alanine has been researched along with Hyperglycemia in 65 studies
Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.
Hyperglycemia: Abnormally high BLOOD GLUCOSE level.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The following evidence suggests that diabetes mellitus may not be the simple consequence of relative or absolute insulin deficiency by itself, but may require the presence of glucagon: (1) relative or absolute hyperglucogonaemia has been identified in every form of endogenous hyperglycaemia, including total pancreatectomy in dogs; (2) insulin lack in the absence of glucagon does not cause endogenous hyperglycaemia, but when endogenous or exogenous glucagon is present, it quickly appears, irrespective of insulin levels at the time." | 7.65 | The essential role of glucagon in the pathogenesis of diabetes mellitus. ( Orci, L; Unger, RH, 1975) |
| "To evaluate the role of glucagon in the pathogenesis of diabetic ketoacidosis in man, we studied the effect of suppression of glucagon secretion by somatostatin on changes in plasma beta-hydroxybutyrate and glucose concentrations (as well as changes in their precursors) after acute withdrawal of insulin from seven patients with juvenile-type diabetes." | 7.65 | Prevention of human diabetic ketoacidosis by somatostatin. Evidence for an essential role of glucagon. ( Bier, DM; Forsham, PH; Gerich, JE; Karam, JH; Lorenzi, M; Schneider, V; Tsalikian, E, 1975) |
| "To assess the role of muscle and liver in the pathogenesis of postprandial hyperglycemia in non-insulin-dependent diabetes mellitus (NIDDM), we administered an oral glucose load enriched with [14C]glucose to 10 NIDDM subjects and 10 age- and weight-matched nondiabetic volunteers and compared muscle glucose disposal by measuring forearm balance of glucose, lactate, alanine, O2, and CO2 (with forearm calorimetry)." | 5.06 | Contribution of abnormal muscle and liver glucose metabolism to postprandial hyperglycemia in NIDDM. ( Gerich, J; Jenssen, T; Kelley, D; Mitrakou, A; Pangburn, T; Reilly, J; Veneman, T, 1990) |
| " An INS mutation, at the position 2 alanine-to-threonine substitution (A2T), was identified and co-segregated with hyperglycemia in a MODY pedigree." | 3.96 | Identification of Ala2Thr mutation in insulin gene from a Chinese MODY10 family. ( Chen, Y; Ge, X; Huang, X; Jiang, M; Li, M; Liu, L; Liu, Y; Lu, M; Song, M; Wang, F; Wang, Y; Yang, D; Yin, J; Zhang, J; Zhang, R, 2020) |
| " Each study consisted of an equilibration (-140 to -40 min), a control (-40 to 0 min), and a test period (0 to 180 min), during which BAY R3401 (10 mg/kg), a glycogen phosphorylase inhibitor, was administered orally, either alone to create mild hypoglycemia or with peripheral glucose infusion to maintain euglycemia or create mild hyperglycemia." | 3.71 | Alpha- and beta-cell responses to small changes in plasma glucose in the conscious dog. ( Cherrington, AD; Emshwiller, MG; Flattem, N; Igawa, K; Neal, DW; Shiota, M, 2001) |
| "To determine the contribution of skeletal muscle to fasting hyperglycemia in noninsulin dependent type II diabetes (NIDDM), the forearm balance of glucose, lactate, and alanine was quantified in 25 control subjects, 21 hyperglycemic (blood glucose: 11." | 3.68 | Glucose and gluconeogenic substrate exchange by the forearm skeletal muscle in hyperglycemic and insulin-treated type II diabetic patients. ( Albano, G; Capaldo, B; Di Bonito, P; Napoli, R; Saccà, L, 1990) |
| "To study the effects of hyperglycemia on the metabolism of alanine and lactate independent of changes in plasma insulin and glucagon, glucose was infused into five 36-h-fasted dogs along with somatostatin and constant replacement amounts of both insulin and glucagon." | 3.66 | Effect of glucose, independent of changes in insulin and glucagon secretion, on alanine metabolism in the conscious dog. ( Cherrington, AD; Keller, U; Lacy, WW; Liljenquist, JE; Shulman, GI; Williams, PE, 1980) |
| "The following evidence suggests that diabetes mellitus may not be the simple consequence of relative or absolute insulin deficiency by itself, but may require the presence of glucagon: (1) relative or absolute hyperglucogonaemia has been identified in every form of endogenous hyperglycaemia, including total pancreatectomy in dogs; (2) insulin lack in the absence of glucagon does not cause endogenous hyperglycaemia, but when endogenous or exogenous glucagon is present, it quickly appears, irrespective of insulin levels at the time." | 3.65 | The essential role of glucagon in the pathogenesis of diabetes mellitus. ( Orci, L; Unger, RH, 1975) |
| "To evaluate the role of glucagon in the pathogenesis of diabetic ketoacidosis in man, we studied the effect of suppression of glucagon secretion by somatostatin on changes in plasma beta-hydroxybutyrate and glucose concentrations (as well as changes in their precursors) after acute withdrawal of insulin from seven patients with juvenile-type diabetes." | 3.65 | Prevention of human diabetic ketoacidosis by somatostatin. Evidence for an essential role of glucagon. ( Bier, DM; Forsham, PH; Gerich, JE; Karam, JH; Lorenzi, M; Schneider, V; Tsalikian, E, 1975) |
| " In addition, we describe acute effect of CS-917 on fasting hyperglycemia in overnight-fasted GK rats and chronic effect of CS-917 in multiple dosing GK rats." | 1.35 | CS-917, a fructose 1,6-bisphosphatase inhibitor, improves postprandial hyperglycemia after meal loading in non-obese type 2 diabetic Goto-Kakizaki rats. ( Fujiwara, T; Hagisawa, Y; Izumi, M; Ohsumi, J; Okuno, A; Takahashi, K; Yoshida, T, 2008) |
| "Thus in type 2 diabetes, postprandial hyperglycemia is primarily due to increased glucose release; hyperglycemia overcomes the effects of impaired insulin secretion and sensitivity on glucose transport, but intracellular defects persist so that pathways of glucose metabolism are abnormal and glucose is shunted away from normal sites of storage (e." | 1.33 | Mechanisms for abnormal postprandial glucose metabolism in type 2 diabetes. ( Dostou, JM; Gerich, JE; Gosmanov, NR; Meyer, C; Szoke, E; Welle, SL; Wittlin, SD; Woerle, HJ, 2006) |
| "Gluconeogenesis is increased in type 2 diabetes and contributes significantly to fasting and postprandial hyperglycemia." | 1.33 | Inhibition of fructose 1,6-bisphosphatase reduces excessive endogenous glucose production and attenuates hyperglycemia in Zucker diabetic fatty rats. ( Chandramouli, VC; Dang, Q; Erion, MD; Landau, BR; Potter, SC; van Poelje, PD, 2006) |
| "We studied seven obese subjects with type 2 diabetes and seven lean and seven obese control subjects (fasting plasma glucose levels, 7." | 1.30 | Glucose production, utilization, and cycling in response to moderate exercise in obese subjects with type 2 diabetes and mild hyperglycemia. ( Giacca, A; Groenewoud, Y; McClean, P; Tsui, E; Zinman, B, 1998) |
| "Hyperglycemia in NIDDM compensated for insulin resistance to the extent that rates of glucose metabolism were the same as those for nondiabetics studied at euglycemia." | 1.29 | Interaction of carbohydrate and fat fuels in human skeletal muscle: impact of obesity and NIDDM. ( Consoli, A; Jain, A; Kelley, DE; Mandarino, LJ, 1996) |
| "Hyperglycemia is common in severely ill patients and is related principally to an increase in glucose production." | 1.29 | In vivo metabolic response of glucose to dichloroacetate in humans. ( Brown, JA; Gore, DC, 1996) |
| " Linear dose-response relationships (p less than 0." | 1.28 | Impaired glucose tolerance is characterized by multiple abnormalities in the regulation of intermediary metabolism. ( Krentz, AJ; Nattrass, M; Singh, BM, 1991) |
| "Thus, fasting hyperglycemia is sufficient to normalize insulin-stimulated muscle glucose uptake in NIDDM, and glucose is distributed normally to glycogenesis and glucose oxidation, possibly by normalization of GS and PDH." | 1.28 | Hyperglycemia normalizes insulin-stimulated skeletal muscle glucose oxidation and storage in noninsulin-dependent diabetes mellitus. ( Kelley, DE; Mandarino, LJ, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 35 (53.85) | 18.7374 |
| 1990's | 12 (18.46) | 18.2507 |
| 2000's | 12 (18.46) | 29.6817 |
| 2010's | 3 (4.62) | 24.3611 |
| 2020's | 3 (4.62) | 2.80 |
| Authors | Studies |
|---|---|
| Martino, MR | 1 |
| Gutiérrez-Aguilar, M | 1 |
| Yiew, NKH | 1 |
| Lutkewitte, AJ | 1 |
| Singer, JM | 1 |
| McCommis, KS | 2 |
| Ferguson, D | 1 |
| Liss, KHH | 1 |
| Yoshino, J | 1 |
| Renkemeyer, MK | 1 |
| Smith, GI | 1 |
| Cho, K | 1 |
| Fletcher, JA | 1 |
| Klein, S | 1 |
| Patti, GJ | 1 |
| Burgess, SC | 2 |
| Finck, BN | 2 |
| Zhang, J | 1 |
| Liu, Y | 1 |
| Li, M | 1 |
| Ge, X | 1 |
| Wang, Y | 3 |
| Huang, X | 1 |
| Yang, D | 1 |
| Zhang, R | 1 |
| Chen, Y | 1 |
| Lu, M | 1 |
| Yin, J | 1 |
| Song, M | 1 |
| Wang, F | 1 |
| Jiang, M | 1 |
| Liu, L | 1 |
| Okun, JG | 1 |
| Rusu, PM | 1 |
| Chan, AY | 1 |
| Wu, Y | 1 |
| Yap, YW | 1 |
| Sharkie, T | 1 |
| Schumacher, J | 1 |
| Schmidt, KV | 1 |
| Roberts-Thomson, KM | 1 |
| Russell, RD | 1 |
| Zota, A | 1 |
| Hille, S | 1 |
| Jungmann, A | 1 |
| Maggi, L | 1 |
| Lee, Y | 1 |
| Blüher, M | 1 |
| Herzig, S | 1 |
| Keske, MA | 1 |
| Heikenwalder, M | 1 |
| Müller, OJ | 1 |
| Rose, AJ | 1 |
| Wang, B | 1 |
| Smyl, C | 1 |
| Chen, CY | 1 |
| Li, XY | 1 |
| Huang, W | 1 |
| Zhang, HM | 1 |
| Pai, VJ | 1 |
| Kang, JX | 1 |
| Chen, Z | 1 |
| Fu, X | 1 |
| McDonald, WG | 1 |
| Colca, JR | 1 |
| Kletzien, RF | 1 |
| Yoshida, T | 1 |
| Okuno, A | 1 |
| Izumi, M | 1 |
| Takahashi, K | 1 |
| Hagisawa, Y | 1 |
| Ohsumi, J | 1 |
| Fujiwara, T | 1 |
| Bokhari, S | 1 |
| Emerson, P | 1 |
| Israelian, Z | 1 |
| Gupta, A | 1 |
| Meyer, C | 2 |
| Jensen-Waern, M | 1 |
| Andersson, M | 1 |
| Kruse, R | 1 |
| Nilsson, B | 1 |
| Larsson, R | 1 |
| Korsgren, O | 1 |
| Essén-Gustavsson, B | 1 |
| Galazis, N | 1 |
| Iacovou, C | 1 |
| Haoula, Z | 1 |
| Atiomo, W | 1 |
| GABURRO, D | 1 |
| VOLPATO, S | 1 |
| SCARPA, P | 1 |
| Woerle, HJ | 1 |
| Szoke, E | 1 |
| Dostou, JM | 1 |
| Wittlin, SD | 1 |
| Gosmanov, NR | 1 |
| Welle, SL | 1 |
| Gerich, JE | 2 |
| Jaziri, R | 1 |
| Lobbens, S | 1 |
| Aubert, R | 1 |
| Péan, F | 1 |
| Lahmidi, S | 1 |
| Vaxillaire, M | 1 |
| Porchay, I | 1 |
| Bellili, N | 1 |
| Tichet, J | 1 |
| Balkau, B | 1 |
| Froguel, P | 1 |
| Marre, M | 1 |
| Fumeron, F | 1 |
| van Poelje, PD | 1 |
| Potter, SC | 1 |
| Chandramouli, VC | 1 |
| Landau, BR | 1 |
| Dang, Q | 1 |
| Erion, MD | 1 |
| Porcellati, F | 1 |
| Pampanelli, S | 2 |
| Rossetti, P | 1 |
| Busciantella Ricci, N | 1 |
| Marzotti, S | 1 |
| Lucidi, P | 1 |
| Santeusanio, F | 2 |
| Bolli, GB | 2 |
| Fanelli, CG | 1 |
| Ray, KK | 1 |
| Cannon, CP | 1 |
| Morrow, DA | 1 |
| Kirtane, AJ | 1 |
| Buros, J | 1 |
| Rifai, N | 1 |
| McCabe, CH | 1 |
| Gibson, CM | 1 |
| Braunwald, E | 1 |
| Marcus, R | 1 |
| Reaven, G | 1 |
| Lowry, SF | 1 |
| Burt, ME | 1 |
| Brennan, MF | 1 |
| Mandarino, L | 1 |
| Tsalikian, E | 2 |
| Bartold, S | 1 |
| Marsh, H | 1 |
| Carney, A | 1 |
| Buerklin, E | 1 |
| Tutwiler, G | 1 |
| Haymond, M | 1 |
| Handwerger, B | 1 |
| Rizza, R | 1 |
| Robert, JJ | 2 |
| Bier, DM | 3 |
| Zhao, XH | 1 |
| Matthews, DE | 1 |
| Young, VR | 2 |
| Simonson, DC | 1 |
| DeFronzo, RA | 1 |
| Nosadini, R | 1 |
| Noy, GA | 1 |
| Alberti, KG | 1 |
| Hodson, A | 1 |
| Orskoy, H | 1 |
| Shulman, GI | 3 |
| Lacy, WW | 2 |
| Liljenquist, JE | 1 |
| Keller, U | 1 |
| Williams, PE | 1 |
| Cherrington, AD | 4 |
| Gore, DC | 2 |
| Jahoor, F | 1 |
| Hibbert, J | 1 |
| DeMaria, EJ | 1 |
| Hamberg, O | 2 |
| Vilstrup, H | 2 |
| Mandarino, LJ | 2 |
| Consoli, A | 1 |
| Jain, A | 1 |
| Kelley, DE | 2 |
| Brown, JA | 1 |
| Perriello, G | 1 |
| Del Sindaco, P | 1 |
| Lalli, C | 1 |
| Ciofetta, M | 1 |
| Volpi, E | 1 |
| Brunetti, P | 1 |
| Giacca, A | 1 |
| Groenewoud, Y | 1 |
| Tsui, E | 1 |
| McClean, P | 1 |
| Zinman, B | 1 |
| Li, PA | 1 |
| Shuaib, A | 1 |
| Miyashita, H | 1 |
| He, QP | 1 |
| Siesjö, BK | 1 |
| Warner, DS | 1 |
| McNulty, PH | 1 |
| Cline, GW | 1 |
| Whiting, JM | 1 |
| Flattem, N | 1 |
| Igawa, K | 1 |
| Shiota, M | 2 |
| Emshwiller, MG | 1 |
| Neal, DW | 2 |
| Moore, MC | 1 |
| Galassetti, P | 1 |
| Monohan, M | 1 |
| Unger, RH | 3 |
| Orci, L | 1 |
| Felig, P | 1 |
| Wahren, J | 1 |
| Sherwin, R | 1 |
| Palaiologos, G | 1 |
| Chiasson, JL | 1 |
| Lorenzi, M | 1 |
| Schneider, V | 1 |
| Karam, JH | 1 |
| Forsham, PH | 1 |
| Kreutner, W | 1 |
| Springer, SC | 1 |
| Sherwood, JE | 1 |
| Ruderman, NB | 1 |
| Kean, EA | 1 |
| Walters, P | 1 |
| Krentz, AJ | 1 |
| Singh, BM | 1 |
| Nattrass, M | 1 |
| Mitrakou, A | 1 |
| Kelley, D | 1 |
| Veneman, T | 1 |
| Jenssen, T | 1 |
| Pangburn, T | 1 |
| Reilly, J | 1 |
| Gerich, J | 1 |
| Hirsch, IB | 1 |
| Smith, LJ | 1 |
| Havlin, CE | 1 |
| Shah, SD | 1 |
| Clutter, WE | 1 |
| Cryer, PE | 1 |
| Capaldo, B | 2 |
| Napoli, R | 1 |
| Di Bonito, P | 1 |
| Albano, G | 1 |
| Saccà, L | 2 |
| Santoro, D | 1 |
| Riccardi, G | 1 |
| Perrotti, N | 1 |
| Mikines, KJ | 1 |
| Farrell, PA | 1 |
| Sonne, B | 1 |
| Tronier, B | 1 |
| Galbo, H | 1 |
| Kalderon, B | 1 |
| Gutman, A | 1 |
| Levy, E | 1 |
| Shafrir, E | 1 |
| Adler, JH | 1 |
| Rao, SP | 1 |
| Castells, S | 1 |
| Beaufrere, B | 1 |
| Koziet, J | 1 |
| Desjeux, JF | 1 |
| Lestradet, H | 1 |
| Philipps, AF | 1 |
| Rosenkrantz, TS | 1 |
| Porte, PJ | 1 |
| Raye, JR | 1 |
| Wapnir, RA | 1 |
| Gorback, MS | 1 |
| Edwards, EH | 1 |
| Hellman, B | 3 |
| Sehlin, J | 4 |
| Täljedal, IB | 2 |
| Cornell, RP | 1 |
| Filkins, JP | 1 |
| Frimpter, GW | 1 |
| Huchzermeyer, H | 1 |
| Rudorff, KH | 1 |
| Staib, W | 1 |
| Hellerström, C | 1 |
| Westman, S | 1 |
| Stork, H | 1 |
| Schmidt, FH | 1 |
| Täljedal, I | 1 |
| Elliott, J | 1 |
| Hems, DA | 1 |
| Beloff-Chain, A | 1 |
| Flock, EV | 2 |
| Tyce, G | 1 |
| Owen, CA | 2 |
| Tyce, GM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An Acute Randomized Dose-finding Equivalence Trial of Small, Catalytic Doses of Fructose and Allulose on Postprandial Carbohydrate Metabolism: The Fructose and Allulose Catalytic Effects (FACE) Study[NCT02459834] | 50 participants (Actual) | Interventional | 2015-11-30 | Completed | |||
| Involvement of Steatosis-induced Glucagon Resistance in Hyperglucagonaemia[NCT02337660] | 30 participants (Actual) | Interventional | 2015-01-31 | Completed | |||
| Evaluation of p21 Induction and Molecular Pathways Related to Short-term Fasting Response[NCT04259879] | 20 participants (Actual) | Interventional | 2016-04-07 | Completed | |||
| Body Composition and Lipid Metabolism at Rest and During Exercise: A Cross-Sectional Analysis.[NCT03029364] | 200 participants (Anticipated) | Observational | 2018-01-08 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for alanine and Hyperglycemia
| Article | Year |
|---|---|
Metabolomic biomarkers of impaired glucose tolerance and type 2 diabetes mellitus with a potential for risk stratification in women with polycystic ovary syndrome.
Topics: Adult; Alanine; Biomarkers; Diabetes Mellitus, Type 2; Female; Glucose Intolerance; Humans; Hypergly | 2012 |
Role of glucagon in the pathogenesis of diabetes: the status of the controversy.
Topics: Alanine; Animals; Antigens; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Type 1; Dietary Pro | 1978 |
Muscle amino acid metabolism and gluconeogenesis.
Topics: Adaptation, Physiological; Alanine; Amino Acids; Aminoacylation; Animals; Fasting; Forearm; Gluconeo | 1975 |
Aminoacidurias due to inherited disorders of metabolism. 2.
Topics: Acidosis; Alanine; Amino Acid Metabolism, Inborn Errors; Arginase; Arginine; Carbamates; Citrulline; | 1973 |
3 trials available for alanine and Hyperglycemia
| Article | Year |
|---|---|
Synergistic relationship between hyperglycaemia and inflammation with respect to clinical outcomes in non-ST-elevation acute coronary syndromes: analyses from OPUS-TIMI 16 and TACTICS-TIMI 18.
Topics: Aged; Alanine; Biomarkers; Blood Glucose; C-Reactive Protein; Chemokine CCL2; Diabetic Angiopathies; | 2007 |
Effects of insulin and glucose on urea synthesis in normal man, independent of pancreatic hormone secretion.
Topics: Adult; Alanine; Amino Acids; Blood Glucose; Female; Glucagon; Glucose; Humans; Hyperglycemia; Hyperi | 1994 |
Contribution of abnormal muscle and liver glucose metabolism to postprandial hyperglycemia in NIDDM.
Topics: Administration, Oral; Alanine; Blood Glucose; Carbon Dioxide; Carbon Radioisotopes; Diabetes Mellitu | 1990 |
58 other studies available for alanine and Hyperglycemia
| Article | Year |
|---|---|
Silencing alanine transaminase 2 in diabetic liver attenuates hyperglycemia by reducing gluconeogenesis from amino acids.
Topics: Alanine; Alanine Transaminase; Amino Acids; Animals; Diabetes Mellitus; Gluconeogenesis; Glucose; Hu | 2022 |
Identification of Ala2Thr mutation in insulin gene from a Chinese MODY10 family.
Topics: Adult; Alanine; Cell Line; China; Diabetes Mellitus, Type 2; Endoplasmic Reticulum Stress; Family He | 2020 |
Liver alanine catabolism promotes skeletal muscle atrophy and hyperglycaemia in type 2 diabetes.
Topics: Alanine; Alanine Transaminase; Animals; Blood Glucose; Diabetes Mellitus, Type 2; Disease Models, An | 2021 |
Suppression of Postprandial Blood Glucose Fluctuations by a Low-Carbohydrate, High-Protein, and High-Omega-3 Diet via Inhibition of Gluconeogenesis.
Topics: Alanine; Alanine Transaminase; Animals; Blood Glucose; Carbon Isotopes; Diabetes Mellitus, Experimen | 2018 |
Loss of Mitochondrial Pyruvate Carrier 2 in the Liver Leads to Defects in Gluconeogenesis and Compensation via Pyruvate-Alanine Cycling.
Topics: Alanine; Animals; Blood Glucose; Cell Line; Citric Acid Cycle; Diabetes Mellitus, Experimental; Gluc | 2015 |
CS-917, a fructose 1,6-bisphosphatase inhibitor, improves postprandial hyperglycemia after meal loading in non-obese type 2 diabetic Goto-Kakizaki rats.
Topics: Alanine; Animals; Blood Glucose; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Drug A | 2008 |
Metabolic fate of plasma glucose during hyperglycemia in impaired glucose tolerance: evidence for further early defects in the pathogenesis of type 2 diabetes.
Topics: Alanine; Blood Glucose; Diabetes Mellitus, Type 2; Fatty Acids, Nonesterified; Female; Glucagon; Glu | 2009 |
Effects of streptozotocin-induced diabetes in domestic pigs with focus on the amino acid metabolism.
Topics: Alanine; Amino Acids; Amino Acids, Branched-Chain; Animals; Blood Glucose; Body Weight; C-Peptide; D | 2009 |
[CONGENITAL DYSMETABOLIC CEREBROPATHY WITH HYPERGLYCEMIA, HYPERALANINURIA AND HYPEROXALURIA].
Topics: Alanine; Brain Diseases; Child; Humans; Hyperglycemia; Hyperoxaluria; Infant; Intellectual Disabilit | 1963 |
Mechanisms for abnormal postprandial glucose metabolism in type 2 diabetes.
Topics: Alanine; Blood Glucose; Carbon Dioxide; Diabetes Mellitus, Type 2; Fatty Acids, Nonesterified; Femal | 2006 |
The PPARG Pro12Ala polymorphism is associated with a decreased risk of developing hyperglycemia over 6 years and combines with the effect of the APM1 G-11391A single nucleotide polymorphism: the Data From an Epidemiological Study on the Insulin Resistance
Topics: Adiponectin; Adult; Alanine; Amino Acid Substitution; Diabetes Mellitus; Genotype; Humans; Hyperglyc | 2006 |
Inhibition of fructose 1,6-bisphosphatase reduces excessive endogenous glucose production and attenuates hyperglycemia in Zucker diabetic fatty rats.
Topics: Alanine; Animals; Blood Glucose; Body Weight; Cholesterol; Diabetes Mellitus, Type 2; Eating; Female | 2006 |
Effect of the amino acid alanine on glucagon secretion in non-diabetic and type 1 diabetic subjects during hyperinsulinaemic euglycaemia, hypoglycaemia and post-hypoglycaemic hyperglycaemia.
Topics: Adolescent; Adult; Alanine; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 1; Epinephrine; Female | 2007 |
Glutamate-induced hyperglycemia.
Topics: Adrenal Glands; Adrenalectomy; Alanine; Animals; Blood Glucose; Carbon Isotopes; Glucagon; Gluconeog | 1967 |
Glucose turnover and gluconeogenesis in a patient with somatostatinoma.
Topics: Adenoma, Islet Cell; Alanine; Gluconeogenesis; Glucose; Glucose Tolerance Test; Humans; Hyperglycemi | 1981 |
Mechanism of hyperglycemia and response to treatment with an inhibitor of fatty acid oxidation in a patient with insulin resistance due to antiinsulin receptor antibodies.
Topics: Adipose Tissue; Alanine; Epoxy Compounds; Erythrocytes; Ethers, Cyclic; Fatty Acids, Nonesterified; | 1984 |
Glucose and insulin effects on the novo amino acid synthesis in young men: studies with stable isotope labeled alanine, glycine, leucine, and lysine.
Topics: Adult; Alanine; Amino Acids; Blood Glucose; Glucose; Glycine; Humans; Hyperglycemia; Infusions, Pare | 1982 |
Glucagon physiology and aging: evidence for enhanced hepatic sensitivity.
Topics: Adult; Aged; Aging; Alanine; Female; Glucagon; Glucose; Glucose Tolerance Test; Humans; Hyperglycemi | 1983 |
The metabolic response to hyperglycaemic clamping in insulin-dependent diabetes.
Topics: Adult; Alanine; Blood Glucose; Diabetes Mellitus; Fatty Acids, Nonesterified; Glucagon; Glycerol; Hu | 1981 |
Effect of glucose, independent of changes in insulin and glucagon secretion, on alanine metabolism in the conscious dog.
Topics: Alanine; Animals; Blood Glucose; Dogs; Female; Glucagon; Glucose; Hyperglycemia; Insulin; Insulin Se | 1980 |
Except for alanine, muscle protein catabolism is not influenced by alterations in glucose metabolism during sepsis.
Topics: Adult; Aged; Alanine; Case-Control Studies; Cohort Studies; Female; Glucose; Humans; Hyperglycemia; | 1995 |
Effects of glucose on hepatic conversion of aminonitrogen to urea in patients with cirrhosis: relationship to glucagon.
Topics: Adult; Aged; Aged, 80 and over; Alanine; Amino Acids; Blood Glucose; Female; Glucagon; Glucose; Huma | 1994 |
Interaction of carbohydrate and fat fuels in human skeletal muscle: impact of obesity and NIDDM.
Topics: Adult; Alanine; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Type 2; Energy Metabolism; Fatt | 1996 |
In vivo metabolic response of glucose to dichloroacetate in humans.
Topics: Adult; Alanine; Dichloroacetic Acid; Feedback; Glucose; Humans; Hyperglycemia; Lactates; Lactic Acid | 1996 |
Evidence of increased systemic glucose production and gluconeogenesis in an early stage of NIDDM.
Topics: Alanine; Blood Glucose; Carbon Radioisotopes; Cohort Studies; Diabetes Mellitus, Type 2; Epinephrine | 1997 |
Glucose production, utilization, and cycling in response to moderate exercise in obese subjects with type 2 diabetes and mild hyperglycemia.
Topics: Adult; Alanine; Blood Glucose; C-Peptide; Diabetes Mellitus; Diabetes Mellitus, Type 2; Exercise; Fe | 1998 |
Hyperglycemia enhances extracellular glutamate accumulation in rats subjected to forebrain ischemia.
Topics: Alanine; Animals; Brain Ischemia; Glutamic Acid; Glutamine; Glycine; Hyperglycemia; Male; Prosenceph | 2000 |
Regulation of myocardial [(13)C]glucose metabolism in conscious rats.
Topics: Alanine; Animals; Blood Glucose; Carbon Isotopes; Citric Acid Cycle; Consciousness; Fasting; Glucose | 2000 |
Alpha- and beta-cell responses to small changes in plasma glucose in the conscious dog.
Topics: Alanine; Animals; Arteries; Blood Glucose; Dogs; Female; Gluconeogenesis; Glucose; Glycerol; Glycoge | 2001 |
Inclusion of low amounts of fructose with an intraduodenal glucose load markedly reduces postprandial hyperglycemia and hyperinsulinemia in the conscious dog.
Topics: Alanine; Animals; Blood Glucose; Dogs; Duodenum; Fructose; Glucagon; Gluconeogenesis; Glucose; Glyce | 2002 |
The essential role of glucagon in the pathogenesis of diabetes mellitus.
Topics: Alanine; Animals; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Experimental; Dogs; Glucagon; | 1975 |
Amino acid and protein metabolism in diabetes mellitus.
Topics: Alanine; Amino Acids; Animals; Diabetes Mellitus; Diabetic Ketoacidosis; Dietary Proteins; Fasting; | 1977 |
Effect of glucagon on glucose production during insulin deficiency in the dog.
Topics: Alanine; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Female; Glucagon; Gluconeoge | 1978 |
Prevention of human diabetic ketoacidosis by somatostatin. Evidence for an essential role of glucagon.
Topics: Adult; Alanine; Blood Glucose; Depression, Chemical; Diabetes Mellitus, Type 1; Diabetic Ketoacidosi | 1975 |
Resistance of gluconeogenic and glycogenic pathways in obese-hyperglycemic mice.
Topics: Alanine; Animals; Enzyme Activation; Female; Genotype; Gluconeogenesis; Glucose Tolerance Test; Glyc | 1975 |
Counteraction of glucocorticoid--induced hyperglycaemia by hypoglycin.
Topics: Alanine; Animals; Cyclopropanes; Glucocorticoids; Gluconeogenesis; Hyperglycemia; Hypoglycemia; Hypo | 1975 |
Impaired glucose tolerance is characterized by multiple abnormalities in the regulation of intermediary metabolism.
Topics: Alanine; Blood Glucose; C-Peptide; Fatty Acids, Nonesterified; Glucose Tolerance Test; Glycerol; Hum | 1991 |
Hyperglycemia normalizes insulin-stimulated skeletal muscle glucose oxidation and storage in noninsulin-dependent diabetes mellitus.
Topics: Alanine; Calorimetry; Diabetes Mellitus, Type 2; Glucose; Glycogen Synthase; Glycolysis; Humans; Hyp | 1990 |
Failure of nocturnal hypoglycemia to cause daytime hyperglycemia in patients with IDDM.
Topics: 3-Hydroxybutyric Acid; Adult; Alanine; Blood Glucose; Circadian Rhythm; Diabetes Mellitus, Type 1; E | 1990 |
Glucose and gluconeogenic substrate exchange by the forearm skeletal muscle in hyperglycemic and insulin-treated type II diabetic patients.
Topics: Adult; Alanine; Blood Glucose; Diabetes Mellitus, Type 2; Fasting; Female; Forearm; Gluconeogenesis; | 1990 |
Direct evidence for a stimulatory effect of hyperglycemia per se on peripheral glucose disposal in type II diabetes.
Topics: 3-Hydroxybutyric Acid; Adult; Alanine; C-Peptide; Diabetes Mellitus, Type 2; Female; Hemoglobin A; H | 1986 |
Postexercise dose-response relationship between plasma glucose and insulin secretion.
Topics: 3-Hydroxybutyric Acid; Adult; Alanine; Blood Glucose; Blood Pressure; C-Peptide; Calorimetry; Epinep | 1988 |
Characterization of stages in development of obesity-diabetes syndrome in sand rat (Psammomys obesus).
Topics: Adipose Tissue; Age Factors; Alanine; Animals; Arvicolinae; Blood Glucose; Carbon Radioisotopes; Dia | 1986 |
Hyperglucagonemia in L-asparaginase induced diabetes mellitus.
Topics: Alanine; Asparaginase; Child; Diabetes Mellitus, Type 2; Female; Glucagon; Humans; Hyperglycemia; In | 1986 |
Whole body de novo amino acid synthesis in type I (insulin-dependent) diabetes studied with stable isotope-labeled leucine, alanine, and glycine.
Topics: Adolescent; Adult; Alanine; Amino Acids; Diabetes Mellitus, Type 1; Glucose; Glycine; Humans; Hyperg | 1985 |
The effects of chronic fetal hyperglycemia on substrate uptake by the ovine fetus and conceptus.
Topics: Alanine; Animals; Arteries; Blood; Blood Glucose; Chronic Disease; Embryo, Mammalian; Female; Fetal | 1985 |
Hyperglycemia and starvation: contrast in rat brain gluconeogenic amino acids and glycogen.
Topics: Alanine; Animals; Blood Glucose; Brain Chemistry; Diabetes Mellitus; Gluconeogenesis; Glutamates; Gl | 1972 |
Transport of -aminoisobutyric acid in mammalian pancretic -cells.
Topics: Alanine; Amino Acids; Aminoisobutyric Acids; Animals; Biological Transport; Butyrates; Cyclic AMP; D | 1971 |
Effects of glucose and other modifiers of insulin release on the oxidative metabolism of amino acids in micro-dissected pancreatic islets.
Topics: Alanine; Amino Acids; Animals; Arginine; Carbon Isotopes; Citrates; Cyclic AMP; Depression, Chemical | 1971 |
Depression of hepatic gluconeogenesis by acute lead administration.
Topics: Alanine; Animals; Blood Glucose; Carbon Radioisotopes; Fasting; Gluconeogenesis; Glucose; Glucose Ox | 1974 |
Insulin-glucagon ratio.
Topics: Alanine; Animals; Blood Glucose; Diet; Dietary Carbohydrates; Dietary Proteins; Dogs; Fasting; Gluca | 1972 |
Uptake and oxidation of glutamic acid in mammalian pancreatic islets.
Topics: Alanine; Animals; Arginine; Carbon Isotopes; Female; Galactose; Glucose; Glutamates; Glyburide; Hype | 1972 |
[Experimental studies on the problem of insulin resistance in adipositas and diabetes mellitus, with the aid of New Zealand obese mice. Pathogenesis of the obese-hyperglycaemic syndrome (author's transl)].
Topics: Adipose Tissue; Aging; Alanine; Animals; Body Weight; Carbon Radioisotopes; Diabetes Mellitus, Exper | 1973 |
[Effect of blood sugar decreasing sulfonylureas on the in vitro metabolism of glucose and amino acids in the beta-cells of the pancreas in mice].
Topics: Alanine; Amino Acids; Animals; Arginine; Carbon Isotopes; Depression, Chemical; Female; Glucose; Hyp | 1969 |
Uptake of alanine, arginine and leucine by mammalian pancreatic beta-cells.
Topics: Alanine; Animals; Arginine; Carbon Isotopes; Diazoxide; Fructose; Glucose; Glyburide; Hyperglycemia; | 1971 |
Carbohydrate metabolism of the isolated perfused liver of normal and genetically obese--hyperglycaemic (ob-ob) mice.
Topics: Alanine; Animals; Carbohydrate Metabolism; Carbon Isotopes; Genes, Recessive; Gluconeogenesis; Gluco | 1971 |
Regulatory effects of insulin and liver on brain glucose metabolism.
Topics: Alanine; Aminobutyrates; Animals; Aspartic Acid; Autoanalysis; Blood Glucose; Brain; Carbon Isotopes | 1969 |
Glucose metabolism in brains of diabetic rats.
Topics: Alanine; Aminobutyrates; Animals; Aspartic Acid; Brain; Carbon Isotopes; Diabetes Mellitus; Diabetes | 1969 |