Page last updated: 2024-11-08

alanine and Duhring Disease

alanine has been researched along with Duhring Disease in 2 studies

Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19902 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Silk, DB2
Kumar, PJ1
Perrett, D1
Clark, ML2
Dawson, AM1
Kumar, P1
Dawson, M1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Acute Glycine Pharmacodynamic Study[NCT01610011]21 participants (Actual)Interventional2010-07-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Brain Glycine Increments After Oral Glycine Administration Measured With MRS as Glycine/Total Creatine, Normalized to the Glycine Dose Administered (g/kg).

Brain and plasma glycine levels are measured with proton magnetic resonance spectroscopy at 4T and analytically, respectively. Because glycine doses were limited to 30 g to avoid nausea and vomiting, some subjects with higher weights were administered lower doses per body weight of glycine (g/kg). Therefore, we corrected MRS data by the actual glycine dose administered (g/kg) to account for dosing differences. (NCT01610011)
Timeframe: For up to 2 hours

InterventionPercent brain glycine/creatine increase (Mean)
Glycine Administration Controls393
Glycine Administration GLDC Mutation Subjects677

Other Studies

2 other studies available for alanine and Duhring Disease

ArticleYear
Amino acid and peptide absorption in patients with coeliac disease and dermatitis herpetiformis.
    Gut, 1974, Volume: 15, Issue:1

    Topics: Adult; Aged; Alanine; Amino Acids; Celiac Disease; Dermatitis Herpetiformis; Dipeptides; Glycine; Hu

1974
Change in jejunal structure and function in dermatitis herpetiformis: effect of gluten-free diet and corticosteroids.
    Gut, 1972, Volume: 13, Issue:10

    Topics: Adrenal Cortex Hormones; Alanine; Bicarbonates; Dermatitis Herpetiformis; Diet Therapy; Glucose; Glu

1972