alanine has been researched along with Kidney Diseases in 40 studies
Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.
Kidney Diseases: Pathological processes of the KIDNEY or its component tissues.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The antiviral agent tenofovir is highly effective for the treatment of HIV and hepatitis B virus infections, and the older prodrug tenofovir disoproxil fumarate (TDF) is also a component of daily preexposure prophylaxis (PrEP) to reduce the risk of HIV infection in high-risk populations." | 4.98 | Potential kidney toxicity from the antiviral drug tenofovir: new indications, new formulations, and a new prodrug. ( Asriel, B; Chan, L; Eaton, EF; Wyatt, CM, 2018) |
| " Recommendations were made based on available data, consideration of pharmacokinetic properties (including variability), the dosing and anticipated treatment duration of each regimen in COVID-19 and known toxicities." | 2.72 | Recommendations for Dosing of Repurposed COVID-19 Medications in Patients with Renal and Hepatic Impairment. ( Back, D; Boyle, A; Burger, D; Davidson, K; El-Sherif, O; Gibbons, S; Khoo, S; Marra, F; Marzolini, C; Siccardi, M; Smolders, EJ; Sommerville, AJ, 2021) |
| "In individuals with a history of PRT on TDF, 96 weeks of TAF was not associated with recurrent PRT or adverse effects on renal tubular function, bone turnover, or BMD." | 1.62 | Safety of Tenofovir Alafenamide in People With HIV Who Experienced Proximal Renal Tubulopathy on Tenofovir Disoproxil Fumarate. ( Barbini, B; Burling, K; Campbell, L; Cromarty, B; Hamzah, L; Johnson, M; Jones, R; Post, FA; Samarawickrama, A; Williams, D; Winston, A, 2021) |
| "Use of nonsteroidal anti-inflammatory drugs (NSAIDs) is primarily limited by renal and gastrointestinal adverse effects." | 1.39 | Effects of rebamipide on nephrotoxicity associated with selected NSAIDs in rats. ( Bullins, KW; Denham, JW; Hanley, AV; Hanley, GA; Harirforoosh, S; Panus, PC; Wood, RC; Wyatt, JE, 2013) |
| "3." | 1.31 | High-resolution magic angle spinning 1H-NMR spectroscopy studies on the renal biochemistry in the bank vole (Clethrionomys glareolus) and the effects of arsenic (As3+) toxicity. ( Griffin, JL; Nicholson, JK; Shore, RF; Walker, L, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (47.50) | 18.7374 |
| 1990's | 4 (10.00) | 18.2507 |
| 2000's | 3 (7.50) | 29.6817 |
| 2010's | 7 (17.50) | 24.3611 |
| 2020's | 7 (17.50) | 2.80 |
| Authors | Studies |
|---|---|
| Campbell, L | 2 |
| Barbini, B | 2 |
| Burling, K | 2 |
| Cromarty, B | 1 |
| Hamzah, L | 2 |
| Johnson, M | 1 |
| Jones, R | 2 |
| Samarawickrama, A | 1 |
| Williams, D | 2 |
| Winston, A | 1 |
| Post, FA | 2 |
| Sukeishi, A | 1 |
| Itohara, K | 1 |
| Yonezawa, A | 1 |
| Sato, Y | 1 |
| Matsumura, K | 1 |
| Katada, Y | 1 |
| Nakagawa, T | 1 |
| Hamada, S | 1 |
| Tanabe, N | 1 |
| Imoto, E | 1 |
| Kai, S | 1 |
| Hirai, T | 1 |
| Yanagita, M | 1 |
| Ohtsuru, S | 1 |
| Terada, T | 1 |
| Ito, I | 1 |
| Cheng, M | 1 |
| Fowler, R | 1 |
| Murthy, S | 1 |
| Pinto, R | 1 |
| Sheehan, NL | 1 |
| Tseng, A | 1 |
| Bailey, AC | 1 |
| Ibrahim, F | 1 |
| Musso, CG | 1 |
| Lee, CJ | 1 |
| Qiu, TA | 1 |
| Sweedler, JV | 1 |
| Surial, B | 1 |
| Béguelin, C | 1 |
| Chave, JP | 1 |
| Stöckle, M | 1 |
| Boillat-Blanco, N | 1 |
| Doco-Lecompte, T | 1 |
| Bernasconi, E | 1 |
| Fehr, J | 1 |
| Günthard, HF | 1 |
| Schmid, P | 1 |
| Walti, LN | 1 |
| Furrer, H | 1 |
| Rauch, A | 1 |
| Wandeler, G | 1 |
| Marra, F | 1 |
| Smolders, EJ | 1 |
| El-Sherif, O | 1 |
| Boyle, A | 1 |
| Davidson, K | 1 |
| Sommerville, AJ | 1 |
| Marzolini, C | 1 |
| Siccardi, M | 1 |
| Burger, D | 1 |
| Gibbons, S | 1 |
| Khoo, S | 1 |
| Back, D | 1 |
| Gallagher, A | 1 |
| Quan, D | 1 |
| Gracey, DM | 1 |
| Novick, TK | 1 |
| Choi, MJ | 1 |
| Rosenberg, AZ | 1 |
| McMahon, BA | 1 |
| Fine, D | 1 |
| Atta, MG | 1 |
| Chan, L | 1 |
| Asriel, B | 1 |
| Eaton, EF | 1 |
| Wyatt, CM | 1 |
| Negredo, E | 1 |
| Clotet, B | 1 |
| Fong, TL | 1 |
| Lee, BT | 1 |
| Tien, A | 1 |
| Chang, M | 1 |
| Lim, C | 1 |
| Ahn, A | 1 |
| Bae, HS | 1 |
| Wood, RC | 1 |
| Wyatt, JE | 1 |
| Bullins, KW | 1 |
| Hanley, AV | 1 |
| Hanley, GA | 1 |
| Denham, JW | 1 |
| Panus, PC | 1 |
| Harirforoosh, S | 1 |
| Zou, ZJ | 1 |
| Xie, YY | 1 |
| Gong, MJ | 1 |
| Han, B | 1 |
| Wang, SM | 1 |
| Liang, SW | 1 |
| KMETEC, E | 1 |
| HEYMANN, W | 1 |
| CUPPAGE, F | 1 |
| LEWY, P | 1 |
| Ozkaya, O | 1 |
| Söylemezoğlu, O | 1 |
| Gönen, S | 1 |
| Misirlioğlu, M | 1 |
| Tuncer, S | 1 |
| Kalman, S | 1 |
| Buyan, N | 1 |
| Hasanoğlu, E | 1 |
| Klingensmith, WC | 2 |
| Fritzberg, AR | 2 |
| Spitzer, VM | 2 |
| Johnson, DL | 1 |
| Kuni, CC | 2 |
| Williamson, MR | 1 |
| Washer, G | 1 |
| Weil, R | 1 |
| Hirouchi, Y | 1 |
| Naganuma, H | 1 |
| Kawahara, Y | 1 |
| Okada, R | 1 |
| Kamiya, A | 1 |
| Inui, K | 1 |
| Hori, R | 1 |
| Endre, ZH | 1 |
| Cowin, GJ | 1 |
| Stewart-Richardson, P | 1 |
| Cross, M | 1 |
| Willgoss, DA | 1 |
| Duggleby, RG | 1 |
| Anthony, ML | 1 |
| Beddell, CR | 1 |
| Lindon, JC | 1 |
| Nicholson, JK | 2 |
| Imai, K | 1 |
| Fukushima, T | 1 |
| Santa, T | 1 |
| Homma, H | 1 |
| Huang, Y | 1 |
| Sakai, K | 1 |
| Kato, M | 1 |
| Griffin, JL | 1 |
| Walker, L | 1 |
| Shore, RF | 1 |
| Rankin, GO | 1 |
| Hong, SK | 1 |
| Anestis, DK | 1 |
| Henderson, TT | 1 |
| Ball, JG | 1 |
| Valentovic, MA | 1 |
| Brown, PI | 1 |
| Thiele, KG | 1 |
| Scherberich, JE | 2 |
| Mondorf, WA | 1 |
| van der Helm, HJ | 1 |
| Hische, EA | 1 |
| Bannister, DW | 1 |
| Evans, AJ | 1 |
| Whitehead, CC | 1 |
| Burchardt, U | 3 |
| Haschen, RJ | 2 |
| Krosch, H | 1 |
| Mondorf, AW | 2 |
| Soini, I | 1 |
| Vorne, M | 1 |
| Karhunen, M | 1 |
| Latteier, JL | 1 |
| Parrish, AE | 1 |
| Zikria, M | 1 |
| Kenney, RA | 1 |
| Falkenberg, FW | 1 |
| Müller, H | 1 |
| Pfleiderer, G | 1 |
| Mampel, E | 2 |
| Woodard, JC | 1 |
| Short, DD | 1 |
| Peters, JE | 1 |
| Schneider, I | 1 |
| Fukala, E | 1 |
| Ahrens, I | 1 |
| Dotchev, D | 1 |
| Hungerland, H | 1 |
| Liappis, N | 1 |
| Baumgartner, R | 1 |
| Scheidegger, S | 1 |
| Stalder, G | 1 |
| Hottinger, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Multi-centre, Adaptive, Randomized, Open-label, Controlled Clinical Trial of the Safety and Efficacy of Investigational Therapeutics for the Treatment of COVID-19 in Hospitalized Patients (CATCO: Canadian Treatments for COVID-19), in Conjunction With th[NCT04330690] | Phase 3 | 2,900 participants (Anticipated) | Interventional | 2020-03-18 | Active, not recruiting | ||
| Prospective Cohort Study to Assess the Safety and Efficacy of Replacing Tenofovir Disoproxil Fumarate by Tenofovir Alafenamide in HIV/HBV-coinfected Patients With Mild or Moderate Renal Dysfunction[NCT03115736] | Phase 2 | 24 participants (Actual) | Interventional | 2017-05-23 | Completed | ||
| "Analysis of Proximal Renal Tubular Function of Real World Chronic Hepatitis B (CHB) Patients Who Are Suppressed on TDF and Switched to TAF"[NCT02957994] | Phase 4 | 82 participants (Actual) | Interventional | 2016-12-22 | Active, not recruiting | ||
| The Effects of Vitamin D and Calcium Supplementation to Parathyroid Hormone in CHB Patients Treated With Tenofovir Disoproxil Fumarate[NCT05313477] | Phase 4 | 64 participants (Anticipated) | Interventional | 2022-05-01 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for alanine and Kidney Diseases
| Article | Year |
|---|---|
d-Alanine: Distribution, origin, physiological relevance, and implications in disease.
Topics: Alanine; Animals; Diabetes Mellitus; Humans; Kidney Diseases; Liver Cirrhosis; Mental Disorders; Neo | 2020 |
Recommendations for Dosing of Repurposed COVID-19 Medications in Patients with Renal and Hepatic Impairment.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Clinical Trials as Topic; COVID-19; COVID-19 Dru | 2021 |
Potential kidney toxicity from the antiviral drug tenofovir: new indications, new formulations, and a new prodrug.
Topics: Adenine; Alanine; Antiviral Agents; Bone Density; Drug Interactions; Glomerular Filtration Rate; Hep | 2018 |
Distribution of free D-amino acids in tissues and body fluids of vertebrates.
Topics: Alanine; Animals; Aspartic Acid; Humans; Kidney Diseases; Receptors, N-Methyl-D-Aspartate; Serine; S | 1997 |
[Determination of urinary enzyme activities in kidney diseases].
Topics: Acetylglucosaminidase; Acute Disease; Alanine; Alkaline Phosphatase; Chronic Disease; gamma-Glutamyl | 1976 |
Processed protein foods and lysinoalanine.
Topics: Alanine; Animals; Cooking; Dietary Proteins; Dipeptides; Foodborne Diseases; Humans; Kidney Diseases | 1976 |
Nutritional value of alkali-treated soy protein.
Topics: Alanine; Animal Nutritional Physiological Phenomena; Animals; Dipeptides; Female; Glycine max; Hydro | 1973 |
2 trials available for alanine and Kidney Diseases
| Article | Year |
|---|---|
Remdesivir in Patients With Severe Kidney Dysfunction: A Secondary Analysis of the CATCO Randomized Trial.
Topics: Adenosine Monophosphate; Alanine; Humans; Kidney; Kidney Diseases | 2022 |
Early safety of tenofovir alafenamide in patients with a history of tubulopathy on tenofovir disoproxil fumarate: a randomized controlled clinical trial.
Topics: Adenine; Alanine; Creatinine; Drug Administration Schedule; Drug Therapy, Combination; Emtricitabine | 2020 |
31 other studies available for alanine and Kidney Diseases
| Article | Year |
|---|---|
Safety of Tenofovir Alafenamide in People With HIV Who Experienced Proximal Renal Tubulopathy on Tenofovir Disoproxil Fumarate.
Topics: Adenine; Adult; Alanine; Anti-HIV Agents; Creatinine; Cystatin C; Female; HIV Infections; Humans; Ki | 2021 |
Population pharmacokinetic modeling of GS-441524, the active metabolite of remdesivir, in Japanese COVID-19 patients with renal dysfunction.
Topics: Adenosine; Adenosine Monophosphate; Aged; Aged, 80 and over; Alanine; Body Surface Area; COVID-19; C | 2022 |
Brief Report: Switching From TDF to TAF in HIV/HBV-Coinfected Individuals With Renal Dysfunction-A Prospective Cohort Study.
Topics: Adenine; Aged; Alanine; Anti-HIV Agents; Female; Glomerular Filtration Rate; Hepatitis B; Hepatitis | 2020 |
Improvement in renal function and resolution of proteinuria in an HIV-infected patient switched from tenofovir disoproxil fumarate to tenofovir alafenamide.
Topics: Adenine; Alanine; Antiviral Agents; Drug Substitution; Female; HIV Infections; Humans; Kidney Diseas | 2017 |
Tenofovir alafenamide nephrotoxicity in an HIV-positive patient: A case report.
Topics: Adenine; Alanine; Anti-HIV Agents; HIV Infections; Humans; Kidney Diseases; Male; Middle Aged; Mitoc | 2017 |
Efficacy of single-tablet darunavir, cobicistat, emtricitabine, and tenofovir alafenamide in the treatment of HIV-1.
Topics: Adenine; Alanine; Anti-HIV Agents; Clinical Trials as Topic; Cobicistat; Darunavir; Drug Resistance, | 2018 |
Improvement of bone mineral density and markers of proximal renal tubular function in chronic hepatitis B patients switched from tenofovir disoproxil fumarate to tenofovir alafenamide.
Topics: Adenine; Adolescent; Adult; Aged; Aged, 80 and over; Alanine; Bone Density; Drug Substitution; Femal | 2019 |
Improvement of bone mineral density and markers of proximal renal tubular function in chronic hepatitis B patients switched from tenofovir disoproxil fumarate to tenofovir alafenamide.
Topics: Adenine; Adolescent; Adult; Aged; Aged, 80 and over; Alanine; Bone Density; Drug Substitution; Femal | 2019 |
Improvement of bone mineral density and markers of proximal renal tubular function in chronic hepatitis B patients switched from tenofovir disoproxil fumarate to tenofovir alafenamide.
Topics: Adenine; Adolescent; Adult; Aged; Aged, 80 and over; Alanine; Bone Density; Drug Substitution; Femal | 2019 |
Improvement of bone mineral density and markers of proximal renal tubular function in chronic hepatitis B patients switched from tenofovir disoproxil fumarate to tenofovir alafenamide.
Topics: Adenine; Adolescent; Adult; Aged; Aged, 80 and over; Alanine; Bone Density; Drug Substitution; Femal | 2019 |
Effects of rebamipide on nephrotoxicity associated with selected NSAIDs in rats.
Topics: Alanine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Celecoxib; Cell Adhesi | 2013 |
[Urine metabonomic study of intervention effects of Morinda officinalis how. on 'kidney-yang deficiency syndrome'].
Topics: Alanine; Animals; Betaine; Biomarkers; Citric Acid; Drugs, Chinese Herbal; Hydrocortisone; Ketogluta | 2013 |
RESPIRATION OF RAT KIDNEY CORTEX SLICES IN EXPERIMENTAL PROTEINURIA AND RENALE DISEASE.
Topics: Alanine; Animals; Autoimmune Diseases; Blood Chemical Analysis; Cattle; Freund's Adjuvant; Fructose; | 1964 |
Renin-angiotensin system gene polymorphisms: association with susceptibility to Henoch-Schonlein purpura and renal involvement.
Topics: Adolescent; Alanine; Angiotensinogen; Child; Child, Preschool; Cysteine; DNA Transposable Elements; | 2006 |
Clinical evaluation of Tc-99m N,N'-bis(mercaptoacetyl)-2,3-diaminopropanoate as a replacement for I-131 hippurate: concise communication.
Topics: Alanine; beta-Alanine; Computers; Computers, Analog; Hippurates; Humans; Iodine Radioisotopes; Kidne | 1984 |
Preventive effect of betamipron on nephrotoxicity and uptake of carbapenems in rabbit renal cortex.
Topics: Alanine; Animals; Carbapenems; Glycosuria, Renal; Imipenem; In Vitro Techniques; Kidney Cortex; Kidn | 1994 |
23Na NMR detects protection by glycine and alanine against hypoxic injury in the isolated perfused rat kidney.
Topics: Alanine; Animals; Glycine; Hypoxia; In Vitro Techniques; Kidney Diseases; Magnetic Resonance Spectro | 1994 |
Raised transaminase activity of blood plasma from rats with experimentally-induced kidney damage detected by spin-echo 1H-NMR spectroscopy.
Topics: Alanine; Animals; Cephaloridine; Kidney Diseases; Magnetic Resonance Spectroscopy; Male; Rats; Rats, | 1993 |
High-resolution magic angle spinning 1H-NMR spectroscopy studies on the renal biochemistry in the bank vole (Clethrionomys glareolus) and the effects of arsenic (As3+) toxicity.
Topics: Alanine; Animals; Arsenic; Arvicolinae; Creatine; Glutamic Acid; Glutamine; Kidney; Kidney Diseases; | 2001 |
Effect of three n-acetylamino acids on N-(3,5-dichlorophenyl)succinimide (NDPS) and ndps metabolite nephrotoxicity in Fischer 344 rats.
Topics: Acetylcysteine; Alanine; Amino Acids; Animals; Fungicides, Industrial; Injections, Intraperitoneal; | 2002 |
Excretion of kidney brush border antigens as a quantitative indicator of tubular damage.
Topics: Alanine; Alkaline Phosphatase; Aminopeptidases; Antigens; Cell Membrane; Fluorescent Antibody Techni | 1979 |
Screening hypertensive patients for renal disease: Lessons from Bayes' theorem.
Topics: Acetylglucosaminidase; Alanine; Aminopeptidases; Bayes Theorem; Diagnostic Errors; Evaluation Studie | 1979 |
Evidence for a lesion in carbohydrate metabolism in fatty liver and kidney syndrome in chicks.
Topics: Alanine; Animals; Biotin; Carbohydrate Metabolism; Chickens; Fatty Liver; Fructosephosphates; Glucon | 1975 |
Clinical usefulness of enzyme determinations in urine.
Topics: Alanine; Aminopeptidases; Clinical Laboratory Techniques; Disease; Enzymes; Glucuronidase; Humans; K | 1979 |
Investigations on the potential nephrotoxicity of cefazedone and gentamicin and of their combination, in comparison with the combination of cefazolin and cephalothin with gentamicin.
Topics: Adolescent; Adult; Alanine; Aminopeptidases; Cefazolin; Cephalosporins; Cephalothin; Creatinine; Dru | 1979 |
[New indications of kidney function by gamma imaging].
Topics: Adult; Aged; Aged, 80 and over; Alanine; beta-Alanine; Female; Humans; Iodohippuric Acid; Kidney Dis | 1989 |
Clinical comparison of technetium-99m-N,N-bis(mercaptoacetyl)-2,3-diaminopropanoate with technetium-99m DTPA for renal imaging.
Topics: Alanine; beta-Alanine; Humans; Kidney; Kidney Diseases; Organotechnetium Compounds; Pentetic Acid; R | 1985 |
Oxygen uptake in exercising subjects with minimal renal disease.
Topics: Adult; Alanine; Humans; Kidney Diseases; Lactates; Middle Aged; Oxygen Consumption; Physical Exertio | 1985 |
Biochemical and immunological studies on isolated brush border membranes of human kidney cortex and their membrane surface proteins.
Topics: Alanine; Alkaline Phosphatase; Aminopeptidases; Animals; Cell Membrane; Centrifugation, Density Grad | 1974 |
[Behavior of alanine aminopeptidase excretion after administration of Visotrast as diagnostic means].
Topics: Alanine; Aminopeptidases; Cholangitis; Cholelithiasis; Contrast Media; Hodgkin Disease; Humans; Kidn | 1974 |
Toxicity of alkali-treated soyprotein in rats.
Topics: Alanine; Amino Acids; Animals; Chromatography, Ion Exchange; Chromatography, Thin Layer; Drug Stabil | 1973 |
[Alanine aminopeptidase in urine in renal diseases].
Topics: Adolescent; Adult; Aged; Alanine; Aminopeptidases; Child; Child, Preschool; Chronic Disease; Electro | 1972 |
[Free amino acids in the blood serum of patients with endemic (balkan) nephropathy].
Topics: Adult; Aged; Alanine; Amino Acids; Autoanalysis; Bulgaria; Female; Humans; Kidney Diseases; Male; Mi | 1972 |
[Argininosuccinic aciduria disease of the newborn with lethal course].
Topics: Adult; Alanine; Amino Acids; Aminobutyrates; Anticonvulsants; Aspartic Acid; Brain Diseases; Chromat | 1968 |