alanine has been researched along with Lung Neoplasms in 47 studies
Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.
Lung Neoplasms: Tumors or cancer of the LUNG.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Our aim was to study gluconeogenesis from alanine in lung cancer patients and to analyze its relation to the degree of weight loss." | 9.09 | Weight loss and elevated gluconeogenesis from alanine in lung cancer patients. ( Dagnelie, PC; Hordijk-Luijk, CH; Leij-Halfwerk, S; van Den Berg, JW; Wattimena, JD; Wilson, JP, 2000) |
| "We conducted parallel phase II trials of cimetidine as a single agent and the combination N-phosphonacetyl-L-aspartate (PALA) plus L-alanosine among 40 previously untreated patients with biopsy-proven, measurable disseminated malignant melanoma." | 9.06 | Phase II studies of single-agent cimetidine and the combination N-phosphonacetyl-L-aspartate (NSC-224131) plus L-alanosine (NSC-153353) in advanced malignant melanoma. ( Chang, M; Creagan, ET; Cullinan, SA; Ebbert, L; Mailliard, JA; Morton, RF; Veeder, MH, 1987) |
| "Our aim was to study gluconeogenesis from alanine in lung cancer patients and to analyze its relation to the degree of weight loss." | 5.09 | Weight loss and elevated gluconeogenesis from alanine in lung cancer patients. ( Dagnelie, PC; Hordijk-Luijk, CH; Leij-Halfwerk, S; van Den Berg, JW; Wattimena, JD; Wilson, JP, 2000) |
| "We conducted parallel phase II trials of cimetidine as a single agent and the combination N-phosphonacetyl-L-aspartate (PALA) plus L-alanosine among 40 previously untreated patients with biopsy-proven, measurable disseminated malignant melanoma." | 5.06 | Phase II studies of single-agent cimetidine and the combination N-phosphonacetyl-L-aspartate (NSC-224131) plus L-alanosine (NSC-153353) in advanced malignant melanoma. ( Chang, M; Creagan, ET; Cullinan, SA; Ebbert, L; Mailliard, JA; Morton, RF; Veeder, MH, 1987) |
| "Treatment with gefitinib alone for chemotherapy-naïve NSCLC patients with EGFR mutations could achieve a high efficacy with acceptable toxicity." | 2.72 | Prospective phase II study of gefitinib for chemotherapy-naive patients with advanced non-small-cell lung cancer with epidermal growth factor receptor gene mutations. ( Fukuhara, T; Inoue, A; Kimura, Y; Maemondo, M; Morikawa, N; Nukiwa, T; Saijo, Y; Suzuki, T; Watanabe, H, 2006) |
| "FGFR1 amplification in lung squamous cell carcinoma is required for the survival of FGFR1-amplified cell lines." | 2.49 | Role of FGF receptors as an emerging therapeutic target in lung squamous cell carcinoma. ( Cho, BC; Kim, HR; Lim, SM; Shim, HS; Soo, RA, 2013) |
| "A series of amino acid ester prodrugs of the dual VEGFR-2/FGFR-1 kinase inhibitor 1 (BMS-540215) was prepared in an effort to improve the aqueous solubility and oral bioavailability of the parent compound." | 1.35 | Discovery of brivanib alaninate ((S)-((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan-2-yl)2-aminopropanoate), a novel prodrug of dual vascular endothelial growth factor receptor-2 and fibroblast growth fa ( Barbosa, S; Barrish, JC; Bhide, RS; Borzilleri, RM; Cai, ZW; D'Arienzo, C; Derbin, G; Fan, J; Fargnoli, J; Hunt, JT; Jeyaseelan, R; Kamath, A; Kukral, DW; Lombardo, LJ; Marathe, P; Mortillo, S; Qian, L; Robl, JA; Shi, Z; Wautlet, BS; Wei, D; Wu, L; Zhang, Y; Zheng, X, 2008) |
| "To assess the effect on metastasis, XV454 was administered intravenous or orally 10 minutes and 3 hrs before tumor cell injection, respectively." | 1.32 | Inhibition of tumor cell-induced platelet aggregation and lung metastasis by the oral GpIIb/IIIa antagonist XV454. ( Amaya, M; Amirkhosravi, A; Blaydes, S; Desai, H; Francis, JL; Meyer, T; Mousa, SA, 2003) |
| " The inhibition of (+)-leader RNA and mRNA synthesis by wt C proteins (nonfusion) showed nearly identical dose-response curves, suggesting that inhibition occurs early in RNA synthesis." | 1.31 | Sendai virus wild-type and mutant C proteins show a direct correlation between L polymerase binding and inhibition of viral RNA synthesis. ( Grogan, CC; Moyer, SA, 2001) |
| "In patients with Pneumocystis carinii pneumonia, CPM activity was elevated to 26." | 1.29 | Carboxypeptidase M activity is increased in bronchoalveolar lavage in human lung disease. ( Becker, RP; Dragović, T; Erdös, EG; Schraufnagel, DE; Sekosan, M; Votta-Velis, EG, 1995) |
| "In lung cancer tissue, the activity of aminopeptidase toward L-leucinamide was abnormally low, while the activity of arylamidase toward L-leucyl-beta-napthylamide was similar to that in normal lung." | 1.25 | Aminopeptidases and arylamidases in normal and cancer tissues in humans. ( Arima, T; Fujii, S; Niinobe, M; Okuda, H; Tamura, Y, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (19.15) | 18.7374 |
| 1990's | 5 (10.64) | 18.2507 |
| 2000's | 14 (29.79) | 29.6817 |
| 2010's | 11 (23.40) | 24.3611 |
| 2020's | 8 (17.02) | 2.80 |
| Authors | Studies |
|---|---|
| Chiappori, AA | 1 |
| Creelan, B | 1 |
| Tanvetyanon, T | 1 |
| Gray, JE | 1 |
| Haura, EB | 1 |
| Thapa, R | 1 |
| Barlow, ML | 1 |
| Chen, Z | 1 |
| Chen, DT | 1 |
| Beg, AA | 1 |
| Boyle, TA | 1 |
| Castro, J | 1 |
| Morgan, L | 1 |
| Morris, E | 1 |
| Aregay, M | 1 |
| Hurtado, FK | 1 |
| Manenti, L | 1 |
| Antonia, S | 1 |
| Suksamai, D | 1 |
| Racha, S | 1 |
| Sriratanasak, N | 1 |
| Chaotham, C | 1 |
| Aphicho, K | 1 |
| Lin, ACK | 1 |
| Chansriniyom, C | 1 |
| Suwanborirux, K | 1 |
| Chamni, S | 1 |
| Chanvorachote, P | 1 |
| Kawashima, S | 1 |
| Yoshida, D | 1 |
| Yoshioka, T | 1 |
| Ogasawara, A | 1 |
| Fujita, K | 1 |
| Yanagiya, M | 1 |
| Nagano, M | 1 |
| Konoeda, C | 1 |
| Hino, H | 1 |
| Kitano, K | 1 |
| Sato, M | 1 |
| Hino, R | 1 |
| Kojima, R | 1 |
| Komatsu, T | 1 |
| Kamiya, M | 1 |
| Urano, Y | 1 |
| Nakajima, J | 1 |
| Lu, YY | 1 |
| Huang, X | 1 |
| Luo, ZC | 1 |
| Qi, MY | 1 |
| Shan, JJ | 1 |
| Zhang, W | 1 |
| DI, LQ | 1 |
| Caiola, E | 1 |
| Colombo, M | 1 |
| Sestito, G | 1 |
| Lupi, M | 1 |
| Marabese, M | 1 |
| Pastorelli, R | 1 |
| Broggini, M | 1 |
| Brunelli, L | 1 |
| Lee, JH | 1 |
| Yoo, SS | 1 |
| Hong, MJ | 1 |
| Choi, JE | 1 |
| Kim, S | 1 |
| Kang, HG | 1 |
| Do, SK | 1 |
| Kim, JH | 1 |
| Baek, SA | 1 |
| Lee, WK | 1 |
| Do Yoo, J | 1 |
| Choi, SH | 2 |
| Lee, YH | 1 |
| Seo, H | 1 |
| Lee, J | 1 |
| Lee, SY | 1 |
| Cha, SI | 1 |
| Kim, CH | 1 |
| Park, JY | 1 |
| Rogado, J | 1 |
| Gullón, P | 1 |
| Obispo, B | 1 |
| Serrano, G | 1 |
| Lara, MÁ | 1 |
| Lu, H | 1 |
| Li, Y | 2 |
| Zhang, H | 1 |
| Chingin, K | 1 |
| Wei, Y | 1 |
| Huang, K | 1 |
| Feng, S | 1 |
| Ishii, N | 1 |
| Kawano, Y | 1 |
| Sakai, H | 1 |
| Hayashi, S | 1 |
| Akizuki, N | 1 |
| Komoda, M | 1 |
| Hanawa, T | 1 |
| Videira, RA | 1 |
| Andrade, PB | 1 |
| Monteiro, LS | 1 |
| Valentão, P | 1 |
| Ferreira, PMT | 1 |
| Pereira, DM | 1 |
| Lim, SM | 1 |
| Kim, HR | 1 |
| Shim, HS | 1 |
| Soo, RA | 1 |
| Cho, BC | 1 |
| An, YJ | 1 |
| Cho, HR | 1 |
| Kim, TM | 1 |
| Keam, B | 1 |
| Kim, JW | 1 |
| Wen, H | 1 |
| Park, CK | 1 |
| Lee, SH | 1 |
| Im, SA | 1 |
| Kim, JE | 1 |
| Park, S | 1 |
| Kompella, SN | 1 |
| Hung, A | 1 |
| Clark, RJ | 1 |
| Marí, F | 1 |
| Adams, DJ | 1 |
| Lee, M | 1 |
| Venkitaraman, AR | 1 |
| Marostica, LL | 1 |
| de Barros, AL | 1 |
| Silva, JO | 1 |
| Lopes, SC | 1 |
| Salgado, BS | 1 |
| Chondrogiannis, S | 1 |
| Rubello, D | 1 |
| Cassali, GD | 1 |
| Schenkel, EP | 1 |
| Cardoso, VN | 1 |
| Simões, CM | 1 |
| Oliveira, MC | 1 |
| Knudtsen, IS | 1 |
| Svestad, JG | 1 |
| Skaug Sande, EP | 1 |
| Rekstad, BL | 1 |
| Rødal, J | 1 |
| van Elmpt, W | 1 |
| Öllers, M | 1 |
| Hole, EO | 1 |
| Malinen, E | 1 |
| Bushey, RT | 1 |
| Moody, MA | 1 |
| Nicely, NL | 1 |
| Haynes, BF | 1 |
| Alam, SM | 1 |
| Keir, ST | 1 |
| Bentley, RC | 1 |
| Roy Choudhury, K | 1 |
| Gottlin, EB | 1 |
| Campa, MJ | 1 |
| Liao, HX | 1 |
| Patz, EF | 1 |
| Deshmukh, M | 1 |
| Chao, P | 1 |
| Kutscher, HL | 1 |
| Gao, D | 1 |
| Sinko, PJ | 1 |
| Beuster, G | 1 |
| Zarse, K | 1 |
| Kaleta, C | 1 |
| Thierbach, R | 1 |
| Kiehntopf, M | 1 |
| Steinberg, P | 1 |
| Schuster, S | 1 |
| Ristow, M | 1 |
| Raffo, AJ | 1 |
| Drew, L | 1 |
| Mao, Y | 1 |
| Tran, A | 1 |
| Petrylak, DP | 1 |
| Fine, RL | 1 |
| Amirkhosravi, A | 1 |
| Mousa, SA | 1 |
| Amaya, M | 1 |
| Blaydes, S | 1 |
| Desai, H | 1 |
| Meyer, T | 1 |
| Francis, JL | 1 |
| DIETRICH, FS | 1 |
| COPE, C | 1 |
| RIVERS, S | 1 |
| KRANTZ, S | 1 |
| BAUM, G | 1 |
| BECK, HJ | 1 |
| RODENSKY, PL | 1 |
| Kittiniyom, K | 1 |
| Mastronardi, M | 1 |
| Roemer, M | 1 |
| Wells, WA | 1 |
| Greenberg, ER | 1 |
| Titus-Ernstoff, L | 1 |
| Newsham, IF | 1 |
| Wrensch, MR | 1 |
| Miike, R | 1 |
| Sison, JD | 1 |
| Kelsey, KT | 1 |
| Liu, M | 1 |
| McMillan, A | 1 |
| Quesenberry, C | 1 |
| Wiencke, JK | 1 |
| Mikawa, M | 1 |
| Wang, H | 1 |
| Guo, L | 1 |
| Liu, R | 1 |
| Marik, J | 1 |
| Takada, Y | 1 |
| Lam, K | 1 |
| Lau, D | 1 |
| Debniak, T | 1 |
| Scott, RJ | 1 |
| Huzarski, T | 1 |
| Byrski, T | 1 |
| Rozmiarek, A | 1 |
| Debniak, B | 1 |
| Górski, B | 1 |
| Cybulski, C | 1 |
| Medrek, K | 1 |
| Mierzejewski, M | 1 |
| Masojc, B | 1 |
| Matyjasik, J | 1 |
| Złowocka, E | 1 |
| Teodorczyk, U | 1 |
| Lener, M | 1 |
| Klujszo-Grabowska, E | 1 |
| Nej-Wołosiak, K | 1 |
| Jaworowska, E | 1 |
| Oszutowska, D | 1 |
| Szymańska, A | 1 |
| Szymańska, J | 1 |
| Castaneda, J | 1 |
| van de Wetering, T | 1 |
| Suchy, J | 1 |
| Kurzawski, G | 1 |
| Oszurek, O | 1 |
| Narod, S | 1 |
| Lubinski, J | 1 |
| Inoue, A | 1 |
| Suzuki, T | 1 |
| Fukuhara, T | 1 |
| Maemondo, M | 1 |
| Kimura, Y | 1 |
| Morikawa, N | 1 |
| Watanabe, H | 1 |
| Saijo, Y | 1 |
| Nukiwa, T | 1 |
| Cai, ZW | 1 |
| Zhang, Y | 1 |
| Borzilleri, RM | 1 |
| Qian, L | 1 |
| Barbosa, S | 1 |
| Wei, D | 1 |
| Zheng, X | 1 |
| Wu, L | 1 |
| Fan, J | 1 |
| Shi, Z | 1 |
| Wautlet, BS | 1 |
| Mortillo, S | 1 |
| Jeyaseelan, R | 1 |
| Kukral, DW | 1 |
| Kamath, A | 1 |
| Marathe, P | 1 |
| D'Arienzo, C | 1 |
| Derbin, G | 1 |
| Barrish, JC | 1 |
| Robl, JA | 1 |
| Hunt, JT | 1 |
| Lombardo, LJ | 1 |
| Fargnoli, J | 1 |
| Bhide, RS | 1 |
| Dragović, T | 1 |
| Schraufnagel, DE | 1 |
| Becker, RP | 1 |
| Sekosan, M | 1 |
| Votta-Velis, EG | 1 |
| Erdös, EG | 1 |
| Hori, H | 1 |
| Tran, P | 1 |
| Carrera, CJ | 1 |
| Hori, Y | 1 |
| Rosenbach, MD | 1 |
| Carson, DA | 1 |
| Nobori, T | 1 |
| Paranavitana, CM | 1 |
| Starkey, JR | 1 |
| Dai, S | 1 |
| Dratz, EA | 1 |
| Leij-Halfwerk, S | 4 |
| Dagnelie, PC | 3 |
| van Den Berg, JW | 3 |
| Wattimena, JD | 1 |
| Hordijk-Luijk, CH | 2 |
| Wilson, JP | 1 |
| Sijens, PE | 2 |
| Wilson, JH | 2 |
| Oudkerk, M | 2 |
| Agteresch, HJ | 1 |
| Dagneli, PC | 1 |
| Kappert, P | 1 |
| Grogan, CC | 1 |
| Moyer, SA | 1 |
| Wang, LI | 1 |
| Miller, DP | 1 |
| Sai, Y | 1 |
| Liu, G | 1 |
| Su, L | 1 |
| Wain, JC | 1 |
| Lynch, TJ | 1 |
| Christiani, DC | 1 |
| Tamura, Y | 1 |
| Niinobe, M | 1 |
| Arima, T | 1 |
| Okuda, H | 1 |
| Fujii, S | 1 |
| Jackson, D | 1 |
| Waibel, R | 1 |
| Weber, E | 1 |
| Bell, J | 1 |
| Stahel, RA | 1 |
| Kono, A | 1 |
| Hara, Y | 1 |
| Furusawa, M | 1 |
| Pizurki, L | 1 |
| Rizzoli, R | 1 |
| Moseley, J | 1 |
| Martin, TJ | 1 |
| Caverzasio, J | 1 |
| Bonjour, JP | 1 |
| Morton, RF | 1 |
| Creagan, ET | 1 |
| Cullinan, SA | 1 |
| Mailliard, JA | 1 |
| Ebbert, L | 1 |
| Veeder, MH | 1 |
| Chang, M | 1 |
| Heber, D | 1 |
| Byerly, LO | 1 |
| Chlebowski, RT | 1 |
| Spellman, CM | 1 |
| Fottrell, PF | 1 |
| Kellen, JA | 1 |
| Lustig, V | 1 |
| Bojan, O | 1 |
| Mustea, I | 1 |
| Preda, N | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase I/Ib Trial of Single Agent PBF-509 and in Combination With PDR001 for Patients With Advanced NSCLC[NCT02403193] | Phase 1 | 92 participants (Actual) | Interventional | 2015-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for alanine and Lung Neoplasms
| Article | Year |
|---|---|
Role of FGF receptors as an emerging therapeutic target in lung squamous cell carcinoma.
Topics: Alanine; Antineoplastic Agents; Benzimidazoles; Carcinoma, Squamous Cell; Gene Amplification; Humans | 2013 |
5 trials available for alanine and Lung Neoplasms
| Article | Year |
|---|---|
Phase I Study of Taminadenant (PBF509/NIR178), an Adenosine 2A Receptor Antagonist, with or without Spartalizumab (PDR001), in Patients with Advanced Non-Small Cell Lung Cancer.
Topics: Adenosine; Alanine; Antibodies, Monoclonal, Humanized; Aspartate Aminotransferases; Carcinoma, Non-S | 2022 |
Prospective phase II study of gefitinib for chemotherapy-naive patients with advanced non-small-cell lung cancer with epidermal growth factor receptor gene mutations.
Topics: Adult; Aged; Aged, 80 and over; Alanine; Antineoplastic Agents; Arginine; Carcinoma, Non-Small-Cell | 2006 |
Weight loss and elevated gluconeogenesis from alanine in lung cancer patients.
Topics: Aged; Alanine; Carbon Radioisotopes; Carcinoma, Non-Small-Cell Lung; Cross-Sectional Studies; Deuter | 2000 |
Effects of ATP infusion on glucose turnover and gluconeogenesis in patients with advanced non-small-cell lung cancer.
Topics: Adenosine Triphosphate; Aged; Alanine; Carcinoma, Non-Small-Cell Lung; Dose-Response Relationship, D | 2000 |
Phase II studies of single-agent cimetidine and the combination N-phosphonacetyl-L-aspartate (NSC-224131) plus L-alanosine (NSC-153353) in advanced malignant melanoma.
Topics: Alanine; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Cimetidine; Drug Evaluation; | 1987 |
41 other studies available for alanine and Lung Neoplasms
| Article | Year |
|---|---|
5-
Topics: Alanine; Apoptosis; Cell Line, Tumor; Cell Proliferation; Humans; Lung Neoplasms; Neoplastic Stem Ce | 2022 |
Rapid imaging of lung cancer using a red fluorescent probe to detect dipeptidyl peptidase 4 and puromycin-sensitive aminopeptidase activities.
Topics: Alanine; Aminopeptidases; Dipeptidyl Peptidase 4; Fluorescent Dyes; Glutamine; Humans; Lung Neoplasm | 2022 |
[Mechanism of Cordyceps militaris against non-small cell lung cancer: based on serum metabolomics].
Topics: Alanine; Animals; Arginine; Aspartic Acid; Carcinoma, Non-Small-Cell Lung; Cisplatin; Cordyceps; Glu | 2022 |
Glutaminase Inhibition on NSCLC Depends on Extracellular Alanine Exploitation.
Topics: Alanine; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Glutaminase; Humans; Lung Neoplasms | 2020 |
Impact of immune checkpoint gene CD155 Ala67Thr and CD226 Gly307Ser polymorphisms on small cell lung cancer clinical outcome.
Topics: Aged; Alanine; Amino Acid Substitution; Antigens, Differentiation, T-Lymphocyte; Carcinoma, Small Ce | 2021 |
Prolonged SARS-CoV-2 viral shedding in patients with solid tumours and associated factors.
Topics: Adenosine Monophosphate; Aged; Alanine; Antineoplastic Agents; Antiviral Agents; Breast Neoplasms; C | 2021 |
Direct quantitative profiling of amino acids in tissues for the assessment of lung cancer.
Topics: Alanine; Amino Acids; Humans; Isoleucine; Leucine; Lung Neoplasms; Lysine | 2021 |
Effects of a Rebamipide Mouthwash on Stomatitis Caused by Cancer Chemotherapy-Evaluation of the Efficacy by Patients Themselves.
Topics: Aged; Aged, 80 and over; Alanine; Antineoplastic Agents; Colorectal Neoplasms; Humans; Lung Neoplasm | 2017 |
Toxicity and structure-activity relationship (SAR) of α,β-dehydroamino acids against human cancer cell lines.
Topics: Alanine; Antineoplastic Agents; Apoptosis; Caspases; Cell Line; Cell Line, Tumor; Cell Shape; Drug D | 2018 |
An NMR metabolomics approach for the diagnosis of leptomeningeal carcinomatosis in lung adenocarcinoma cancer patients.
Topics: Adenocarcinoma; Alanine; Area Under Curve; Biomarkers, Tumor; Case-Control Studies; Citric Acid; Cre | 2015 |
Alanine scan of α-conotoxin RegIIA reveals a selective α3β4 nicotinic acetylcholine receptor antagonist.
Topics: Acetylcholine; Alanine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Conotoxins; Conus Snail; H | 2015 |
A cancer-associated mutation inactivates a region of the high-mobility group protein HMG20b essential for cytokinesis.
Topics: Alanine; BRCA2 Protein; Cytokinesis; DNA-Binding Proteins; HeLa Cells; High Mobility Group Proteins; | 2014 |
Feasibility study with 99mTc-HYNIC-βAla-Bombesin(7-14) as an agent to early visualization of lung tumour cells in nude mice.
Topics: A549 Cells; Alanine; Animals; Bombesin; Cell Transformation, Neoplastic; Feasibility Studies; Female | 2016 |
Validation of dose painting of lung tumours using alanine/EPR dosimetry.
Topics: Alanine; Electron Spin Resonance Spectroscopy; Fluorodeoxyglucose F18; Humans; Lung Neoplasms; Posit | 2016 |
A Therapeutic Antibody for Cancer, Derived from Single Human B Cells.
Topics: Alanine; Animals; Antibodies, Monoclonal; Autoantibodies; B-Lymphocytes; Cell Line, Tumor; Cell Prol | 2016 |
A series of alpha-amino acid ester prodrugs of camptothecin: in vitro hydrolysis and A549 human lung carcinoma cell cytotoxicity.
Topics: Alanine; Aminobutyrates; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Proliferation; Cell S | 2010 |
Inhibition of alanine aminotransferase in silico and in vivo promotes mitochondrial metabolism to impair malignant growth.
Topics: Adenosine Triphosphate; Adenylate Kinase; Alanine; Alanine Transaminase; Animals; Binding, Competiti | 2011 |
Fas-mediated apoptosis is dependent on wild-type p53 status in human cancer cells expressing a temperature-sensitive p53 mutant alanine-143.
Topics: Adenocarcinoma; Alanine; Antibodies, Monoclonal; Apoptosis; Caspase 3; Caspase 8; Caspase 9; Caspase | 2003 |
Inhibition of tumor cell-induced platelet aggregation and lung metastasis by the oral GpIIb/IIIa antagonist XV454.
Topics: Administration, Oral; Alanine; Animals; Carcinoma, Lewis Lung; Cell Line, Tumor; Drug Evaluation, Pr | 2003 |
Clinical trial with alanine mustard.
Topics: Alanine; Lung Neoplasms; Lymphoma; Mustard Plant; Nitrogen Mustard Compounds; Stomach Neoplasms | 1962 |
Allele-specific loss of heterozygosity at the DAL-1/4.1B (EPB41L3) tumor-suppressor gene locus in the absence of mutation.
Topics: Adult; Alanine; Alleles; Amino Acid Sequence; Amino Acid Substitution; Animals; Base Sequence; Breas | 2004 |
CYP1A1 variants and smoking-related lung cancer in San Francisco Bay area Latinos and African Americans.
Topics: Aged; Alanine; Black or African American; Case-Control Studies; Confounding Factors, Epidemiologic; | 2005 |
Novel peptide ligands for integrin alpha 4 beta 1 overexpressed in cancer cells.
Topics: Alanine; Animals; Binding Sites; Cell Adhesion; Cell Line; Cell Line, Tumor; Cell Proliferation; CHO | 2004 |
CDKN2A common variant and multi-organ cancer risk--a population-based study.
Topics: Adult; Aged; Alanine; Colorectal Neoplasms; Cyclin-Dependent Kinase Inhibitor p16; Female; Genes, p1 | 2006 |
Discovery of brivanib alaninate ((S)-((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan-2-yl)2-aminopropanoate), a novel prodrug of dual vascular endothelial growth factor receptor-2 and fibroblast growth fa
Topics: Administration, Oral; Alanine; Animals; Biological Availability; Carcinoma; Cell Proliferation; Clin | 2008 |
Carboxypeptidase M activity is increased in bronchoalveolar lavage in human lung disease.
Topics: Alanine; Arginine; Bronchoalveolar Lavage Fluid; Cell Count; Cell Membrane; Dansyl Compounds; Female | 1995 |
Methylthioadenosine phosphorylase cDNA transfection alters sensitivity to depletion of purine and methionine in A549 lung cancer cells.
Topics: Alanine; Antimetabolites, Antineoplastic; Drug Resistance, Neoplasm; Feasibility Studies; Genetic Ve | 1996 |
Non-radioactive detection of K-ras mutations by nested allele specific PCR and oligonucleotide hybridization.
Topics: Alanine; Amino Acid Substitution; Animals; Aspartic Acid; Breast Neoplasms; Codon; Colonic Neoplasms | 1998 |
Sidechain and backbone requirements for anti-invasive activity of laminin peptide 11.
Topics: Alanine; Animals; Basement Membrane; Drug Design; Female; Laminin; Lung Neoplasms; Magnetic Resonanc | 1998 |
Altered hepatic gluconeogenesis during L-alanine infusion in weight-losing lung cancer patients as observed by phosphorus magnetic resonance spectroscopy and turnover measurements.
Topics: Adult; Aged; Aged, 80 and over; Alanine; Carcinoma, Non-Small-Cell Lung; Female; Glucagon; Gluconeog | 2000 |
Decreased energy and phosphorylation status in the liver of lung cancer patients with weight loss.
Topics: Adenosine Triphosphate; Adult; Aged; Aged, 80 and over; Alanine; Carcinoma, Non-Small-Cell Lung; Ene | 2000 |
Sendai virus wild-type and mutant C proteins show a direct correlation between L polymerase binding and inhibition of viral RNA synthesis.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Base Sequence; Binding Sites; Humans; Lung Ne | 2001 |
Manganese superoxide dismutase alanine-to-valine polymorphism at codon 16 and lung cancer risk.
Topics: Adult; Age Factors; Aged; Alanine; Alleles; Case-Control Studies; Codon; Female; Genotype; Humans; L | 2001 |
Aminopeptidases and arylamidases in normal and cancer tissues in humans.
Topics: Alanine; Amides; Aminopeptidases; Colon; Digestive System; Humans; Ileum; Kidney; Leucine; Liver; Li | 1975 |
CD24, a signal-transducing molecule expressed on human B cells, is a major surface antigen on small cell lung carcinomas.
Topics: Alanine; Amino Acid Sequence; Animals; Antibodies, Monoclonal; Antigens, CD; Antigens, Neoplasm; Ant | 1992 |
[Effect of uracil on the both reactions, 5-fluorouracil degradation into 2-fluoro-beta-alanine and 5-fluorouracil splitting from tegafur in human tumor].
Topics: Adenocarcinoma, Papillary; Alanine; beta-Alanine; Fluorouracil; Humans; Lung Neoplasms; Tegafur; Tum | 1989 |
Effect of synthetic tumoral PTH-related peptide on cAMP production and Na-dependent Pi transport.
Topics: Alanine; Animals; Biological Transport; Carcinoma, Squamous Cell; Cyclic AMP; Humans; Kinetics; Lung | 1988 |
Metabolic abnormalities in the cancer patient.
Topics: Alanine; Amino Acids, Branched-Chain; Blood Glucose; Body Weight; Cachexia; Glucose Tolerance Test; | 1985 |
Similarities between pyruvate kinase from human placenta and tumours.
Topics: Adenosine Triphosphate; Alanine; Carcinoma; Chromatography, Gel; Chromatography, Ion Exchange; Elect | 1973 |
Patterns of amino-acid inhibition of alkaline phosphatases as an aid in cancer diagnosis.
Topics: Adenocarcinoma; Alanine; Alkaline Phosphatase; Amino Acids; Animals; Arginine; Colonic Neoplasms; Fe | 1971 |
[Modification of some free amino acids in the serum of cancer patients under the influence of glucose on tumoral metabolism].
Topics: Alanine; Amino Acids; Breast Neoplasms; Chromatography, Paper; Dietary Carbohydrates; Dietary Protei | 1969 |