alanine has been researched along with MELAS in 6 studies
Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome is a genetically heterogeneous disorder caused by mitochondrial DNA (mtDNA) mutations in the MT-TL1 gene." | 8.12 | Elevated glutamate and decreased glutamine levels in the cerebrospinal fluid of patients with MELAS syndrome. ( Arenas, J; Arranz-Canales, E; Delmiro, A; Domínguez-González, C; González de la Aleja, J; Guerrero-Molina, MP; Martín, MA; Morales-Conejo, M; Morán, M; Ramos-González, A, 2022) |
| "3243A>G variant is the most common heteroplasmic mitochondrial DNA mutation and underlies a spectrum of diseases, notably mitochondrial encephalomyopathy lactic acidosis and stroke-like episodes (MELAS)." | 5.41 | Circulating markers of NADH-reductive stress correlate with mitochondrial disease severity. ( Clish, CB; De Vivo, DC; Engelstad, K; Fryer, R; Haller, RG; Hirano, M; Khatri, A; Mao, X; Mootha, VK; Oglesbee, D; Pierce, K; Reinstadler, B; Sharma, R; Shungu, DC; Skinner, OS; Stackowitz, E; Walker, MA, 2021) |
| "Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome is a genetically heterogeneous disorder caused by mitochondrial DNA (mtDNA) mutations in the MT-TL1 gene." | 4.12 | Elevated glutamate and decreased glutamine levels in the cerebrospinal fluid of patients with MELAS syndrome. ( Arenas, J; Arranz-Canales, E; Delmiro, A; Domínguez-González, C; González de la Aleja, J; Guerrero-Molina, MP; Martín, MA; Morales-Conejo, M; Morán, M; Ramos-González, A, 2022) |
| "The MELAS has been related to mutation A3243G in most cases, but some other mitochondrial DNA mutations were described in the background of this syndrome as well." | 1.37 | A8344G mutation of the mitochondrial DNA with typical mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes syndrome. ( Gál, A; Lukács, T; Molnár, MJ; Reményi, V; Semjén, J; Valikovics, A; Vastagh, I, 2011) |
| "Cerebral focal lesions in MELAS might have a metabolic nature and several pathogenetic mechanisms might be involved in the genesis of stroke-like episodes when there is a local increased ATP demand." | 1.32 | MELAS: clinical phenotype and morphological brain abnormalities. ( Bartolomei, L; Cavallaro, T; Grauso, M; Morelli, L; Piscioli, F; Rizzuto, N; Simonati, A; Sparaco, M, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 2 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Guerrero-Molina, MP | 1 |
| Morales-Conejo, M | 1 |
| Delmiro, A | 1 |
| Morán, M | 1 |
| Domínguez-González, C | 1 |
| Arranz-Canales, E | 1 |
| Ramos-González, A | 1 |
| Arenas, J | 1 |
| Martín, MA | 1 |
| González de la Aleja, J | 1 |
| Sharma, R | 1 |
| Reinstadler, B | 1 |
| Engelstad, K | 1 |
| Skinner, OS | 1 |
| Stackowitz, E | 1 |
| Haller, RG | 1 |
| Clish, CB | 1 |
| Pierce, K | 1 |
| Walker, MA | 1 |
| Fryer, R | 1 |
| Oglesbee, D | 1 |
| Mao, X | 1 |
| Shungu, DC | 1 |
| Khatri, A | 1 |
| Hirano, M | 1 |
| De Vivo, DC | 1 |
| Mootha, VK | 1 |
| Ikawa, M | 1 |
| Arakawa, K | 1 |
| Hamano, T | 1 |
| Nagata, M | 1 |
| Nakamoto, Y | 1 |
| Kuriyama, M | 1 |
| Koga, Y | 1 |
| Yoneda, M | 1 |
| Vastagh, I | 1 |
| Gál, A | 1 |
| Reményi, V | 1 |
| Semjén, J | 1 |
| Lukács, T | 1 |
| Valikovics, A | 1 |
| Molnár, MJ | 1 |
| Latvala, T | 1 |
| Mustonen, E | 1 |
| Uusitalo, R | 1 |
| Majamaa, K | 1 |
| Sparaco, M | 1 |
| Simonati, A | 1 |
| Cavallaro, T | 1 |
| Bartolomei, L | 1 |
| Grauso, M | 1 |
| Piscioli, F | 1 |
| Morelli, L | 1 |
| Rizzuto, N | 1 |
1 trial available for alanine and MELAS
| Article | Year |
|---|---|
Circulating markers of NADH-reductive stress correlate with mitochondrial disease severity.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alanine; Biomarkers; Child; Child, Preschool; Female; Gr | 2021 |
5 other studies available for alanine and MELAS
| Article | Year |
|---|---|
Elevated glutamate and decreased glutamine levels in the cerebrospinal fluid of patients with MELAS syndrome.
Topics: Adult; Alanine; Case-Control Studies; DNA, Mitochondrial; Female; Glutamic Acid; Glutamine; Humans; | 2022 |
Evaluation of systemic redox states in patients carrying the MELAS A3243G mutation in mitochondrial DNA.
Topics: Adolescent; Adult; Alanine; Antioxidants; DNA, Mitochondrial; Female; Glycine; Humans; Hydrogen Pero | 2012 |
A8344G mutation of the mitochondrial DNA with typical mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes syndrome.
Topics: Acidosis, Lactic; Adult; Alanine; Brain Ischemia; DNA, Mitochondrial; Glycine; Humans; Male; MELAS S | 2011 |
Pigmentary retinopathy in patients with the MELAS mutation 3243A-->G in mitochondrial DNA.
Topics: Adult; Aged; Alanine; DNA, Mitochondrial; Eye Diseases; Female; Glycine; Humans; Male; MELAS Syndrom | 2002 |
MELAS: clinical phenotype and morphological brain abnormalities.
Topics: Adenosine Triphosphatases; Adult; Alanine; Brain; Carboxylic Ester Hydrolases; Child; DNA, Mitochond | 2003 |