alanine and Genetic Predisposition studies

Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.

Research Excerpts

Excerpt	Relevance	Reference
" In a previous report there was evidence that an alanine/threonine polymorphism was associated with the risk factor for aneurysmal subarachnoid hemorrhage (SAH) in a Polish population."	7.74	The alanine/threonine polymorphism of the alpha-1-antichymotrypsin (SERPINA3) gene and ruptured intracranial aneurysms in the Japanese population. ( Akagawa, H; Hori, T; Inoue, I; Kasuya, H; Krischek, B; Narita, A; Tajima, A, 2007)
"Obesity is an important correlate of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels."	7.74	Parental obesity and offspring serum alanine and aspartate aminotransferase levels: the Framingham heart study. ( D'Agostino, RB; Ellison, RC; Fox, CS; Hwang, SJ; Liang, TJ; Loomba, R; O'Donnell, CJ; Vasan, RS, 2008)
"The genetic susceptibility to Graves' disease and type 1 (insulin-dependent) diabetes mellitus is conferred by genes in the human leukocyte antigen region on the short arm of chromosome 6, but several other genes are presumed to determine disease susceptibility."	5.30	CTLA4 alanine-17 confers genetic susceptibility to Graves' disease and to type 1 diabetes mellitus. ( Badenhoop, K; Braun, J; Donner, H; Finke, R; Herwig, J; Rau, H; Siegmund, T; Usadel, KH; Walfish, PG, 1997)
" The 2 populations studied were as follows: (1) a cross-sectional study of 703 acute coronary syndrome (ACS) patients with myocardial infarction (MI) and unstable angina, and (2) a prospective study of 924 Caucasian patients from the OPUS (Orbofiban in Patients with Unstable coronary Syndromes)-TIMI-16 trial of the oral GPIIb/IIIa antagonist orbofiban."	5.10	Genetic variability in the extracellular matrix as a determinant of cardiovascular risk: association of type III collagen COL3A1 polymorphisms with coronary artery disease. ( Fitzgerald, A; Fitzgerald, DJ; Muckian, C; O'Byrne, A; O'Neill, A; Shields, DC, 2002)
"The purpose of this study was to examine whether a Proline (Pro)-to-Alanine (Ala) exchange at codon 12 (Pro12Ala) polymorphism of the peroxisome proliferator-activated receptor-gamma (PPARγ) is associated with susceptibility to nonalcoholic fatty liver disease (NAFLD), rheumatoid arthritis (RA), and psoriatic arthritis (PsA)."	4.90	Meta-analysis of associations between the peroxisome proliferator-activated receptor-γ Pro12Ala polymorphism and susceptibility to nonalcoholic fatty liver disease, rheumatoid arthritis, and psoriatic arthritis. ( Bae, SC; Lee, YH; Song, GG, 2014)
" An INS mutation, at the position 2 alanine-to-threonine substitution (A2T), was identified and co-segregated with hyperglycemia in a MODY pedigree."	3.96	Identification of Ala2Thr mutation in insulin gene from a Chinese MODY10 family. ( Chen, Y; Ge, X; Huang, X; Jiang, M; Li, M; Liu, L; Liu, Y; Lu, M; Song, M; Wang, F; Wang, Y; Yang, D; Yin, J; Zhang, J; Zhang, R, 2020)
" In a previous report there was evidence that an alanine/threonine polymorphism was associated with the risk factor for aneurysmal subarachnoid hemorrhage (SAH) in a Polish population."	3.74	The alanine/threonine polymorphism of the alpha-1-antichymotrypsin (SERPINA3) gene and ruptured intracranial aneurysms in the Japanese population. ( Akagawa, H; Hori, T; Inoue, I; Kasuya, H; Krischek, B; Narita, A; Tajima, A, 2007)
"Obesity is an important correlate of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels."	3.74	Parental obesity and offspring serum alanine and aspartate aminotransferase levels: the Framingham heart study. ( D'Agostino, RB; Ellison, RC; Fox, CS; Hwang, SJ; Liang, TJ; Loomba, R; O'Donnell, CJ; Vasan, RS, 2008)
"Our study clearly shows that alanine in position 73 is significantly associated with psoriasis vulgaris in Jewish patients."	3.69	Do specific pockets of HLA-C molecules predispose Jewish patients to psoriasis vulgaris? ( Asahina, A; Battat, S; Ben Hammo, R; Brautbar, C; Friedmann, A; Roitberg-Tambur, A; Safirman, C; Tokunaga, K; Tzfoni, EE, 1994)
"A total of 39 studies with 16,783 cancer cases and 23,063 control subjects were included in the meta-analysis on the basis of the inclusion and exclusion criteria."	2.50	PARP-1 Val762Ala polymorphism and risk of cancer: a meta-analysis based on 39 case-control studies. ( Cheng, H; Lu, J; Qin, Q; Sun, X; Xu, L; Yang, X; Zhan, L; Zhang, C; Zhu, H, 2014)
"Insulin resistance plays a part in diabetic nephropathy (DN)."	2.48	Peroxisome proliferator-activated receptor γ polymorphism Pro12Ala Is associated with nephropathy in type 2 diabetes: evidence from meta-analysis of 18 studies. ( Chen, H; Chen, J; Hu, H; Mohan, V; Tang, Y; Venkatesan, R; Wang, J; Zhang, H; Zhu, S, 2012)
"Our meta-analysis on total of 7,366 cancer cases and 9,102 controls from 13 published case-control studies showed no overall association of this polymorphism either with breast cancer risk or for cancer risk as such (for Ala homozygous odds ratio, 0."	2.44	Target sequence polymorphism of human manganese superoxide dismutase gene and its association with cancer risk: a review. ( Bag, A; Bag, N, 2008)
"Odds ratios (ORs) for prostate cancer were estimated by unconditional logistic and polytomous regression."	2.42	ELAC2/HPC2 polymorphisms, prostate-specific antigen levels, and prostate cancer. ( Boyle, P; English, DR; Giles, GG; Hopper, JL; McCredie, MR; Morris, H; Neufing, P; Severi, G; Southey, MC; Tesoriero, A; Tilley, W, 2003)
"Children at increased genetic risk for type 1 diabetes (T1D) after environmental exposures may develop pancreatic islet autoantibodies (IA) at a very young age."	1.56	Longitudinal Metabolome-Wide Signals Prior to the Appearance of a First Islet Autoantibody in Children Participating in the TEDDY Study. ( Akolkar, B; Butterworth, MD; Fan, S; Fiehn, O; Hagopian, W; Krischer, JP; Lernmark, Å; Li, Q; Parikh, H; Rewers, M; She, JX; Toppari, J; Ziegler, AG, 2020)
"The T300A variant is among the most Crohn's disease (CD) associated genetic variants."	1.48	T300A variant of AT16L1 gene in a cohort of Algerian Crohn disease patients. ( Aida, I; Aouichat-Bouguerra, S; Belhocine, K; Boussafsaf, MA; Bousseloub, A; Chaib, S; Debzi, N; Gamar, L; Kadiri, H; Kecili, L; Meddour, Y; Smara, M, 2018)
"To study parkinsonism, dementia, dystonia, and amyotrophy as subphenotypes of SCA2, and to explore the effect of CAG repeats at different loci and of mitochondrial polymorphism A10398G as modifiers of phenotype."	1.46	Neurological phenotypes in spinocerebellar ataxia type 2: Role of mitochondrial polymorphism A10398G and other risk factors. ( Augustin, MC; Barsottini, O; Jardim, LB; Locks-Coelho, LD; Monte, TL; Pedroso, JL; Pereira, FS; Reckziegel, EDR; Santos, ASP; Saraiva-Pereira, ML; Vargas, FR, 2017)
"The association between idiopathic Parkinson's disease (PD) and the ATP13A2 (PARK9) Ala746Thr variant, associated with Kufor-Rakeb syndrome, is controversial."	1.39	The role of the Ala746Thr variant in the ATP13A2 gene among Chinese patients with Parkinson's disease. ( Baum, L; Chan, AY; Hui, KF; Kuo, SH; Kwan, JY; Lau, CY; Mizuno, Y; Mok, VC; Ng, PW; Tang, NL, 2013)
"Obesity is for many scholars the most important starting status that gives rise to Metabolic Syndrome (MS) and Type 2 Diabetes (T2D)."	1.39	Amerindians show no association of PPAR-γ2 gene Ala12 allele and obesity: an "unthrifty" variant population genetics. ( Abd-El-Fatah-Khalil, S; Algora, M; Areces, C; Arnaiz-Villena, A; Arribas, I; Coca, C; Enríquez-de-Salamanca, M; Fernández-Honrado, M; Rey, D, 2013)
"A total of 130 patients with type 2 diabetes and 133 healthy subjects as control were randomly selected from January 2008 to January 2011 in endocrine wards of Zhengzhou People's Hospital."	1.39	Association of the G-250A promoter polymorphism in the hepatic lipase gene with the risk of type 2 diabetes mellitus. ( Fan, S; Guo, Y; Ou, L; Yao, L, 2013)
"Different Bcl-2 protein levels in breast cancer cell lines were determined using western blot."	1.37	BCL-2 (-938C > A) polymorphism is associated with breast cancer susceptibility. ( Haffty, BG; Jiang, L; Li, X; Liang, F; Ma, T; Moran, MS; Tao, K; Yan, S; Yang, Q; Yuan, C; Zhang, N, 2011)
"Since NAION may occur when compromised watershed microcirculation is combined with insufficient autoregulation of systematic circulation, polymorphisms of genes involved in systematic circulation, such as the RAAS genes, may be associated with NAION occurrence."	1.37	Renin-angiotensin-aldosterone system genes and nonarteritic anterior ischemic optic neuropathy. ( Asproudis, I; Bagli, E; Georgiou, I; Giannopoulos, S; Kostoulas, C; Kyritsis, AP; Markoula, S; Nikas, A, 2011)
"Hypertension is a major risk factor for cardiovascular disease."	1.36	Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. ( Aoyagi, Y; Kato, K; Metoki, N; Nozawa, Y; Oguri, M; Satoh, K; Watanabe, S; Yamada, Y; Yokoi, K; Yoshida, H; Yoshida, T, 2010)
"For the purpose, 195 subjects with type 2 diabetes with PDR were compared with 143 subjects with type 2 diabetes of duration of more than 10 years who had no clinical signs of diabetic retinopathy."	1.35	K469E polymorphism of the intracellular adhesion molecule 1 gene is associated with proliferative diabetic retinopathy in Caucasians with type 2 diabetes. ( Osredkar, J; Petrovic, D; Petrovic, MG; Saraga-Babić, M, 2008)
"Part of the inherited susceptibility to colorectal cancer (CRC) is caused by the coinheritance of common low risk variants."	1.35	The CDH1-160C>A polymorphism is a risk factor for colorectal cancer. ( Broderick, P; Chandler, I; Houlston, RS; Lubbe, S; Penegar, S; Pittman, AM; Twiss, P, 2009)
"Our results for a sample of Iranian type 2 diabetes cases and controls provide evidence that the Pro/Ala genotype of the PPARgamma-2 gene is associated with insulin sensitivity and may also have protective role against type 2 diabetes."	1.34	Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma2 (PPARgamma-2) gene is associated with greater insulin sensitivity and decreased risk of type 2 diabetes in an Iranian population. ( Adeli, K; Bahrami, Y; Ghaemi, A; Khatami, S; Khoshbin, E; Larijani, B; Meshkani, R; Mirkhani, F; Molapour, A; Sadeghi, S; Taghikhani, M, 2007)
"Leprosy is the major cause of non-traumatic neuropathy."	1.34	Ninjurin 1 asp110ala single nucleotide polymorphism is associated with protection in leprosy nerve damage. ( Cardoso, CC; de Oliveira, RB; Dias-Neto, E; Guimarães, PE; Illarramendi, X; Martinez, AN; Mendes, CT; Moraes, MO; Pacheco, AG; Sampaio, EP; Sarno, EN; Teles, RM, 2007)
"To examine a possible role of the genetic susceptibility to dioxins in the development of micropenis (MP), we studied the Arg554Lys polymorphism of the gene for aryl hydrocarbon receptor (AHR) and the Pro185Ala polymorphism of the gene for aryl hydrocarbon receptor repressor (AHRR), in 73 boys with MP (34 boys with mild MP from -2."	1.33	Association of micropenis with Pro185Ala polymorphism of the gene for aryl hydrocarbon receptor repressor involved in dioxin signaling. ( Fujimoto, M; Fukami, M; Hasegawa, T; Koitabashi, Y; Ogata, T; Soneda, S, 2005)
"Autism is a spectrum of neurodevelopmental disorders with a primarily genetic etiology exhibiting deficits in (1) development of language and (2) social relationships and (3) patterns of repetitive, restricted behaviors or interests and resistance to change."	1.33	Allelic heterogeneity at the serotonin transporter locus (SLC6A4) confers susceptibility to autism and rigid-compulsive behaviors. ( Blakely, RD; Delahanty, RJ; Folstein, SE; Han, Q; Jiang, L; Li, C; McCauley, JL; Prasad, HC; Sutcliffe, JS, 2005)
"To determine the role of PPAR-gamma2 in genetic susceptibility to ischemic stroke in type 2 diabetes, we genotyped 302 ischemic stroke patients, 283 healthy controls and 141 type 2 diabetic patients without ischemic stroke (diabetes duration >10 years) for PPAR-gamma2 Pro12Ala polymorphism by polymerase chain reaction-restriction fragment length polymorphism methods."	1.33	Peroxisome proliferator-activated receptor-gamma2 Pro12Ala polymorphism is associated with reduced risk for ischemic stroke with type 2 diabetes. ( Chung, JH; Lee, BC; Lee, HJ, 2006)
"The susceptibility of sheep to scrapie infection is influenced by prion gene alleles, which are modulated by polymorphic variations corresponding to amino acid positions 136, 154 and 173 of the prion protein (PrP)."	1.32	Neuronal accumulation of abnormal prion protein in sheep carrying a scrapie-resistant genotype (PrPARR/ARR). ( Buschmann, A; Erhardt, G; Groschup, MH; Lühken, G; Schultz, J, 2004)
"One hundred thirty-three patients with type 2 diabetes and 97 control subjects were investigated."	1.32	The frequency of alleles of the Pro12Ala polymorphism in PPARgamma2 is different between healthy controls and patients with type 2 diabetes. ( Andel, M; Cerná, M; Cimburová, M; Kolostová, K; Kubena, A; Novota, P; Pintérová, D; Romzová, M, 2004)
"This gene is located near the IDDM7 region and one of its amino acid polymorphisms, Ala45Thr, has been associated with type 1 diabetes (T1DM) in Japanese and Danish populations."	1.32	The Ala45Thr polymorphism of BETA2/NeuroD1 gene and susceptibility to type 1 diabetes mellitus in caucasians. ( Klupa, T; Malecki, MT; Moczulski, DK; Rogus, JJ, 2003)
"Unadjusted and adjusted odds ratios of type 2 diabetes were 0."	1.32	Prospective study of the association between the proline to alanine codon 12 polymorphism in the PPARgamma gene and type 2 diabetes. ( Altshuler, DM; Hankinson, SE; Hu, FB; Hunter, DJ; Liu, S; Manson, JE; Meigs, JB; Memisoglu, A, 2003)
"The odds ratio of having diabetic nephropathy for Ala carriers was 0."	1.32	The human peroxisome proliferator-activated receptor gamma2 (PPARgamma2) Pro12Ala polymorphism is associated with decreased risk of diabetic nephropathy in patients with type 2 diabetes. ( Canani, LH; Caramori, ML; Costa, LA; Gross, JL, 2003)
"The adjusted OR for bladder cancer was 2."	1.32	Increased risk of bladder cancer associated with a glutathione peroxidase 1 codon 198 variant. ( Habuchi, T; Ichimura, Y; Kato, T; Nishiyama, H; Ogawa, O; Oyama, C; Sato, K; Tsuchiya, N; Wang, L, 2004)
"Hereditary nonpolyposis colorectal cancer (HNPCC) is caused by mutations in the mismatch-repair genes."	1.31	The founder mutation MSH2*1906G-->C is an important cause of hereditary nonpolyposis colorectal cancer in the Ashkenazi Jewish population. ( Bonner, JD; Boyd, J; Chong, G; De La Chapelle, A; Ellis, NA; Farber, D; Figer, A; Foulkes, WD; Friedman, E; Gaff, CL; Gebert, J; Gordon, PH; Greenwood, CM; Gregersen, PK; Gruber, SB; Hamel, N; Hampel, H; Horwitz, M; King, MC; Lee, C; MacNamara, E; Macrae, FA; Marcus, V; Markowitz, A; Nafa, K; Offit, K; Paillerets, BB; Rennert, G; Shia, J; Thiffault, I; Tomsho, L; Walsh, T; Weitzel, JN, 2002)
"Eighty patients with child-onset Type 1 diabetes were examined along with 121 non-diabetic subjects as the controls."	1.31	The association of Ala45Thr polymorphism in NeuroD with child-onset Type 1a diabetes in Japanese. ( Amemiya, S; Aya, M; Ishihara, T; Kasuga, A; Kato, K; Kobayashi, K; Mochizuki, M; Nakazawa, S, 2002)
"The genetic susceptibility to Graves' disease and type 1 (insulin-dependent) diabetes mellitus is conferred by genes in the human leukocyte antigen region on the short arm of chromosome 6, but several other genes are presumed to determine disease susceptibility."	1.30	CTLA4 alanine-17 confers genetic susceptibility to Graves' disease and to type 1 diabetes mellitus. ( Badenhoop, K; Braun, J; Donner, H; Finke, R; Herwig, J; Rau, H; Siegmund, T; Usadel, KH; Walfish, PG, 1997)
"Susceptibility and resistance to type 1 diabetes are associated with MHC class II alleles that carry non-Asp and Asp at residue 57 of their beta chain respectively."	1.30	The P9 pocket of HLA-DQ2 (non-Aspbeta57) has no particular preference for negatively charged anchor residues found in other type 1 diabetes-predisposing non-Aspbeta57 MHC class II molecules. ( Buus, S; Holm, A; Johansen, BH; Paulsen, G; Quarsten, H; Sollid, LM; Thorpe, CJ, 1998)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	7 (3.95)	18.2507
2000's	112 (63.28)	29.6817
2010's	54 (30.51)	24.3611
2020's	4 (2.26)	2.80

Trial	Enrollment	Study Type	Start Date	Status
A Pilot Study to Determine the Effect of Dietary Intervention on Novel Biomarkers of Breast Cancer Risk.[NCT00555386]	27 participants (Actual)	Interventional	2007-04-30	Completed
Selenoproteins as Prognostic Markers and Therapeutic Targets in Breast Cancer.[NCT05817227]	300 participants (Anticipated)	Observational	2022-05-19	Recruiting
Parkin Mutations and Their Functional Consequences[NCT00136721]	2,500 participants	Observational	2002-06-30	Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Sex-specific effect of CPB2 Ala147Thr but not Thr325Ile variants on the risk of venous thrombosis: A comprehensive meta-analysis. PloS one, 2017, Volume: 12, Issue:5 Topics: Alanine; Carboxypeptidase B2; Female; Genetic Predisposition to Disease; Humans; Isoleucine; Male; R	2017
MTHFR C677T and A1298C polymorphisms were associated with bladder cancer risk and disease progression: a meta-analysis. DNA and cell biology, 2013, Volume: 32, Issue:5 Topics: Alanine; Amino Acid Substitution; Carcinoma; Case-Control Studies; Cysteine; Disease Progression; Ge	2013
Polymorphisms of ERBB2 and breast cancer risk: a meta-analysis of 26 studies involving 35,088 subjects. Journal of surgical oncology, 2013, Volume: 108, Issue:6 Topics: Adult; Aged; Alanine; Alleles; Asian People; Black People; Breast Neoplasms; Case-Control Studies; F	2013
Effects of Pro12Ala polymorphism in peroxisome proliferator-activated receptor-γ2 gene on metabolic syndrome risk: a meta-analysis. Gene, 2014, Feb-01, Volume: 535, Issue:1 Topics: Alanine; Case-Control Studies; Genetic Predisposition to Disease; Humans; Metabolic Syndrome; Polymo	2014
Meta-analysis of associations between the peroxisome proliferator-activated receptor-γ Pro12Ala polymorphism and susceptibility to nonalcoholic fatty liver disease, rheumatoid arthritis, and psoriatic arthritis. Genetic testing and molecular biomarkers, 2014, Volume: 18, Issue:5 Topics: Alanine; Arthritis, Psoriatic; Arthritis, Rheumatoid; Genetic Predisposition to Disease; Humans; Non	2014
PARP-1 Val762Ala polymorphism and risk of cancer: a meta-analysis based on 39 case-control studies. PloS one, 2014, Volume: 9, Issue:5 Topics: Alanine; Case-Control Studies; Genetic Predisposition to Disease; Humans; Neoplasms; Poly (ADP-Ribos	2014
Lack of association between MTHFR A1298C variant and Alzheimer's disease: evidence from a systematic review and cumulative meta-analysis. Neurological research, 2017, Volume: 39, Issue:5 Topics: Alanine; Alzheimer Disease; Cysteine; Genetic Association Studies; Genetic Predisposition to Disease	2017
Target sequence polymorphism of human manganese superoxide dismutase gene and its association with cancer risk: a review. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2008, Volume: 17, Issue:12 Topics: Alanine; Alleles; Antioxidants; Breast Neoplasms; Genetic Predisposition to Disease; Humans; Neoplas	2008
IGFBP3 polymorphisms and risk of cancer: a meta-analysis. Molecular biology reports, 2010, Volume: 37, Issue:1 Topics: Alanine; Alleles; Amino Acid Substitution; Case-Control Studies; Confidence Intervals; Genetic Predi	2010
Population description and its role in the interpretation of genetic association. Human genetics, 2010, Volume: 127, Issue:5 Topics: Alanine; Diabetes Mellitus, Type 2; Gene Frequency; Genetic Predisposition to Disease; Humans; Patie	2010
Amyloid neuropathy with transthyretin mutations: overview and unique Ala97Ser in Taiwan. Acta neurologica Taiwanica, 2011, Volume: 20, Issue:2 Topics: Age of Onset; Alanine; Amyloid Neuropathies; Female; Genetic Predisposition to Disease; Humans; Male	2011
Peroxisome proliferator-activated receptor γ polymorphism Pro12Ala Is associated with nephropathy in type 2 diabetes: evidence from meta-analysis of 18 studies. Diabetes care, 2012, Volume: 35, Issue:6 Topics: Alanine; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Genetic Predisposition to Diseas	2012
ELAC2/HPC2 polymorphisms, prostate-specific antigen levels, and prostate cancer. Journal of the National Cancer Institute, 2003, Jun-04, Volume: 95, Issue:11 Topics: Aged; Alanine; Case-Control Studies; Genetic Predisposition to Disease; Heterozygote; Homozygote; Hu	2003
[PPARgamma gene Pro12Ala polymorphism in diabetes mellitus]. Nihon rinsho. Japanese journal of clinical medicine, 2005, Volume: 63 Suppl 2 Topics: Alanine; Alleles; Amino Acid Substitution; Animals; Diabetes Mellitus; Environment; Genetic Predispo	2005
[Fatty acid binding protein-2 (FABP2) gene polymorphism in diabetes]. Nihon rinsho. Japanese journal of clinical medicine, 2005, Volume: 63 Suppl 2 Topics: Adipocytes; Alanine; Amino Acid Substitution; Carrier Proteins; Diabetes Mellitus; Fatty Acid-Bindin	2005
The varitint-waddler mouse phenotypes and the TRPML3 ion channel mutation: cause and consequence. Pflugers Archiv : European journal of physiology, 2008, Volume: 457, Issue:2 Topics: Alanine; Animals; Calcium; Genetic Predisposition to Disease; Genotype; Hair Color; Hearing; Hearing	2008

Article	Year
Impact of the PPAR-gamma2 Pro12Ala polymorphism and ACE inhibitor therapy on new-onset microalbuminuria in type 2 diabetes: evidence from BENEDICT. Diabetes, 2009, Volume: 58, Issue:12 Topics: Adult; Aged; Alanine; Albuminuria; Alleles; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure	2009
Genetic variability in the extracellular matrix as a determinant of cardiovascular risk: association of type III collagen COL3A1 polymorphisms with coronary artery disease. Blood, 2002, Aug-15, Volume: 100, Issue:4 Topics: Alanine; Alleles; Angina, Unstable; Collagen; Collagen Type III; Coronary Disease; Cross-Sectional S	2002

Article	Year
Longitudinal Metabolome-Wide Signals Prior to the Appearance of a First Islet Autoantibody in Children Participating in the TEDDY Study. Diabetes, 2020, Volume: 69, Issue:3 Topics: Alanine; Amino Acids, Branched-Chain; Autoantibodies; Child, Preschool; Dehydroascorbic Acid; Diabet	2020
Identification of Ala2Thr mutation in insulin gene from a Chinese MODY10 family. Molecular and cellular biochemistry, 2020, Volume: 470, Issue:1-2 Topics: Adult; Alanine; Cell Line; China; Diabetes Mellitus, Type 2; Endoplasmic Reticulum Stress; Family He	2020
Description of a family with X-linked oculo-auriculo-vertebral spectrum associated with polyalanine tract expansion in ZIC3. Clinical genetics, 2020, Volume: 98, Issue:4 Topics: Adolescent; Adult; Alanine; Anal Canal; Branchial Region; Child; Child, Preschool; DNA Copy Number V	2020
SARS-CoV-2 Triggering Severe Acute Respiratory Distress Syndrome and Secondary Hemophagocytic Lymphohistiocytosis in a 3-Year-Old Child With Down Syndrome. Journal of the Pediatric Infectious Diseases Society, 2021, Apr-30, Volume: 10, Issue:4 Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Child, Preschool; COVID-19; COVID-19 Drug Treatm	2021
Neurological phenotypes in spinocerebellar ataxia type 2: Role of mitochondrial polymorphism A10398G and other risk factors. Parkinsonism & related disorders, 2017, Volume: 42 Topics: Adult; Aged; Alanine; Ataxin-2; Dementia; Dystonia; Female; Genetic Predisposition to Disease; Glyci	2017
Combined effect of glutamine at position 70 of HLA-DRB1 and alanine at position 57 of HLA-DQB1 in type 1 diabetes: An epitope analysis. PloS one, 2018, Volume: 13, Issue:3 Topics: Age of Onset; Alanine; Binding Sites; Cohort Studies; Cyprus; Diabetes Mellitus, Type 1; Epitope Map	2018
T300A variant of AT16L1 gene in a cohort of Algerian Crohn disease patients. Current research in translational medicine, 2018, Volume: 66, Issue:1 Topics: Adolescent; Adult; Age of Onset; Alanine; Algeria; Amino Acid Substitution; Autophagy-Related Protei	2018
HLA-DQB1 Position 57 Defines Susceptibility to Isolated and Polyglandular Autoimmunity in Adults: Interaction With Gender. The Journal of clinical endocrinology and metabolism, 2019, 06-01, Volume: 104, Issue:6 Topics: Addison Disease; Adult; Alanine; Amino Acid Substitution; Asparagine; Case-Control Studies; Diabetes	2019
The role of the Ala746Thr variant in the ATP13A2 gene among Chinese patients with Parkinson's disease. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2013, Volume: 20, Issue:5 Topics: Age of Onset; Alanine; Asian People; Genetic Predisposition to Disease; Hong Kong; Humans; Middle Ag	2013
Association study between FSHR Ala307Thr and Ser680Asn variants and polycystic ovary syndrome (PCOS) in Northern Chinese Han women. Journal of assisted reproduction and genetics, 2013, Volume: 30, Issue:5 Topics: Adult; Alanine; Amino Acid Substitution; Asian People; Asparagine; Case-Control Studies; China; Fema	2013
A Pro 12 Ala substitution in the PPARγ2 polymorphism may decrease the number of diseased vessels and the severity of angiographic coronary artery. Coronary artery disease, 2013, Volume: 24, Issue:5 Topics: Adult; Aged; Aged, 80 and over; Alanine; Amino Acid Substitution; Biomarkers; Blood Glucose; Case-Co	2013
The association between the Pro12Ala variant in the PPARγ2 gene and type 2 diabetes mellitus and obesity in a Chinese population. PloS one, 2013, Volume: 8, Issue:8 Topics: Adult; Alanine; Amino Acid Substitution; Asian People; Blood Glucose; Body Mass Index; China; Diabet	2013
The gender-specific association of CXCL16 A181V gene polymorphism with susceptibility to multiple sclerosis, and its effects on PBMC mRNA and plasma soluble CXCL16 levels: preliminary findings. Journal of neurology, 2014, Volume: 261, Issue:8 Topics: Adult; Alanine; Analysis of Variance; Case-Control Studies; Chemokine CXCL16; Chemokines, CXC; Disab	2014
PPARγ2 Pro12Ala polymorphism was associated with favorable cardiometabolic risk profile in HIV/HCV coinfected patients: a cross-sectional study. Journal of translational medicine, 2014, Aug-27, Volume: 12 Topics: Adult; Alanine; Amino Acid Substitution; Cardiovascular Diseases; Coinfection; Cross-Sectional Studi	2014
Variation in PPARG is associated with longitudinal change in insulin resistance in Mexican Americans at risk for type 2 diabetes. The Journal of clinical endocrinology and metabolism, 2015, Volume: 100, Issue:3 Topics: Adult; Alanine; Amino Acid Substitution; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female;	2015
Positive Association of the Cathepsin D Ala224Val Gene Polymorphism With the Risk of Alzheimer's Disease. The American journal of the medical sciences, 2015, Volume: 350, Issue:4 Topics: Aged; Alanine; Alleles; Alzheimer Disease; Case-Control Studies; Cathepsin D; Cystatin C; Ecuador; F	2015
Association of Pro12Ala Polymorphism of Peroxisome Proliferator-Activated Receptor gamma 2 (PPARγ2) Gene with Type 2 Diabetes Mellitus in Ethnic Kashmiri Population. Biochemical genetics, 2017, Volume: 55, Issue:1 Topics: Adult; Alanine; Asian People; Diabetes Mellitus, Type 2; Female; Genetic Predisposition to Disease;	2017
Genetic polymorphisms in extracellular superoxide dismutase Leu53Leu, Arg213Gly, and Ala40Thr and susceptibility to type 2 diabetes mellitus. Genetics and molecular research : GMR, 2016, Dec-02, Volume: 15, Issue:4 Topics: Adult; Alanine; Arginine; Asian People; Diabetes Mellitus, Type 2; Female; Genetic Predisposition to	2016
Alanine-scanning mutagenesis of human signal transducer and activator of transcription 1 to estimate loss- or gain-of-function variants. The Journal of allergy and clinical immunology, 2017, Volume: 140, Issue:1 Topics: Alanine; Biological Assay; Female; Genetic Predisposition to Disease; Humans; Male; Mutagenesis; Mut	2017
Manganese superoxide dismutase gene Ala-9Val polymorphism might be related to the severity of abnormal involuntary movements in Korean schizophrenic patients. Progress in neuro-psychopharmacology & biological psychiatry, 2008, Dec-12, Volume: 32, Issue:8 Topics: Adult; Alanine; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Korea;	2008
K469E polymorphism of the intracellular adhesion molecule 1 gene is associated with proliferative diabetic retinopathy in Caucasians with type 2 diabetes. Clinical & experimental ophthalmology, 2008, Volume: 36, Issue:5 Topics: Aged; Alanine; Case-Control Studies; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Diabetic Re	2008
Association of the PPARgamma gene polymorphism Pro12Ala with delayed onset of multiple sclerosis. Neuroscience letters, 2009, Jan-02, Volume: 449, Issue:1 Topics: Adolescent; Adult; Age of Onset; Aged; Alanine; Case-Control Studies; Community Health Planning; Fem	2009
The manganese superoxide dismutase Val16Ala polymorphism is associated with decreased risk of diabetic nephropathy in Chinese patients with type 2 diabetes. Molecular and cellular biochemistry, 2009, Volume: 322, Issue:1-2 Topics: Aged; Alanine; Alleles; Asian People; Cohort Studies; Diabetes Mellitus, Type 2; Diabetic Nephropath	2009
Novel ATP13A2 variant associated with Parkinson disease in Taiwan and Singapore. Neurology, 2008, Nov-18, Volume: 71, Issue:21 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alanine; Asian People; DNA Mutational Analysis; Exons; F	2008
The Val762Ala polymorphism in the poly(ADP-ribose) polymerase-1 gene is not associated with susceptibility in Turkish rheumatoid arthritis patients. Rheumatology international, 2009, Volume: 29, Issue:7 Topics: Adult; Aged; Alanine; Amino Acid Substitution; Arthritis, Rheumatoid; DNA Mutational Analysis; Femal	2009
Association of LT-alpha Ala252Gly gene polymorphism and the genetic predisposition of coronary heart disease in Chinese. Molecular biology reports, 2010, Volume: 37, Issue:1 Topics: Alanine; Asian People; Case-Control Studies; China; Coronary Disease; Female; Genetic Predisposition	2010
The proline 12 alanine substitution in the PPARgamma2 gene is associated with increased extent of coronary artery disease in men. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 2009, Volume: 117, Issue:9 Topics: Age Factors; Aged; Alanine; Alleles; Angiography; Coronary Artery Disease; Gene Frequency; Genetic P	2009
Polymorphism of Pro12Ala in the peroxisome proliferator-activated receptor gamma2 gene in Iranian diabetic and obese subjects. Metabolic syndrome and related disorders, 2009, Volume: 7, Issue:5 Topics: Alanine; Asian People; Body Mass Index; Case-Control Studies; Cross-Sectional Studies; Diabetes Mell	2009
The CDH1-160C>A polymorphism is a risk factor for colorectal cancer. International journal of cancer, 2009, Oct-01, Volume: 125, Issue:7 Topics: Aged; Alanine; Antigens, CD; Cadherins; Case-Control Studies; Colorectal Neoplasms; Cysteine; Female	2009
Ala147Thr substitution in translocator protein is associated with adult separation anxiety in patients with depression. Psychiatric genetics, 2009, Volume: 19, Issue:2 Topics: Adult; Alanine; Amino Acid Substitution; Anxiety, Separation; Depression; Female; Genetic Predisposi	2009
Type 2 deiodinase Thr92Ala polymorphism impact on clinical course and myocardial remodeling in patients with Graves' disease. Cell cycle (Georgetown, Tex.), 2009, Aug-15, Volume: 8, Issue:16 Topics: Adult; Alanine; Echocardiography; Female; Gene Frequency; Genetic Predisposition to Disease; Genotyp	2009
Rippling muscle disease and cardiomyopathy associated with a mutation in the CAV3 gene. Neuromuscular disorders : NMD, 2009, Volume: 19, Issue:11 Topics: Adult; Alanine; Cardiomyopathies; Caveolin 3; Electrocardiography; Electromyography; Family Health;	2009
Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. American journal of hypertension, 2010, Volume: 23, Issue:1 Topics: Aged; Alanine; Asian People; Cell Adhesion Molecules; Cysteine; Female; Genetic Predisposition to Di	2010
Interaction of maternal peroxisome proliferator-activated receptor gamma2 Pro12Ala polymorphism with fetal sex affects maternal glycemic control during pregnancy. Pharmacogenetics and genomics, 2010, Volume: 20, Issue:2 Topics: Adult; Alanine; Amino Acid Substitution; Blood Glucose; Female; Fetus; Genetic Predisposition to Dis	2010
Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice. Neuron, 2009, Dec-24, Volume: 64, Issue:6 Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Amyloid; Animals; Aspartic Acid; Disease Mode	2009
Analysis of two polymorphisms of the manganese superoxide dismutase gene (Ile-58Thr and Ala-9Val) in patients with recurrent depressive disorder. Psychiatry research, 2010, Aug-30, Volume: 179, Issue:1 Topics: Alanine; Amino Acids; Case-Control Studies; Depression; Female; Gene Frequency; Genetic Predispositi	2010
Neuropathology of the recessive A673V APP mutation: Alzheimer disease with distinctive features. Acta neuropathologica, 2010, Volume: 120, Issue:6 Topics: Alanine; Alzheimer Disease; Amino Acid Substitution; Amyloid beta-Peptides; Amyloid beta-Protein Pre	2010
Polymorphism Ala54Thr of fatty acid-binding protein 2: Allelic frequencies and influence on cardiovascular risk factors in a multicenter study of Castilla y Leon. Annals of nutrition & metabolism, 2010, Volume: 57, Issue:3-4 Topics: Adult; Alanine; Anthropometry; Body Mass Index; C-Reactive Protein; Cardiovascular Diseases; Cross-S	2010
Blind attraction: the mechanism of an inherited congenital cataract. Proceedings of the National Academy of Sciences of the United States of America, 2011, Jan-11, Volume: 108, Issue:2 Topics: Alanine; Cataract; Crystallins; Genetic Predisposition to Disease; Humans; Lens, Crystalline; Light;	2011
Large proportion of amyotrophic lateral sclerosis cases in Sardinia due to a single founder mutation of the TARDBP gene. Archives of neurology, 2011, Volume: 68, Issue:5 Topics: Aged; Alanine; Amino Acid Substitution; Amyotrophic Lateral Sclerosis; Case-Control Studies; DNA Mut	2011
BCL-2 (-938C > A) polymorphism is associated with breast cancer susceptibility. BMC medical genetics, 2011, Apr-01, Volume: 12 Topics: Adult; Aged; Alanine; Biomarkers, Tumor; Blotting, Western; Breast Neoplasms; Case-Control Studies;	2011
PPAR-gamma2 pro12Ala polymorphism is associated with post-challenge abnormalities of glucose homeostasis in children and adolescents with obesity. Journal of pediatric endocrinology & metabolism : JPEM, 2011, Volume: 24, Issue:1-2 Topics: Adolescent; Alanine; Amino Acid Substitution; Child; Cohort Studies; Diabetes Mellitus, Type 2; Fema	2011
Frequency of uridine monophosphate synthase Gly(213)Ala polymorphism in Caucasian gastrointestinal cancer patients and healthy subjects, investigated by means of new, rapid genotyping assays. Genetic testing and molecular biomarkers, 2011, Volume: 15, Issue:10 Topics: Adult; Aged; Aged, 80 and over; Alanine; Amino Acid Substitution; Carcinoma; Chromatography, High Pr	2011
Renin-angiotensin-aldosterone system genes and nonarteritic anterior ischemic optic neuropathy. Molecular vision, 2011, Volume: 17 Topics: Age Factors; Aged; Aged, 80 and over; Alanine; Alleles; Angiotensinogen; Confidence Intervals; Cyste	2011
[Implication of platelet-activating factor receptor A224D mutation in susceptibility to relapsing-remitting multiple sclerosis: A Tunisian population study]. Pathologie-biologie, 2012, Volume: 60, Issue:3 Topics: Adult; Alanine; Amino Acid Substitution; Aspartic Acid; Disease Progression; Female; Genetic Associa	2012
Broadening the phenotype of TARDBP mutations: the TARDBP Ala382Thr mutation and Parkinson's disease in Sardinia. Neurogenetics, 2011, Volume: 12, Issue:3 Topics: Aged; Alanine; Amino Acid Substitution; Case-Control Studies; Cohort Studies; DNA Mutational Analysi	2011
Pro12Ala polymorphism in human peroxisome proliferator activated receptor gamma is associated with hyperlipidaemia in obstructive sleep apnoea hypopnoea syndrome. The Journal of laryngology and otology, 2011, Volume: 125, Issue:10 Topics: Adult; Alanine; Amino Acid Substitution; Body Mass Index; Case-Control Studies; China; Female; Gene	2011
Dominant-negative control of cAMP-dependent IKs upregulation in human long-QT syndrome type 1. Circulation research, 2012, Jan-20, Volume: 110, Issue:2 Topics: Adrenergic beta-Agonists; Alanine; Animals; Aspartic Acid; Blotting, Western; CHO Cells; Computer Si	2012
The ATP-sensitive K(+) channel ABCC8 S1369A type 2 diabetes risk variant increases MgATPase activity. Diabetes, 2012, Volume: 61, Issue:1 Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Alanine; Amino Acid Substitution; ATP-Binding Cas	2012
RASSF1A Ala133Ser polymorphism is associated with increased susceptibility to hepatocellular carcinoma in a Turkish population. Gene, 2012, May-01, Volume: 498, Issue:2 Topics: Aged; Alanine; Amino Acid Substitution; Carcinoma, Hepatocellular; Case-Control Studies; Female; Gen	2012
SLC6A4 rare variant associated with eating disorders in Mexican patients. Journal of psychiatric research, 2012, Volume: 46, Issue:8 Topics: Adolescent; Alanine; DNA Mutational Analysis; Feeding and Eating Disorders; Female; Gene Frequency;	2012
Pooling/bootstrap-based GWAS (pbGWAS) identifies new loci modifying the age of onset in PSEN1 p.Glu280Ala Alzheimer's disease. Molecular psychiatry, 2013, Volume: 18, Issue:5 Topics: Age of Onset; Alanine; Alzheimer Disease; Cohort Studies; Databases, Factual; Female; Founder Effect	2013
Screening for POLG W748S and A467T mutations in ataxia patients from Spain. Movement disorders : official journal of the Movement Disorder Society, 2012, Sep-01, Volume: 27, Issue:10 Topics: Adult; Age of Onset; Aged; Alanine; Ataxia; DNA Polymerase gamma; DNA-Directed DNA Polymerase; Femal	2012
Analysis of mitochondrial haplogroups associated with TTR Val30Ala familial amyloidotic polyneuropathy in Chinese patients. The International journal of neuroscience, 2012, Volume: 122, Issue:12 Topics: Adult; Age of Onset; Aged; Alanine; Amyloid Neuropathies, Familial; Asian People; DNA, Mitochondrial	2012
Association of manganese superoxide dismutase and glutathione S-transferases genotypes with myocardial infarction in patients with type 2 diabetes mellitus. Diabetes research and clinical practice, 2012, Volume: 98, Issue:1 Topics: Alanine; Biomarkers; Blood Glucose; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Diabetic Ang	2012
Risk for myasthenia gravis maps to a (151) Pro→Ala change in TNIP1 and to human leukocyte antigen-B08. Annals of neurology, 2012, Volume: 72, Issue:6* Topics: Adult; Age of Onset; Alanine; Case-Control Studies; DNA-Binding Proteins; Europe; Female; Gene Frequ	2012
Amerindians show no association of PPAR-γ2 gene Ala12 allele and obesity: an "unthrifty" variant population genetics. Molecular biology reports, 2013, Volume: 40, Issue:2 Topics: Adult; Aged; Alanine; Amino Acid Substitution; Female; Gene Frequency; Genetic Association Studies;	2013
What is influencing the phenotype of the common homozygous polymerase-γ mutation p.Ala467Thr? Brain : a journal of neurology, 2012, Volume: 135, Issue:Pt 12 Topics: Adolescent; Adult; Age of Onset; Alanine; Child; Cohort Studies; Diffuse Cerebral Sclerosis of Schil	2012
The p.Ala510Val mutation in the SPG7 (paraplegin) gene is the most common mutation causing adult onset neurogenetic disease in patients of British ancestry. Journal of neurology, 2013, Volume: 260, Issue:5 Topics: Adult; Age of Onset; Alanine; ATPases Associated with Diverse Cellular Activities; Female; Genetic P	2013
Association of the G-250A promoter polymorphism in the hepatic lipase gene with the risk of type 2 diabetes mellitus. Annales d'endocrinologie, 2013, Volume: 74, Issue:1 Topics: Adult; Aged; Alanine; Amino Acid Substitution; Asian People; Case-Control Studies; Diabetes Mellitus	2013
Comment: studies of the Pro12Ala polymorphism of the PPAR-gamma gene in the Danish MONICA cohort: homozygosity of the Ala allele confers a decreased risk of the insulin resistance syndrome. The Journal of clinical endocrinology and metabolism, 2002, Volume: 87, Issue:8 Topics: Adult; Aged; Alanine; Cohort Studies; Denmark; Disease Susceptibility; Female; Gene Frequency; Genet	2002
The founder mutation MSH21906G-->C is an important cause of hereditary nonpolyposis colorectal cancer in the Ashkenazi Jewish population. American journal of human genetics, 2002, Volume: 71, Issue:6* Topics: Alanine; Case-Control Studies; Chromosomes, Human, Pair 2; Colorectal Neoplasms, Hereditary Nonpolyp	2002
Influence of interleukin-12 receptor beta1 polymorphisms on tuberculosis. Human genetics, 2003, Volume: 112, Issue:3 Topics: Adult; Aged; Alanine; Asian People; Blotting, Western; Case-Control Studies; Cysteine; Female; Genet	2003
Exploring the effects of methylenetetrahydrofolate reductase gene variants C677T and A1298C on the risk of orofacial clefts in 261 Norwegian case-parent triads. American journal of epidemiology, 2003, Jun-15, Volume: 157, Issue:12 Topics: Adolescent; Adult; Alanine; Case-Control Studies; Cleft Lip; Cleft Palate; Cysteine; Female; Folic A	2003
Association between the Ala379Val variant of the lipoprotein associated phospholipase A2 and risk of myocardial infarction in the north and south of Europe. Atherosclerosis, 2003, Volume: 168, Issue:2 Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Alanine; Alleles; Case-Control Studies; Europe; Gene	2003
Role of glutathione peroxidase 1 in breast cancer: loss of heterozygosity and allelic differences in the response to selenium. Cancer research, 2003, Jun-15, Volume: 63, Issue:12 Topics: Adenocarcinoma; Alanine; Alleles; Amino Acid Substitution; Breast Neoplasms; Codon; DNA, Neoplasm; E	2003
Role of glutathione peroxidase 1 in breast cancer: loss of heterozygosity and allelic differences in the response to selenium. Cancer research, 2003, Jun-15, Volume: 63, Issue:12 Topics: Adenocarcinoma; Alanine; Alleles; Amino Acid Substitution; Breast Neoplasms; Codon; DNA, Neoplasm; E	2003
Role of glutathione peroxidase 1 in breast cancer: loss of heterozygosity and allelic differences in the response to selenium. Cancer research, 2003, Jun-15, Volume: 63, Issue:12 Topics: Adenocarcinoma; Alanine; Alleles; Amino Acid Substitution; Breast Neoplasms; Codon; DNA, Neoplasm; E	2003
Role of glutathione peroxidase 1 in breast cancer: loss of heterozygosity and allelic differences in the response to selenium. Cancer research, 2003, Jun-15, Volume: 63, Issue:12 Topics: Adenocarcinoma; Alanine; Alleles; Amino Acid Substitution; Breast Neoplasms; Codon; DNA, Neoplasm; E	2003
The Ala45Thr polymorphism of BETA2/NeuroD1 gene and susceptibility to type 2 diabetes mellitus in a Polish population. Acta diabetologica, 2003, Volume: 40, Issue:2 Topics: Adult; Alanine; Amino Acid Substitution; Basic Helix-Loop-Helix Transcription Factors; Case-Control	2003
[Significance of Factor V gene A506G mutation (Leiden) in the pathogenesis of ischemic stroke]. Ideggyogyaszati szemle, 2003, May-20, Volume: 56, Issue:5-6 Topics: Adult; Age of Onset; Alanine; Brain Ischemia; DNA Mutational Analysis; Factor V; Female; Genetic Pre	2003
Investigation of an LDLR gene polymorphism (19p13.2) in susceptibility to migraine without aura. Journal of the neurological sciences, 2003, Sep-15, Volume: 213, Issue:1-2 Topics: Adolescent; Adult; Alanine; Alleles; Child; Chromosome Mapping; Chromosomes, Human, Pair 19; Exons;	2003
Methionine synthase polymorphism is a risk factor for Alzheimer disease. Neuroreport, 2003, Jul-18, Volume: 14, Issue:10 Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Age of Onset; Aged; Aged, 80 and over; Ag	2003
The Ala45Thr polymorphism of BETA2/NeuroD1 gene and susceptibility to type 1 diabetes mellitus in caucasians. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 2003, Volume: 111, Issue:5 Topics: Adult; Age of Onset; Alanine; Amino Acid Substitution; Base Sequence; Basic Helix-Loop-Helix Transcr	2003
Methylenetetrahydrofolate reductase gene polymorphisms in patients with schizophrenia. Brain research. Molecular brain research, 2003, Sep-10, Volume: 117, Issue:1 Topics: Alanine; Alleles; Chi-Square Distribution; Cysteine; DNA Mutational Analysis; Gene Frequency; Geneti	2003
Prospective study of the association between the proline to alanine codon 12 polymorphism in the PPARgamma gene and type 2 diabetes. Diabetes care, 2003, Volume: 26, Issue:10 Topics: Alanine; Case-Control Studies; Diabetes Mellitus, Type 2; Female; Genetic Predisposition to Disease;	2003
The Pro12Ala polymorphism of PPARgamma2 gene and susceptibility to type 2 diabetes mellitus in a Polish population. Diabetes research and clinical practice, 2003, Volume: 62, Issue:2 Topics: Age of Onset; Alanine; Amino Acid Substitution; Body Mass Index; Diabetes Mellitus, Type 2; Genetic	2003
MDR1 Ala893 polymorphism is associated with inflammatory bowel disease. American journal of human genetics, 2003, Volume: 73, Issue:6 Topics: Alanine; Chromosomes, Human, Pair 7; DNA Primers; Gene Frequency; Genes, MDR; Genetic Predisposition	2003
The human peroxisome proliferator-activated receptor gamma2 (PPARgamma2) Pro12Ala polymorphism is associated with decreased risk of diabetic nephropathy in patients with type 2 diabetes. Diabetes, 2003, Volume: 52, Issue:12 Topics: Aged; Alanine; Case-Control Studies; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Gene	2003
CD24 is a genetic modifier for risk and progression of multiple sclerosis. Proceedings of the National Academy of Sciences of the United States of America, 2003, Dec-09, Volume: 100, Issue:25 Topics: Alanine; Alleles; Animals; Antigens, CD; CD24 Antigen; CD3 Complex; Cell Membrane; Cloning, Molecula	2003
Alcoholism-related phenotypes and genetic variants of the CB1 receptor. European archives of psychiatry and clinical neuroscience, 2003, Volume: 253, Issue:6 Topics: Adult; Alanine; Alcoholism; Analysis of Variance; Case-Control Studies; Chitinases; Delirium; Drosop	2003
Support for RGS4 as a susceptibility gene for schizophrenia. Biological psychiatry, 2004, Jan-15, Volume: 55, Issue:2 Topics: Adult; Alanine; Alleles; Case-Control Studies; Chi-Square Distribution; Diagnostic and Statistical M	2004
Association between the HOXA1 A218G polymorphism and increased head circumference in patients with autism. Biological psychiatry, 2004, Feb-15, Volume: 55, Issue:4 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alanine; Americas; Asperger Syndrome; Autistic Disorder;	2004
Cu/Zn-superoxide dismutase (GLY93-->ALA) mutation alters AMPA receptor subunit expression and function and potentiates kainate-mediated toxicity in motor neurons in culture. Neurobiology of disease, 2004, Volume: 15, Issue:2 Topics: Alanine; Amyotrophic Lateral Sclerosis; Animals; Cells, Cultured; Drug Resistance; Fetus; Genetic Pr	2004
Possible association of interleukin 1 gene locus polymorphisms with low back pain. Pain, 2004, Volume: 109, Issue:1-2 Topics: Adult; Alanine; Alleles; Cohort Studies; Cysteine; Finland; Genetic Predisposition to Disease; Genot	2004
Lack of major involvement of human uroplakin genes in vesicoureteral reflux: implications for disease heterogeneity. Kidney international, 2004, Volume: 66, Issue:1 Topics: Alanine; Amino Acid Substitution; Animals; Base Sequence; Case-Control Studies; Chromosome Mapping;	2004
Manganese superoxide dismutase Ala-9Val polymorphism and risk of breast cancer in a population-based case-control study of African Americans and whites. Breast cancer research : BCR, 2004, Volume: 6, Issue:4 Topics: Adult; Alanine; Alleles; Amino Acid Substitution; Black or African American; Breast Neoplasms; Case-	2004
Increased risk of bladder cancer associated with a glutathione peroxidase 1 codon 198 variant. The Journal of urology, 2004, Volume: 172, Issue:2 Topics: Aged; Alanine; Asian People; Carcinoma, Transitional Cell; Female; Genetic Predisposition to Disease	2004
The factor V G1691A mutation is a risk for porencephaly: A case-control study. Annals of neurology, 2004, Volume: 56, Issue:2 Topics: Alanine; Brain Diseases; Case-Control Studies; Chi-Square Distribution; Child; Factor V; Female; Gen	2004
Neuronal accumulation of abnormal prion protein in sheep carrying a scrapie-resistant genotype (PrPARR/ARR). The Journal of general virology, 2004, Volume: 85, Issue:Pt 9 Topics: Alanine; Alleles; Animals; Arginine; Brain; Genetic Predisposition to Disease; Genotype; Germany; Ho	2004
Interaction between matrix metalloproteinase 3 and the epsilon4 allele of apolipoprotein E increases the risk of Alzheimer's disease in Finns. Neuroscience letters, 2004, Sep-09, Volume: 367, Issue:3 Topics: Aged; Aged, 80 and over; Alanine; Alleles; Alzheimer Disease; Apolipoprotein E4; Apolipoproteins E;	2004
Association of estrogen receptor alpha polymorphisms with susceptibility to chronic hepatitis B virus infection. Hepatology (Baltimore, Md.), 2004, Volume: 40, Issue:2 Topics: Adult; Alanine; Alleles; Asian People; Chromosome Mapping; Cysteine; Estrogen Receptor alpha; Female	2004
Association of male infertility with Pro185Ala polymorphism in the aryl hydrocarbon receptor repressor gene: implication for the susceptibility to dioxins. Fertility and sterility, 2004, Volume: 82 Suppl 3 Topics: Adult; Alanine; Alleles; Basic Helix-Loop-Helix Transcription Factors; Case-Control Studies; Dioxins	2004
No association of the A260G and A386G DAZL single nucleotide polymorphisms with male infertility in a Caucasian population. Human reproduction (Oxford, England), 2004, Volume: 19, Issue:12 Topics: Alanine; Amino Acid Sequence; Base Sequence; Case-Control Studies; Gene Frequency; Genetic Predispos	2004
Genetic polymorphism in the manganese superoxide dismutase gene, antioxidant intake, and breast cancer risk: results from the Shanghai Breast Cancer Study. Breast cancer research : BCR, 2004, Volume: 6, Issue:6 Topics: Adult; Alanine; Alleles; Antioxidants; Breast Neoplasms; Case-Control Studies; Cocarcinogenesis; Die	2004
The frequency of alleles of the Pro12Ala polymorphism in PPARgamma2 is different between healthy controls and patients with type 2 diabetes. Folia biologica, 2004, Volume: 50, Issue:5 Topics: Adult; Aged; Alanine; Alleles; Case-Control Studies; Czech Republic; Diabetes Mellitus, Type 2; Fema	2004
Ethnic origin determines the impact of genetic variants in dopamine receptor gene (DRD1) concerning essential hypertension. American journal of hypertension, 2004, Volume: 17, Issue:12 Pt 1 Topics: Adult; Aged; Alanine; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Female; Gene Frequency;	2004
Association of Ala72Ser polymorphism with COMT enzyme activity and the risk of schizophrenia in Koreans. Human genetics, 2005, Volume: 116, Issue:4 Topics: Alanine; Base Sequence; Catechol O-Methyltransferase; DNA Primers; Genetic Predisposition to Disease	2005
Association of micropenis with Pro185Ala polymorphism of the gene for aryl hydrocarbon receptor repressor involved in dioxin signaling. Endocrine journal, 2005, Volume: 52, Issue:1 Topics: Adolescent; Alanine; Arginine; Basic Helix-Loop-Helix Transcription Factors; Case-Control Studies; C	2005
Implication of the Pro12Ala polymorphism of the PPAR-gamma 2 gene in type 2 diabetes and obesity in the French population. BMC medical genetics, 2005, Mar-22, Volume: 6 Topics: Adolescent; Adult; Alanine; Amino Acid Substitution; Case-Control Studies; Child; Diabetes Mellitus,	2005
The A140V mutation in the MECP2 gene is not a common etiological factor among Brazilian mentally retarded males. Neuroscience letters, 2005, Apr-29, Volume: 379, Issue:1 Topics: Adolescent; Alanine; Brazil; Child; Child, Preschool; DNA Mutational Analysis; DNA-Binding Proteins;	2005
Presence of alanine-to-valine substitutions in myofibrillogenesis regulator 1 in paroxysmal nonkinesigenic dyskinesia: confirmation in 2 kindreds. Archives of neurology, 2005, Volume: 62, Issue:4 Topics: Alanine; Amino Acid Substitution; Chorea; Chromosome Mapping; Chromosomes, Human, Pair 2; DNA Mutati	2005
Allelic heterogeneity at the serotonin transporter locus (SLC6A4) confers susceptibility to autism and rigid-compulsive behaviors. American journal of human genetics, 2005, Volume: 77, Issue:2 Topics: Alanine; Alleles; Autistic Disorder; Blood Platelets; Chromosomes, Human, Pair 17; Compulsive Behavi	2005
The 5alpha-reductase type II A49T and V89L high-activity allelic variants are more common in men with prostate cancer compared with the general population. European urology, 2005, Volume: 48, Issue:4 Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Aged; Alanine; Alleles; Arginine; Biomarkers, Tumor; Case-Con	2005
Association of severe micropenis with Gly146Ala polymorphism in the gene for steroidogenic factor-1. Endocrine journal, 2005, Volume: 52, Issue:4 Topics: Adolescent; Alanine; Child; Child, Preschool; Genetic Predisposition to Disease; Glycine; Homeodomai	2005
The prevalence of C807T mutation of glycoprotein Ia gene among young male survivors of myocardial infarction: a relation with coronary angiography results. Kardiologia polska, 2005, Volume: 63, Issue:2 Topics: Adult; Alanine; Case-Control Studies; Coronary Angiography; Cysteine; Gene Expression; Gene Frequenc	2005
Association of the 1438G/A and 102T/C polymorphism of the 5-HT2A receptor gene with irritable bowel syndrome 5-HT2A gene polymorphism in irritable bowel syndrome. Journal of clinical gastroenterology, 2005, Volume: 39, Issue:9 Topics: Alanine; Case-Control Studies; Cysteine; Gene Frequency; Genetic Predisposition to Disease; Genotype	2005
Association study of Glutathione S-transferase P1 (GSTP1) with asthma and bronchial hyper-responsiveness in two German pediatric populations. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2005, Volume: 16, Issue:6 Topics: Adolescent; Alanine; Asthma; Bronchial Hyperreactivity; Child; Child, Preschool; Dermatitis, Atopic;	2005
Collagen morphology is not associated with the Ala549Pro polymorphism of the COL1A2 gene. Stroke, 2005, Volume: 36, Issue:10 Topics: Alanine; Collagen; Collagen Type I; DNA Mutational Analysis; Genetic Predisposition to Disease; Gene	2005
Polymorphisms of ADPRT Val762Ala and XRCC1 Arg399Glu and risk of breast cancer in Chinese women: a case control analysis. Oncology reports, 2006, Volume: 15, Issue:1 Topics: Adult; Alanine; Amino Acid Substitution; Arginine; Asian People; Breast Neoplasms; Case-Control Stud	2006
Examining the relationships between the Pro12Ala variant in PPARG and Type 2 diabetes-related traits in UK samples. Diabetic medicine : a journal of the British Diabetic Association, 2005, Volume: 22, Issue:12 Topics: Age of Onset; Alanine; Amino Acid Substitution; Body Mass Index; Case-Control Studies; Diabetes Mell	2005
Renin-angiotensin system gene polymorphisms: association with susceptibility to Henoch-Schonlein purpura and renal involvement. Clinical rheumatology, 2006, Volume: 25, Issue:6 Topics: Adolescent; Alanine; Angiotensinogen; Child; Child, Preschool; Cysteine; DNA Transposable Elements;	2006
The Gly146Ala variation in human SF-1 gene: its association with insulin resistance and type 2 diabetes in Chinese. Diabetes research and clinical practice, 2006, Volume: 73, Issue:3 Topics: Alanine; Chi-Square Distribution; China; Diabetes Mellitus, Type 2; Female; Gene Frequency; Genetic	2006
A91V perforin variation in healthy subjects and FHLH patients. International journal of immunogenetics, 2006, Volume: 33, Issue:2 Topics: Alanine; Amino Acid Substitution; Gene Frequency; Genetic Carrier Screening; Genetic Predisposition	2006
Role of genetic polymorphism peroxisome proliferator-activated receptor-gamma2 Pro12Ala on ethnic susceptibility to diabetes in South-Asian and Caucasian subjects: Evidence for heterogeneity. Diabetes care, 2006, Volume: 29, Issue:5 Topics: Absorptiometry, Photon; Adult; Aged; Alanine; Amino Acid Substitution; Asian People; DNA Primers; Fe	2006
The influence of the Pro12Ala mutation of PPARgamma2 receptor gene on beta-cells restoration and insulin resistance in type 2 diabetes with hypertension. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, 2005, Volume: 25, Issue:6 Topics: Alanine; Diabetes Mellitus, Type 2; Genetic Predisposition to Disease; Hypertension; Insulin Resista	2005
Ala45Thr variation in neuroD1 gene is associated with early-onset type 2 diabetes with or without diabetic pedigree in Chinese. Molecular and cellular biochemistry, 2006, Volume: 290, Issue:1-2 Topics: Adult; Aged; Alanine; Amino Acid Substitution; Basic Helix-Loop-Helix Transcription Factors; Case-Co	2006
Interaction of CTSD and A2M polymorphisms in the risk for Alzheimer's disease. Journal of the neurological sciences, 2006, Sep-25, Volume: 247, Issue:2 Topics: Aged; Aged, 80 and over; Alanine; alpha-Macroglobulins; Alzheimer Disease; Cathepsin D; DNA Mutation	2006
[Influence of polymorphism pro12Ala of PPARgamma gene on endothelium destruction in patients with diabetes mellitus t. 2]. Polskie Archiwum Medycyny Wewnetrznej, 2005, Volume: 114, Issue:5 Topics: Adult; Aged; Alanine; Amino Acid Substitution; Blood Pressure; Body Mass Index; Diabetes Mellitus, T	2005
Evaluation of oral tenofovir disoproxil fumarate and topical tenofovir GS-7340 to protect infant macaques against repeated oral challenges with virulent simian immunodeficiency virus. Journal of acquired immune deficiency syndromes (1999), 2006, Volume: 43, Issue:1 Topics: Adenine; Administration, Oral; Administration, Topical; Alanine; Animals; Anti-HIV Agents; Genetic P	2006
Associations of a novel IL4RA polymorphism, Ala57Thr, in Greenlander Inuit. The Journal of allergy and clinical immunology, 2006, Volume: 118, Issue:3 Topics: Adult; Alanine; Alleles; Amino Acid Substitution; Denmark; Female; Gene Frequency; Genetic Predispos	2006
Juvenile-onset Parkinsonism as a result of the first mutation in the adenosine triphosphate orientation domain of PINK1. Archives of neurology, 2006, Volume: 63, Issue:9 Topics: Adenosine Triphosphate; Adolescent; Adult; Age of Onset; Alanine; Amino Acid Sequence; Aspartic Acid	2006
The alanine/threonine polymorphism of the alpha-1-antichymotrypsin (SERPINA3) gene and ruptured intracranial aneurysms in the Japanese population. Cerebrovascular diseases (Basel, Switzerland), 2007, Volume: 23, Issue:1 Topics: Alanine; Aneurysm, Ruptured; Asian People; Case-Control Studies; Female; Gene Frequency; Genetic Pre	2007
The P1812A and P25T BRCA1 and the 5164del4 BRCA2 mutations: occurrence in high-risk non-Ashkenazi Jews. Genetic testing, 2006,Fall, Volume: 10, Issue:3 Topics: Adult; Aged; Alanine; Amino Acid Sequence; Amino Acid Substitution; Base Sequence; BRCA1 Protein; BR	2006
No association between Ala9Val functional polymorphism of MnSOD gene and schizophrenia in a representative Italian sample. Neuroscience letters, 2006, Dec-27, Volume: 410, Issue:3 Topics: Adult; Alanine; Case-Control Studies; Female; Gene Frequency; Genetic Predisposition to Disease; Gen	2006
Peroxisome proliferator-activated receptor-gamma2 Pro12Ala polymorphism is associated with reduced risk for ischemic stroke with type 2 diabetes. Neuroscience letters, 2006, Dec-20, Volume: 410, Issue:2 Topics: Aged; Alanine; Diabetes Mellitus, Type 2; Female; Gene Frequency; Genetic Predisposition to Disease;	2006
Ala394Thr polymorphism in the clock gene NPAS2: a circadian modifier for the risk of non-Hodgkin's lymphoma. International journal of cancer, 2007, Jan-15, Volume: 120, Issue:2 Topics: Aged; Alanine; Amino Acid Substitution; Basic Helix-Loop-Helix Transcription Factors; Circadian Rhyt	2007
Antithrombin Cambridge II (A384S): an underestimated genetic risk factor for venous thrombosis. Blood, 2007, May-15, Volume: 109, Issue:10 Topics: Adult; Alanine; Antithrombin III; Case-Control Studies; Cohort Studies; DNA Mutational Analysis; Fem	2007
Functional P2X7 receptor polymorphisms (His155Tyr, Arg307Gln, Glu496Ala) in patients with Crohn's disease. Scandinavian journal of immunology, 2007, Volume: 65, Issue:2 Topics: Alanine; Amino Acid Substitution; Arginine; Case-Control Studies; Crohn Disease; Female; Genetic Pre	2007
Genetic variation in thrombin-activatable fibrinolysis inhibitor (TAFI) is associated with the risk of splanchnic vein thrombosis. Thrombosis and haemostasis, 2007, Volume: 97, Issue:2 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alanine; Budd-Chiari Syndrome; Carboxypeptidase B2; Case	2007
Association between the MnSOD Ala-9Val polymorphism and development of schizophrenia and abnormal involuntary movements in the Xhosa population. Progress in neuro-psychopharmacology & biological psychiatry, 2007, Apr-13, Volume: 31, Issue:3 Topics: Adult; Africa, Southern; Alanine; Chi-Square Distribution; Female; Gene Frequency; Genetic Predispos	2007
Peroxisome proliferator-activated receptor-gamma Pro12Ala polymorphism is associated with the susceptibility to ischemic stroke in Taeeumin classified by Sasang medicine. Neurological research, 2007, Volume: 29 Suppl 1 Topics: Aged; Alanine; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Male; Me	2007
Alanine to serine polymorphism at position 986 of the calcium-sensing receptor associated with coronary heart disease, myocardial infarction, all-cause, and cardiovascular mortality. The Journal of clinical endocrinology and metabolism, 2007, Volume: 92, Issue:6 Topics: Adult; Aged; Alanine; Calcium; Cause of Death; Coronary Angiography; Coronary Disease; Female; Genet	2007
An analysis of peroxisome proliferator-activated receptor gamma (PPAR-gamma 2) Pro12Ala polymorphism distribution and prevalence of type 2 diabetes mellitus (T2DM) in world populations in relation to dietary habits. Nutrition, metabolism, and cardiovascular diseases : NMCD, 2007, Volume: 17, Issue:9 Topics: Adult; Aged; Aged, 80 and over; Alanine; Benin; Climate; Diabetes Mellitus, Type 2; Dietary Fats; Ec	2007
Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma2 (PPARgamma-2) gene is associated with greater insulin sensitivity and decreased risk of type 2 diabetes in an Iranian population. Clinical chemistry and laboratory medicine, 2007, Volume: 45, Issue:4 Topics: Alanine; Base Sequence; Diabetes Mellitus, Type 2; DNA Primers; Genetic Predisposition to Disease; H	2007
Intragenic Cis and Trans modification of genetic susceptibility in DYT1 torsion dystonia. American journal of human genetics, 2007, Volume: 80, Issue:6 Topics: Alanine; Alleles; Amino Acid Substitution; Aspartic Acid; Case-Control Studies; DNA Mutational Analy	2007
The LOC387715 polymorphism, inflammatory markers, smoking, and age-related macular degeneration. A population-based case-control study. Ophthalmology, 2008, Volume: 115, Issue:4 Topics: Aged; Aged, 80 and over; Alanine; Biomarkers; C-Reactive Protein; Case-Control Studies; Genetic Pred	2008
Ninjurin 1 asp110ala single nucleotide polymorphism is associated with protection in leprosy nerve damage. Journal of neuroimmunology, 2007, Volume: 190, Issue:1-2 Topics: Adult; Alanine; Amino Acid Substitution; Aspartic Acid; Cell Adhesion Molecules, Neuronal; DNA Mutat	2007
The m.5650G>A mitochondrial tRNAAla mutation is pathogenic and causes a phenotype of pure myopathy. Neuromuscular disorders : NMD, 2008, Volume: 18, Issue:1 Topics: Adult; Alanine; Base Sequence; Child; DNA Mutational Analysis; Female; Genetic Markers; Genetic Pred	2008
Association between migraine and the G1246A polymorphism in the hypocretin receptor 2 gene. Headache, 2007, Volume: 47, Issue:8 Topics: Adult; Alanine; Chi-Square Distribution; DNA Mutational Analysis; Female; Genetic Predisposition to	2007
The MnSOD Val9Ala polymorphism, dietary antioxidant intake, risk and survival in ovarian cancer (Australia). Gynecologic oncology, 2007, Volume: 107, Issue:3 Topics: Adult; Alanine; Antioxidants; Australia; Case-Control Studies; Diet; Female; Genetic Predisposition	2007
Transthyretin Ala97Ser in Chinese-Taiwanese patients with familial amyloid polyneuropathy: genetic studies and phenotype expression. Journal of the neurological sciences, 2008, Apr-15, Volume: 267, Issue:1-2 Topics: Aged; Alanine; Amino Acid Substitution; Amyloid Neuropathies, Familial; Asian People; Axons; DNA Mut	2008
Genetic polymorphism in the manganese superoxide dismutase gene is associated with an increased risk for hepatocellular carcinoma in HCV-infected Moroccan patients. Mutation research, 2008, Jan-08, Volume: 649, Issue:1-2 Topics: Aged; Alanine; Carcinoma, Hepatocellular; Female; Gene Frequency; Genetic Predisposition to Disease;	2008
Identification of BRCA1 missense substitutions that confer partial functional activity: potential moderate risk variants? Breast cancer research : BCR, 2007, Volume: 9, Issue:6 Topics: Alanine; Arginine; Biomarkers, Tumor; Breast Neoplasms; Centrosome; DNA, Complementary; Factor Analy	2007
Polymorphisms in the low-density lipoprotein receptor-related protein 5 (LRP5) gene are associated with peak bone mass in non-sedentary men: results from the Odense androgen study. Calcified tissue international, 2007, Volume: 81, Issue:6 Topics: Absorptiometry, Photon; Alanine; Androgens; Bone Density; Gene Frequency; Genetic Predisposition to	2007
Protective effect of noninherited maternal HLA-DR antigens on rheumatoid arthritis development. Proceedings of the National Academy of Sciences of the United States of America, 2007, Dec-11, Volume: 104, Issue:50 Topics: Alanine; Alleles; Arginine; Arthritis, Rheumatoid; Aspartic Acid; Child; Cohort Studies; Epitopes; F	2007
Parental obesity and offspring serum alanine and aspartate aminotransferase levels: the Framingham heart study. Gastroenterology, 2008, Volume: 134, Issue:4 Topics: Adult; Age of Onset; Alanine; Aspartate Aminotransferases; Biomarkers; Cardiovascular Diseases; Fema	2008
Do specific pockets of HLA-C molecules predispose Jewish patients to psoriasis vulgaris? Journal of the American Academy of Dermatology, 1994, Volume: 31, Issue:6 Topics: Alanine; Amino Acid Sequence; Aspartic Acid; Case-Control Studies; Chromosome Mapping; DNA; Female;	1994
CTLA4 alanine-17 confers genetic susceptibility to Graves' disease and to type 1 diabetes mellitus. The Journal of clinical endocrinology and metabolism, 1997, Volume: 82, Issue:1 Topics: Abatacept; Adolescent; Adult; Alanine; Alleles; Antigens, CD; Antigens, Differentiation; Child; Chil	1997
The P9 pocket of HLA-DQ2 (non-Aspbeta57) has no particular preference for negatively charged anchor residues found in other type 1 diabetes-predisposing non-Aspbeta57 MHC class II molecules. International immunology, 1998, Volume: 10, Issue:8 Topics: Alanine; Alleles; Aspartic Acid; B-Lymphocytes; Binding Sites; Cell Line; Computer Simulation; Diabe	1998
Genetic polymorphism of cathepsin D is strongly associated with the risk for developing sporadic Alzheimer's disease. Neuroscience letters, 1999, Mar-12, Volume: 262, Issue:3 Topics: Aged; Aged, 80 and over; Alanine; Alzheimer Disease; Amino Acid Substitution; Apolipoprotein E4; Apo	1999
The development of Graves' disease and the CTLA-4 gene on chromosome 2q33. The Journal of clinical endocrinology and metabolism, 1999, Volume: 84, Issue:7 Topics: Abatacept; Alanine; Alleles; Antigens, CD; Antigens, Differentiation; Case-Control Studies; Chromoso	1999
Association between alpha-1-antichymotrypsin polymorphism and susceptibility to chronic obstructive pulmonary disease. European journal of clinical investigation, 2000, Volume: 30, Issue:6 Topics: Adult; Alanine; Alleles; alpha 1-Antichymotrypsin; Amino Acid Substitution; Genetic Predisposition t	2000
Is the Ala138Gly alteration of MEFV gene important for amyloidosis? Human mutation, 2001, Volume: 17, Issue:1 Topics: Alanine; Amino Acid Substitution; Amyloidosis; Cytoskeletal Proteins; Familial Mediterranean Fever;	2001
A Pro12Ala polymorphism in the human peroxisome proliferator-activated receptor-gamma 2 is associated with combined hyperlipidaemia in obesity. European journal of endocrinology, 2001, Volume: 144, Issue:3 Topics: Aging; Alanine; Alleles; Amino Acid Substitution; Anthropometry; Australia; Blood Pressure; Choleste	2001
Homozygosity for alanine in the mitochondrial targeting sequence of superoxide dismutase and risk for severe alcoholic liver disease. Gastroenterology, 2001, Volume: 120, Issue:6 Topics: Adult; Aged; Alanine; Female; Genetic Predisposition to Disease; Genotype; Homozygote; Humans; Liver	2001
A novel mutation in glial fibrillary acidic protein gene in a patient with Alexander disease. Neuroscience letters, 2001, Oct-19, Volume: 312, Issue:2 Topics: Alanine; Brain; Child; DNA Mutational Analysis; Gene Frequency; Genetic Predisposition to Disease; G	2001
The association of Ala45Thr polymorphism in NeuroD with child-onset Type 1a diabetes in Japanese. Diabetes research and clinical practice, 2002, Volume: 55, Issue:1 Topics: Adolescent; Age of Onset; Alanine; Alleles; Asian People; Basic Helix-Loop-Helix Transcription Facto	2002
Mutation A1555G in the 12S rRNA gene and its epidemiological importance in German, Hungarian, and Polish patients. Human mutation, 2002, Volume: 19, Issue:3 Topics: Adult; Aged; Alanine; Amino Acid Substitution; Child; Child, Preschool; Female; Genetic Predispositi	2002
Presence of the 5,10-methylenetetrahydrofolate reductase C677T mutation in Puerto Rican patients with neural tube defects. Journal of child neurology, 2002, Volume: 17, Issue:1 Topics: Adult; Alanine; Alleles; Amino Acid Substitution; Female; Genetic Predisposition to Disease; Hispani	2002
Rheumatoid arthritis in Israeli Jews: shared sequences in the third hypervariable region of DRB1 alleles are associated with susceptibility. The Journal of rheumatology, 1991, Volume: 18, Issue:6 Topics: Alanine; Alleles; Amino Acid Sequence; Arthritis, Rheumatoid; Genetic Predisposition to Disease; Gly	1991
HLA-DQB 1 codon 57 and genetic susceptibility to type 1 (insulin-dependent) diabetes mellitus in French children. Diabetologia, 1990, Volume: 33, Issue:3 Topics: Alanine; Alleles; Aspartic Acid; Child; Codon; Diabetes Mellitus, Type 1; France; Gene Frequency; Ge	1990

alanine and Genetic Predisposition

Research Excerpts

Research

Studies (177)

Authors

Clinical Trials (3)

Trial Overview

Reviews

Trials

Other Studies

Authors	Studies
Li, Q	2
Parikh, H	1
Butterworth, MD	1
Lernmark, Å	1
Hagopian, W	1
Rewers, M	1
She, JX	1
Toppari, J	1
Ziegler, AG	1
Akolkar, B	1
Fiehn, O	1
Fan, S	2
Krischer, JP	1
Zhang, J	4
Liu, Y	2
Li, M	3
Ge, X	1
Wang, Y	4
Huang, X	3
Yang, D	1
Zhang, R	3
Chen, Y	1
Lu, M	1
Yin, J	1
Song, M	1
Wang, F	2
Jiang, M	1
Liu, L	5
Trimouille, A	1
Tingaud-Sequeira, A	1
Lacombe, D	1
Duelund Hjortshøj, T	1
Kreiborg, S	1
Buciek Hove, H	1
Rooryck, C	1
Kim-Hellmuth, S	1
Hermann, M	1
Eilenberger, J	1
Ley-Zaporozhan, J	1
Fischer, M	1
Hauck, F	1
Klein, C	1
Haas, N	1
Kappler, M	1
Huebner, J	1
Jakob, A	1
von Both, U	1
Zwingerman, N	1
Medina-Rivera, A	1
Kassam, I	1
Wilson, MD	1
Morange, PE	1
Trégouët, DA	1
Gagnon, F	1
Monte, TL	1
Pereira, FS	1
Reckziegel, EDR	1
Augustin, MC	1
Locks-Coelho, LD	1
Santos, ASP	1
Pedroso, JL	1
Barsottini, O	1
Vargas, FR	1
Saraiva-Pereira, ML	1
Jardim, LB	1
Gerasimou, P	1
Nicolaidou, V	1
Skordis, N	1
Picolos, M	1
Monos, D	1
Costeas, PA	1
Aida, I	1
Meddour, Y	1
Kadiri, H	1
Smara, M	1
Bousseloub, A	1
Kecili, L	1
Gamar, L	1
Belhocine, K	1
Boussafsaf, MA	1
Debzi, N	1
Aouichat-Bouguerra, S	1
Chaib, S	1
Kraus, AU	1
Penna-Martinez, M	1
Shoghi, F	1
Seidl, C	1
Meyer, G	1
Badenhoop, K	2
Chan, AY	1
Baum, L	1
Tang, NL	1
Lau, CY	1
Ng, PW	1
Hui, KF	1
Mizuno, Y	1
Kwan, JY	1
Mok, VC	1
Kuo, SH	1
Fu, L	1
Zhang, Z	2
Zhang, A	2
Xu, J	1
Zheng, Q	1
Cao, Y	1
Wang, L	2
Du, J	1
You, W	1
Li, Z	1
Jing, C	1
Qian-Wei, X	1
Yu-Ping, Z	1
Weng-Guang, L	1
Hua-Lei, L	1
Youssef, SM	1
Mohamed, N	1
Afef, S	1
Khaldoun, BH	1
Fadoua, N	1
Fadhel, NM	1
Naceur, SM	1
Wang, H	1
Lang, Z	1
Guo, S	1
Gong, H	1
Guan, H	1
Liu, B	1
Wang, X	3
Liu, J	2
Ouyang, Y	1
Fang, M	1
Gao, H	2
Wang, J	2
Yang, R	1
Sun, J	1
Chen, R	1
Luo, H	1
Liu, D	1
Cai, D	1
Lee, YH	1
Bae, SC	1
Song, GG	1
Qin, Q	2
Lu, J	1
Zhu, H	1
Xu, L	1
Cheng, H	1
Zhan, L	1
Yang, X	1
Zhang, C	1
Sun, X	1
Stojković, L	1
Stanković, A	1
Djurić, T	1
Dinčić, E	1
Alavantić, D	1
Zivković, M	1
García-Broncano, P	1
Berenguer, J	1
Fernández-Rodríguez, A	1
Pineda-Tenor, D	1
Jiménez-Sousa, MÁ	1
García-Alvarez, M	1
Miralles, P	1
Aldámiz-Echevarria, T	1
López, JC	1
Micheloud, D	1
Resino, S	1
Black, MH	1
Wu, J	1
Takayanagi, M	1
Wang, N	2
Taylor, KD	1
Haritunians, T	1
Trigo, E	1
Lawrence, JM	1
Watanabe, RM	1
Buchanan, TA	1
Xiang, AH	1
Paz-Y-Miño, CA	1
García-Cárdenas, JM	1
López-Cortés, A	1
Salazar, C	1
Serrano, M	1
Leone, PE	1
Majid, M	1
Masood, A	1
Kadla, SA	1
Hameed, I	1
Ganai, BA	1
Yang, YM	1
Xie, XR	1
Jin, AL	1
Kagawa, R	1
Fujiki, R	1
Tsumura, M	1
Sakata, S	1
Nishimura, S	1
Itan, Y	1
Kong, XF	1
Kato, Z	1
Ohnishi, H	1
Hirata, O	1
Saito, S	1
Ikeda, M	1
El Baghdadi, J	1
Bousfiha, A	1
Fujiwara, K	1
Oleastro, M	1
Yancoski, J	1
Perez, L	1
Danielian, S	1
Ailal, F	1
Takada, H	1
Hara, T	1
Puel, A	1
Boisson-Dupuis, S	1
Bustamante, J	1
Casanova, JL	1
Ohara, O	1
Okada, S	1
Kobayashi, M	1
Liu, S	2
Wu, Y	1
Liu, X	2
Zhou, J	1
Wang, Z	1
He, Z	1
Huang, Z	1
Kang, SG	1
Choi, JE	1
An, H	1
Park, YM	1
Lee, HJ	2
Han, C	1
Kim, YK	1
Kim, SH	1
Cho, SN	1
Joe, SH	1
Jung, IK	1
Kim, L	1
Lee, MS	1
Petrovic, MG	1
Osredkar, J	1
Saraga-Babić, M	1
Petrovic, D	2
Klotz, L	1
Schmidt, S	1
Heun, R	2
Klockgether, T	1
Kölsch, H	1
Zheng, T	3
Jiang, J	1
Zhao, R	1
Li, L	2
Zhao, W	1
Zhu, Q	1
Jia, W	2
Lin, CH	1
Tan, EK	1
Chen, ML	2
Tan, LC	1
Lim, HQ	1
Chen, GS	1
Wu, RM	1
Onaran, I	1
Tezcan, G	1
Ozgönenel, L	1
Cetin, E	1
Ozdemir, AT	1
Kanigür-Sultuybek, G	1
Bag, A	1
Bag, N	1
Zhao, N	1
Bai, M	1
Huo, K	1
Schneider, JG	1
Schiekofer, S	1
von Eynatten, M	1
Schlimmer, P	1
Dugi, KA	1
Mirzaei, H	1
Akrami, SM	1
Golmohammadi, T	1
Doosti, M	1
Heshmat, R	1
Nakhjavani, M	1
Amiri, P	1
Pittman, AM	1
Twiss, P	1
Broderick, P	1
Lubbe, S	1
Chandler, I	1
Penegar, S	1
Houlston, RS	1
Costa, B	1
Pini, S	1
Martini, C	1
Abelli, M	1
Gabelloni, P	1
Landi, S	1
Muti, M	1
Gesi, C	1
Lari, L	1
Cardini, A	1
Galderisi, S	1
Mucci, A	1
Lucacchini, A	1
Cassano, GB	1
Grineva, E	1
Babenko, A	1
Vahrameeva, N	1
Bogdanova, M	1
Kostareva, A	1
Popcova, D	1
Larionova, V	1
De Cosmo, S	1
Motterlini, N	1
Prudente, S	1
Pellegrini, F	1
Trevisan, R	1
Bossi, A	1
Remuzzi, G	1
Trischitta, V	1
Ruggenenti, P	1
Catteruccia, M	1
Sanna, T	1
Santorelli, FM	1
Tessa, A	1
Di Giacopo, R	1
Sauchelli, D	1
Verbo, A	1
Lo Monaco, M	1
Servidei, S	1
Oguri, M	1
Kato, K	2
Yokoi, K	1
Yoshida, T	1
Watanabe, S	1
Metoki, N	1
Yoshida, H	1
Satoh, K	1
Aoyagi, Y	1
Nozawa, Y	1
Yamada, Y	1
Hocher, B	1
Schlemm, L	1
Haumann, H	1
Poralla, C	1
Chen, YP	1
Li, J	1
Guthmann, F	1
Bamberg, C	1
Kalache, KD	1
Pfab, T	1
Gu, X	1
Greiner, ER	1
Mishra, R	1
Kodali, R	1
Osmand, A	1
Finkbeiner, S	1
Steffan, JS	1
Thompson, LM	1
Wetzel, R	1
Yang, XW	1
Fullerton, SM	1
Yu, JH	1
Crouch, J	1
Fryer-Edwards, K	1
Burke, W	1
Gałecki, P	1
Smigielski, J	1
Florkowski, A	1
Bobińska, K	1
Pietras, T	1
Szemraj, J	1
Giaccone, G	1
Morbin, M	1
Moda, F	1
Botta, M	1
Mazzoleni, G	1
Uggetti, A	1
Catania, M	1
Moro, ML	1
Redaelli, V	1
Spagnoli, A	1
Rossi, RS	1
Salmona, M	1
Di Fede, G	1
Tagliavini, F	1
de Luis, DA	1
Ballesteros, M	1
Ruiz, E	1
Cordero, M	1
Muñoz, C	1
Penacho, MA	1
Iglesias, P	1
Lopez Guzman, A	1
Maldonado, A	1
San Martin, L	1
Puigdevall, V	1
Romero, E	1
Gonzalez Sagrado, M	1
Izaola, O	1
Conde, R	1
Asherie, N	1
Chiò, A	1
Borghero, G	1
Pugliatti, M	1
Ticca, A	2
Calvo, A	1
Moglia, C	1
Mutani, R	1
Brunetti, M	1
Ossola, I	1
Marrosu, MG	1
Murru, MR	1
Floris, G	1
Cannas, A	1
Parish, LD	1
Cossu, P	1
Abramzon, Y	1
Johnson, JO	1
Nalls, MA	1
Arepalli, S	1
Chong, S	1
Hernandez, DG	1
Traynor, BJ	1
Restagno, G	1
Zhang, N	1
Li, X	2
Tao, K	1
Jiang, L	2
Ma, T	1
Yan, S	1
Yuan, C	1
Moran, MS	1
Liang, F	1
Haffty, BG	1
Yang, Q	1
Jermendy, A	1
Körner, A	1
Kovács, M	1
Madácsy, L	1
Cseh, K	1
Gusella, M	1
Bertolaso, L	1
Bolzonella, C	1
Pasini, F	1
Padrini, R	1
Markoula, S	1
Giannopoulos, S	1
Asproudis, I	1
Kostoulas, C	1
Nikas, A	1
Bagli, E	1
Kyritsis, AP	1
Georgiou, I	1
Messadi, A	1
Fekih-Mrissa, N	1
Zaouali, J	1
Layouni, S	1
Nsiri, B	1
Yedeas, M	1
Raies, A	1
Mrissa, R	1
Gritli, N	1
Quadri, M	1
Cossu, G	1
Saddi, V	1
Simons, EJ	1
Murgia, D	1
Melis, M	1
Oostra, BA	1
Bonifati, V	1
Guan, J	1
Yi, H	1
Wu, X	1
Su, K	1
Tao, M	1
Yin, S	1
Hsieh, ST	1
Heijman, J	1
Spätjens, RL	1
Seyen, SR	1
Lentink, V	1
Kuijpers, HJ	1
Boulet, IR	1
de Windt, LJ	1
David, M	1
Volders, PG	1
Fatehi, M	1
Raja, M	1
Carter, C	1
Soliman, D	1
Holt, A	1
Light, PE	1
Bayram, S	1
Zhang, H	1
Zhu, S	1
Chen, J	1
Tang, Y	1
Hu, H	1
Mohan, V	2
Venkatesan, R	1
Chen, H	1
Camarena, B	1
González, L	1
Hernández, S	1
Caballero, A	1
Vélez, JI	1
Chandrasekharappa, SC	1
Henao, E	1
Martinez, AF	1
Harper, U	1
Jones, M	1
Solomon, BD	1
Lopez, L	1
Garcia, G	1
Aguirre-Acevedo, DC	1
Acosta-Baena, N	1
Correa, JC	1
Lopera-Gómez, CM	1
Jaramillo-Elorza, MC	1
Rivera, D	1
Kosik, KS	1
Schork, NJ	1
Swanson, JM	1
Lopera, F	1
Arcos-Burgos, M	1
Pelayo-Negro, AL	1
Sánchez-Quintana, C	1
Rodríguez-Oroz, MC	1
Volpini, V	1
Zeviani, M	1
Tola-Arribas, MA	1
Berciano, J	1
Infante, J	1
Liu, JY	1
Jiang, XM	1
Zhang, M	2
Guo, YJ	1
Kariž, S	1
Nikolajević Starčević, J	1
Gregersen, PK	2
Kosoy, R	1
Lee, AT	1
Lamb, J	1
Sussman, J	1
McKee, D	1
Simpfendorfer, KR	1
Pirskanen-Matell, R	1
Piehl, F	1
Pan-Hammarstrom, Q	1
Verschuuren, JJ	1
Titulaer, MJ	1
Niks, EH	1
Marx, A	1
Ströbel, P	1
Tackenberg, B	1
Pütz, M	1
Maniaol, A	1
Elsais, A	1
Tallaksen, C	1
Harbo, HF	1
Lie, BA	1
Raychaudhuri, S	1
de Bakker, PI	1
Melms, A	1
Garchon, HJ	1
Willcox, N	1
Hammarstrom, L	1
Seldin, MF	1
Arnaiz-Villena, A	1
Fernández-Honrado, M	1
Areces, C	1
Enríquez-de-Salamanca, M	1
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