alanine has been researched along with HbS Disease in 9 studies
Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The biosynthesis of two types of human fetal hemoglobin (Hb F), namely Hb F with G gamma chains having glycine in position 136 and Hb F with A gamma chains having alanine in position 136, was studied in blood samples and in cultures of erythroid precursors from blood of patients with different hemoglobinopathies." | 3.66 | The synthesis of fetal hemoglobin types in red blood cells and in BFU-E derived colonies from peripheral blood of patients with sickle cell anemia, beta+ - and delta beta-thalassemia, various forms of hereditary persistence of fetal hemoglobin, normal adu ( Efremov, GD; Gravely, ME; Harris, HF; Howard, JS; Huisman, TH; Reese, AL; Wilson, JB, 1979) |
| "In the sickle cell anemia patients, the frequency of Val/Val genotype was approximately 1." | 1.37 | Ala-9Val polymorphism of Mn-SOD gene in sickle cell anemia. ( Gali, E; Kaya, H; Oktar, S; Ozcelik, N; Sogut, S; Tutanc, M; Yigit, A; Yilmaz, HR; Yonden, Z, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (55.56) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sogut, S | 1 |
| Yonden, Z | 1 |
| Kaya, H | 1 |
| Oktar, S | 1 |
| Tutanc, M | 1 |
| Yilmaz, HR | 1 |
| Yigit, A | 1 |
| Ozcelik, N | 1 |
| Gali, E | 1 |
| Gauthier, E | 1 |
| Rahuel, C | 1 |
| Wautier, MP | 1 |
| El Nemer, W | 1 |
| Gane, P | 1 |
| Wautier, JL | 1 |
| Cartron, JP | 1 |
| Colin, Y | 1 |
| Le Van Kim, C | 1 |
| Takekoshi, KJ | 1 |
| Oh, YH | 1 |
| Westerman, KW | 1 |
| London, IM | 1 |
| Leboulch, P | 1 |
| Moo-Penn, WF | 1 |
| Schmidt, RM | 1 |
| Jue, DL | 1 |
| Bechtel, KC | 1 |
| Wright, JM | 1 |
| Horne, MK | 1 |
| Haycraft, GL | 1 |
| Roth, EF | 1 |
| Nagel, RL | 1 |
| Alter, BP | 1 |
| Huisman, TH | 2 |
| Efremov, GD | 1 |
| Reese, AL | 1 |
| Howard, JS | 1 |
| Gravely, ME | 1 |
| Harris, HF | 1 |
| Wilson, JB | 1 |
| Adachi, K | 1 |
| Kim, J | 1 |
| Asakura, T | 1 |
| Schwartz, E | 1 |
| Schroeder, WA | 1 |
| Bouver, NG | 1 |
| Miller, A | 1 |
| Shelton, JR | 1 |
| Shelton, JB | 1 |
| Apell, G | 1 |
| Beresford, CH | 1 |
| Clegg, JB | 1 |
| Weatherall, DJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Sickle Cell Disease (SCD) Biochip': Towards a Simple and Reliable Way to Monitor Sickle Cell Disease[NCT02824471] | 100 participants (Anticipated) | Observational | 2014-10-31 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 other studies available for alanine and HbS Disease
| Article | Year |
|---|---|
Ala-9Val polymorphism of Mn-SOD gene in sickle cell anemia.
Topics: Adolescent; Adult; Alanine; Alleles; Amino Acid Substitution; Anemia, Sickle Cell; Child; Child, Pre | 2011 |
Protein kinase A-dependent phosphorylation of Lutheran/basal cell adhesion molecule glycoprotein regulates cell adhesion to laminin alpha5.
Topics: Adrenergic beta-Antagonists; Alanine; Amino Acid Sequence; Anemia, Sickle Cell; Animals; Blotting, W | 2005 |
Retroviral transfer of a human beta-globin/delta-globin hybrid gene linked to beta locus control region hypersensitive site 2 aimed at the gene therapy of sickle cell disease.
Topics: 3T3 Cells; Alanine; Amino Acid Sequence; Anemia, Sickle Cell; Animals; Base Sequence; Conserved Sequ | 1995 |
Hemoglobin S Travis: a sickling hemoglobin with two amino acid substitutions [beta6(A3)glutamic acid leads to valine and beta142 (h20) alanine leads to valine).
Topics: Alanine; Amino Acids; Anemia, Sickle Cell; Female; Genetic Variation; Glutamates; Hemoglobin, Sickle | 1977 |
The G gamma:A gamma composition of fetal hemoglobin in fetuses and newborns.
Topics: Alanine; Anemia, Sickle Cell; Electrophoresis, Polyacrylamide Gel; Female; Fetal Hemoglobin; Fetus; | 1979 |
The synthesis of fetal hemoglobin types in red blood cells and in BFU-E derived colonies from peripheral blood of patients with sickle cell anemia, beta+ - and delta beta-thalassemia, various forms of hereditary persistence of fetal hemoglobin, normal adu
Topics: Adult; Alanine; Anemia, Sickle Cell; Cells, Cultured; Chromatography, High Pressure Liquid; Clone Ce | 1979 |
Characterization of two types of fetal hemoglobin: alpha 2G gamma 2 and alpha 2A gamma 2.
Topics: Alanine; Anemia, Sickle Cell; Fetal Blood; Glycine; Hemoglobin, Sickle; Hemoglobins; Humans; Oxygen; | 1990 |
Chemical heterogeneity of fetal hemoglobin in subjects with sickle cell anemia, homozygous Hb-C disease, SC disease, and various combinations of hemoglobin variants.
Topics: Adolescent; Adult; Aged; Aging; Alanine; Anemia, Sickle Cell; Child; Child, Preschool; Chromatograph | 1972 |
Haemoglobin Ocho Rios ( beta52 (D3) aspartic acid leads to alanine): a new beta-chain variant of haemoglobin A found in combination with haemoglobin S.
Topics: Alanine; Amino Acid Sequence; Anemia, Sickle Cell; Aspartic Acid; Blood Protein Electrophoresis; Chr | 1972 |