Page last updated: 2024-11-08

alanine and Huntington Disease

alanine has been researched along with Huntington Disease in 10 studies

Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.

Huntington Disease: A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)

Research Excerpts

ExcerptRelevanceReference
" We found that S421 phosphorylation mitigates neurodegeneration by increasing proteasome-dependent turnover of mHTT and reducing the presence of a toxic mHTT conformer."1.43Serine 421 regulates mutant huntingtin toxicity and clearance in mice. ( Daub, AC; Finkbeiner, S; Gu, X; Humbert, S; Kratter, IH; Lau, A; Masliah, E; Osmand, A; Saudou, F; Steffan, JS; Tsvetkov, AS; Weiberth, KF; Yang, XW; Zahed, H, 2016)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19904 (40.00)18.7374
1990's2 (20.00)18.2507
2000's3 (30.00)29.6817
2010's1 (10.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kratter, IH1
Zahed, H1
Lau, A1
Tsvetkov, AS1
Daub, AC1
Weiberth, KF1
Gu, X2
Saudou, F1
Humbert, S1
Yang, XW2
Osmand, A2
Steffan, JS2
Masliah, E1
Finkbeiner, S2
Greiner, ER1
Mishra, R1
Kodali, R1
Thompson, LM1
Wetzel, R1
Squitieri, F1
Cannella, M1
Simonelli, M1
COWIE, V1
SEAKINS, JW1
Reilmann, R1
Rolf, LH1
Lange, HW1
Harris, CA1
Miranda, AF1
Tanguay, JJ1
Boegman, RJ1
Beninger, RJ1
Jhamandas, K1
Holbert, S1
Denghien, I1
Kiechle, T1
Rosenblatt, A1
Wellington, C1
Hayden, MR1
Margolis, RL1
Ross, CA1
Dausset, J1
Ferrante, RJ1
NĂ©ri, C1
Perry, TL2
Diamond, S1
Hansen, S2
Stedman, D1
Insarova, NG1
Lesk, D1

Other Studies

10 other studies available for alanine and Huntington Disease

ArticleYear
Serine 421 regulates mutant huntingtin toxicity and clearance in mice.
    The Journal of clinical investigation, 2016, 09-01, Volume: 126, Issue:9

    Topics: Alanine; Animals; Aspartic Acid; Behavior, Animal; Chromosomes, Artificial, Bacterial; Disease Model

2016
Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice.
    Neuron, 2009, Dec-24, Volume: 64, Issue:6

    Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Amyloid; Animals; Aspartic Acid; Disease Mode

2009
CAG mutation effect on rate of progression in Huntington's disease.
    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2002, Volume: 23 Suppl 2

    Topics: Age of Onset; Alanine; Cysteine; Disease Progression; DNA Mutational Analysis; Female; Follow-Up Stu

2002
Urinary alanine excretor in a Huntington's chorea family.
    The Journal of mental science, 1962, Volume: 108

    Topics: Alanine; Body Fluids; Chorea; Humans; Huntington Disease

1962
Decreased plasma alanine and isoleucine in Huntington's disease.
    Acta neurologica Scandinavica, 1995, Volume: 91, Issue:3

    Topics: Adult; Alanine; Female; Humans; Huntington Disease; Isoleucine; Male; Middle Aged; Plasma

1995
Modulation of striatal quinolinate neurotoxicity by elevation of endogenous brain kynurenic acid.
    British journal of pharmacology, 1998, Volume: 124, Issue:2

    Topics: Alanine; Animals; Anticonvulsants; Corpus Striatum; Dose-Response Relationship, Drug; Drug Synergism

1998
The Gln-Ala repeat transcriptional activator CA150 interacts with huntingtin: neuropathologic and genetic evidence for a role in Huntington's disease pathogenesis.
    Proceedings of the National Academy of Sciences of the United States of America, 2001, Feb-13, Volume: 98, Issue:4

    Topics: Age of Onset; Alanine; Animals; Brain; Caenorhabditis elegans; Dinucleotide Repeats; Glutamine; Helm

2001
Plasma-aminoacid levels in Huntington's chorea.
    Lancet (London, England), 1969, Apr-19, Volume: 1, Issue:7599

    Topics: Adult; Alanine; Amino Acids; Female; Humans; Huntington Disease; Isoleucine; Leucine; Male; Middle A

1969
[Urinary excretion of free amino acids in families of patints with Huntington's chorea].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1969, Volume: 69, Issue:6

    Topics: Adult; Aged; Alanine; Amino Acids; Chromatography, Paper; Female; Glutamates; Humans; Huntington Dis

1969
[Plasma amino acid levels in children of patients with Huntington's chorea].
    Neurology, 1972, Volume: 22, Issue:1

    Topics: Adolescent; Adult; Alanine; Amino Acids; Child; Child, Preschool; Female; Humans; Huntington Disease

1972