alanine has been researched along with Experimental Neoplasms in 41 studies
Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.
| Excerpt | Relevance | Reference |
|---|---|---|
| "L-alanosine is an antitumor compound which has recently entered clinical trials." | 1.27 | Effect of L-alanosine on immune response. ( Bassi, L; Mistrello, G, 1984) |
| "Alanosine treatment results in the inhibition of cell division, DNA synthesis, RNA and protein synthesis (in this order), and a depletion of the cells of adenosine triphosphate." | 1.26 | Alanosine toxicity in Novikoff rat hepatoma cells due to inhibition of the conversion of inosine monophosphate to adenosine monophosphate. ( Graff, JC; Plagemann, PG, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 33 (80.49) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (9.76) | 29.6817 |
| 2010's | 4 (9.76) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Varma, G | 1 |
| Wang, X | 2 |
| Vinogradov, E | 1 |
| Bhatt, RS | 1 |
| Sukhatme, VP | 1 |
| Seth, P | 1 |
| Lenkinski, RE | 1 |
| Alsop, DC | 1 |
| Grant, AK | 1 |
| Vallespi, MG | 1 |
| Fernandez, JR | 1 |
| Torrens, I | 1 |
| Garcia, I | 1 |
| Garay, H | 1 |
| Mendoza, O | 1 |
| Granadillo, M | 1 |
| Falcon, V | 1 |
| Acevedo, B | 1 |
| Ubieta, R | 1 |
| Guillen, GE | 1 |
| Reyes, O | 1 |
| Schulte, RF | 1 |
| Sperl, JI | 1 |
| Weidl, E | 1 |
| Menzel, MI | 1 |
| Janich, MA | 1 |
| Khegai, O | 1 |
| Durst, M | 1 |
| Ardenkjaer-Larsen, JH | 2 |
| Glaser, SJ | 1 |
| Haase, A | 1 |
| Schwaiger, M | 1 |
| Wiesinger, F | 1 |
| Wang, CL | 1 |
| Lee, O | 1 |
| Huang, CF | 1 |
| Li, EI | 1 |
| Teng, CM | 1 |
| Pan, SL | 1 |
| Lian, JF | 1 |
| Chang, FS | 1 |
| Liou, JP | 1 |
| Wang, HP | 1 |
| Hirao, A | 1 |
| Cheung, A | 1 |
| Duncan, G | 1 |
| Girard, PM | 1 |
| Elia, AJ | 1 |
| Wakeham, A | 1 |
| Okada, H | 1 |
| Sarkissian, T | 1 |
| Wong, JA | 1 |
| Sakai, T | 1 |
| De Stanchina, E | 1 |
| Bristow, RG | 1 |
| Suda, T | 1 |
| Lowe, SW | 1 |
| Jeggo, PA | 1 |
| Elledge, SJ | 1 |
| Mak, TW | 1 |
| Purro, SA | 1 |
| Bisig, CG | 1 |
| Contin, MA | 1 |
| Barra, HS | 1 |
| Arce, CA | 1 |
| JACQUEZ, JA | 1 |
| BARCLAY, RK | 1 |
| STOCK, CC | 1 |
| RUTMAN, RJ | 1 |
| CANTAROW, A | 1 |
| PASCHKIS, KE | 1 |
| CHRISTENSEN, HN | 1 |
| HESS, B | 1 |
| RIGGS, TR | 1 |
| SCHUBERT, G | 1 |
| BETTENDORF, G | 1 |
| KUNKEL, HA | 1 |
| MAASS, H | 1 |
| RATHGEN, GH | 1 |
| BALDINI, L | 1 |
| BRAMBILLA, G | 1 |
| MATTIOLI, F | 1 |
| WAGLE, SR | 1 |
| MORRIS, HP | 2 |
| WEBER, G | 1 |
| ATCHLEY, WA | 1 |
| BHAGAVAN, NV | 1 |
| Mizushima, H | 1 |
| Adachi, S | 1 |
| Ohishi, M | 1 |
| Iwamoto, R | 1 |
| Mekada, E | 1 |
| Golman, K | 1 |
| Zandt, RI | 1 |
| Lerche, M | 1 |
| Pehrson, R | 1 |
| Mohri, T | 1 |
| Fox, BW | 1 |
| Fox, M | 2 |
| Mistrello, G | 1 |
| Bassi, L | 1 |
| Mokotoff, M | 1 |
| Logue, LW | 1 |
| Tyagi, AK | 3 |
| Cooney, DA | 3 |
| Jayaram, HN | 2 |
| Swiniarski, JK | 1 |
| Johnson, RK | 1 |
| Toide, H | 1 |
| Akiyoshi, H | 1 |
| Minato, Y | 1 |
| Okuda, H | 1 |
| Fujii, S | 1 |
| Brummel, MC | 1 |
| Carlotti, RJ | 1 |
| Stegink, LD | 1 |
| Shepherd, JA | 1 |
| Vestling, CS | 1 |
| Graff, JC | 1 |
| Plagemann, PG | 1 |
| Lowry, SF | 1 |
| Norton, JA | 1 |
| Brennan, MF | 1 |
| Anandaraj, S | 1 |
| Montgomery, JA | 1 |
| Kelley, JA | 1 |
| Kelley, J | 1 |
| Adamson, RH | 1 |
| Tamemasa, O | 1 |
| Goto, R | 1 |
| Suzuki, T | 1 |
| Matthews, RH | 1 |
| Sardovia, M | 1 |
| Lewis, NJ | 1 |
| Zand, R | 1 |
| Byvoet, P | 2 |
| Aviv, H | 1 |
| Boime, I | 1 |
| Leder, P | 1 |
| Imamura, K | 1 |
| Taniuchi, K | 1 |
| Tanaka, T | 1 |
| Mercier, J | 1 |
| Befort, N | 1 |
| Beck, JP | 1 |
| Ebel, JP | 1 |
| Dybing, E | 1 |
| Schachtschabel, DO | 1 |
| Leising, H | 1 |
| DeWys, WD | 1 |
| Hall, TC | 1 |
| Wein, J | 1 |
| Roberts, E | 1 |
| Weinstein, C | 1 |
| Ermol'eva, ZV | 2 |
| Pokidova, NV | 2 |
| Kolosova, IV | 2 |
| Taylor, MW | 1 |
| Granger, GA | 1 |
| Buck, CA | 1 |
| Holland, JJ | 1 |
| Silaev, AB | 1 |
| Iulikova, EP | 1 |
| Pasternak, NA | 1 |
| Evseenko, LK | 1 |
| Shenderovich, VA | 1 |
| Loeser, CN | 1 |
| Clark, E | 1 |
| Maher, M | 1 |
| Tarkmeel, H | 1 |
41 other studies available for alanine and Experimental Neoplasms
| Article | Year |
|---|---|
Selective spectroscopic imaging of hyperpolarized pyruvate and its metabolites using a single-echo variable phase advance method in balanced SSFP.
Topics: A549 Cells; Alanine; Algorithms; Animals; Biomarkers, Tumor; Carbon Isotopes; Carbon-13 Magnetic Res | 2016 |
Identification of a novel antitumor peptide based on the screening of an Ala-library derived from the LALF(32-51) region.
Topics: Alanine; Amino Acid Sequence; Animals; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumo | 2010 |
Saturation-recovery metabolic-exchange rate imaging with hyperpolarized [1-13C] pyruvate using spectral-spatial excitation.
Topics: Alanine; Animals; Bicarbonates; Carbon Isotopes; Cell Line, Tumor; Female; Lactic Acid; Magnetic Res | 2013 |
Azatyrosinamides: novel RAS-related anticancer agents.
Topics: Alanine; Animals; Antineoplastic Agents; Genes, ras; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; | 2013 |
Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alanine; Animals; Apoptosis; Ataxia Telangiectasia Mutated Protein | 2002 |
Post-translational incorporation of the antiproliferative agent azatyrosine into the C-terminus of alpha-tubulin.
Topics: Alanine; Animals; Antibiotics, Antineoplastic; Brain Chemistry; Carboxypeptidases; Cell Division; Ce | 2003 |
Transamination in the metabolism of beta-2-thienyl-DL-alanine in normal and neoplastic cells in vitro.
Topics: Alanine; Animals; beta-Alanine; In Vitro Techniques; Mice; Neoplasms, Experimental; Rats | 1952 |
Studies in 2-acetylaminofluorene carcinogenesis. II. The in vitro uptake of alanine-1-C14 by preneoplastic liver and hepatoma mitochondrial protein.
Topics: 2-Acetylaminofluorene; Alanine; Carcinogenesis; Carcinoma, Hepatocellular; Fluorenes; In Vitro Techn | 1954 |
Concentration of taurine, beta-alanine, and triiodothyronine by ascites carcinoma cells.
Topics: Alanine; Animals; Ascites; beta-Alanine; Bile Acids and Salts; Humans; Neoplasms, Experimental; Salt | 1954 |
[Studies on the influence of roentgen rays on C14-alanine incorporation in proteins of liver homogenates and tumor cells].
Topics: Alanine; Animals; Liver; Neoplasms, Experimental; Proteins; X-Rays | 1958 |
[Diazo derivatives of amino acids and peptides as possible antineoplastic chemotherapeutic agents. V. Experimental anticancerigenic activity of diazoacetyl-D,L-alanine ethyl ester].
Topics: Alanine; Amino Acids; Animals; Antineoplastic Agents; Neoplasms, Experimental; Peptides | 1961 |
COMPARATIVE BIOCHEMISTRY OF HEPATOMAS. V. STUDIES ON AMINO ACID INCORPORATION IN LIVER TUMORS OF DIFFERENT GROWTH RATES.
Topics: Alanine; Amino Acids; Aspartic Acid; Carcinoma, Hepatocellular; Glycine; Histocytochemistry; Isoleuc | 1963 |
SALINE-SOLUBLE PREPARATIONS OF DEOXYRIBONUCLEOPROTEINS.
Topics: Acetates; Alanine; Aminobutyrates; Aminocaproates; Aminocaproic Acid; Animals; Cadmium; Caprylates; | 1964 |
Cytoplasmic domain phosphorylation of heparin-binding EGF-like growth factor.
Topics: Alanine; Amino Acid Sequence; Animals; Anisomycin; Cell Line; Chlorocebus aethiops; Cytoplasm; Epide | 2006 |
Metabolic imaging by hyperpolarized 13C magnetic resonance imaging for in vivo tumor diagnosis.
Topics: Alanine; Animals; Carbon Isotopes; Lactic Acid; Magnetic Resonance Imaging; Male; Neoplasms, Experim | 2006 |
Effects of cortisol and 19-nortestosterone on the free amino acid pools and amino acid uptake of cultured cells.
Topics: Alanine; Amino Acids; Aspartic Acid; Biological Transport; Carbon Isotopes; Culture Techniques; Glyc | 1967 |
Effect of methyl methanesulfonate on macromolecular biosynthesis in P388F cells.
Topics: Alanine; Animals; Culture Techniques; DNA, Neoplasm; Glycine; Lymphoma; Mice; Neoplasm Proteins; Neo | 1967 |
Effect of L-alanosine on immune response.
Topics: Alanine; Animals; Antibiotics, Antineoplastic; Antibody Formation; Cells, Cultured; Cytotoxicity Tes | 1984 |
Potential inhibitors of L-asparagine biosynthesis. 5. Electrophilic amide analogues of (S)-2,3-diaminopropionic acid.
Topics: Alanine; Amides; Animals; Asparagine; beta-Alanine; Cells, Cultured; Chemical Phenomena; Chemistry; | 1981 |
Studies on the mechanism of resistance of selected murine tumors to L-alanosine.
Topics: Adenosine Monophosphate; Alanine; Animals; Antibiotics, Antineoplastic; DNA; Drug Resistance; Leukem | 1981 |
Identification of the antimetabolite of L-alanosine, L-alanosyl-5-amino-4-imidazolecarboxylic acid ribonucleotide, in tumors and assessment of its inhibition of adenylosuccinate synthetase.
Topics: Adenylosuccinate Synthase; Alanine; Animals; Antibiotics, Antineoplastic; Biotransformation; DNA, Ne | 1980 |
Comparative studies on the metabolism of 2-(tetrahydrofuryl)-5-fluorouracil and 5-fluorouracil.
Topics: Alanine; Animals; DNA, Neoplasm; Fluorouracil; In Vitro Techniques; Male; Mice; Microsomes, Liver; N | 1977 |
Amino- and carboxyl-terminal analyses of hepatoma lactate dehydrogenase isozymes.
Topics: Alanine; Animals; Carcinoma, Hepatocellular; Isoenzymes; L-Lactate Dehydrogenase; Liver; Liver Neopl | 1975 |
Alanosine toxicity in Novikoff rat hepatoma cells due to inhibition of the conversion of inosine monophosphate to adenosine monophosphate.
Topics: Adenine; Adenosine Monophosphate; Adenosine Triphosphate; Alanine; Aspartic Acid; Carcinoma, Hepatoc | 1976 |
Glucose turnover and gluconeogenesis from alanine in tumor-bearing animals.
Topics: Alanine; Animals; Blood Glucose; Gluconeogenesis; Male; Neoplasms, Experimental; Rats | 1978 |
Metabolites of alanosine, an antitumor antibiotic.
Topics: Alanine; Amines; Animals; Antibiotics, Antineoplastic; Blood Proteins; Decarboxylation; Hemoglobins; | 1979 |
Preferential incorporation of some 14C-labeled D-amino acids into tumor-bearing animals.
Topics: Alanine; Amino Acids; Animals; Carbon Radioisotopes; Carcinoma, Ehrlich Tumor; Leucine; Leukemia L12 | 1978 |
Biphasic kinetic plots and specific analogs distinguishing and describing amino acid transport sites in S37 ascites tumor cells.
Topics: Alanine; Amino Acids; Animals; Biological Transport, Active; Cell Membrane; Histidine; Kinetics; Leu | 1975 |
Differences in turnover between histones and their acetyl N-terminal groups.
Topics: Acetates; Alanine; Animals; Carbon Isotopes; Carcinoma 256, Walker; Carcinoma, Hepatocellular; DNA; | 1968 |
N-acetylation of arginine-rich hepatoma histones.
Topics: Acetates; Alanine; Animals; Arginine; Carbon Isotopes; Carcinoma, Hepatocellular; Half-Life; Histone | 1971 |
Protein synthesis directed by encephalomyocarditis virus RNA: properties of a transfer RNA-dependent system.
Topics: Alanine; Amino Acids; Animals; Autoradiography; Carbon Isotopes; Encephalomyocarditis virus; Escheri | 1971 |
Multimolecular forms of pyruvate kinase. II. Purification of M 2 -type pyruvate kinase from Yoshida ascites hepatoma 130 cells and comparative studies on the enzymological and immunological properties of the three types of pyruvate kinases, L, M 1 , and M
Topics: Adenosine Triphosphate; Alanine; Animals; Carcinoma, Hepatocellular; Chloromercuribenzoates; Female; | 1972 |
[Comparative study of transfer ribonucleic acids extracted from rat liver and Zajdela hepatoma. I. Study of the acceptor properties of tRNA].
Topics: Acylation; Alanine; Animals; Arginine; Ascites; Carcinoma, Hepatocellular; Cell Differentiation; Cel | 1972 |
Inhibitory effects of chlorpromazine and diethylaminoethyl diphenylvalerate (SKF 525-A) on alanine incorporation into protein and -aminoisobutyric acid uptake in rat hepatoma cells in culture.
Topics: Alanine; Aminobutyrates; Animals; Carbon Isotopes; Carcinoma, Hepatocellular; Cells, Cultured; Chlor | 1973 |
Proceedings: Growth pattern, melanin synthesis, production of lactate, pyruvate and alanine by 2 lines of Harding Passey melanoma cells in culture.
Topics: Alanine; Animals; Cell Division; Cell Line; Lactates; Melanins; Melanoma; Mice; Neoplasms, Experimen | 1974 |
Studies on the effect of tumor type and route of administration on the antitumor activity of the amino acid mimosine (NSC-69188).
Topics: Administration, Oral; Alanine; Alkalies; Animals; Antineoplastic Agents; Body Weight; Carcinoma 256, | 1973 |
Free amino acids in E.L.4 mouse ascites tumor cells taken from susceptible (C57BL) and resistant (B10.D2) mice.
Topics: Alanine; Amino Acids; Animals; Arginine; Cell Line; Computers; Depression, Chemical; Glycine; Histid | 1973 |
[Fractionation of triprotamines from sturgeon milk].
Topics: Alanine; Animals; Cellulose; Chromatography; Chromatography, Ion Exchange; Fishes; Male; Mice; Neopl | 1971 |
Similarities and differences among specific tRNA's in mammalian tissues.
Topics: Alanine; Animals; Brain Chemistry; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Cattle; Chick Embryo; | 1967 |
[Study of chemical composition and antineoplastic effect of protamines isolated from the milt of sturgeon fishes].
Topics: Alanine; Amino Acids; Animals; Antineoplastic Agents; Arginine; Aspartic Acid; Chromatography, Thin | 1970 |
Fluorescence decay time of aminonaphthylalanine in living cell suspensions.
Topics: Alanine; Animals; Ascitic Fluid; Chickens; Computers; Fibroblasts; Fluorescence; Mice; Naphthalenes; | 1970 |