alanine has been researched along with Liver Failure, Acute in 7 studies
Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.
Liver Failure, Acute: A form of rapid-onset LIVER FAILURE, also known as fulminant hepatic failure, caused by severe liver injury or massive loss of HEPATOCYTES. It is characterized by sudden development of liver dysfunction and JAUNDICE. Acute liver failure may progress to exhibit cerebral dysfunction even HEPATIC COMA depending on the etiology that includes hepatic ISCHEMIA, drug toxicity, malignant infiltration, and viral hepatitis such as post-transfusion HEPATITIS B and HEPATITIS C.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this prospective study of patients with fulminant hepatic failure (FHF), we tested the hypothesis that arterial hyperammonemia results in cerebral accumulation of the osmotic active amino acids glutamine and alanine, processes that were expected to correlate with intracranial pressure (ICP)." | 7.73 | Persistent arterial hyperammonemia increases the concentration of glutamine and alanine in the brain and correlates with intracranial pressure in patients with fulminant hepatic failure. ( Hansen, BA; Hauerberg, J; Jørgensen, L; Larsen, FS; Pedersen, CB; Tofteng, F, 2006) |
| "In this prospective study of patients with fulminant hepatic failure (FHF), we tested the hypothesis that arterial hyperammonemia results in cerebral accumulation of the osmotic active amino acids glutamine and alanine, processes that were expected to correlate with intracranial pressure (ICP)." | 3.73 | Persistent arterial hyperammonemia increases the concentration of glutamine and alanine in the brain and correlates with intracranial pressure in patients with fulminant hepatic failure. ( Hansen, BA; Hauerberg, J; Jørgensen, L; Larsen, FS; Pedersen, CB; Tofteng, F, 2006) |
| "In patients with acute liver failure, hyperammonemia is associated with cerebral herniation." | 1.31 | Splanchnic and leg exchange of amino acids and ammonia in acute liver failure. ( Clemmesen, JO; Kondrup, J; Ott, P, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 4 (57.14) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Carothers, C | 1 |
| Birrer, K | 1 |
| Vo, M | 1 |
| Chavarria, L | 1 |
| Romero-Giménez, J | 1 |
| Monteagudo, E | 1 |
| Lope-Piedrafita, S | 1 |
| Cordoba, J | 1 |
| Jeong, HG | 1 |
| You, HJ | 1 |
| Park, SJ | 1 |
| Moon, AR | 1 |
| Chung, YC | 1 |
| Kang, SK | 1 |
| Chun, HK | 1 |
| Chatauret, N | 1 |
| Zwingmann, C | 1 |
| Rose, C | 1 |
| Leibfritz, D | 1 |
| Butterworth, RF | 1 |
| Tofteng, F | 1 |
| Hauerberg, J | 1 |
| Hansen, BA | 1 |
| Pedersen, CB | 1 |
| Jørgensen, L | 1 |
| Larsen, FS | 1 |
| Maezono, K | 1 |
| Mawatari, K | 1 |
| Kajiwara, K | 1 |
| Shinkai, A | 1 |
| Maki, T | 1 |
| Clemmesen, JO | 1 |
| Kondrup, J | 1 |
| Ott, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Cerebral Microdialysis in Patients With Fulminant Hepatic Failure[NCT00836420] | 50 participants (Actual) | Observational | 2000-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 other studies available for alanine and Liver Failure, Acute
| Article | Year |
|---|---|
Acetylcysteine for the Treatment of Suspected Remdesivir-Associated Acute Liver Failure in COVID-19: A Case Series.
Topics: Acetylcysteine; Adenosine Monophosphate; Aged; Aged, 80 and over; Alanine; Antiviral Agents; COVID-1 | 2020 |
Real-time assessment of ¹³C metabolism reveals an early lactate increase in the brain of rats with acute liver failure.
Topics: Alanine; Animals; Brain; Carbon; Carbon Isotopes; Computer Systems; Disease Progression; Lactic Acid | 2015 |
Hepatoprotective effects of 18beta-glycyrrhetinic acid on carbon tetrachloride-induced liver injury: inhibition of cytochrome P450 2E1 expression.
Topics: Administration, Topical; Alanine; Animals; Anti-Inflammatory Agents; Ascorbic Acid; Aspartate Aminot | 2002 |
Effects of hypothermia on brain glucose metabolism in acute liver failure: a H/C-nuclear magnetic resonance study.
Topics: Alanine; Amino Acids; Animals; Brain; Citric Acid Cycle; Glucose; Hypothermia, Induced; Lactic Acid; | 2003 |
Persistent arterial hyperammonemia increases the concentration of glutamine and alanine in the brain and correlates with intracranial pressure in patients with fulminant hepatic failure.
Topics: Adolescent; Adult; Aged; Alanine; Brain; Female; Glutamine; Humans; Hyperammonemia; Intracranial Hyp | 2006 |
Effect of alanine on D-galactosamine-induced acute liver failure in rats.
Topics: Adenosine Triphosphate; Alanine; Animals; DNA; Galactosamine; Ketone Bodies; Liver; Liver Failure, A | 1996 |
Splanchnic and leg exchange of amino acids and ammonia in acute liver failure.
Topics: Adult; Alanine; Amino Acids; Ammonia; Blood Urea Nitrogen; Citrulline; Female; Femoral Artery; Femor | 2000 |