alanine and MPTP Neurotoxicity Syndrome studies

alanine and MPTP Neurotoxicity Syndrome

Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.

Research Excerpts

Excerpt	Relevance	Reference
"Safinamide has neuroprotective and neurorescuing effects in MPTP-treated mice, in the rat kainic acid, and in the gerbil ischemia model."	2.43	Safinamide: from molecular targets to a new anti-Parkinson drug. ( Caccia, C; Calabresi, M; Curatolo, L; Faravelli, L; Fariello, RG; Maestroni, S; Maj, R; Salvati, P, 2006)

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (50.00)	29.6817
2010's	1 (50.00)	24.3611
2020's	0 (0.00)	2.80

Timeframe

Studies, this research(%)

All Research%

pre-1990

0 (0.00)

18.7374

1990's

0 (0.00)

18.2507

2000's

1 (50.00)

29.6817

2010's

1 (50.00)

24.3611

2020's

0 (0.00)

2.80

Authors

Authors	Studies
Szego, ÉM	1
Gerhardt, E	1
Outeiro, TF	1
Kermer, P	1
Caccia, C	1
Maj, R	1
Calabresi, M	1
Maestroni, S	1
Faravelli, L	1
Curatolo, L	1
Salvati, P	1
Fariello, RG	1

Studies

Szego, ÉM

Gerhardt, E

Outeiro, TF

Kermer, P

Caccia, C

Maj, R

Calabresi, M

Maestroni, S

Faravelli, L

Curatolo, L

Salvati, P

Fariello, RG

Clinical Trials (1)

Trial Overview

Trial	Phase	Enrollment	Study Type	Start Date	Status
"An Observational, Prospective, Multinational, Multicentre Study Comparing the Effectiveness of Safinamide, Rasagiline and Other Standard Of Care as Add-On Therapy to Levodopa (L-Dopa) in Parkinson's Disease (Pd) Fluctuating Patients"[NCT03994328]		1,235 participants (Actual)	Observational	2019-12-03	Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial

Phase

Enrollment

Study Type

Start Date

Status

"An Observational, Prospective, Multinational, Multicentre Study Comparing the Effectiveness of Safinamide, Rasagiline and Other Standard Of Care as Add-On Therapy to Levodopa (L-Dopa) in Parkinson's Disease (Pd) Fluctuating Patients"[NCT03994328]

1,235 participants (Actual)

Observational

2019-12-03

Active, not recruiting

[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for alanine and MPTP Neurotoxicity Syndrome

Article	Year
Safinamide: from molecular targets to a new anti-Parkinson drug. Neurology, 2006, Oct-10, Volume: 67, Issue:7 Suppl 2 Topics: Alanine; Animals; Antiparkinson Agents; Benzylamines; Brain Ischemia; Disease Models, Animal; Gerbil	2006

Article

Year

Safinamide: from molecular targets to a new anti-Parkinson drug.

Neurology, 2006, Oct-10, Volume: 67, Issue:7 Suppl 2

Topics: Alanine; Animals; Antiparkinson Agents; Benzylamines; Brain Ischemia; Disease Models, Animal; Gerbil

2006

Other Studies

1 other study available for alanine and MPTP Neurotoxicity Syndrome

Article	Year
Dopamine-depletion and increased α-synuclein load induce degeneration of cortical cholinergic fibers in mice. Journal of the neurological sciences, 2011, Nov-15, Volume: 310, Issue:1-2 Topics: Acetylcholinesterase; Alanine; alpha-Synuclein; Analysis of Variance; Animals; bcl-2-Associated X Pr	2011

Article

Year

Dopamine-depletion and increased α-synuclein load induce degeneration of cortical cholinergic fibers in mice.

Journal of the neurological sciences, 2011, Nov-15, Volume: 310, Issue:1-2

Topics: Acetylcholinesterase; Alanine; alpha-Synuclein; Analysis of Variance; Animals; bcl-2-Associated X Pr

2011