alanine has been researched along with Glioblastoma in 13 studies
Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.
Glioblastoma: A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In developing iodine-123-labelled amino acid derivatives for imaging cerebral gliomas by single-photon emission tomography (SPET), we compared p-[123I]iodo-L-phenylalanine (IPA), L-[123I]iodo-1,2,3,4-tetrahydro-7-hydroxyisoquinoline-3-carboxylic acid (ITIC) and L-3-[123I]iodo-alpha-methyltyrosine (IMT) with regard to their uptake in human glioblastoma T99 and T3868 cells, and thereafter studied the mechanisms promoting the cellular uptake." | 3.70 | Investigation of iodine-123-labelled amino acid derivatives for imaging cerebral gliomas: uptake in human glioma cells and evaluation in stereotactically implanted C6 glioma rats. ( Feiden, W; Heimann, A; Kempski, O; Kirsch, CM; Richter, S; Romeike, BF; Samnick, S, 2000) |
| " The spectra from meningiomas, neuroblastomas, and glioblastomas displayed, in addition to similarities-including the presence of signals from leucine, isoleucine, valine, threonine, lactate, acetate, glutamate, choline-containing compounds and glycine-certain distinguishing metabolic features." | 3.69 | Characteristic metabolic profiles revealed by 1H NMR spectroscopy for three types of human brain and nervous system tumours. ( Bhakoo, KK; Florian, CL; Noble, M; Preece, NE; Williams, SR, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (23.08) | 18.7374 |
| 1990's | 2 (15.38) | 18.2507 |
| 2000's | 5 (38.46) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 3 (23.08) | 2.80 |
| Authors | Studies |
|---|---|
| Seidel, EC | 1 |
| Birkemeyer, C | 1 |
| Baran-Schmidt, R | 1 |
| Meixensberger, J | 1 |
| Oppermann, H | 1 |
| Gaunitz, F | 1 |
| Yang, SH | 1 |
| Choi, Y | 1 |
| Park, M | 1 |
| Son, HY | 1 |
| Huh, YM | 1 |
| Joo, CG | 1 |
| Žukauskas, M | 1 |
| Grybaitė, B | 1 |
| Jonutė, P | 1 |
| Vaickelionienė, R | 1 |
| Gibieža, P | 1 |
| Vaickelionis, G | 1 |
| Dragūnaitė, B | 1 |
| Anusevičius, K | 1 |
| Mickevičius, V | 1 |
| Petrikaitė, V | 1 |
| Majós, C | 1 |
| Alonso, J | 1 |
| Aguilera, C | 1 |
| Serrallonga, M | 1 |
| Acebes, JJ | 1 |
| Arús, C | 1 |
| Gili, J | 1 |
| Howe, FA | 1 |
| Barton, SJ | 1 |
| Cudlip, SA | 1 |
| Stubbs, M | 1 |
| Saunders, DE | 1 |
| Murphy, M | 1 |
| Wilkins, P | 1 |
| Opstad, KS | 1 |
| Doyle, VL | 1 |
| McLean, MA | 1 |
| Bell, BA | 1 |
| Griffiths, JR | 1 |
| Bulakbasi, N | 1 |
| Kocaoglu, M | 1 |
| Ors, F | 1 |
| Tayfun, C | 1 |
| Uçöz, T | 1 |
| Laws, ER | 1 |
| Florian, CL | 1 |
| Preece, NE | 1 |
| Bhakoo, KK | 1 |
| Williams, SR | 1 |
| Noble, M | 1 |
| Samnick, S | 1 |
| Richter, S | 1 |
| Romeike, BF | 1 |
| Heimann, A | 1 |
| Feiden, W | 1 |
| Kempski, O | 1 |
| Kirsch, CM | 1 |
| Auer, DP | 1 |
| Gössl, C | 1 |
| Schirmer, T | 1 |
| Czisch, M | 1 |
| van Veelen, CW | 2 |
| Verbiest, H | 2 |
| Vlug, AM | 2 |
| Rijksen, G | 2 |
| Staal, GE | 2 |
| Zülch, KJ | 1 |
| van Ketel, BA | 1 |
| van der Vlist, MJ | 1 |
| Mostert, HW | 1 |
| de Both, NJ | 1 |
| Rhijnsburger, EH | 1 |
| Mackay, WM | 1 |
| van den Berge, JH | 1 |
| Stefanko, SZ | 1 |
13 other studies available for alanine and Glioblastoma
| Article | Year |
|---|---|
Viability of Glioblastoma Cells and Fibroblasts in the Presence of Imidazole-Containing Compounds.
Topics: Alanine; beta-Alanine; Carnosine; Fibroblasts; Glioblastoma; Histamine; Histidine; Humans; Imidazole | 2022 |
MRI measurement of alanine uptake in a mouse xenograft model of U-87 MG glioblastoma.
Topics: Alanine; Amino Acid Transport System ASC; Animals; Glioblastoma; Heterografts; Humans; Magnetic Reso | 2022 |
Evaluation of N-aryl-β-alanine derivatives as anticancer agents in triple-negative breast cancer and glioblastoma in vitro models.
Topics: Alanine; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response R | 2021 |
Adult primitive neuroectodermal tumor: proton MR spectroscopic findings with possible application for differential diagnosis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alanine; Astrocytoma; Brain; Brain Neoplasms; Diagnosis, | 2002 |
Metabolic profiles of human brain tumors using quantitative in vivo 1H magnetic resonance spectroscopy.
Topics: Alanine; Aspartic Acid; Astrocytoma; Brain Neoplasms; Choline; Creatine; Glioblastoma; Humans; Inosi | 2003 |
Combination of single-voxel proton MR spectroscopy and apparent diffusion coefficient calculation in the evaluation of common brain tumors.
Topics: Adolescent; Adult; Aged; Alanine; Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Choline; Creat | 2003 |
Imaging brain tumors -- beyond three dimensions.
Topics: Aged; Alanine; Brain Neoplasms; Choline; Female; Glioblastoma; Humans; Lactates; Lactic Acid; Magnet | 1996 |
Characteristic metabolic profiles revealed by 1H NMR spectroscopy for three types of human brain and nervous system tumours.
Topics: Alanine; Amino Acids; Brain Neoplasms; Choline; Chromatography, High Pressure Liquid; Creatine; Glio | 1995 |
Investigation of iodine-123-labelled amino acid derivatives for imaging cerebral gliomas: uptake in human glioma cells and evaluation in stereotactically implanted C6 glioma rats.
Topics: Alanine; Amino Acids; Amino Acids, Cyclic; Animals; beta-Alanine; Binding, Competitive; Blood-Brain | 2000 |
Improved analysis of 1H-MR spectra in the presence of mobile lipids.
Topics: Alanine; Artifacts; Brain; Brain Diseases; Brain Neoplasms; Glioblastoma; Glioma; Humans; Image Enha | 2001 |
Isozymes of pyruvate kinase from human brain, meningiomas, and malignant gliomas.
Topics: Alanine; Brain; Brain Neoplasms; Fetus; Glioblastoma; Glioma; Humans; Infant, Newborn; Isoenzymes; K | 1978 |
L-alpha-alanine inhibition of pyruvate kinase from tumors of the human central nervous system.
Topics: Adult; Alanine; Astrocytoma; Brain Neoplasms; Child; Child, Preschool; Glioblastoma; Glioma; Humans; | 1979 |
Pyruvate kinase inhibition in the diagnosis of gliomas with an intermediate degree of malignancy.
Topics: Alanine; Astrocytoma; Biopsy; Brain Neoplasms; Clinical Enzyme Tests; Diagnosis, Differential; Elect | 1986 |