Page last updated: 2024-11-08

alanine and Grippe

alanine has been researched along with Grippe in 10 studies

Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.

Research Excerpts

ExcerptRelevanceReference
"The International Society for Influenza and other Respiratory Virus Diseases held its 6th Antiviral Group (isirv-AVG) conference in Rockville, Maryland, November 13-15, 2018."2.61Advances in respiratory virus therapeutics - A meeting report from the 6th isirv Antiviral Group conference. ( Adams, PL; Beigel, JH; El-Kamary, SS; Ince, WL; Krafft, A; Nam, HH; Sims, AC, 2019)
"In mice infected with influenza A virus (IAV) and in patients with severe COVID-19 requiring artificial ventilation or extracorporeal membrane oxygenation, blood levels of d-amino acids, including d-alanine, were reduced significantly compared with those of uninfected mice or healthy controls."1.91d-Alanine as a biomarker and a therapeutic option for severe influenza virus infection and COVID-19. ( Asaka, MN; Isaka, Y; Kimura, T; Kimura-Ohba, S; Takabatake, Y; Takahashi, A; Utsumi, D; Yasutomi, Y, 2023)
"The nucleoprotein (NP) of influenza A virus is transported into the nucleus via the classical importin α/β pathway, and proceeds via nuclear localization signals (NLSs) recognized by importin α molecules."1.39Importin α3/Qip1 is involved in multiplication of mutant influenza virus with alanine mutation at amino acid 9 independently of nuclear transport function. ( Aida, Y; Hagiwara, K; Kakisaka, M; Murakami, T; Sasaki, Y; Yamada, K, 2013)
"A mutant influenza A virus expressing the L69,77A NS1 protein was generated using reverse genetics."1.37Alanine substitutions within a linker region of the influenza A virus non-structural protein 1 alter its subcellular localization and attenuate virus replication. ( Li, W; Noah, DL; Noah, JW, 2011)
"The interest in broad-range anti-influenza A monoclonal antibodies (mAbs) has recently been strengthened by the identification of anti-hemagglutinin (HA) mAbs endowed with heterosubtypic neutralizing activity to be used in the design of "universal" prophylactic or therapeutic tools."1.37A human monoclonal antibody with neutralizing activity against highly divergent influenza subtypes. ( Burioni, R; Clementi, M; Clementi, N; De Marco, D; Di Pietro, A; Gubareva, LV; Mancini, N; Mishin, V; Moreno, GJ; Siccardi, AG; Solforosi, L; Vicenzi, E, 2011)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19901 (10.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (40.00)24.3611
2020's5 (50.00)2.80

Authors

AuthorsStudies
Kimura-Ohba, S1
Asaka, MN1
Utsumi, D1
Takabatake, Y1
Takahashi, A1
Yasutomi, Y1
Isaka, Y1
Kimura, T1
Li, G1
De Clercq, E1
Anderson, PO1
Milano, G1
Dolgin, E1
Beigel, JH1
Nam, HH1
Adams, PL1
Krafft, A1
Ince, WL1
El-Kamary, SS1
Sims, AC1
Knight, CA1
Li, W1
Noah, JW1
Noah, DL1
Clementi, N1
De Marco, D1
Mancini, N1
Solforosi, L1
Moreno, GJ1
Gubareva, LV1
Mishin, V1
Di Pietro, A1
Vicenzi, E1
Siccardi, AG1
Clementi, M1
Burioni, R1
Sasaki, Y1
Hagiwara, K1
Kakisaka, M1
Yamada, K1
Murakami, T1
Aida, Y1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Assessment of Netosis During COVID-19, Under Treatment With Anakinra, an Interleukin-1 Receptor Antagonist[NCT04594356]120 participants (Actual)Observational2020-11-19Completed
Use of cSVF For Residual Lung Damage (COPD/Fibrotic Lung Disease After Symptomatic COVID-19 Infection For Residual Pulmonary Injury or Post-Adult Respiratory Distress Syndrome Following Viral (SARS-Co-2) Infection[NCT04326036]Early Phase 110 participants (Anticipated)Interventional2020-03-25Enrolling by invitation
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for alanine and Grippe

ArticleYear
Advances in respiratory virus therapeutics - A meeting report from the 6th isirv Antiviral Group conference.
    Antiviral research, 2019, Volume: 167

    Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Coronavirus Infections; Humans; Influenza, Human

2019

Other Studies

9 other studies available for alanine and Grippe

ArticleYear
d-Alanine as a biomarker and a therapeutic option for severe influenza virus infection and COVID-19.
    Biochimica et biophysica acta. Molecular basis of disease, 2023, 01-01, Volume: 1869, Issue:1

    Topics: Alanine; Animals; Biomarkers; Communicable Diseases; COVID-19 Drug Treatment; Humans; Influenza, Hum

2023
Therapeutic options for the 2019 novel coronavirus (2019-nCoV).
    Nature reviews. Drug discovery, 2020, Volume: 19, Issue:3

    Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-1

2020
Therapeutic options for the 2019 novel coronavirus (2019-nCoV).
    Nature reviews. Drug discovery, 2020, Volume: 19, Issue:3

    Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-1

2020
Therapeutic options for the 2019 novel coronavirus (2019-nCoV).
    Nature reviews. Drug discovery, 2020, Volume: 19, Issue:3

    Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-1

2020
Therapeutic options for the 2019 novel coronavirus (2019-nCoV).
    Nature reviews. Drug discovery, 2020, Volume: 19, Issue:3

    Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-1

2020
Breastfeeding and Respiratory Antivirals: Coronavirus and Influenza.
    Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine, 2020, Volume: 15, Issue:3

    Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Breast Feeding; Coronavirus Inf

2020
[Scientific research in times of pandemics.]
    Recenti progressi in medicina, 2021, Volume: 112, Issue:3

    Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19; COVID-19 Vaccines; Disease Outbreaks;

2021
The race for antiviral drugs to beat COVID - and the next pandemic.
    Nature, 2021, Volume: 592, Issue:7854

    Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Birds; Clinical Trials as Topic; Corona

2021
AMINO ACID COMPOSITION OF HIGHLY PURIFIED VIRAL PARTICLES OF INFLUENZA A AND B.
    The Journal of experimental medicine, 1947, Jul-31, Volume: 86, Issue:2

    Topics: Alanine; Amino Acids; Arginine; Aspartic Acid; Glutamates; Glycine; Histidine; Humans; Influenza, Hu

1947
Alanine substitutions within a linker region of the influenza A virus non-structural protein 1 alter its subcellular localization and attenuate virus replication.
    The Journal of general virology, 2011, Volume: 92, Issue:Pt 8

    Topics: Alanine; Amino Acid Motifs; Amino Acid Substitution; Animals; Cell Line; Dogs; Humans; Influenza A v

2011
A human monoclonal antibody with neutralizing activity against highly divergent influenza subtypes.
    PloS one, 2011, Volume: 6, Issue:12

    Topics: Alanine; Animals; Antibodies, Monoclonal; Antibodies, Neutralizing; Cell Line; Cluster Analysis; Dog

2011
Importin α3/Qip1 is involved in multiplication of mutant influenza virus with alanine mutation at amino acid 9 independently of nuclear transport function.
    PloS one, 2013, Volume: 8, Issue:1

    Topics: Active Transport, Cell Nucleus; Alanine; alpha Karyopherins; Amino Acid Sequence; Animals; Cell Line

2013