Page last updated: 2024-11-08

alanine and Down Syndrome

alanine has been researched along with Down Syndrome in 5 studies

Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.

Down Syndrome: A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19901 (20.00)18.7374
1990's1 (20.00)18.2507
2000's1 (20.00)29.6817
2010's0 (0.00)24.3611
2020's2 (40.00)2.80

Authors

AuthorsStudies
Rodriguez, Z1
Shane, AL1
Verkerke, H1
Lough, C1
Zimmerman, MG1
Suthar, M1
Wrammert, J1
MacDonald, H1
Wolf, M1
Clarke, S1
Roback, JD1
Arthur, CM1
Stowell, SR1
Josephson, CD1
Kim-Hellmuth, S1
Hermann, M1
Eilenberger, J1
Ley-Zaporozhan, J1
Fischer, M1
Hauck, F1
Klein, C1
Haas, N1
Kappler, M1
Huebner, J1
Jakob, A1
von Both, U1
Rosenberg, RN1
Yao, FS1
Caserta, MT1
Wyrwicz, AM1

Reviews

1 review available for alanine and Down Syndrome

ArticleYear
A causal role for amyloid in Alzheimer's disease: the end of the beginning.
    Neurology, 1993, Volume: 43, Issue:5

    Topics: Alanine; Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Amyloid beta-Protein Precurs

1993

Other Studies

4 other studies available for alanine and Down Syndrome

ArticleYear
COVID-19 convalescent plasma clears SARS-CoV-2 refractory to remdesivir in an infant with congenital heart disease.
    Blood advances, 2020, 09-22, Volume: 4, Issue:18

    Topics: Adenosine Monophosphate; Alanine; Antibodies, Neutralizing; Antiviral Agents; Coronavirus Infections

2020
SARS-CoV-2 Triggering Severe Acute Respiratory Distress Syndrome and Secondary Hemophagocytic Lymphohistiocytosis in a 3-Year-Old Child With Down Syndrome.
    Journal of the Pediatric Infectious Diseases Society, 2021, Apr-30, Volume: 10, Issue:4

    Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Child, Preschool; COVID-19; COVID-19 Drug Treatm

2021
In vitro 1H and 31P NMR spectroscopic evidence of multiple aberrant biochemical pathways in murine trisomy 16 brain development.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2000, Volume: 18, Issue:8

    Topics: Alanine; Animals; Aspartic Acid; Biomarkers; Brain Chemistry; Choline; Creatine; Disease Models, Ani

2000
Genetic causes of mental subnormality.
    Lancet (London, England), 1973, Jul-14, Volume: 2, Issue:7820

    Topics: Alanine; Amino Acid Metabolism, Inborn Errors; Aneuploidy; Chromosome Aberrations; Chromosome Disord

1973