alanine has been researched along with Diabetes Mellitus in 122 studies
Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.
Diabetes Mellitus: A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the association between alanine transaminase (ALT) and in-hospital death in patients admitted to the intensive care unit for diabetic ketoacidosis (DKA)." | 8.31 | Elevated alanine transaminase is nonlinearly associated with in-hospital death in ICU-admitted diabetic ketoacidosis patients. ( Geng, Y; Gong, C; Liu, Q; You, J, 2023) |
| "Persistent serum alanine aminotransferase (ALT) elevation in nucleotide/nucleoside analogue (NA)-treated patients with chronic hepatitis B (CHB) has been associated with unfavorable long-term outcomes." | 8.12 | Tenofovir Alafenamide Attenuates Effects of Diabetes and Body Mass on Serum Alanine Aminotransferase Activities in Patients With Chronic Hepatitis B. ( Daugherty, T; Goel, A; Kim, WR; Kwo, PY; Kwong, A; Mannalithara, A; Sripongpun, P, 2022) |
| "Alanine was selected for study as a representative circulating glucose precursor in relation to the question of the source of the excess circulating glucose in diabetes mellitus." | 7.66 | Circulating alanine disposal in diabetes mellitus. ( Bowen, HF; Chochinov, RH; Moorhouse, JA, 1978) |
| "The following evidence suggests that diabetes mellitus may not be the simple consequence of relative or absolute insulin deficiency by itself, but may require the presence of glucagon: (1) relative or absolute hyperglucogonaemia has been identified in every form of endogenous hyperglycaemia, including total pancreatectomy in dogs; (2) insulin lack in the absence of glucagon does not cause endogenous hyperglycaemia, but when endogenous or exogenous glucagon is present, it quickly appears, irrespective of insulin levels at the time." | 7.65 | The essential role of glucagon in the pathogenesis of diabetes mellitus. ( Orci, L; Unger, RH, 1975) |
| "The present studies demonstrate that endogenous glucagon is hyperglycaemic, lipolytic and ketogenic in man, and that insulin deficiency is necessary, but is in itself not sufficient, to cause fulminant diabetic ketoacidosis." | 7.65 | Role of glucagon in human diabetic ketoacidosis: studies using somatostatin. ( Bier, DM; Forsham, PH; Gerich, JE; Karam, JH; Lorenzi, M; Schneider, VS; Tsalikian, E, 1976) |
| "Recent evidence continues to contribute to the evidence for weight gain associated with INSTIs, especially when used with newer nucleoside reverse transcriptase inhibitor, tenofovir alafenamide (TAF)." | 5.12 | Risks of metabolic syndrome and diabetes with integrase inhibitor-based therapy. ( Hill, A; Shah, S, 2021) |
| "To investigate the association between alanine transaminase (ALT) and in-hospital death in patients admitted to the intensive care unit for diabetic ketoacidosis (DKA)." | 4.31 | Elevated alanine transaminase is nonlinearly associated with in-hospital death in ICU-admitted diabetic ketoacidosis patients. ( Geng, Y; Gong, C; Liu, Q; You, J, 2023) |
| "Persistent serum alanine aminotransferase (ALT) elevation in nucleotide/nucleoside analogue (NA)-treated patients with chronic hepatitis B (CHB) has been associated with unfavorable long-term outcomes." | 4.12 | Tenofovir Alafenamide Attenuates Effects of Diabetes and Body Mass on Serum Alanine Aminotransferase Activities in Patients With Chronic Hepatitis B. ( Daugherty, T; Goel, A; Kim, WR; Kwo, PY; Kwong, A; Mannalithara, A; Sripongpun, P, 2022) |
| " In the diabetic group, blood glucose levels, serum alanine, aspartate transaminase, alkaline phosphatase activities, total lipids, sialic and uric acid levels, liver lipid peroxidation (LPO), and nonenzymatic glycosylation (NEG) levels increased, while blood glutathione, body weight, and liver glutathione (GSH) levels decreased." | 3.72 | Effects of chard (Beta vulgaris L. var cicla) on the liver of the diabetic rats: a morphological and biochemical study. ( Bolkent, S; Karabulut-Bulan, O; Ozgey, Y; Ozsoy-Sacan, O; Yanardag, R, 2004) |
| "Alterations in plasma branched-chain amino acids (valine, isoleucine and leucine) and alanine have been described in patients with insulin-dependent diabetes mellitus who have poor metabolic control." | 3.66 | Branched-chain amino acids and alanine as indices of the metabolic control in type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetic patients. ( Angiolini, A; Ciavarella, A; Forlani, G; Marchesini, G; Pisi, E; Vannini, P; Zoli, M, 1982) |
| "The following evidence suggests that diabetes mellitus may not be the simple consequence of relative or absolute insulin deficiency by itself, but may require the presence of glucagon: (1) relative or absolute hyperglucogonaemia has been identified in every form of endogenous hyperglycaemia, including total pancreatectomy in dogs; (2) insulin lack in the absence of glucagon does not cause endogenous hyperglycaemia, but when endogenous or exogenous glucagon is present, it quickly appears, irrespective of insulin levels at the time." | 3.65 | The essential role of glucagon in the pathogenesis of diabetes mellitus. ( Orci, L; Unger, RH, 1975) |
| "The present studies demonstrate that endogenous glucagon is hyperglycaemic, lipolytic and ketogenic in man, and that insulin deficiency is necessary, but is in itself not sufficient, to cause fulminant diabetic ketoacidosis." | 3.65 | Role of glucagon in human diabetic ketoacidosis: studies using somatostatin. ( Bier, DM; Forsham, PH; Gerich, JE; Karam, JH; Lorenzi, M; Schneider, VS; Tsalikian, E, 1976) |
| "The risk for type 2 diabetes increased also in subjects who gained weight or belonged to the control group." | 2.70 | Association of the Pro12Ala polymorphism in the PPAR-gamma2 gene with 3-year incidence of type 2 diabetes and body weight change in the Finnish Diabetes Prevention Study. ( Eriksson, JG; Hämäläinen, H; Ilanne-Parikka, P; Keinänen-Kiukaanniemi, S; Laakso, M; Lindi, VI; Lindström, J; Louheranta, A; Tuomilehto, J; Uusitupa, MI; Valle, TT, 2002) |
| "Acute pancreatitis has also been reported recently with another INSTI, dolutegravir." | 1.56 | Severe rhabdomyolysis and acute asymptomatic pancreatitis following the concomitant use of Biktarvy in the setting of hyperosmolar diabetic crisis. ( Goffard, JC; Henrard, S; Noure, L; Simeni Njonnou, SR, 2020) |
| "Melatonin-induced increase in glucose and lactate synthesis was accompanied by an enhancement of alanine and glycerol consumption." | 1.33 | Melatonin-induced modulation of glucose metabolism in primary cultures of rabbit kidney-cortex tubules. ( Bryla, J; Derlacz, RA; Jagielski, AK; Napierala, M; Poplawski, P, 2005) |
| "Insulin resistance was evaluated with fasting insulin, fasting glucose/insulin ratio, and homeostasis model assessment index for insulin resistance (HOMAIR)." | 1.33 | Abnormal glucose tolerance and insulin resistance in polycystic ovary syndrome amongst the Taiwanese population- not correlated with insulin receptor substrate-1 Gly972Arg/Ala513Pro polymorphism. ( Gong, KB; Ku, DC; Kuo, TC; Liang, SF; Lin, TC; Wu, MJ; Yen, JM, 2006) |
| " Oral hypoglycaemic agent dosage fell from a median of eight (IQ 6-12) to two (IQ 0-8) tablets per day (P = 0." | 1.30 | Very low calorie diet (VLCD): a useful alternative in the treatment of the obese NIDDM patient. ( Brooks, BA; Burns, CM; Capstick, F; Steinbeck, KS; Yue, DK; Zilkens, RR, 1997) |
| "We studied seven obese subjects with type 2 diabetes and seven lean and seven obese control subjects (fasting plasma glucose levels, 7." | 1.30 | Glucose production, utilization, and cycling in response to moderate exercise in obese subjects with type 2 diabetes and mild hyperglycemia. ( Giacca, A; Groenewoud, Y; McClean, P; Tsui, E; Zinman, B, 1998) |
| "Hyperglycemia in NIDDM compensated for insulin resistance to the extent that rates of glucose metabolism were the same as those for nondiabetics studied at euglycemia." | 1.29 | Interaction of carbohydrate and fat fuels in human skeletal muscle: impact of obesity and NIDDM. ( Consoli, A; Jain, A; Kelley, DE; Mandarino, LJ, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 71 (58.20) | 18.7374 |
| 1990's | 12 (9.84) | 18.2507 |
| 2000's | 18 (14.75) | 29.6817 |
| 2010's | 5 (4.10) | 24.3611 |
| 2020's | 16 (13.11) | 2.80 |
| Authors | Studies |
|---|---|
| Kaye, AD | 1 |
| Cornett, EM | 1 |
| Brondeel, KC | 1 |
| Lerner, ZI | 1 |
| Knight, HE | 1 |
| Erwin, A | 1 |
| Charipova, K | 1 |
| Gress, KL | 1 |
| Urits, I | 1 |
| Urman, RD | 1 |
| Fox, CJ | 1 |
| Kevil, CG | 1 |
| Yuan, M | 1 |
| Hu, W | 1 |
| Feng, Y | 1 |
| Tong, Y | 1 |
| Wang, X | 4 |
| Tan, B | 1 |
| Xu, H | 1 |
| Liu, J | 1 |
| Martino, MR | 1 |
| Gutiérrez-Aguilar, M | 1 |
| Yiew, NKH | 1 |
| Lutkewitte, AJ | 1 |
| Singer, JM | 1 |
| McCommis, KS | 1 |
| Ferguson, D | 1 |
| Liss, KHH | 1 |
| Yoshino, J | 1 |
| Renkemeyer, MK | 1 |
| Smith, GI | 1 |
| Cho, K | 1 |
| Fletcher, JA | 1 |
| Klein, S | 1 |
| Patti, GJ | 1 |
| Burgess, SC | 1 |
| Finck, BN | 1 |
| Du, X | 3 |
| Yang, L | 3 |
| Kong, L | 3 |
| Sun, Y | 3 |
| Shen, K | 3 |
| Cai, Y | 3 |
| Sun, H | 3 |
| Zhang, B | 3 |
| Guo, S | 3 |
| Zhang, A | 3 |
| Nakade, Y | 2 |
| Iwata, Y | 2 |
| Sakai, N | 2 |
| Mita, M | 2 |
| Nakane, M | 2 |
| Hamase, K | 2 |
| Suda, W | 2 |
| Toyama, T | 2 |
| Kitajima, S | 2 |
| Hara, A | 2 |
| Shimizu, M | 2 |
| Ogushi, C | 2 |
| Furuichi, K | 2 |
| Koshino, Y | 2 |
| Morita, H | 2 |
| Hattori, M | 2 |
| Wada, T | 2 |
| Liu, Q | 1 |
| Gong, C | 1 |
| Geng, Y | 1 |
| You, J | 1 |
| Huang, X | 1 |
| Zhao, JV | 1 |
| Ferguson, J | 1 |
| Rosser, JI | 1 |
| Quintero, O | 1 |
| Scott, J | 1 |
| Subramanian, A | 1 |
| Gumma, M | 1 |
| Rogers, A | 1 |
| Kappagoda, S | 1 |
| Simeni Njonnou, SR | 1 |
| Henrard, S | 1 |
| Noure, L | 1 |
| Goffard, JC | 1 |
| Lee, CJ | 1 |
| Qiu, TA | 1 |
| Sweedler, JV | 1 |
| Wang, Y | 1 |
| Foo, R | 1 |
| Thum, T | 1 |
| Holeček, M | 1 |
| Shah, S | 1 |
| Hill, A | 1 |
| Sripongpun, P | 1 |
| Kim, WR | 1 |
| Mannalithara, A | 1 |
| Kwong, A | 1 |
| Daugherty, T | 1 |
| Goel, A | 1 |
| Kwo, PY | 1 |
| Haji Aghajani, M | 1 |
| Moradi, O | 1 |
| Amini, H | 1 |
| Azhdari Tehrani, H | 1 |
| Pourheidar, E | 1 |
| Rabiei, MM | 1 |
| Sistanizad, M | 1 |
| Qureshi, QH | 1 |
| Ashraf, T | 1 |
| Rehman, K | 1 |
| Khosa, MK | 1 |
| Akash, MSH | 1 |
| Adeva-Andany, M | 1 |
| López-Ojén, M | 1 |
| Funcasta-Calderón, R | 1 |
| Ameneiros-Rodríguez, E | 1 |
| Donapetry-García, C | 1 |
| Vila-Altesor, M | 1 |
| Rodríguez-Seijas, J | 1 |
| Avital-Shmilovici, M | 1 |
| Whittaker, J | 1 |
| Weiss, MA | 1 |
| Kent, SB | 1 |
| Duan, J | 1 |
| Merrill, AH | 1 |
| Bordbar, A | 1 |
| Feist, AM | 1 |
| Usaite-Black, R | 1 |
| Woodcock, J | 1 |
| Palsson, BO | 1 |
| Famili, I | 1 |
| Itoh, S | 1 |
| Matsuoka, H | 1 |
| Yasuda, Y | 1 |
| Miyake, N | 1 |
| Suzuki, K | 1 |
| Yorifuji, T | 1 |
| Sugihara, S | 1 |
| Lindi, VI | 1 |
| Uusitupa, MI | 1 |
| Lindström, J | 1 |
| Louheranta, A | 1 |
| Eriksson, JG | 1 |
| Valle, TT | 1 |
| Hämäläinen, H | 1 |
| Ilanne-Parikka, P | 1 |
| Keinänen-Kiukaanniemi, S | 1 |
| Laakso, M | 1 |
| Tuomilehto, J | 1 |
| Gault, VA | 2 |
| O'Harte, FP | 2 |
| Harriott, P | 2 |
| Flatt, PR | 3 |
| STEINBORN, K | 1 |
| OJI, N | 1 |
| Verspohl, EJ | 1 |
| Hohmeier, N | 1 |
| Lempka, M | 1 |
| Akbari, M | 1 |
| Skjelbred, C | 1 |
| Følling, I | 1 |
| Sagen, J | 1 |
| Krokan, HE | 1 |
| Wang, C | 1 |
| Zhai, F | 1 |
| Chi, Y | 1 |
| Wang, G | 1 |
| Green, BD | 1 |
| Greer, B | 1 |
| Ozsoy-Sacan, O | 1 |
| Karabulut-Bulan, O | 1 |
| Bolkent, S | 1 |
| Yanardag, R | 1 |
| Ozgey, Y | 1 |
| Derlacz, RA | 1 |
| Poplawski, P | 1 |
| Napierala, M | 1 |
| Jagielski, AK | 1 |
| Bryla, J | 1 |
| Yasuda, K | 1 |
| Ishii, T | 1 |
| Hirose, H | 1 |
| Jaziri, R | 1 |
| Lobbens, S | 1 |
| Aubert, R | 1 |
| Péan, F | 1 |
| Lahmidi, S | 1 |
| Vaxillaire, M | 1 |
| Porchay, I | 1 |
| Bellili, N | 1 |
| Tichet, J | 1 |
| Balkau, B | 1 |
| Froguel, P | 1 |
| Marre, M | 1 |
| Fumeron, F | 1 |
| Lin, TC | 1 |
| Yen, JM | 1 |
| Gong, KB | 1 |
| Kuo, TC | 1 |
| Ku, DC | 1 |
| Liang, SF | 1 |
| Wu, MJ | 1 |
| Radha, V | 1 |
| Vimaleswaran, KS | 1 |
| Babu, S | 1 |
| Deepa, R | 1 |
| Anjana, M | 1 |
| Ghosh, S | 1 |
| Majumder, PP | 1 |
| Rao, MR | 1 |
| Mohan, V | 1 |
| Stubbs, SM | 1 |
| Brudenell, JM | 1 |
| Pyke, DA | 2 |
| Watkins, PJ | 1 |
| Stubbs, WA | 3 |
| Alberti, KG | 18 |
| Lager, I | 1 |
| Jagenburg, R | 1 |
| von Schenck, H | 1 |
| Smith, U | 1 |
| Metzger, BE | 1 |
| Ravnikar, V | 1 |
| Vileisis, RA | 1 |
| Freinkel, N | 1 |
| Hetenyi, G | 1 |
| Perez, G | 1 |
| Vranic, M | 1 |
| Avogaro, A | 2 |
| Duner, E | 1 |
| Marescotti, C | 1 |
| Ferrara, D | 1 |
| Del Prato, S | 1 |
| Nosadini, R | 3 |
| Tiengo, A | 2 |
| Noy, GA | 3 |
| Nattrass, M | 7 |
| Johnston, DG | 1 |
| Home, PD | 2 |
| Orskov, H | 1 |
| Massi-Benedetti, M | 1 |
| Gill, GV | 1 |
| Capaldo, B | 1 |
| Shepherd, GA | 1 |
| Barnett, AH | 1 |
| Spiliopoulos, AJ | 1 |
| Burrin, J | 2 |
| Vannini, P | 1 |
| Marchesini, G | 1 |
| Forlani, G | 1 |
| Angiolini, A | 1 |
| Ciavarella, A | 1 |
| Zoli, M | 1 |
| Pisi, E | 1 |
| Sheppard, MC | 1 |
| Sherwin, RS | 1 |
| Robinson, AM | 1 |
| Williamson, DH | 3 |
| Hodson, A | 1 |
| Orskoy, H | 1 |
| Piniewska, D | 1 |
| Elia, M | 1 |
| Ilic, V | 1 |
| Bacon, S | 1 |
| Smith, R | 2 |
| Czyzyk, A | 1 |
| Lao, B | 1 |
| Orłowska, K | 1 |
| Szczepanik, Z | 1 |
| Bartosiewicz, W | 1 |
| Clore, JN | 1 |
| Blackard, WG | 1 |
| Mandarino, LJ | 1 |
| Consoli, A | 1 |
| Jain, A | 1 |
| Kelley, DE | 1 |
| Andrikopoulos, S | 1 |
| Proietto, J | 1 |
| Capstick, F | 1 |
| Brooks, BA | 1 |
| Burns, CM | 1 |
| Zilkens, RR | 1 |
| Steinbeck, KS | 1 |
| Yue, DK | 1 |
| Chen, D | 1 |
| Crimmins, DL | 1 |
| Hsu, FF | 1 |
| Lindberg, FP | 1 |
| Scott, MG | 1 |
| Giacca, A | 1 |
| Groenewoud, Y | 1 |
| Tsui, E | 1 |
| McClean, P | 1 |
| Zinman, B | 3 |
| Ringel, J | 1 |
| Engeli, S | 1 |
| Distler, A | 1 |
| Sharma, AM | 1 |
| Stumvoll, M | 1 |
| Perriello, G | 1 |
| Meyer, C | 1 |
| Gerich, J | 1 |
| Gray, AM | 1 |
| Koch, M | 1 |
| Rett, K | 1 |
| Maerker, E | 1 |
| Volk, A | 1 |
| Haist, K | 1 |
| Deninger, M | 1 |
| Renn, W | 1 |
| Häring, HU | 1 |
| Oh, EY | 1 |
| Min, KM | 1 |
| Chung, JH | 1 |
| Min, YK | 1 |
| Lee, MS | 1 |
| Kim, KW | 1 |
| Lee, MK | 1 |
| Hasstedt, SJ | 1 |
| Ren, QF | 1 |
| Teng, K | 1 |
| Elbein, SC | 1 |
| Swarbrick, MM | 1 |
| Chapman, CM | 1 |
| McQuillan, BM | 1 |
| Hung, J | 1 |
| Thompson, PL | 1 |
| Beilby, JP | 1 |
| Hamarat Baysal, S | 1 |
| Uslan, AH | 1 |
| Yim, MB | 1 |
| Yim, HS | 1 |
| Lee, C | 1 |
| Kang, SO | 1 |
| Chock, PB | 1 |
| Fuller, DJ | 1 |
| Wedge, JH | 1 |
| Unger, RH | 4 |
| Orci, L | 1 |
| Barnes, AJ | 1 |
| Bloom, A | 1 |
| Crowley, MF | 1 |
| Tuttlebee, JW | 1 |
| Bloom, SR | 1 |
| Smythe, P | 3 |
| Turnell, D | 2 |
| Pickup, JC | 2 |
| Keen, H | 2 |
| Parsons, JA | 2 |
| Rowe, AS | 1 |
| Hinks, L | 3 |
| Todd, PG | 4 |
| Karl, IE | 2 |
| Garber, AJ | 2 |
| Kipnis, DM | 2 |
| Epstein, M | 1 |
| Chez, RA | 1 |
| Oakes, GK | 1 |
| Mintz, DH | 1 |
| Dunn, A | 1 |
| Chenoweth, M | 1 |
| Bever, K | 1 |
| Felig, P | 7 |
| Viberti, GC | 1 |
| Buckle, AL | 1 |
| Cluett, B | 1 |
| Jaspan, JB | 1 |
| Walton, R | 1 |
| Wahren, J | 2 |
| Sherwin, R | 1 |
| Palaiologos, G | 1 |
| Lloyd, B | 1 |
| Hall, SE | 1 |
| Braaten, JT | 1 |
| McKendry, JB | 1 |
| Bolton, T | 1 |
| Foster, D | 1 |
| Berman, M | 1 |
| Stokes, EF | 2 |
| Albisser, AM | 2 |
| Hanna, AK | 1 |
| Minuk, HL | 1 |
| Stein, AN | 1 |
| Leibel, BS | 2 |
| Marliss, EB | 2 |
| Assan, R | 1 |
| Heuclin, C | 1 |
| Girard, JR | 1 |
| Reach, G | 1 |
| Basdevant, A | 1 |
| Predine, J | 1 |
| Kumar, D | 1 |
| Katsoyannis, PG | 1 |
| De Silva, SR | 1 |
| Betteridge, DJ | 1 |
| Shawe, JE | 1 |
| Cudworth, AG | 1 |
| Stacpoole, PW | 1 |
| Moore, GW | 1 |
| Kornhauser, DM | 1 |
| Chochinov, RH | 1 |
| Bowen, HF | 1 |
| Moorhouse, JA | 1 |
| Wicklmayr, M | 1 |
| Dietze, G | 1 |
| Mehnert, H | 1 |
| Floyd, JC | 1 |
| Fajans, SS | 1 |
| Pek, S | 1 |
| Gerich, JE | 2 |
| Lorenzi, M | 2 |
| Bier, DM | 2 |
| Tsalikian, E | 2 |
| Schneider, V | 1 |
| Karam, JH | 2 |
| Forsham, PH | 2 |
| Schneider, VS | 1 |
| Murray, FT | 1 |
| McClean, PA | 1 |
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| Nakhooda, AF | 1 |
| Labadie, P | 1 |
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| Agius, L | 1 |
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| Kunieda, T | 1 |
| Nomura, T | 1 |
| Kakuta, H | 1 |
| Tamagawa, T | 1 |
| Sakamoto, N | 1 |
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| Brown, JC | 1 |
| Sadler, PJ | 1 |
| Macleod, AF | 1 |
| Sönksen, PH | 1 |
| Hughes, RD | 1 |
| Williams, R | 1 |
| Kalderon, B | 1 |
| Gutman, A | 1 |
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| Adler, JH | 1 |
| Freyse, EJ | 1 |
| Fischer, U | 1 |
| Albrecht, G | 1 |
| Salzsieder, E | 1 |
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| Wapnir, RA | 1 |
| Gorback, MS | 1 |
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| Berger, M | 1 |
| Exton, JH | 1 |
| Mallette, LE | 1 |
| Jefferson, LS | 1 |
| Wong, EH | 1 |
| Friedmann, N | 1 |
| Miller, TB | 1 |
| Park, CR | 1 |
| Wise, JK | 1 |
| Hendler, R | 1 |
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| Burman, KD | 1 |
| Cunningham, EJ | 1 |
| Klachko, DM | 1 |
| Burns, TW | 1 |
| Panksepp, J | 1 |
| Flock, EV | 1 |
| Tyce, GM | 1 |
| Owen, CA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Finnish Diabetes Prevention Study: A Follow-up Study on the Effect of a Dietary and Exercise Intervention in the Prevention of Diabetes and Its Vascular Complications[NCT00518167] | 522 participants (Actual) | Interventional | 1993-11-30 | Active, not recruiting | |||
| Do Preoperative Carbohydrate Drinks Prevent Preoperative Catabolism in Mothers Undergoing Elective Caesarean Section? A Randomised Controlled Study[NCT03220997] | 200 participants (Anticipated) | Interventional | 2017-08-31 | Not yet recruiting | |||
| A Single-centre, Randomised, Single-blinded Crossover Study Evaluating the Metabolic Effects of a Ketone Ester Food Supplement in People With Type 1 Diabetes[NCT04487678] | 0 participants (Actual) | Interventional | 2023-08-31 | Withdrawn (stopped due to Prioritization of other projects) | |||
| Effects of Very Low Calorie Ketogenic Diet on Microbiota, Adipose Tissue and Immunitary Regulation: Pilot Study on Patients With Metabolic Syndrome[NCT05275608] | 40 participants (Anticipated) | Interventional | 2022-11-07 | Recruiting | |||
| Modulation of Insulin Secretion and Insulin Sensitivity in Bangladeshi Type 2 Diabetic Subjects by an Insulin Sensitizer Pioglitazone and T2DM Association With PPARG Gene Polymorphism.[NCT01589445] | Phase 4 | 77 participants (Actual) | Interventional | 2008-11-30 | Completed | ||
| Involvement of Steatosis-induced Glucagon Resistance in Hyperglucagonaemia[NCT02337660] | 30 participants (Actual) | Interventional | 2015-01-31 | Completed | |||
| Pharmacotoxicology of Trichloroethylene Metabolites: Short-term Effect of DCA on in Vivo Tyrosine Catabolism and MAAI Expression[NCT00865514] | 2 participants (Actual) | Interventional | 2011-08-31 | Terminated (stopped due to Difficulty in obtaining the solution from the compounding pharmacies caused a two year delay in start-up; the funding ended prior to study completion.) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Response rate was defined by ≥10% decrease of FSG or/and ≥1% decrease of HbA1c from the baseline values after 3 months treatment.48 responded to pioglitazone and 32 responded to metformin. (NCT01589445)
Timeframe: 3 months for each drug
| Intervention | mmol/l (Mean) | |
|---|---|---|
| Baseline FSG | 3rd Month FSG | |
| Metformin ( 002 Group) | 6.2 | 6.5 |
| Pioglitazone (001 Group) | 6.9 | 5.4 |
Response rate was defined by ≥10% decrease of FSG or/and ≥1% decrease of HbA1c from the baseline values after 3 months treatment.48 responded to pioglitazone and 32 responded to metformin. (NCT01589445)
Timeframe: 3 months for each drug
| Intervention | μU/ml (Mean) | |
|---|---|---|
| Baseline FSI | 3rd month FSI | |
| Metformin ( 002 Group) | 13.0 | 13.9 |
| Pioglitazone (001 Group) | 16.2 | 12.3 |
Response rate was defined by ≥10% decrease of FSG or/and ≥1% decrease of HbA1c from the baseline values after 3 months treatment.48 responded to pioglitazone and 32 responded to metformin. (NCT01589445)
Timeframe: 3 months for each drug
| Intervention | percentage (Mean) | |
|---|---|---|
| Baseline HbA1c | 3rd month HbA1c | |
| Metformin ( 002 Group) | 7.8 | 7.0 |
| Pioglitazone (001 Group) | 7.3 | 6.7 |
"Response rate was defined by ≥10% decrease of FSG or/and ≥1% decrease of HbA1c from the baseline values after 3 months treatment.48 responded to pioglitazone and 32 responded to metformin.~Analysis 1: Homeostatic Model Assessment of Beta cell function(HOMA percent B) Analysis 2: Homeostatic Model Assessment of Insulin Sensitivity (Homa percent S)" (NCT01589445)
Timeframe: 3 months for each drug
| Intervention | percentage (Mean) | |||
|---|---|---|---|---|
| Baseline HOMA percent beta cells function | 3rd month HOMA percent beta cells function | Baseline HOMA percent sensitivity | 3rd month HOMA percent sensitivity | |
| Metformin ( 002 Group) | 109.3 | 116.0 | 76.2 | 67.2 |
| Pioglitazone (001 Group) | 118.9 | 132.3 | 51.1 | 69.3 |
"Response rate was defined by ≥10% decrease of FSG or/and ≥1% decrease of HbA1c from the baseline values after 3 months treatment.48 responded to pioglitazone and 32 responded to metformin.~Analysis 1: Homeostasis Model Assessment Insulin Resistance(HOMA IR) Analysis 2: Quantitative Insulin sensitivity Check Index(QUICKI)" (NCT01589445)
Timeframe: 3 months for each drug
| Intervention | Score on a scale ( SI unit) (Mean) | |||
|---|---|---|---|---|
| Baseline QUICKI | 3rd month QUICKI | Baseline HOMA IR | 3rd month HOMA IR | |
| Metformin ( 002 Group) | 0.57 | 0.54 | 3.7 | 4.3 |
| Pioglitazone (001 Group) | 0.52 | 0.59 | 5.1 | 2.9 |
"Response rate was defined by ≥10% decrease of FSG or/and ≥1% decrease of HbA1c from the baseline values after 3 months treatment.48 responded to pioglitazone and 32 responded to metformin.~Analysis 1:Total Cholesterol(TC) Analysis 2:Triglyceride(TG) Analysis 3:High Density Lipoprotein(HDL) Analysis 4:Low Density Lipoprotein(LDL)" (NCT01589445)
Timeframe: 3 months for each drug
| Intervention | mg/dl (Mean) | |||||||
|---|---|---|---|---|---|---|---|---|
| Baseline TC | 3rd month TC | Baseline TG | 3rd month TG | Baseline HDL | 3rd month HDL | Baseline LDL | 3rd month LDL | |
| Metformin (002 Group) | 193.0 | 177.0 | 166.0 | 175.0 | 34.4 | 34.7 | 125.6 | 112.0 |
| Pioglitazone (001 Group) | 182.0 | 178 | 183 | 195 | 33 | 33.2 | 112.8 | 105.5 |
20 reviews available for alanine and Diabetes Mellitus
| Article | Year |
|---|---|
Biology of COVID-19 and related viruses: Epidemiology, signs, symptoms, diagnosis, and treatment.
Topics: Adenosine Monophosphate; Adrenal Cortex Hormones; Alanine; Animals; Antiviral Agents; Coronavirus; C | 2021 |
Metabolomics of various samples advancing biomarker discovery and pathogenesis elucidation for diabetic retinopathy.
Topics: Aged; Alanine; Biomarkers; Diabetes Mellitus; Diabetic Retinopathy; Glutamine; Humans; Lactates; Mid | 2022 |
Metabolomics of various samples advancing biomarker discovery and pathogenesis elucidation for diabetic retinopathy.
Topics: Aged; Alanine; Biomarkers; Diabetes Mellitus; Diabetic Retinopathy; Glutamine; Humans; Lactates; Mid | 2022 |
Metabolomics of various samples advancing biomarker discovery and pathogenesis elucidation for diabetic retinopathy.
Topics: Aged; Alanine; Biomarkers; Diabetes Mellitus; Diabetic Retinopathy; Glutamine; Humans; Lactates; Mid | 2022 |
Metabolomics of various samples advancing biomarker discovery and pathogenesis elucidation for diabetic retinopathy.
Topics: Aged; Alanine; Biomarkers; Diabetes Mellitus; Diabetic Retinopathy; Glutamine; Humans; Lactates; Mid | 2022 |
Metabolomics of various samples advancing biomarker discovery and pathogenesis elucidation for diabetic retinopathy.
Topics: Aged; Alanine; Biomarkers; Diabetes Mellitus; Diabetic Retinopathy; Glutamine; Humans; Lactates; Mid | 2022 |
Metabolomics of various samples advancing biomarker discovery and pathogenesis elucidation for diabetic retinopathy.
Topics: Aged; Alanine; Biomarkers; Diabetes Mellitus; Diabetic Retinopathy; Glutamine; Humans; Lactates; Mid | 2022 |
Metabolomics of various samples advancing biomarker discovery and pathogenesis elucidation for diabetic retinopathy.
Topics: Aged; Alanine; Biomarkers; Diabetes Mellitus; Diabetic Retinopathy; Glutamine; Humans; Lactates; Mid | 2022 |
Metabolomics of various samples advancing biomarker discovery and pathogenesis elucidation for diabetic retinopathy.
Topics: Aged; Alanine; Biomarkers; Diabetes Mellitus; Diabetic Retinopathy; Glutamine; Humans; Lactates; Mid | 2022 |
Metabolomics of various samples advancing biomarker discovery and pathogenesis elucidation for diabetic retinopathy.
Topics: Aged; Alanine; Biomarkers; Diabetes Mellitus; Diabetic Retinopathy; Glutamine; Humans; Lactates; Mid | 2022 |
d-Alanine: Distribution, origin, physiological relevance, and implications in disease.
Topics: Alanine; Animals; Diabetes Mellitus; Humans; Kidney Diseases; Liver Cirrhosis; Mental Disorders; Neo | 2020 |
Why Are Branched-Chain Amino Acids Increased in Starvation and Diabetes?
Topics: Alanine; Amino Acids, Branched-Chain; Diabetes Mellitus; Fatty Acids; Female; Glycolysis; Humans; In | 2020 |
Risks of metabolic syndrome and diabetes with integrase inhibitor-based therapy.
Topics: Alanine; Anti-HIV Agents; Diabetes Mellitus; HIV Infections; HIV Integrase Inhibitors; Humans; Metab | 2021 |
Comprehensive review on lactate metabolism in human health.
Topics: Alanine; Carbon Dioxide; Diabetes Mellitus; Glucose; Humans; Lactic Acid; Metabolic Networks and Pat | 2014 |
1-Deoxysphingolipids Encountered Exogenously and Made de Novo: Dangerous Mysteries inside an Enigma.
Topics: Alanine; Animals; Diabetes Mellitus; Humans; Lipids; Mutation; Non-alcoholic Fatty Liver Disease; Pe | 2015 |
[PPARgamma gene Pro12Ala polymorphism in diabetes mellitus].
Topics: Alanine; Alleles; Amino Acid Substitution; Animals; Diabetes Mellitus; Environment; Genetic Predispo | 2005 |
[Fatty acid binding protein-2 (FABP2) gene polymorphism in diabetes].
Topics: Adipocytes; Alanine; Amino Acid Substitution; Carrier Proteins; Diabetes Mellitus; Fatty Acid-Bindin | 2005 |
Turnover and precursor-product relationships of nonlipid metabolites.
Topics: Alanine; Amino Acids; Animals; Catecholamines; Cyclic AMP; Cyclic GMP; Diabetes Mellitus; Dogs; Gluc | 1983 |
Physiological roles of ketone bodies as substrates and signals in mammalian tissues.
Topics: Adipose Tissue; Alanine; Animals; Biological Transport; Brain; Diabetes Mellitus; Dogs; Fatty Acids, | 1980 |
Alcohol, glucose metabolism and diabetes.
Topics: Alanine; Alcohol Drinking; Animals; Diabetes Mellitus; Ethanol; Fatty Acids, Nonesterified; Glucose; | 1993 |
Role of glutamine in human carbohydrate metabolism in kidney and other tissues.
Topics: Alanine; Animals; Carbohydrate Metabolism; Diabetes Mellitus; Gluconeogenesis; Glutamine; Glycogen; | 1999 |
Protein glycation: creation of catalytic sites for free radical generation.
Topics: Aging; Alanine; Amino Acids; Animals; Arteriosclerosis; Catalytic Domain; Cations; Cattle; Cytochrom | 2001 |
Role of glucagon in the pathogenesis of diabetes: the status of the controversy.
Topics: Alanine; Animals; Antigens; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Type 1; Dietary Pro | 1978 |
Amino acid metabolism in man.
Topics: Alanine; Amino Acids; Brain; Diabetes Mellitus; Erythrocytes; Glucagon; Glucocorticoids; Gluconeogen | 1975 |
The hormonal control of hepatic gluconeogenesis.
Topics: Adrenal Glands; Adrenalectomy; Alanine; Amino Acids; Animals; Carbon Isotopes; Cyclic AMP; Dexametha | 1970 |
The glucose-alanine cycle.
Topics: Alanine; Amino Acids; Diabetes Mellitus; Female; Glucagon; Glucocorticoids; Gluconeogenesis; Glucose | 1973 |
Protein turnover and amino acid metabolism in the regulation of gluconeogenesis.
Topics: Alanine; Amino Acids; Arteries; Diabetes Mellitus; Erythrocytes; Glucagon; Gluconeogenesis; Humans; | 1974 |
Glucagon physiology and pathophysiology.
Topics: Alanine; Amino Acids; Animals; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Experimental; Di | 1971 |
5 trials available for alanine and Diabetes Mellitus
| Article | Year |
|---|---|
Association of the Pro12Ala polymorphism in the PPAR-gamma2 gene with 3-year incidence of type 2 diabetes and body weight change in the Finnish Diabetes Prevention Study.
Topics: Alanine; Amino Acid Substitution; Blood Glucose; Body Constitution; Body Mass Index; Body Weight; Di | 2002 |
Management of the pregnant diabetic: home or hospital, with or without glucose meters?
Topics: Adolescent; Adult; Alanine; Blood Glucose; Blood Specimen Collection; Diabetes Mellitus; Evaluation | 1980 |
Effect of beta-blockade on hormone release during hypoglycaemia in insulin-dependent diabetics.
Topics: Adrenergic beta-Antagonists; Adult; Alanine; Blood Glucose; Catecholamines; Diabetes Mellitus; Femal | 1980 |
Metformin and clofibrate in maturity onset diabetes mellitus: advantages of combined treatment.
Topics: Alanine; Blood Glucose; Cholesterol; Circadian Rhythm; Clofibrate; Diabetes Mellitus; Drug Synergism | 1979 |
Metabolic effects of suppression of nonesterified fatty acid levels with acipimox in obese NIDDM subjects.
Topics: 3-Hydroxybutyric Acid; Alanine; Blood Glucose; Cholesterol; Diabetes Mellitus; Diabetes Mellitus, Ty | 1992 |
97 other studies available for alanine and Diabetes Mellitus
| Article | Year |
|---|---|
Development and validation of an LC-MS/MS method for simultaneous determination of remdesivir and its hydrolyzed metabolite and nucleoside, and its application in a pharmacokinetic study of normal and diabetic nephropathy mice.
Topics: Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Chromatography, Liquid; COVID-19 Drug T | 2022 |
Silencing alanine transaminase 2 in diabetic liver attenuates hyperglycemia by reducing gluconeogenesis from amino acids.
Topics: Alanine; Alanine Transaminase; Amino Acids; Animals; Diabetes Mellitus; Gluconeogenesis; Glucose; Hu | 2022 |
Increased levels of oral Streptococcus-derived D-alanine in patients with chronic kidney disease and diabetes mellitus.
Topics: Adult; Alanine; Bacteria; Diabetes Mellitus; Humans; Renal Insufficiency, Chronic; RNA, Ribosomal, 1 | 2022 |
Increased levels of oral Streptococcus-derived D-alanine in patients with chronic kidney disease and diabetes mellitus.
Topics: Adult; Alanine; Bacteria; Diabetes Mellitus; Humans; Renal Insufficiency, Chronic; RNA, Ribosomal, 1 | 2022 |
Increased levels of oral Streptococcus-derived D-alanine in patients with chronic kidney disease and diabetes mellitus.
Topics: Adult; Alanine; Bacteria; Diabetes Mellitus; Humans; Renal Insufficiency, Chronic; RNA, Ribosomal, 1 | 2022 |
Increased levels of oral Streptococcus-derived D-alanine in patients with chronic kidney disease and diabetes mellitus.
Topics: Adult; Alanine; Bacteria; Diabetes Mellitus; Humans; Renal Insufficiency, Chronic; RNA, Ribosomal, 1 | 2022 |
Elevated alanine transaminase is nonlinearly associated with in-hospital death in ICU-admitted diabetic ketoacidosis patients.
Topics: Alanine; Alanine Transaminase; Diabetes Mellitus; Diabetic Ketoacidosis; Hospital Mortality; Humans; | 2023 |
The Associations of Genetically Predicted Plasma Alanine with Coronary Artery Disease and its Risk Factors: A Mendelian Randomization Study.
Topics: Alanine; Apolipoproteins; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Coronary Artery Disease; | 2023 |
Characteristics and Outcomes of Coronavirus Disease Patients under Nonsurge Conditions, Northern California, USA, March-April 2020.
Topics: Adenosine Monophosphate; Aged; Aged, 80 and over; Alanine; Asthma; Azithromycin; Betacoronavirus; Ca | 2020 |
Severe rhabdomyolysis and acute asymptomatic pancreatitis following the concomitant use of Biktarvy in the setting of hyperosmolar diabetic crisis.
Topics: Adenine; Alanine; Anti-HIV Agents; Cholangiopancreatography, Magnetic Resonance; Diabetes Mellitus; | 2020 |
Using "old" medications to fight new COVID-19: Re-purposing with a purpose.
Topics: Adenosine Monophosphate; Alanine; Angiotensin-Converting Enzyme Inhibitors; Antiviral Agents; Betaco | 2020 |
Tenofovir Alafenamide Attenuates Effects of Diabetes and Body Mass on Serum Alanine Aminotransferase Activities in Patients With Chronic Hepatitis B.
Topics: Alanine; Alanine Transaminase; Antiviral Agents; Diabetes Mellitus; Hepatitis B, Chronic; Humans; Te | 2022 |
Decreased in-hospital mortality associated with aspirin administration in hospitalized patients due to severe COVID-19.
Topics: Adenosine Monophosphate; Adult; Aged; Alanine; Antiviral Agents; Aspirin; Blood Platelets; Coronary | 2021 |
Therapeutic interventions of remdesivir in diabetic and nondiabetic COVID-19 patients: A prospective observational study conducted on Pakistani population.
Topics: Adenosine Monophosphate; Adolescent; Adult; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Diab | 2021 |
Deciphering a molecular mechanism of neonatal diabetes mellitus by the chemical synthesis of a protein diastereomer, [D-AlaB8]human proinsulin.
Topics: Alanine; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Diabetes Mellitus; Hum | 2014 |
A multi-tissue type genome-scale metabolic network for analysis of whole-body systems physiology.
Topics: Adipocytes; Alanine; Computer Simulation; Diabetes Mellitus; Genome, Human; Hepatocytes; Humans; Met | 2011 |
DEND syndrome due to V59A mutation in KCNJ11 gene: unresponsive to sulfonylureas.
Topics: Alanine; Amino Acid Substitution; Diabetes Mellitus; Epilepsies, Myoclonic; Female; Humans; Hypoglyc | 2013 |
Degradation, cyclic adenosine monophosphate production, insulin secretion, and glycemic effects of two novel N-terminal Ala2-substituted analogs of glucose-dependent insulinotropic polypeptide with preserved biological activity in vivo.
Topics: Alanine; Amino Acid Substitution; Aminobutyrates; Animals; Blood; Cell Line; Cricetinae; Cricetulus; | 2003 |
[Therapy of diabetic ketonemia].
Topics: Alanine; Diabetes Mellitus; Humans; Ketosis; Pyruvates | 1953 |
The influence of steroid hormones on gluconeogenesis in rats with experimental diabetes.
Topics: Alanine; Animals; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Experimental; Gluconeogenesis | 1963 |
Diadenosine tetraphosphate (Ap4A) induces a diabetogenic situation: its impact on blood glucose, plasma insulin, gluconeogenesis, glucose uptake and GLUT-4 transporters.
Topics: 3T3 Cells; Adenosine; Adenosine Triphosphate; Adipocytes; Alanine; Animals; Blood Glucose; Blotting, | 2003 |
A gel electrophoresis method for detection of mitochondrial DNA mutation (3243 tRNA(Leu (UUR))) applied to a Norwegian family with diabetes mellitus and hearing loss.
Topics: Alanine; Diabetes Complications; Diabetes Mellitus; DNA Mutational Analysis; DNA, Mitochondrial; Ele | 2004 |
[Association of Pro12Ala mutation in peroxisome proliferator-activated receptor gamma 2 with obesity and diabetes in Chinese population].
Topics: Adult; Alanine; Diabetes Mellitus; Female; Gene Frequency; Humans; Male; Mutation; Obesity; Polymorp | 2004 |
Comparative effects of GLP-1 and GIP on cAMP production, insulin secretion, and in vivo antidiabetic actions following substitution of Ala8/Ala2 with 2-aminobutyric acid.
Topics: Adenylyl Cyclases; Alanine; Aminobutyrates; Animals; Cells, Cultured; Chromatography, High Pressure | 2004 |
Effects of chard (Beta vulgaris L. var cicla) on the liver of the diabetic rats: a morphological and biochemical study.
Topics: Alanine; Alkaline Phosphatase; Animals; Beta vulgaris; Blood Glucose; Body Weight; Diabetes Mellitus | 2004 |
Melatonin-induced modulation of glucose metabolism in primary cultures of rabbit kidney-cortex tubules.
Topics: Alanine; Animals; Diabetes Mellitus; Fructose-Bisphosphatase; Gluconeogenesis; Glucose; Glycerol; In | 2005 |
The PPARG Pro12Ala polymorphism is associated with a decreased risk of developing hyperglycemia over 6 years and combines with the effect of the APM1 G-11391A single nucleotide polymorphism: the Data From an Epidemiological Study on the Insulin Resistance
Topics: Adiponectin; Adult; Alanine; Amino Acid Substitution; Diabetes Mellitus; Genotype; Humans; Hyperglyc | 2006 |
Abnormal glucose tolerance and insulin resistance in polycystic ovary syndrome amongst the Taiwanese population- not correlated with insulin receptor substrate-1 Gly972Arg/Ala513Pro polymorphism.
Topics: Adolescent; Adult; Alanine; Amino Acid Substitution; Arginine; Diabetes Mellitus; Female; Glucose In | 2006 |
Lack of association between serum adiponectin levels and the Pro12Ala polymorphism in Asian Indians.
Topics: Adiponectin; Adult; Alanine; Asian People; Diabetes Mellitus; Epidemiologic Studies; Female; Genotyp | 2007 |
"Accelerated starvation" and the skipped breakfast in late normal pregnancy.
Topics: 3-Hydroxybutyric Acid; Alanine; Blood Glucose; Diabetes Mellitus; Fasting; Fatty Acids, Nonesterifie | 1982 |
Metabolic effects of moderate alcohol intake with meals in insulin-dependent diabetics controlled by artificial endocrine pancreas (AEP) and in normal subjects.
Topics: Adult; Alanine; Alcohol Drinking; Blood Glucose; Diabetes Mellitus; Diet; Ethanol; Fatty Acids, None | 1983 |
The metabolic and hormonal response to acute normoglycaemia in type 1 (insulin-dependent) diabetes: studies with a glucose controlled insulin infusion system (artificial endocrine pancreas).
Topics: Adult; Alanine; Blood Glucose; Diabetes Mellitus; Fatty Acids, Nonesterified; Female; Glucagon; Glyc | 1982 |
Impaired subcutaneous absorption of insulin in 'brittle' diabetics.
Topics: 3-Hydroxybutyric Acid; Adolescent; Adult; Alanine; Blood Glucose; C-Peptide; Diabetes Mellitus; Fema | 1982 |
Metabolic studies in unaffected co-twins of non-insulin-dependent diabetics.
Topics: Adult; Alanine; Blood Glucose; Diabetes Mellitus; Diseases in Twins; Female; Glucose Tolerance Test; | 1981 |
Branched-chain amino acids and alanine as indices of the metabolic control in type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetic patients.
Topics: Alanine; Amino Acids, Branched-Chain; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Type 1; F | 1982 |
The effect of diet on intermediary metabolite concentrations in Type 2 (non-insulin-dependent) diabetes mellitus.
Topics: 3-Hydroxybutyric Acid; Adult; Aged; Alanine; Diabetes Mellitus; Female; Glycerol; Humans; Hydroxybut | 1983 |
The effect of ketone bodies and dietary carbohydrate intake on protein metabolism.
Topics: 3-Hydroxybutyric Acid; Alanine; Diabetes Mellitus; Dietary Carbohydrates; Humans; Hydroxybutyrates; | 1981 |
The metabolic response to hyperglycaemic clamping in insulin-dependent diabetes.
Topics: Adult; Alanine; Blood Glucose; Diabetes Mellitus; Fatty Acids, Nonesterified; Glucagon; Glycerol; Hu | 1981 |
Effect of short-term phenformin administration on the pattern of free amino acids in the plasma of healthy subjects and patients with non insulin-dependent diabetes.
Topics: Adolescent; Adult; Alanine; Amino Acids; Amino Acids, Essential; Dexamethasone; Diabetes Mellitus; F | 1982 |
Relationship between the basal blood alanine concentration and the removal of an alanine load in various clinical states in man.
Topics: Adolescent; Adult; Aged; Alanine; Basal Metabolism; Blood Glucose; Diabetes Mellitus; Female; Half-L | 1980 |
[Post-exertion alaninemia in healthy persons and patients with insulin-independent diabetes].
Topics: Adult; Alanine; Diabetes Mellitus; Female; Humans; Male; Middle Aged; Muscles; Physical Exertion | 1980 |
Suppression of gluconeogenesis after a 3-day fast does not deplete liver glycogen in patients with NIDDM.
Topics: Adult; Alanine; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Type 2; Ethanol; Fasting; Fatty | 1994 |
Interaction of carbohydrate and fat fuels in human skeletal muscle: impact of obesity and NIDDM.
Topics: Adult; Alanine; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Type 2; Energy Metabolism; Fatt | 1996 |
The biochemical basis of increased hepatic glucose production in a mouse model of type 2 (non-insulin-dependent) diabetes mellitus.
Topics: Alanine; Animals; Body Mass Index; Diabetes Mellitus; Diabetes Mellitus, Type 2; Dietary Fats; Disea | 1995 |
Very low calorie diet (VLCD): a useful alternative in the treatment of the obese NIDDM patient.
Topics: Adult; Alanine; Blood Glucose; Blood Pressure; Body Weight; Diabetes Mellitus; Diabetes Mellitus, Ty | 1997 |
Hemoglobin Raleigh as the cause of a falsely increased hemoglobin A1C in an automated ion-exchange HPLC method.
Topics: Aged; Alanine; Amino Acid Substitution; Autoanalysis; Chromatography, High Pressure Liquid; Chromato | 1998 |
Glucose production, utilization, and cycling in response to moderate exercise in obese subjects with type 2 diabetes and mild hyperglycemia.
Topics: Adult; Alanine; Blood Glucose; C-Peptide; Diabetes Mellitus; Diabetes Mellitus, Type 2; Exercise; Fe | 1998 |
Pro12Ala missense mutation of the peroxisome proliferator activated receptor gamma and diabetes mellitus.
Topics: Adult; Alanine; Amino Acid Substitution; Cholesterol; Codon; Coronary Disease; Diabetes Mellitus; Di | 1999 |
Insulin-secreting activity of the traditional antidiabetic plant Viscum album (mistletoe).
Topics: 1-Methyl-3-isobutylxanthine; Alanine; Analysis of Variance; Animals; Cell Line; Diabetes Mellitus; G | 1999 |
The PPARgamma2 amino acid polymorphism Pro 12 Ala is prevalent in offspring of Type II diabetic patients and is associated to increased insulin sensitivity in a subgroup of obese subjects.
Topics: Adult; Alanine; Amino Acid Substitution; Codon; Diabetes Mellitus; Diabetes Mellitus, Type 2; Female | 1999 |
Significance of Pro12Ala mutation in peroxisome proliferator-activated receptor-gamma2 in Korean diabetic and obese subjects.
Topics: Alanine; Amino Acid Substitution; Asian People; Body Mass Index; Diabetes Mellitus; Female; Genotype | 2000 |
Effect of the peroxisome proliferator-activated receptor-gamma 2 pro(12)ala variant on obesity, glucose homeostasis, and blood pressure in members of familial type 2 diabetic kindreds.
Topics: Alanine; Amino Acid Substitution; Blood Glucose; Blood Pressure; Body Mass Index; Chromosomes, Human | 2001 |
A Pro12Ala polymorphism in the human peroxisome proliferator-activated receptor-gamma 2 is associated with combined hyperlipidaemia in obesity.
Topics: Aging; Alanine; Alleles; Amino Acid Substitution; Anthropometry; Australia; Blood Pressure; Choleste | 2001 |
Encapsulation of PEG-urease/PEG-AlaDH enzyme system in erythrocyte.
Topics: Alanine; Alanine Dehydrogenase; Amino Acid Oxidoreductases; Ammonia; Diabetes Mellitus; Drug Compoun | 2001 |
Initial effect of injury on ketone bodies and other blood metabolites.
Topics: Adolescent; Adult; Alanine; Blood Glucose; Blood Specimen Collection; Circadian Rhythm; Colorimetry; | 1975 |
The essential role of glucagon in the pathogenesis of diabetes mellitus.
Topics: Alanine; Animals; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Experimental; Dogs; Glucagon; | 1975 |
Is glucagon important in stable insulin-dependent diabetics?
Topics: Adolescent; Adult; Aged; Alanine; Blood Glucose; Diabetes Mellitus; Fatty Acids, Nonesterified; Gluc | 1975 |
Continuous subcutaneous insulin infusion: improved blood-glucose and intermediary-metabolite control in diabetics.
Topics: Adolescent; Adult; Aged; Alanine; Blood Glucose; Diabetes Mellitus; Female; Humans; Hydroxybutyrates | 1979 |
Comparative effects of two doses of glibenclamide upon metabolic rhythms in maturity-onset diabetics.
Topics: Aged; Alanine; Blood Glucose; Circadian Rhythm; Diabetes Mellitus; Fatty Acids, Nonesterified; Glybu | 1978 |
Alanine and glutamine synthesis and release from skeletal muscle. III. Dietary and hormonal regulation.
Topics: Alanine; Amino Acids; Animals; Cortisone; Cycloheximide; Diabetes Mellitus; Fasting; Glutamates; Glu | 1976 |
Fetal pancreatic glucagon responses in glucose-intolerant nonhuman primate pregnancy.
Topics: Alanine; Animals; Blood Glucose; Diabetes Mellitus; Female; Glucagon; Haplorhini; Levodopa; Macaca m | 1977 |
Alanine and glutamine synthesis and release from skeletal muscle. IV. beta-Adrenergic inhibition of amino acid release.
Topics: Alanine; Animals; Bucladesine; Cortisone; Diabetes Mellitus; Epinephrine; Glucagon; Glutamine; In Vi | 1976 |
Use of 3H and 14C doubly labeled glucose and amino acids in the study of hormonal regulation of gluconeogenesis in rats.
Topics: Adrenalectomy; Alanine; Alanine Transaminase; Amino Acids; Animals; Aspartate Aminotransferases; Asp | 1977 |
Amino acid metabolism in exercise.
Topics: Alanine; Amino Acids; Diabetes Mellitus; Dietary Carbohydrates; Energy Metabolism; Gluconeogenesis; | 1977 |
Clinical application of pre-programmed insulin infusion: continuous subcutaneous insulin therapy with a portable infusion system.
Topics: Alanine; Artificial Organs; Blood Glucose; Diabetes Mellitus; Feedback; Humans; Infusions, Parentera | 1979 |
Metabolic studies during normoglycaemic clamping of insulin-dependent diabetics using a glucose-controlled insulin infusion system.
Topics: Adult; Alanine; Artificial Organs; Blood Glucose; Computers; Diabetes Mellitus; Fatty Acids, Noneste | 1979 |
Amino acid and protein metabolism in diabetes mellitus.
Topics: Alanine; Amino Acids; Animals; Diabetes Mellitus; Diabetic Ketoacidosis; Dietary Proteins; Fasting; | 1977 |
Comparative effects of phenformin, metformin and glibenclamide on metabolic rhythms in maturity-onset diabetics.
Topics: Aged; Alanine; Blood Glucose; Circadian Rhythm; Diabetes Mellitus; Female; Gluconeogenesis; Glyburid | 1977 |
Normal alanine-glucose relationships and their changes in diabetic patients before and after insulin treatment.
Topics: Adult; Aged; Alanine; Blood Glucose; Diabetes Mellitus; Female; Humans; Insulin; Isoleucine; Ketones | 1979 |
The metabolic response to glycemic control by the artificial pancreas in diabetic man.
Topics: Adult; Aged; Alanine; Blood Glucose; Computers; Diabetes Mellitus; Diet; Fatty Acids, Nonesterified; | 1979 |
Insulin-induced hypoglycemia is not aggravated by somatostatin in insulin-dependent diabetes.
Topics: Alanine; Amines; Blood Glucose; Diabetes Mellitus; Fatty Acids, Nonesterified; Glucagon; Growth Horm | 1979 |
Metabolic effects of combined sulphonylurea and metformin therapy in maturity-onset diabetice.
Topics: Adult; Aged; Alanine; Blood Glucose; Circadian Rhythm; Diabetes Mellitus; Female; Humans; Insulin; K | 1979 |
Immunoreactivity of insulin antibodies in insulin-treated diabetics: significance of the beta-chain carboxy-terminal amino acid (B-30) of insulin.
Topics: Adult; Aged; Alanine; Animals; Diabetes Mellitus; Humans; Insulin; Insulin Antibodies; Middle Aged; | 1979 |
New synthetic insulins.
Topics: Alanine; Animals; Diabetes Mellitus; Disulfides; Homocysteine; Humans; Insulin; Macromolecular Subst | 1979 |
Metabolic effects of dichloroacetate in patients with diabetes mellitus and hyperlipoproteinemia.
Topics: Acetates; Acidosis; Adult; Aged; Alanine; Animals; Blood Glucose; Cholesterol; Diabetes Mellitus; Di | 1978 |
Circulating alanine disposal in diabetes mellitus.
Topics: Adult; Aged; Alanine; Blood Glucose; Diabetes Mellitus; Fasting; Female; Humans; Male; Middle Aged; | 1978 |
Metabolic abnormalities during combined sulphonylurea and phenformin therapy in maturity-onset diabetics.
Topics: Adult; Aged; Alanine; Blood Glucose; Diabetes Mellitus; Drug Therapy, Combination; Fatty Acids, None | 1978 |
Effect of phenformin on substrate metabolism of working muscle in maturity onset diabetics.
Topics: Aged; Alanine; Blood Glucose; Diabetes Mellitus; Female; Forearm; Humans; Lactates; Male; Middle Age | 1978 |
Regulation in healthy subjects of the secretion of human pancreatic polypeptide, a newly recognized pancreatic islet polypeptide.
Topics: Alanine; Arginine; Blood Glucose; Diabetes Mellitus; Dietary Proteins; Glucagon; Glucose; Humans; In | 1976 |
Effects of physiologic levels of glucagon and growth hormone on human carbohydrate and lipid metabolism. Studies involving administration of exogenous hormone during suppression of endogenous hormone secretion with somatostatin.
Topics: Adult; Alanine; Blood Glucose; Carbohydrate Metabolism; Depression, Chemical; Diabetes Mellitus; Dia | 1976 |
Role of glucagon in human diabetic ketoacidosis: studies using somatostatin.
Topics: Adult; Alanine; Blood Glucose; Diabetes Mellitus; Diabetic Ketoacidosis; Fatty Acids, Nonesterified; | 1976 |
The metabolic response to moderate exercise in diabetic man receiving intravenous and subcutaneous insulin.
Topics: Adult; Alanine; Antigens; Diabetes Mellitus; Fatty Acids, Nonesterified; Female; Glucagon; Glycerol; | 1977 |
[Glucose-alanine cycle].
Topics: Alanine; Diabetes Mellitus; Fasting; Glucose; Humans; Liver; Muscles | 1976 |
Effect of pregnancy on serum alanine concentration in normal and genetically diabetic mice.
Topics: Alanine; Animals; Blood Glucose; Diabetes Mellitus; Fasting; Female; Pregnancy; Pregnancy in Diabeti | 1976 |
Pancreatic alpha- and beta-cell function and metabolic changes during oral L-alanine and glucose administration: comparative studies between normal, diabetic and cirrhotic subjects.
Topics: Administration, Oral; Adult; Alanine; Blood Glucose; Diabetes Mellitus; Female; Glucose; Glucose Tol | 1989 |
High resolution proton nuclear magnetic resonance studies of human cerebrospinal fluid.
Topics: Acetates; Adolescent; Adult; Aged; Alanine; Child, Preschool; Citrates; Diabetes Mellitus; Female; F | 1987 |
Characterization of stages in development of obesity-diabetes syndrome in sand rat (Psammomys obesus).
Topics: Adipose Tissue; Age Factors; Alanine; Animals; Arvicolinae; Blood Glucose; Carbon Radioisotopes; Dia | 1986 |
Alterations in alanine metabolism in diabetic dogs during short-term treatment with an artificial B cell.
Topics: Alanine; Animals; Blood Glucose; Carbon Radioisotopes; Diabetes Mellitus; Dogs; Female; Glucose; Ins | 1985 |
Glucagon secretion in obesity.
Topics: Adult; Alanine; Child; Diabetes Mellitus; Fasting; Glucagon; Gluconeogenesis; Glucose; Humans; Insul | 1973 |
Effect of oral alanine on blood beta-hydroxybutyrate and plasma glucose, insulin, free fatty acids, and growth hormone in normal and diabetic subjects.
Topics: Administration, Oral; Adult; Alanine; Blood Glucose; Diabetes Mellitus; Diabetic Ketoacidosis; Fatty | 1974 |
Lacticacidosis, ketoacidosis, and hyperalaninaemia in a phenformintreated diabetic patient.
Topics: Acetoacetates; Alanine; Amitriptyline; Bicarbonates; Blood Glucose; Chlorpropamide; Diabetes Mellitu | 1974 |
Hyperglycemia and starvation: contrast in rat brain gluconeogenic amino acids and glycogen.
Topics: Alanine; Animals; Blood Glucose; Brain Chemistry; Diabetes Mellitus; Gluconeogenesis; Glutamates; Gl | 1972 |
The formation of glutamine and alanine in skeletal muscle.
Topics: Alanine; Amino Acids; Animals; Arteries; Diabetes Mellitus; Electric Stimulation; Fasting; Female; G | 1974 |
Evaluation of alpha-cell function by infusion of alanine in normal, diabetic and obese subjects.
Topics: Adolescent; Adult; Alanine; Blood Glucose; Diabetes Mellitus; Glucagon; Humans; Injections, Intraven | 1973 |
Changes of free amino acids in pancreatic beta-cells after starvation and substrate deprivation.
Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Carbon Radioisotopes; Chromatography, | 1974 |
Interaction of insulin and amino acid metabolism in the regulation of gluconeogenesis.
Topics: Alanine; Amino Acids; Blood Glucose; Carbon Isotopes; Diabetes Mellitus; Diabetic Ketoacidosis; Fast | 1972 |
Sucessful treatment of insulin resistance with dealaninated pork insulin (DPI) .
Topics: Alanine; Amino Acid Sequence; Animals; Diabetes Mellitus; Female; Humans; Insulin; Insulin Resistanc | 1973 |
Hypothalamic radioactivity after intragastric glucose- 14 C in rats.
Topics: Alanine; Animals; Carbon Isotopes; Diabetes Mellitus; Feeding Behavior; Food Deprivation; Glucose; G | 1972 |
Glucagon and the insulin: glucagon ratio in diabetes and other catabolic illnesses.
Topics: Adipose Tissue; Alanine; Bacterial Infections; Body Weight; Burns; Diabetes Mellitus; Dietary Carboh | 1971 |
Glucose metabolism in brains of diabetic rats.
Topics: Alanine; Aminobutyrates; Animals; Aspartic Acid; Brain; Carbon Isotopes; Diabetes Mellitus; Diabetes | 1969 |