alanine has been researched along with Epilepsies, Partial in 7 studies
Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.
Epilepsies, Partial: Conditions characterized by recurrent paroxysmal neuronal discharges which arise from a focal region of the brain. Partial seizures are divided into simple and complex, depending on whether consciousness is unaltered (simple partial seizure) or disturbed (complex partial seizure). Both types may feature a wide variety of motor, sensory, and autonomic symptoms. Partial seizures may be classified by associated clinical features or anatomic location of the seizure focus. A secondary generalized seizure refers to a partial seizure that spreads to involve the brain diffusely. (From Adams et al., Principles of Neurology, 6th ed, pp317)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Amino acid analysis of plasma and urine obtained from 12 patients with epilepsy indicated that the plasma concentrations of taurine and glutamic acid were much higher than might have been expected." | 7.65 | Biochemical observations following administration of taurine to patients with epilepsy. ( Anderman, F; Sacks, C; Sherwin, AL; Van Gelder, NM, 1975) |
| "Penicillin seizures do not cause a change in levels of GABA, but result in a decrease in glutamate within the focus." | 5.26 | Effect of amino-oxyacetic acid (AOAA) on focal penicillin seizures. ( Collins, RC; Mehta, S, 1978) |
| "Amino acid analysis of plasma and urine obtained from 12 patients with epilepsy indicated that the plasma concentrations of taurine and glutamic acid were much higher than might have been expected." | 3.65 | Biochemical observations following administration of taurine to patients with epilepsy. ( Anderman, F; Sacks, C; Sherwin, AL; Van Gelder, NM, 1975) |
| "VGB is an effective drug for partial epilepsy." | 1.29 | Reduction of plasma alanine aminotransferase during vigabatrin treatment. ( Bachmann, C; Delisle, MC; Foletti, GB, 1995) |
| "Penicillin seizures do not cause a change in levels of GABA, but result in a decrease in glutamate within the focus." | 1.26 | Effect of amino-oxyacetic acid (AOAA) on focal penicillin seizures. ( Collins, RC; Mehta, S, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (57.14) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Freilich, ER | 1 |
| Jones, JM | 1 |
| Gaillard, WD | 1 |
| Conry, JA | 1 |
| Tsuchida, TN | 1 |
| Reyes, C | 1 |
| Dib-Hajj, S | 1 |
| Waxman, SG | 1 |
| Meisler, MH | 1 |
| Pearl, PL | 1 |
| Leschziner, GD | 1 |
| Coffey, AJ | 1 |
| Andrew, T | 1 |
| Gregorio, SP | 1 |
| Dias-Neto, E | 1 |
| Calafato, M | 1 |
| Bentley, DR | 1 |
| Kinton, L | 1 |
| Sander, JW | 1 |
| Johnson, MR | 1 |
| Foletti, GB | 1 |
| Delisle, MC | 1 |
| Bachmann, C | 1 |
| Collins, RC | 1 |
| Mehta, S | 1 |
| Van Gelder, NM | 3 |
| Sherwin, AL | 2 |
| Sacks, C | 1 |
| Anderman, F | 1 |
| Rasmussen, T | 1 |
| Courtois, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Taurine as an Anti-Manic Agent: A Double-Blind, Placebo-Controlled Study in Adolescents With Bipolar Disorder[NCT00391001] | Phase 1 | 4 participants (Actual) | Interventional | 2006-02-28 | Terminated | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 other studies available for alanine and Epilepsies, Partial
| Article | Year |
|---|---|
Novel SCN1A mutation in a proband with malignant migrating partial seizures of infancy.
Topics: Alanine; Amino Acid Substitution; Brain; Electroencephalography; Epilepsies, Partial; Female; Glutam | 2011 |
Q8IYL2 is a candidate gene for the familial epilepsy syndrome of Partial Epilepsy with Pericentral Spikes (PEPS).
Topics: Alanine; Brazil; Computational Biology; DNA Copy Number Variations; Epilepsies, Partial; Family Heal | 2011 |
Reduction of plasma alanine aminotransferase during vigabatrin treatment.
Topics: Adolescent; Adult; Alanine; Alanine Transaminase; Anticonvulsants; Blood Glucose; Epilepsies, Partia | 1995 |
Effect of amino-oxyacetic acid (AOAA) on focal penicillin seizures.
Topics: Acetates; Alanine; Aminooxyacetic Acid; Animals; Aspartic Acid; Cerebral Cortex; Disease Models, Ani | 1978 |
Biochemical observations following administration of taurine to patients with epilepsy.
Topics: Adolescent; Adult; Alanine; Anticonvulsants; Aspartic Acid; Cerebral Cortex; Child; Child, Preschool | 1975 |
Amino acid content of epileptogenic human brain: focal versus surrounding regions.
Topics: Adolescent; Adult; Alanine; Amino Acids; Aminobutyrates; Aspartic Acid; Brain; Cerebral Cortex; Chil | 1972 |
Close correlation between changing content of specific amino acids in epileptogenic cortex of cats, and severity of epilepsy.
Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Cats; Cerebral Cortex; Cobalt; Electro | 1972 |