alanine has been researched along with Hyperammonemia in 9 studies
Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.
Hyperammonemia: Elevated level of AMMONIA in the blood. It is a sign of defective CATABOLISM of AMINO ACIDS or ammonia to UREA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study was to investigate the effects of ammonia and manganese in the metabolism of minimal hepatic encephalopathy (MHE)." | 8.31 | The interaction of ammonia and manganese in abnormal metabolism of minimal hepatic encephalopathy: A comparison metabolomics study. ( Li, Y; Liu, XF; Lu, JJ; Qiang, JW; Yang, XY, 2023) |
| "In this prospective study of patients with fulminant hepatic failure (FHF), we tested the hypothesis that arterial hyperammonemia results in cerebral accumulation of the osmotic active amino acids glutamine and alanine, processes that were expected to correlate with intracranial pressure (ICP)." | 7.73 | Persistent arterial hyperammonemia increases the concentration of glutamine and alanine in the brain and correlates with intracranial pressure in patients with fulminant hepatic failure. ( Hansen, BA; Hauerberg, J; Jørgensen, L; Larsen, FS; Pedersen, CB; Tofteng, F, 2006) |
| "Hyperornithinemia, hyperammonemia, and homocitrullinuria (HHH) syndrome is caused by mutations in the SLC25A15 (ORNT1) gene encoding the mitochondrial ornithine transporter, but the mechanism of pathogenesis of the encephalopathy, spastic paraparesis and hepatopathy remains undetermined." | 7.72 | Hyperornithinemia, hyperammonemia, and homocitrullinuria syndrome with evidence of mitochondrial dysfunction due to a novel SLC25A15 (ORNT1) gene mutation in a Palestinian family. ( Abu-Libdeh, B; Gutman, A; Kanazawa, N; Korman, SH; Tsujino, S, 2004) |
| "A random retrospective chart review was conducted to document serum carnitine levels on 100 children with autism." | 7.72 | Relative carnitine deficiency in autism. ( Cummings, C; Filipek, PA; Gargus, JJ; Juranek, J; Nguyen, MT, 2004) |
| "Hyperammonemia is a major etiological toxic factor in the development of hepatic encephalopathy." | 5.39 | Brain alanine formation as an ammonia-scavenging pathway during hyperammonemia: effects of glutamine synthetase inhibition in rats and astrocyte-neuron co-cultures. ( Bak, LK; Dadsetan, S; Keiding, S; Kukolj, E; Ott, P; Schousboe, A; Sørensen, M; Vilstrup, H; Waagepetersen, HS, 2013) |
| "This study was to investigate the effects of ammonia and manganese in the metabolism of minimal hepatic encephalopathy (MHE)." | 4.31 | The interaction of ammonia and manganese in abnormal metabolism of minimal hepatic encephalopathy: A comparison metabolomics study. ( Li, Y; Liu, XF; Lu, JJ; Qiang, JW; Yang, XY, 2023) |
| " plantarum strains were administered in ornithine transcarbamoylase-deficient Sparse-fur mice, a model of constitutive hyperammonemia, in a carbon tetrachloride rat model of chronic liver insufficiency and in a thioacetamide-induced acute liver failure mice model." | 3.74 | Control of acute, chronic, and constitutive hyperammonemia by wild-type and genetically engineered Lactobacillus plantarum in rodents. ( Demetter, P; Devière, J; Goffin, P; Gustot, T; Hols, P; Moreno, C; Nicaise, C; Prozzi, D; Quertinmont, E; Suain, V; Viaene, E, 2008) |
| "In this prospective study of patients with fulminant hepatic failure (FHF), we tested the hypothesis that arterial hyperammonemia results in cerebral accumulation of the osmotic active amino acids glutamine and alanine, processes that were expected to correlate with intracranial pressure (ICP)." | 3.73 | Persistent arterial hyperammonemia increases the concentration of glutamine and alanine in the brain and correlates with intracranial pressure in patients with fulminant hepatic failure. ( Hansen, BA; Hauerberg, J; Jørgensen, L; Larsen, FS; Pedersen, CB; Tofteng, F, 2006) |
| "Hyperornithinemia, hyperammonemia, and homocitrullinuria (HHH) syndrome is caused by mutations in the SLC25A15 (ORNT1) gene encoding the mitochondrial ornithine transporter, but the mechanism of pathogenesis of the encephalopathy, spastic paraparesis and hepatopathy remains undetermined." | 3.72 | Hyperornithinemia, hyperammonemia, and homocitrullinuria syndrome with evidence of mitochondrial dysfunction due to a novel SLC25A15 (ORNT1) gene mutation in a Palestinian family. ( Abu-Libdeh, B; Gutman, A; Kanazawa, N; Korman, SH; Tsujino, S, 2004) |
| "A random retrospective chart review was conducted to document serum carnitine levels on 100 children with autism." | 3.72 | Relative carnitine deficiency in autism. ( Cummings, C; Filipek, PA; Gargus, JJ; Juranek, J; Nguyen, MT, 2004) |
| "Propionic acidemia is an inborn error of metabolism caused by a deficiency in the mitochondrial enzyme propionyl-CoA carboxylase that converts the propionyl CoA to methyl malonyl CoA." | 1.72 | Interorgan amino acid interchange in propionic acidemia: the missing key to understanding its physiopathology. ( Arrieta, F; Belanger-Quintana, A; Del Valle, M; Fernandez-Felix, BM; Garcia, F; Martinez-Pardo, M; Ruiz-Sala, P; Stanescu, S, 2022) |
| "Hyperammonemia is a major etiological toxic factor in the development of hepatic encephalopathy." | 1.39 | Brain alanine formation as an ammonia-scavenging pathway during hyperammonemia: effects of glutamine synthetase inhibition in rats and astrocyte-neuron co-cultures. ( Bak, LK; Dadsetan, S; Keiding, S; Kukolj, E; Ott, P; Schousboe, A; Sørensen, M; Vilstrup, H; Waagepetersen, HS, 2013) |
| "Myo-inositol levels were strongly decreased already at 3h after treatment with NH4Cl; other intracellular osmolytes, such as hypotaurine and choline-containing compounds were also decreased, along with a concomitant increase of both the total concentration and the amount of newly synthesized glutamine, alanine, and glutathione." | 1.33 | Ammonia toxicity under hyponatremic conditions in astrocytes: de novo synthesis of amino acids for the osmoregulatory response. ( Leibfritz, D; Zwingmann, C, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (55.56) | 29.6817 |
| 2010's | 2 (22.22) | 24.3611 |
| 2020's | 2 (22.22) | 2.80 |
| Authors | Studies |
|---|---|
| Stanescu, S | 1 |
| Belanger-Quintana, A | 1 |
| Fernandez-Felix, BM | 1 |
| Ruiz-Sala, P | 1 |
| Del Valle, M | 1 |
| Garcia, F | 1 |
| Arrieta, F | 1 |
| Martinez-Pardo, M | 1 |
| Liu, XF | 1 |
| Lu, JJ | 1 |
| Li, Y | 1 |
| Yang, XY | 1 |
| Qiang, JW | 1 |
| Dadsetan, S | 2 |
| Kukolj, E | 1 |
| Bak, LK | 2 |
| Sørensen, M | 2 |
| Ott, P | 2 |
| Vilstrup, H | 2 |
| Schousboe, A | 2 |
| Keiding, S | 2 |
| Waagepetersen, HS | 2 |
| Nicaise, C | 1 |
| Prozzi, D | 1 |
| Viaene, E | 1 |
| Moreno, C | 1 |
| Gustot, T | 1 |
| Quertinmont, E | 1 |
| Demetter, P | 1 |
| Suain, V | 1 |
| Goffin, P | 1 |
| Devière, J | 1 |
| Hols, P | 1 |
| Leke, R | 1 |
| Korman, SH | 1 |
| Kanazawa, N | 1 |
| Abu-Libdeh, B | 1 |
| Gutman, A | 1 |
| Tsujino, S | 1 |
| Filipek, PA | 1 |
| Juranek, J | 1 |
| Nguyen, MT | 1 |
| Cummings, C | 1 |
| Gargus, JJ | 1 |
| Zwingmann, C | 1 |
| Leibfritz, D | 1 |
| Tofteng, F | 1 |
| Hauerberg, J | 1 |
| Hansen, BA | 1 |
| Pedersen, CB | 1 |
| Jørgensen, L | 1 |
| Larsen, FS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Cerebral Microdialysis in Patients With Fulminant Hepatic Failure[NCT00836420] | 50 participants (Actual) | Observational | 2000-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 other studies available for alanine and Hyperammonemia
| Article | Year |
|---|---|
Interorgan amino acid interchange in propionic acidemia: the missing key to understanding its physiopathology.
Topics: Alanine; Amino Acid Metabolism, Inborn Errors; Amino Acids; Ammonia; Glutamine; Humans; Hyperammonem | 2022 |
The interaction of ammonia and manganese in abnormal metabolism of minimal hepatic encephalopathy: A comparison metabolomics study.
Topics: Alanine; Ammonia; Animals; Arginine; Brain; Citrulline; gamma-Aminobutyric Acid; Glutamic Acid; Glut | 2023 |
Brain alanine formation as an ammonia-scavenging pathway during hyperammonemia: effects of glutamine synthetase inhibition in rats and astrocyte-neuron co-cultures.
Topics: Alanine; Amino Acids; Ammonia; Animals; Astrocytes; Brain Chemistry; Chromatography, High Pressure L | 2013 |
Control of acute, chronic, and constitutive hyperammonemia by wild-type and genetically engineered Lactobacillus plantarum in rodents.
Topics: Acute Disease; Alanine; Ammonia; Animals; Carbon Tetrachloride; Chronic Disease; Disease Models, Ani | 2008 |
Inhibition of glutamine synthesis induces glutamate dehydrogenase-dependent ammonia fixation into alanine in co-cultures of astrocytes and neurons.
Topics: Alanine; Alanine Transaminase; Ammonia; Animals; Astrocytes; Cells, Cultured; Cerebral Cortex; Cocul | 2011 |
Hyperornithinemia, hyperammonemia, and homocitrullinuria syndrome with evidence of mitochondrial dysfunction due to a novel SLC25A15 (ORNT1) gene mutation in a Palestinian family.
Topics: Adolescent; Alanine; Amino Acid Metabolism, Inborn Errors; Amino Acid Transport Systems, Basic; Arab | 2004 |
Relative carnitine deficiency in autism.
Topics: Adolescent; Alanine; Autistic Disorder; Carnitine; Child; Child, Preschool; Diagnostic and Statistic | 2004 |
Ammonia toxicity under hyponatremic conditions in astrocytes: de novo synthesis of amino acids for the osmoregulatory response.
Topics: Alanine; Amino Acids; Ammonia; Ammonium Chloride; Animals; Animals, Newborn; Astrocytes; Brain Edema | 2005 |
Persistent arterial hyperammonemia increases the concentration of glutamine and alanine in the brain and correlates with intracranial pressure in patients with fulminant hepatic failure.
Topics: Adolescent; Adult; Aged; Alanine; Brain; Female; Glutamine; Humans; Hyperammonemia; Intracranial Hyp | 2006 |