, PR | 1 |
Cheroni, C | 1 |
Peviani, M | 1 |
Cascio, P | 1 |
Debiasi, S | 1 |
Monti, C | 1 |
Bendotti, C | 1 |
Gitcho, MA | 1 |
Baloh, RH | 1 |
Chakraverty, S | 1 |
Mayo, K | 1 |
Norton, JB | 1 |
Levitch, D | 1 |
Hatanpaa, KJ | 1 |
White, CL | 1 |
Bigio, EH | 1 |
Caselli, R | 1 |
Baker, M | 1 |
Al-Lozi, MT | 1 |
Morris, JC | 1 |
Pestronk, A | 1 |
Rademakers, R | 1 |
Goate, AM | 1 |
Cairns, NJ | 1 |
Khan, JK | 1 |
Kuo, YH | 1 |
Haque, A | 1 |
Lambein, F | 1 |
Van Landeghem, GF | 1 |
Tabatabaie, P | 1 |
Beckman, G | 1 |
Beckman, L | 1 |
Andersen, PM | 1 |
5 other studies available for alanine and Motor Neuron Disease
Article | Year |
---|---|
Intravenous administration of human umbilical cord blood cells in a mouse model of amyotrophic lateral sclerosis: distribution, migration, and differentiation.
Topics: Alanine; Animals; Cord Blood Stem Cell Transplantation; Disease Models, Animal; Disease Progression; | 2003 |
Accumulation of human SOD1 and ubiquitinated deposits in the spinal cord of SOD1G93A mice during motor neuron disease progression correlates with a decrease of proteasome.
Topics: Alanine; Amino Acid Substitution; Animals; Female; Glycine; Humans; Mice; Mice, Inbred C57BL; Mice, | 2005 |
TDP-43 A315T mutation in familial motor neuron disease.
Topics: Aged; Aged, 80 and over; Alanine; Amino Acid Sequence; Amino Acid Substitution; DNA Mutational Analy | 2008 |
Inhibitory and excitatory amino acids in cerebrospinal fluid of neurolathyrism patients, a highly prevalent motorneurone disease.
Topics: Adolescent; Adult; Aged; Alanine; Aspartic Acid; Eating; Excitatory Amino Acids; Fabaceae; Glutamic | 1995 |
Manganese-containing superoxide dismutase signal sequence polymorphism associated with sporadic motor neuron disease.
Topics: Alanine; Alleles; DNA Mutational Analysis; Female; Humans; Infant, Newborn; Male; Motor Neuron Disea | 1999 |