Page last updated: 2024-11-08

alanine and MELAS

alanine has been researched along with MELAS in 6 studies

Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.

Research Excerpts

ExcerptRelevanceReference
"Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome is a genetically heterogeneous disorder caused by mitochondrial DNA (mtDNA) mutations in the MT-TL1 gene."8.12Elevated glutamate and decreased glutamine levels in the cerebrospinal fluid of patients with MELAS syndrome. ( Arenas, J; Arranz-Canales, E; Delmiro, A; Domínguez-González, C; González de la Aleja, J; Guerrero-Molina, MP; Martín, MA; Morales-Conejo, M; Morán, M; Ramos-González, A, 2022)
"3243A>G variant is the most common heteroplasmic mitochondrial DNA mutation and underlies a spectrum of diseases, notably mitochondrial encephalomyopathy lactic acidosis and stroke-like episodes (MELAS)."5.41Circulating markers of NADH-reductive stress correlate with mitochondrial disease severity. ( Clish, CB; De Vivo, DC; Engelstad, K; Fryer, R; Haller, RG; Hirano, M; Khatri, A; Mao, X; Mootha, VK; Oglesbee, D; Pierce, K; Reinstadler, B; Sharma, R; Shungu, DC; Skinner, OS; Stackowitz, E; Walker, MA, 2021)
"Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome is a genetically heterogeneous disorder caused by mitochondrial DNA (mtDNA) mutations in the MT-TL1 gene."4.12Elevated glutamate and decreased glutamine levels in the cerebrospinal fluid of patients with MELAS syndrome. ( Arenas, J; Arranz-Canales, E; Delmiro, A; Domínguez-González, C; González de la Aleja, J; Guerrero-Molina, MP; Martín, MA; Morales-Conejo, M; Morán, M; Ramos-González, A, 2022)
"The MELAS has been related to mutation A3243G in most cases, but some other mitochondrial DNA mutations were described in the background of this syndrome as well."1.37A8344G mutation of the mitochondrial DNA with typical mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes syndrome. ( Gál, A; Lukács, T; Molnár, MJ; Reményi, V; Semjén, J; Valikovics, A; Vastagh, I, 2011)
"Cerebral focal lesions in MELAS might have a metabolic nature and several pathogenetic mechanisms might be involved in the genesis of stroke-like episodes when there is a local increased ATP demand."1.32MELAS: clinical phenotype and morphological brain abnormalities. ( Bartolomei, L; Cavallaro, T; Grauso, M; Morelli, L; Piscioli, F; Rizzuto, N; Simonati, A; Sparaco, M, 2003)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (33.33)29.6817
2010's2 (33.33)24.3611
2020's2 (33.33)2.80

Authors

AuthorsStudies
Guerrero-Molina, MP1
Morales-Conejo, M1
Delmiro, A1
Morán, M1
Domínguez-González, C1
Arranz-Canales, E1
Ramos-González, A1
Arenas, J1
Martín, MA1
González de la Aleja, J1
Sharma, R1
Reinstadler, B1
Engelstad, K1
Skinner, OS1
Stackowitz, E1
Haller, RG1
Clish, CB1
Pierce, K1
Walker, MA1
Fryer, R1
Oglesbee, D1
Mao, X1
Shungu, DC1
Khatri, A1
Hirano, M1
De Vivo, DC1
Mootha, VK1
Ikawa, M1
Arakawa, K1
Hamano, T1
Nagata, M1
Nakamoto, Y1
Kuriyama, M1
Koga, Y1
Yoneda, M1
Vastagh, I1
Gál, A1
Reményi, V1
Semjén, J1
Lukács, T1
Valikovics, A1
Molnár, MJ1
Latvala, T1
Mustonen, E1
Uusitalo, R1
Majamaa, K1
Sparaco, M1
Simonati, A1
Cavallaro, T1
Bartolomei, L1
Grauso, M1
Piscioli, F1
Morelli, L1
Rizzuto, N1

Trials

1 trial available for alanine and MELAS

ArticleYear
Circulating markers of NADH-reductive stress correlate with mitochondrial disease severity.
    The Journal of clinical investigation, 2021, 01-19, Volume: 131, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alanine; Biomarkers; Child; Child, Preschool; Female; Gr

2021

Other Studies

5 other studies available for alanine and MELAS

ArticleYear
Elevated glutamate and decreased glutamine levels in the cerebrospinal fluid of patients with MELAS syndrome.
    Journal of neurology, 2022, Volume: 269, Issue:6

    Topics: Adult; Alanine; Case-Control Studies; DNA, Mitochondrial; Female; Glutamic Acid; Glutamine; Humans;

2022
Evaluation of systemic redox states in patients carrying the MELAS A3243G mutation in mitochondrial DNA.
    European neurology, 2012, Volume: 67, Issue:4

    Topics: Adolescent; Adult; Alanine; Antioxidants; DNA, Mitochondrial; Female; Glycine; Humans; Hydrogen Pero

2012
A8344G mutation of the mitochondrial DNA with typical mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes syndrome.
    Ideggyogyaszati szemle, 2011, Nov-30, Volume: 64, Issue:11-12

    Topics: Acidosis, Lactic; Adult; Alanine; Brain Ischemia; DNA, Mitochondrial; Glycine; Humans; Male; MELAS S

2011
Pigmentary retinopathy in patients with the MELAS mutation 3243A-->G in mitochondrial DNA.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2002, Volume: 240, Issue:10

    Topics: Adult; Aged; Alanine; DNA, Mitochondrial; Eye Diseases; Female; Glycine; Humans; Male; MELAS Syndrom

2002
MELAS: clinical phenotype and morphological brain abnormalities.
    Acta neuropathologica, 2003, Volume: 106, Issue:3

    Topics: Adenosine Triphosphatases; Adult; Alanine; Brain; Carboxylic Ester Hydrolases; Child; DNA, Mitochond

2003