Page last updated: 2024-11-08

alanine and Hyperglycemia

alanine has been researched along with Hyperglycemia in 65 studies

Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.

Hyperglycemia: Abnormally high BLOOD GLUCOSE level.

Research Excerpts

ExcerptRelevanceReference
"The following evidence suggests that diabetes mellitus may not be the simple consequence of relative or absolute insulin deficiency by itself, but may require the presence of glucagon: (1) relative or absolute hyperglucogonaemia has been identified in every form of endogenous hyperglycaemia, including total pancreatectomy in dogs; (2) insulin lack in the absence of glucagon does not cause endogenous hyperglycaemia, but when endogenous or exogenous glucagon is present, it quickly appears, irrespective of insulin levels at the time."7.65The essential role of glucagon in the pathogenesis of diabetes mellitus. ( Orci, L; Unger, RH, 1975)
"To evaluate the role of glucagon in the pathogenesis of diabetic ketoacidosis in man, we studied the effect of suppression of glucagon secretion by somatostatin on changes in plasma beta-hydroxybutyrate and glucose concentrations (as well as changes in their precursors) after acute withdrawal of insulin from seven patients with juvenile-type diabetes."7.65Prevention of human diabetic ketoacidosis by somatostatin. Evidence for an essential role of glucagon. ( Bier, DM; Forsham, PH; Gerich, JE; Karam, JH; Lorenzi, M; Schneider, V; Tsalikian, E, 1975)
"To assess the role of muscle and liver in the pathogenesis of postprandial hyperglycemia in non-insulin-dependent diabetes mellitus (NIDDM), we administered an oral glucose load enriched with [14C]glucose to 10 NIDDM subjects and 10 age- and weight-matched nondiabetic volunteers and compared muscle glucose disposal by measuring forearm balance of glucose, lactate, alanine, O2, and CO2 (with forearm calorimetry)."5.06Contribution of abnormal muscle and liver glucose metabolism to postprandial hyperglycemia in NIDDM. ( Gerich, J; Jenssen, T; Kelley, D; Mitrakou, A; Pangburn, T; Reilly, J; Veneman, T, 1990)
" An INS mutation, at the position 2 alanine-to-threonine substitution (A2T), was identified and co-segregated with hyperglycemia in a MODY pedigree."3.96Identification of Ala2Thr mutation in insulin gene from a Chinese MODY10 family. ( Chen, Y; Ge, X; Huang, X; Jiang, M; Li, M; Liu, L; Liu, Y; Lu, M; Song, M; Wang, F; Wang, Y; Yang, D; Yin, J; Zhang, J; Zhang, R, 2020)
" Each study consisted of an equilibration (-140 to -40 min), a control (-40 to 0 min), and a test period (0 to 180 min), during which BAY R3401 (10 mg/kg), a glycogen phosphorylase inhibitor, was administered orally, either alone to create mild hypoglycemia or with peripheral glucose infusion to maintain euglycemia or create mild hyperglycemia."3.71Alpha- and beta-cell responses to small changes in plasma glucose in the conscious dog. ( Cherrington, AD; Emshwiller, MG; Flattem, N; Igawa, K; Neal, DW; Shiota, M, 2001)
"To determine the contribution of skeletal muscle to fasting hyperglycemia in noninsulin dependent type II diabetes (NIDDM), the forearm balance of glucose, lactate, and alanine was quantified in 25 control subjects, 21 hyperglycemic (blood glucose: 11."3.68Glucose and gluconeogenic substrate exchange by the forearm skeletal muscle in hyperglycemic and insulin-treated type II diabetic patients. ( Albano, G; Capaldo, B; Di Bonito, P; Napoli, R; Saccà, L, 1990)
"To study the effects of hyperglycemia on the metabolism of alanine and lactate independent of changes in plasma insulin and glucagon, glucose was infused into five 36-h-fasted dogs along with somatostatin and constant replacement amounts of both insulin and glucagon."3.66Effect of glucose, independent of changes in insulin and glucagon secretion, on alanine metabolism in the conscious dog. ( Cherrington, AD; Keller, U; Lacy, WW; Liljenquist, JE; Shulman, GI; Williams, PE, 1980)
"The following evidence suggests that diabetes mellitus may not be the simple consequence of relative or absolute insulin deficiency by itself, but may require the presence of glucagon: (1) relative or absolute hyperglucogonaemia has been identified in every form of endogenous hyperglycaemia, including total pancreatectomy in dogs; (2) insulin lack in the absence of glucagon does not cause endogenous hyperglycaemia, but when endogenous or exogenous glucagon is present, it quickly appears, irrespective of insulin levels at the time."3.65The essential role of glucagon in the pathogenesis of diabetes mellitus. ( Orci, L; Unger, RH, 1975)
"To evaluate the role of glucagon in the pathogenesis of diabetic ketoacidosis in man, we studied the effect of suppression of glucagon secretion by somatostatin on changes in plasma beta-hydroxybutyrate and glucose concentrations (as well as changes in their precursors) after acute withdrawal of insulin from seven patients with juvenile-type diabetes."3.65Prevention of human diabetic ketoacidosis by somatostatin. Evidence for an essential role of glucagon. ( Bier, DM; Forsham, PH; Gerich, JE; Karam, JH; Lorenzi, M; Schneider, V; Tsalikian, E, 1975)
" In addition, we describe acute effect of CS-917 on fasting hyperglycemia in overnight-fasted GK rats and chronic effect of CS-917 in multiple dosing GK rats."1.35CS-917, a fructose 1,6-bisphosphatase inhibitor, improves postprandial hyperglycemia after meal loading in non-obese type 2 diabetic Goto-Kakizaki rats. ( Fujiwara, T; Hagisawa, Y; Izumi, M; Ohsumi, J; Okuno, A; Takahashi, K; Yoshida, T, 2008)
"Thus in type 2 diabetes, postprandial hyperglycemia is primarily due to increased glucose release; hyperglycemia overcomes the effects of impaired insulin secretion and sensitivity on glucose transport, but intracellular defects persist so that pathways of glucose metabolism are abnormal and glucose is shunted away from normal sites of storage (e."1.33Mechanisms for abnormal postprandial glucose metabolism in type 2 diabetes. ( Dostou, JM; Gerich, JE; Gosmanov, NR; Meyer, C; Szoke, E; Welle, SL; Wittlin, SD; Woerle, HJ, 2006)
"Gluconeogenesis is increased in type 2 diabetes and contributes significantly to fasting and postprandial hyperglycemia."1.33Inhibition of fructose 1,6-bisphosphatase reduces excessive endogenous glucose production and attenuates hyperglycemia in Zucker diabetic fatty rats. ( Chandramouli, VC; Dang, Q; Erion, MD; Landau, BR; Potter, SC; van Poelje, PD, 2006)
"We studied seven obese subjects with type 2 diabetes and seven lean and seven obese control subjects (fasting plasma glucose levels, 7."1.30Glucose production, utilization, and cycling in response to moderate exercise in obese subjects with type 2 diabetes and mild hyperglycemia. ( Giacca, A; Groenewoud, Y; McClean, P; Tsui, E; Zinman, B, 1998)
"Hyperglycemia in NIDDM compensated for insulin resistance to the extent that rates of glucose metabolism were the same as those for nondiabetics studied at euglycemia."1.29Interaction of carbohydrate and fat fuels in human skeletal muscle: impact of obesity and NIDDM. ( Consoli, A; Jain, A; Kelley, DE; Mandarino, LJ, 1996)
"Hyperglycemia is common in severely ill patients and is related principally to an increase in glucose production."1.29In vivo metabolic response of glucose to dichloroacetate in humans. ( Brown, JA; Gore, DC, 1996)
" Linear dose-response relationships (p less than 0."1.28Impaired glucose tolerance is characterized by multiple abnormalities in the regulation of intermediary metabolism. ( Krentz, AJ; Nattrass, M; Singh, BM, 1991)
"Thus, fasting hyperglycemia is sufficient to normalize insulin-stimulated muscle glucose uptake in NIDDM, and glucose is distributed normally to glycogenesis and glucose oxidation, possibly by normalization of GS and PDH."1.28Hyperglycemia normalizes insulin-stimulated skeletal muscle glucose oxidation and storage in noninsulin-dependent diabetes mellitus. ( Kelley, DE; Mandarino, LJ, 1990)

Research

Studies (65)

TimeframeStudies, this research(%)All Research%
pre-199035 (53.85)18.7374
1990's12 (18.46)18.2507
2000's12 (18.46)29.6817
2010's3 (4.62)24.3611
2020's3 (4.62)2.80

Authors

AuthorsStudies
Martino, MR1
Gutiérrez-Aguilar, M1
Yiew, NKH1
Lutkewitte, AJ1
Singer, JM1
McCommis, KS2
Ferguson, D1
Liss, KHH1
Yoshino, J1
Renkemeyer, MK1
Smith, GI1
Cho, K1
Fletcher, JA1
Klein, S1
Patti, GJ1
Burgess, SC2
Finck, BN2
Zhang, J1
Liu, Y1
Li, M1
Ge, X1
Wang, Y3
Huang, X1
Yang, D1
Zhang, R1
Chen, Y1
Lu, M1
Yin, J1
Song, M1
Wang, F1
Jiang, M1
Liu, L1
Okun, JG1
Rusu, PM1
Chan, AY1
Wu, Y1
Yap, YW1
Sharkie, T1
Schumacher, J1
Schmidt, KV1
Roberts-Thomson, KM1
Russell, RD1
Zota, A1
Hille, S1
Jungmann, A1
Maggi, L1
Lee, Y1
Blüher, M1
Herzig, S1
Keske, MA1
Heikenwalder, M1
Müller, OJ1
Rose, AJ1
Wang, B1
Smyl, C1
Chen, CY1
Li, XY1
Huang, W1
Zhang, HM1
Pai, VJ1
Kang, JX1
Chen, Z1
Fu, X1
McDonald, WG1
Colca, JR1
Kletzien, RF1
Yoshida, T1
Okuno, A1
Izumi, M1
Takahashi, K1
Hagisawa, Y1
Ohsumi, J1
Fujiwara, T1
Bokhari, S1
Emerson, P1
Israelian, Z1
Gupta, A1
Meyer, C2
Jensen-Waern, M1
Andersson, M1
Kruse, R1
Nilsson, B1
Larsson, R1
Korsgren, O1
Essén-Gustavsson, B1
Galazis, N1
Iacovou, C1
Haoula, Z1
Atiomo, W1
GABURRO, D1
VOLPATO, S1
SCARPA, P1
Woerle, HJ1
Szoke, E1
Dostou, JM1
Wittlin, SD1
Gosmanov, NR1
Welle, SL1
Gerich, JE2
Jaziri, R1
Lobbens, S1
Aubert, R1
Péan, F1
Lahmidi, S1
Vaxillaire, M1
Porchay, I1
Bellili, N1
Tichet, J1
Balkau, B1
Froguel, P1
Marre, M1
Fumeron, F1
van Poelje, PD1
Potter, SC1
Chandramouli, VC1
Landau, BR1
Dang, Q1
Erion, MD1
Porcellati, F1
Pampanelli, S2
Rossetti, P1
Busciantella Ricci, N1
Marzotti, S1
Lucidi, P1
Santeusanio, F2
Bolli, GB2
Fanelli, CG1
Ray, KK1
Cannon, CP1
Morrow, DA1
Kirtane, AJ1
Buros, J1
Rifai, N1
McCabe, CH1
Gibson, CM1
Braunwald, E1
Marcus, R1
Reaven, G1
Lowry, SF1
Burt, ME1
Brennan, MF1
Mandarino, L1
Tsalikian, E2
Bartold, S1
Marsh, H1
Carney, A1
Buerklin, E1
Tutwiler, G1
Haymond, M1
Handwerger, B1
Rizza, R1
Robert, JJ2
Bier, DM3
Zhao, XH1
Matthews, DE1
Young, VR2
Simonson, DC1
DeFronzo, RA1
Nosadini, R1
Noy, GA1
Alberti, KG1
Hodson, A1
Orskoy, H1
Shulman, GI3
Lacy, WW2
Liljenquist, JE1
Keller, U1
Williams, PE1
Cherrington, AD4
Gore, DC2
Jahoor, F1
Hibbert, J1
DeMaria, EJ1
Hamberg, O2
Vilstrup, H2
Mandarino, LJ2
Consoli, A1
Jain, A1
Kelley, DE2
Brown, JA1
Perriello, G1
Del Sindaco, P1
Lalli, C1
Ciofetta, M1
Volpi, E1
Brunetti, P1
Giacca, A1
Groenewoud, Y1
Tsui, E1
McClean, P1
Zinman, B1
Li, PA1
Shuaib, A1
Miyashita, H1
He, QP1
Siesjö, BK1
Warner, DS1
McNulty, PH1
Cline, GW1
Whiting, JM1
Flattem, N1
Igawa, K1
Shiota, M2
Emshwiller, MG1
Neal, DW2
Moore, MC1
Galassetti, P1
Monohan, M1
Unger, RH3
Orci, L1
Felig, P1
Wahren, J1
Sherwin, R1
Palaiologos, G1
Chiasson, JL1
Lorenzi, M1
Schneider, V1
Karam, JH1
Forsham, PH1
Kreutner, W1
Springer, SC1
Sherwood, JE1
Ruderman, NB1
Kean, EA1
Walters, P1
Krentz, AJ1
Singh, BM1
Nattrass, M1
Mitrakou, A1
Kelley, D1
Veneman, T1
Jenssen, T1
Pangburn, T1
Reilly, J1
Gerich, J1
Hirsch, IB1
Smith, LJ1
Havlin, CE1
Shah, SD1
Clutter, WE1
Cryer, PE1
Capaldo, B2
Napoli, R1
Di Bonito, P1
Albano, G1
Saccà, L2
Santoro, D1
Riccardi, G1
Perrotti, N1
Mikines, KJ1
Farrell, PA1
Sonne, B1
Tronier, B1
Galbo, H1
Kalderon, B1
Gutman, A1
Levy, E1
Shafrir, E1
Adler, JH1
Rao, SP1
Castells, S1
Beaufrere, B1
Koziet, J1
Desjeux, JF1
Lestradet, H1
Philipps, AF1
Rosenkrantz, TS1
Porte, PJ1
Raye, JR1
Wapnir, RA1
Gorback, MS1
Edwards, EH1
Hellman, B3
Sehlin, J4
Täljedal, IB2
Cornell, RP1
Filkins, JP1
Frimpter, GW1
Huchzermeyer, H1
Rudorff, KH1
Staib, W1
Hellerström, C1
Westman, S1
Stork, H1
Schmidt, FH1
Täljedal, I1
Elliott, J1
Hems, DA1
Beloff-Chain, A1
Flock, EV2
Tyce, G1
Owen, CA2
Tyce, GM1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
An Acute Randomized Dose-finding Equivalence Trial of Small, Catalytic Doses of Fructose and Allulose on Postprandial Carbohydrate Metabolism: The Fructose and Allulose Catalytic Effects (FACE) Study[NCT02459834]50 participants (Actual)Interventional2015-11-30Completed
Involvement of Steatosis-induced Glucagon Resistance in Hyperglucagonaemia[NCT02337660]30 participants (Actual)Interventional2015-01-31Completed
Evaluation of p21 Induction and Molecular Pathways Related to Short-term Fasting Response[NCT04259879]20 participants (Actual)Interventional2016-04-07Completed
Body Composition and Lipid Metabolism at Rest and During Exercise: A Cross-Sectional Analysis.[NCT03029364]200 participants (Anticipated)Observational2018-01-08Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

4 reviews available for alanine and Hyperglycemia

ArticleYear
Metabolomic biomarkers of impaired glucose tolerance and type 2 diabetes mellitus with a potential for risk stratification in women with polycystic ovary syndrome.
    European journal of obstetrics, gynecology, and reproductive biology, 2012, Volume: 160, Issue:2

    Topics: Adult; Alanine; Biomarkers; Diabetes Mellitus, Type 2; Female; Glucose Intolerance; Humans; Hypergly

2012
Role of glucagon in the pathogenesis of diabetes: the status of the controversy.
    Metabolism: clinical and experimental, 1978, Volume: 27, Issue:11

    Topics: Alanine; Animals; Antigens; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Type 1; Dietary Pro

1978
Muscle amino acid metabolism and gluconeogenesis.
    Annual review of medicine, 1975, Volume: 26

    Topics: Adaptation, Physiological; Alanine; Amino Acids; Aminoacylation; Animals; Fasting; Forearm; Gluconeo

1975
Aminoacidurias due to inherited disorders of metabolism. 2.
    The New England journal of medicine, 1973, Oct-25, Volume: 289, Issue:17

    Topics: Acidosis; Alanine; Amino Acid Metabolism, Inborn Errors; Arginase; Arginine; Carbamates; Citrulline;

1973

Trials

3 trials available for alanine and Hyperglycemia

ArticleYear
Synergistic relationship between hyperglycaemia and inflammation with respect to clinical outcomes in non-ST-elevation acute coronary syndromes: analyses from OPUS-TIMI 16 and TACTICS-TIMI 18.
    European heart journal, 2007, Volume: 28, Issue:7

    Topics: Aged; Alanine; Biomarkers; Blood Glucose; C-Reactive Protein; Chemokine CCL2; Diabetic Angiopathies;

2007
Effects of insulin and glucose on urea synthesis in normal man, independent of pancreatic hormone secretion.
    Journal of hepatology, 1994, Volume: 21, Issue:3

    Topics: Adult; Alanine; Amino Acids; Blood Glucose; Female; Glucagon; Glucose; Humans; Hyperglycemia; Hyperi

1994
Contribution of abnormal muscle and liver glucose metabolism to postprandial hyperglycemia in NIDDM.
    Diabetes, 1990, Volume: 39, Issue:11

    Topics: Administration, Oral; Alanine; Blood Glucose; Carbon Dioxide; Carbon Radioisotopes; Diabetes Mellitu

1990

Other Studies

58 other studies available for alanine and Hyperglycemia

ArticleYear
Silencing alanine transaminase 2 in diabetic liver attenuates hyperglycemia by reducing gluconeogenesis from amino acids.
    Cell reports, 2022, 04-26, Volume: 39, Issue:4

    Topics: Alanine; Alanine Transaminase; Amino Acids; Animals; Diabetes Mellitus; Gluconeogenesis; Glucose; Hu

2022
Identification of Ala2Thr mutation in insulin gene from a Chinese MODY10 family.
    Molecular and cellular biochemistry, 2020, Volume: 470, Issue:1-2

    Topics: Adult; Alanine; Cell Line; China; Diabetes Mellitus, Type 2; Endoplasmic Reticulum Stress; Family He

2020
Liver alanine catabolism promotes skeletal muscle atrophy and hyperglycaemia in type 2 diabetes.
    Nature metabolism, 2021, Volume: 3, Issue:3

    Topics: Alanine; Alanine Transaminase; Animals; Blood Glucose; Diabetes Mellitus, Type 2; Disease Models, An

2021
Suppression of Postprandial Blood Glucose Fluctuations by a Low-Carbohydrate, High-Protein, and High-Omega-3 Diet via Inhibition of Gluconeogenesis.
    International journal of molecular sciences, 2018, Jun-21, Volume: 19, Issue:7

    Topics: Alanine; Alanine Transaminase; Animals; Blood Glucose; Carbon Isotopes; Diabetes Mellitus, Experimen

2018
Loss of Mitochondrial Pyruvate Carrier 2 in the Liver Leads to Defects in Gluconeogenesis and Compensation via Pyruvate-Alanine Cycling.
    Cell metabolism, 2015, Oct-06, Volume: 22, Issue:4

    Topics: Alanine; Animals; Blood Glucose; Cell Line; Citric Acid Cycle; Diabetes Mellitus, Experimental; Gluc

2015
CS-917, a fructose 1,6-bisphosphatase inhibitor, improves postprandial hyperglycemia after meal loading in non-obese type 2 diabetic Goto-Kakizaki rats.
    European journal of pharmacology, 2008, Dec-28, Volume: 601, Issue:1-3

    Topics: Alanine; Animals; Blood Glucose; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Drug A

2008
Metabolic fate of plasma glucose during hyperglycemia in impaired glucose tolerance: evidence for further early defects in the pathogenesis of type 2 diabetes.
    American journal of physiology. Endocrinology and metabolism, 2009, Volume: 296, Issue:3

    Topics: Alanine; Blood Glucose; Diabetes Mellitus, Type 2; Fatty Acids, Nonesterified; Female; Glucagon; Glu

2009
Effects of streptozotocin-induced diabetes in domestic pigs with focus on the amino acid metabolism.
    Laboratory animals, 2009, Volume: 43, Issue:3

    Topics: Alanine; Amino Acids; Amino Acids, Branched-Chain; Animals; Blood Glucose; Body Weight; C-Peptide; D

2009
[CONGENITAL DYSMETABOLIC CEREBROPATHY WITH HYPERGLYCEMIA, HYPERALANINURIA AND HYPEROXALURIA].
    Les Cahiers du College de medecine des hopitaux de Paris, 1963, Oct-15, Volume: 4

    Topics: Alanine; Brain Diseases; Child; Humans; Hyperglycemia; Hyperoxaluria; Infant; Intellectual Disabilit

1963
Mechanisms for abnormal postprandial glucose metabolism in type 2 diabetes.
    American journal of physiology. Endocrinology and metabolism, 2006, Volume: 290, Issue:1

    Topics: Alanine; Blood Glucose; Carbon Dioxide; Diabetes Mellitus, Type 2; Fatty Acids, Nonesterified; Femal

2006
The PPARG Pro12Ala polymorphism is associated with a decreased risk of developing hyperglycemia over 6 years and combines with the effect of the APM1 G-11391A single nucleotide polymorphism: the Data From an Epidemiological Study on the Insulin Resistance
    Diabetes, 2006, Volume: 55, Issue:4

    Topics: Adiponectin; Adult; Alanine; Amino Acid Substitution; Diabetes Mellitus; Genotype; Humans; Hyperglyc

2006
Inhibition of fructose 1,6-bisphosphatase reduces excessive endogenous glucose production and attenuates hyperglycemia in Zucker diabetic fatty rats.
    Diabetes, 2006, Volume: 55, Issue:6

    Topics: Alanine; Animals; Blood Glucose; Body Weight; Cholesterol; Diabetes Mellitus, Type 2; Eating; Female

2006
Effect of the amino acid alanine on glucagon secretion in non-diabetic and type 1 diabetic subjects during hyperinsulinaemic euglycaemia, hypoglycaemia and post-hypoglycaemic hyperglycaemia.
    Diabetologia, 2007, Volume: 50, Issue:2

    Topics: Adolescent; Adult; Alanine; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 1; Epinephrine; Female

2007
Glutamate-induced hyperglycemia.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1967, Volume: 124, Issue:3

    Topics: Adrenal Glands; Adrenalectomy; Alanine; Animals; Blood Glucose; Carbon Isotopes; Glucagon; Gluconeog

1967
Glucose turnover and gluconeogenesis in a patient with somatostatinoma.
    Surgery, 1981, Volume: 89, Issue:3

    Topics: Adenoma, Islet Cell; Alanine; Gluconeogenesis; Glucose; Glucose Tolerance Test; Humans; Hyperglycemi

1981
Mechanism of hyperglycemia and response to treatment with an inhibitor of fatty acid oxidation in a patient with insulin resistance due to antiinsulin receptor antibodies.
    The Journal of clinical endocrinology and metabolism, 1984, Volume: 59, Issue:4

    Topics: Adipose Tissue; Alanine; Epoxy Compounds; Erythrocytes; Ethers, Cyclic; Fatty Acids, Nonesterified;

1984
Glucose and insulin effects on the novo amino acid synthesis in young men: studies with stable isotope labeled alanine, glycine, leucine, and lysine.
    Metabolism: clinical and experimental, 1982, Volume: 31, Issue:12

    Topics: Adult; Alanine; Amino Acids; Blood Glucose; Glucose; Glycine; Humans; Hyperglycemia; Infusions, Pare

1982
Glucagon physiology and aging: evidence for enhanced hepatic sensitivity.
    Diabetologia, 1983, Volume: 25, Issue:1

    Topics: Adult; Aged; Aging; Alanine; Female; Glucagon; Glucose; Glucose Tolerance Test; Humans; Hyperglycemi

1983
The metabolic response to hyperglycaemic clamping in insulin-dependent diabetes.
    Diabetologia, 1981, Volume: 20, Issue:2

    Topics: Adult; Alanine; Blood Glucose; Diabetes Mellitus; Fatty Acids, Nonesterified; Glucagon; Glycerol; Hu

1981
Effect of glucose, independent of changes in insulin and glucagon secretion, on alanine metabolism in the conscious dog.
    The Journal of clinical investigation, 1980, Volume: 65, Issue:2

    Topics: Alanine; Animals; Blood Glucose; Dogs; Female; Glucagon; Glucose; Hyperglycemia; Insulin; Insulin Se

1980
Except for alanine, muscle protein catabolism is not influenced by alterations in glucose metabolism during sepsis.
    Archives of surgery (Chicago, Ill. : 1960), 1995, Volume: 130, Issue:11

    Topics: Adult; Aged; Alanine; Case-Control Studies; Cohort Studies; Female; Glucose; Humans; Hyperglycemia;

1995
Effects of glucose on hepatic conversion of aminonitrogen to urea in patients with cirrhosis: relationship to glucagon.
    Hepatology (Baltimore, Md.), 1994, Volume: 19, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Alanine; Amino Acids; Blood Glucose; Female; Glucagon; Glucose; Huma

1994
Interaction of carbohydrate and fat fuels in human skeletal muscle: impact of obesity and NIDDM.
    The American journal of physiology, 1996, Volume: 270, Issue:3 Pt 1

    Topics: Adult; Alanine; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Type 2; Energy Metabolism; Fatt

1996
In vivo metabolic response of glucose to dichloroacetate in humans.
    The Journal of surgical research, 1996, Volume: 61, Issue:2

    Topics: Adult; Alanine; Dichloroacetic Acid; Feedback; Glucose; Humans; Hyperglycemia; Lactates; Lactic Acid

1996
Evidence of increased systemic glucose production and gluconeogenesis in an early stage of NIDDM.
    Diabetes, 1997, Volume: 46, Issue:6

    Topics: Alanine; Blood Glucose; Carbon Radioisotopes; Cohort Studies; Diabetes Mellitus, Type 2; Epinephrine

1997
Glucose production, utilization, and cycling in response to moderate exercise in obese subjects with type 2 diabetes and mild hyperglycemia.
    Diabetes, 1998, Volume: 47, Issue:11

    Topics: Adult; Alanine; Blood Glucose; C-Peptide; Diabetes Mellitus; Diabetes Mellitus, Type 2; Exercise; Fe

1998
Hyperglycemia enhances extracellular glutamate accumulation in rats subjected to forebrain ischemia.
    Stroke, 2000, Volume: 31, Issue:1

    Topics: Alanine; Animals; Brain Ischemia; Glutamic Acid; Glutamine; Glycine; Hyperglycemia; Male; Prosenceph

2000
Regulation of myocardial [(13)C]glucose metabolism in conscious rats.
    American journal of physiology. Heart and circulatory physiology, 2000, Volume: 279, Issue:1

    Topics: Alanine; Animals; Blood Glucose; Carbon Isotopes; Citric Acid Cycle; Consciousness; Fasting; Glucose

2000
Alpha- and beta-cell responses to small changes in plasma glucose in the conscious dog.
    Diabetes, 2001, Volume: 50, Issue:2

    Topics: Alanine; Animals; Arteries; Blood Glucose; Dogs; Female; Gluconeogenesis; Glucose; Glycerol; Glycoge

2001
Inclusion of low amounts of fructose with an intraduodenal glucose load markedly reduces postprandial hyperglycemia and hyperinsulinemia in the conscious dog.
    Diabetes, 2002, Volume: 51, Issue:2

    Topics: Alanine; Animals; Blood Glucose; Dogs; Duodenum; Fructose; Glucagon; Gluconeogenesis; Glucose; Glyce

2002
The essential role of glucagon in the pathogenesis of diabetes mellitus.
    Lancet (London, England), 1975, Jan-04, Volume: 1, Issue:7897

    Topics: Alanine; Animals; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Experimental; Dogs; Glucagon;

1975
Amino acid and protein metabolism in diabetes mellitus.
    Archives of internal medicine, 1977, Volume: 137, Issue:4

    Topics: Alanine; Amino Acids; Animals; Diabetes Mellitus; Diabetic Ketoacidosis; Dietary Proteins; Fasting;

1977
Effect of glucagon on glucose production during insulin deficiency in the dog.
    The Journal of clinical investigation, 1978, Volume: 62, Issue:3

    Topics: Alanine; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Female; Glucagon; Gluconeoge

1978
Prevention of human diabetic ketoacidosis by somatostatin. Evidence for an essential role of glucagon.
    The New England journal of medicine, 1975, May-08, Volume: 292, Issue:19

    Topics: Adult; Alanine; Blood Glucose; Depression, Chemical; Diabetes Mellitus, Type 1; Diabetic Ketoacidosi

1975
Resistance of gluconeogenic and glycogenic pathways in obese-hyperglycemic mice.
    The American journal of physiology, 1975, Volume: 228, Issue:2

    Topics: Alanine; Animals; Enzyme Activation; Female; Genotype; Gluconeogenesis; Glucose Tolerance Test; Glyc

1975
Counteraction of glucocorticoid--induced hyperglycaemia by hypoglycin.
    The West Indian medical journal, 1975, Volume: 24, Issue:4

    Topics: Alanine; Animals; Cyclopropanes; Glucocorticoids; Gluconeogenesis; Hyperglycemia; Hypoglycemia; Hypo

1975
Impaired glucose tolerance is characterized by multiple abnormalities in the regulation of intermediary metabolism.
    Diabetic medicine : a journal of the British Diabetic Association, 1991, Volume: 8, Issue:9

    Topics: Alanine; Blood Glucose; C-Peptide; Fatty Acids, Nonesterified; Glucose Tolerance Test; Glycerol; Hum

1991
Hyperglycemia normalizes insulin-stimulated skeletal muscle glucose oxidation and storage in noninsulin-dependent diabetes mellitus.
    The Journal of clinical investigation, 1990, Volume: 86, Issue:6

    Topics: Alanine; Calorimetry; Diabetes Mellitus, Type 2; Glucose; Glycogen Synthase; Glycolysis; Humans; Hyp

1990
Failure of nocturnal hypoglycemia to cause daytime hyperglycemia in patients with IDDM.
    Diabetes care, 1990, Volume: 13, Issue:2

    Topics: 3-Hydroxybutyric Acid; Adult; Alanine; Blood Glucose; Circadian Rhythm; Diabetes Mellitus, Type 1; E

1990
Glucose and gluconeogenic substrate exchange by the forearm skeletal muscle in hyperglycemic and insulin-treated type II diabetic patients.
    The Journal of clinical endocrinology and metabolism, 1990, Volume: 71, Issue:5

    Topics: Adult; Alanine; Blood Glucose; Diabetes Mellitus, Type 2; Fasting; Female; Forearm; Gluconeogenesis;

1990
Direct evidence for a stimulatory effect of hyperglycemia per se on peripheral glucose disposal in type II diabetes.
    The Journal of clinical investigation, 1986, Volume: 77, Issue:4

    Topics: 3-Hydroxybutyric Acid; Adult; Alanine; C-Peptide; Diabetes Mellitus, Type 2; Female; Hemoglobin A; H

1986
Postexercise dose-response relationship between plasma glucose and insulin secretion.
    Journal of applied physiology (Bethesda, Md. : 1985), 1988, Volume: 64, Issue:3

    Topics: 3-Hydroxybutyric Acid; Adult; Alanine; Blood Glucose; Blood Pressure; C-Peptide; Calorimetry; Epinep

1988
Characterization of stages in development of obesity-diabetes syndrome in sand rat (Psammomys obesus).
    Diabetes, 1986, Volume: 35, Issue:6

    Topics: Adipose Tissue; Age Factors; Alanine; Animals; Arvicolinae; Blood Glucose; Carbon Radioisotopes; Dia

1986
Hyperglucagonemia in L-asparaginase induced diabetes mellitus.
    The American journal of pediatric hematology/oncology, 1986,Spring, Volume: 8, Issue:1

    Topics: Alanine; Asparaginase; Child; Diabetes Mellitus, Type 2; Female; Glucagon; Humans; Hyperglycemia; In

1986
Whole body de novo amino acid synthesis in type I (insulin-dependent) diabetes studied with stable isotope-labeled leucine, alanine, and glycine.
    Diabetes, 1985, Volume: 34, Issue:1

    Topics: Adolescent; Adult; Alanine; Amino Acids; Diabetes Mellitus, Type 1; Glucose; Glycine; Humans; Hyperg

1985
The effects of chronic fetal hyperglycemia on substrate uptake by the ovine fetus and conceptus.
    Pediatric research, 1985, Volume: 19, Issue:7

    Topics: Alanine; Animals; Arteries; Blood; Blood Glucose; Chronic Disease; Embryo, Mammalian; Female; Fetal

1985
Hyperglycemia and starvation: contrast in rat brain gluconeogenic amino acids and glycogen.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1972, Volume: 141, Issue:2

    Topics: Alanine; Animals; Blood Glucose; Brain Chemistry; Diabetes Mellitus; Gluconeogenesis; Glutamates; Gl

1972
Transport of -aminoisobutyric acid in mammalian pancretic -cells.
    Diabetologia, 1971, Volume: 7, Issue:4

    Topics: Alanine; Amino Acids; Aminoisobutyric Acids; Animals; Biological Transport; Butyrates; Cyclic AMP; D

1971
Effects of glucose and other modifiers of insulin release on the oxidative metabolism of amino acids in micro-dissected pancreatic islets.
    The Biochemical journal, 1971, Volume: 123, Issue:4

    Topics: Alanine; Amino Acids; Animals; Arginine; Carbon Isotopes; Citrates; Cyclic AMP; Depression, Chemical

1971
Depression of hepatic gluconeogenesis by acute lead administration.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1974, Volume: 147, Issue:2

    Topics: Alanine; Animals; Blood Glucose; Carbon Radioisotopes; Fasting; Gluconeogenesis; Glucose; Glucose Ox

1974
Insulin-glucagon ratio.
    Israel journal of medical sciences, 1972, Volume: 8, Issue:3

    Topics: Alanine; Animals; Blood Glucose; Diet; Dietary Carbohydrates; Dietary Proteins; Dogs; Fasting; Gluca

1972
Uptake and oxidation of glutamic acid in mammalian pancreatic islets.
    Hormones, 1972, Volume: 3, Issue:3

    Topics: Alanine; Animals; Arginine; Carbon Isotopes; Female; Galactose; Glucose; Glutamates; Glyburide; Hype

1972
[Experimental studies on the problem of insulin resistance in adipositas and diabetes mellitus, with the aid of New Zealand obese mice. Pathogenesis of the obese-hyperglycaemic syndrome (author's transl)].
    Zeitschrift fur klinische Chemie und klinische Biochemie, 1973, Volume: 11, Issue:6

    Topics: Adipose Tissue; Aging; Alanine; Animals; Body Weight; Carbon Radioisotopes; Diabetes Mellitus, Exper

1973
[Effect of blood sugar decreasing sulfonylureas on the in vitro metabolism of glucose and amino acids in the beta-cells of the pancreas in mice].
    Arzneimittel-Forschung, 1969, Volume: 19, Issue:8

    Topics: Alanine; Amino Acids; Animals; Arginine; Carbon Isotopes; Depression, Chemical; Female; Glucose; Hyp

1969
Uptake of alanine, arginine and leucine by mammalian pancreatic beta-cells.
    Endocrinology, 1971, Volume: 89, Issue:6

    Topics: Alanine; Animals; Arginine; Carbon Isotopes; Diazoxide; Fructose; Glucose; Glyburide; Hyperglycemia;

1971
Carbohydrate metabolism of the isolated perfused liver of normal and genetically obese--hyperglycaemic (ob-ob) mice.
    The Biochemical journal, 1971, Volume: 125, Issue:3

    Topics: Alanine; Animals; Carbohydrate Metabolism; Carbon Isotopes; Genes, Recessive; Gluconeogenesis; Gluco

1971
Regulatory effects of insulin and liver on brain glucose metabolism.
    Endocrinology, 1969, Volume: 84, Issue:2

    Topics: Alanine; Aminobutyrates; Animals; Aspartic Acid; Autoanalysis; Blood Glucose; Brain; Carbon Isotopes

1969
Glucose metabolism in brains of diabetic rats.
    Endocrinology, 1969, Volume: 85, Issue:3

    Topics: Alanine; Aminobutyrates; Animals; Aspartic Acid; Brain; Carbon Isotopes; Diabetes Mellitus; Diabetes

1969