alanine has been researched along with Diabetes Mellitus, Type 1 in 86 studies
Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.
Diabetes Mellitus, Type 1: A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To test the hypothesis that because of sustained glycemic actions, bedtime administration of the glucagon-releasing amino acid alanine or the epinephrine-simulating beta2-adrenergic agonist terbutaline more effectively prevents nocturnal hypoglycemia than a conventional bedtime snack, we studied 15 patients with IDDM." | 9.08 | Alanine and terbutaline in the prevention of nocturnal hypoglycemia in IDDM. ( Cryer, PE; Saleh, TY, 1997) |
| "To test the hypothesis that, in contrast to administration of glucose or glucagon, administration of the amino acid Ala or of the beta 2-adrenergic agonist terbutaline produces sustained glucose recovery from hypoglycemia." | 9.07 | Alanine and terbutaline in treatment of hypoglycemia in IDDM. ( Cryer, PE; Wiethop, BV, 1993) |
| "To evaluate the role of glucagon in the pathogenesis of diabetic ketoacidosis in man, we studied the effect of suppression of glucagon secretion by somatostatin on changes in plasma beta-hydroxybutyrate and glucose concentrations (as well as changes in their precursors) after acute withdrawal of insulin from seven patients with juvenile-type diabetes." | 7.65 | Prevention of human diabetic ketoacidosis by somatostatin. Evidence for an essential role of glucagon. ( Bier, DM; Forsham, PH; Gerich, JE; Karam, JH; Lorenzi, M; Schneider, V; Tsalikian, E, 1975) |
| "Patients with IDDM also had significantly more Ala alleles as homozygotes (19%) or heterozygotes (50%; P = 0." | 5.30 | CTLA4 alanine-17 confers genetic susceptibility to Graves' disease and to type 1 diabetes mellitus. ( Badenhoop, K; Braun, J; Donner, H; Finke, R; Herwig, J; Rau, H; Siegmund, T; Usadel, KH; Walfish, PG, 1997) |
| "To test the hypothesis that because of sustained glycemic actions, bedtime administration of the glucagon-releasing amino acid alanine or the epinephrine-simulating beta2-adrenergic agonist terbutaline more effectively prevents nocturnal hypoglycemia than a conventional bedtime snack, we studied 15 patients with IDDM." | 5.08 | Alanine and terbutaline in the prevention of nocturnal hypoglycemia in IDDM. ( Cryer, PE; Saleh, TY, 1997) |
| "To test the hypothesis that, in contrast to administration of glucose or glucagon, administration of the amino acid Ala or of the beta 2-adrenergic agonist terbutaline produces sustained glucose recovery from hypoglycemia." | 5.07 | Alanine and terbutaline in treatment of hypoglycemia in IDDM. ( Cryer, PE; Wiethop, BV, 1993) |
| " Levels of the gluconeogenic precursors alanine and lactate were increased during pregnancy in both the women without IDDM (from 0." | 3.69 | Glucose turnover and gluconeogenesis during pregnancy in women with and without insulin-dependent diabetes mellitus. ( Bourque, J; Chiasson, JL; Ducros, F; el Achkar, GG; Maheux, P, 1997) |
| "Alterations in plasma branched-chain amino acids (valine, isoleucine and leucine) and alanine have been described in patients with insulin-dependent diabetes mellitus who have poor metabolic control." | 3.66 | Branched-chain amino acids and alanine as indices of the metabolic control in type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetic patients. ( Angiolini, A; Ciavarella, A; Forlani, G; Marchesini, G; Pisi, E; Vannini, P; Zoli, M, 1982) |
| "To evaluate the role of glucagon in the pathogenesis of diabetic ketoacidosis in man, we studied the effect of suppression of glucagon secretion by somatostatin on changes in plasma beta-hydroxybutyrate and glucose concentrations (as well as changes in their precursors) after acute withdrawal of insulin from seven patients with juvenile-type diabetes." | 3.65 | Prevention of human diabetic ketoacidosis by somatostatin. Evidence for an essential role of glucagon. ( Bier, DM; Forsham, PH; Gerich, JE; Karam, JH; Lorenzi, M; Schneider, V; Tsalikian, E, 1975) |
| "The response of the subjects with IDDM was similar to that of the normal subjects." | 2.70 | Effect of protein restriction on (15)N transfer from dietary [(15)N]alanine and [(15)N]Spirulina platensis into urea. ( Hamadeh, MJ; Hoffer, LJ, 2001) |
| "In patients with IDDM it raised glucagon (P = 0." | 2.67 | Glycemic actions of alanine and terbutaline in IDDM. ( Cryer, PE; Wiethop, BV, 1993) |
| "Children at increased genetic risk for type 1 diabetes (T1D) after environmental exposures may develop pancreatic islet autoantibodies (IA) at a very young age." | 1.56 | Longitudinal Metabolome-Wide Signals Prior to the Appearance of a First Islet Autoantibody in Children Participating in the TEDDY Study. ( Akolkar, B; Butterworth, MD; Fan, S; Fiehn, O; Hagopian, W; Krischer, JP; Lernmark, Å; Li, Q; Parikh, H; Rewers, M; She, JX; Toppari, J; Ziegler, AG, 2020) |
| "Pro/Pro genotype and type 1 diabetes was 0." | 1.35 | Peroxisome proliferator-activated receptor-gamma2 Pro12Ala polymorphism, cod liver oil and risk of type 1 diabetes. ( Berg, JP; Joner, G; Rønningen, KS; Stene, LC; Thorsby, PM, 2008) |
| "Overt diabetic nephropathy (n = 619) was defined as having an albumin excretion rate (AER) >200 microg/min or renal replacement therapy; incipient diabetic nephropathy was defined as having an AER of 20-200 microg/min (n = 336)." | 1.34 | A functional polymorphism in the manganese superoxide dismutase gene and diabetic nephropathy. ( Brismar, K; Dahlquist, G; Forsblom, C; Groop, PH; Marklund, SL; Möllsten, A; Parkkonen, M; Svensson, M; Wessman, M, 2007) |
| "This gene is located near the IDDM7 region and one of its amino acid polymorphisms, Ala45Thr, has been associated with type 1 diabetes (T1DM) in Japanese and Danish populations." | 1.32 | The Ala45Thr polymorphism of BETA2/NeuroD1 gene and susceptibility to type 1 diabetes mellitus in caucasians. ( Klupa, T; Malecki, MT; Moczulski, DK; Rogus, JJ, 2003) |
| "We studied the association between type 1 diabetes with autoimmune thyroid disease (AITD) and A/G allele polymorphism in exon 1 of the CTLA-4 gene in a Japanese population." | 1.31 | Association of CTLA-4 gene A/G polymorphism in Japanese type 1 diabetic patients with younger age of onset and autoimmune thyroid disease. ( Akamine, H; Kinjo, Y; Komiya, I; Masuda, M; Takara, M; Takasu, N; Tomoyose, T; Yamashiro, S, 2000) |
| "Eighty patients with child-onset Type 1 diabetes were examined along with 121 non-diabetic subjects as the controls." | 1.31 | The association of Ala45Thr polymorphism in NeuroD with child-onset Type 1a diabetes in Japanese. ( Amemiya, S; Aya, M; Ishihara, T; Kasuga, A; Kato, K; Kobayashi, K; Mochizuki, M; Nakazawa, S, 2002) |
| "Patients with IDDM also had significantly more Ala alleles as homozygotes (19%) or heterozygotes (50%; P = 0." | 1.30 | CTLA4 alanine-17 confers genetic susceptibility to Graves' disease and to type 1 diabetes mellitus. ( Badenhoop, K; Braun, J; Donner, H; Finke, R; Herwig, J; Rau, H; Siegmund, T; Usadel, KH; Walfish, PG, 1997) |
| "Susceptibility and resistance to type 1 diabetes are associated with MHC class II alleles that carry non-Asp and Asp at residue 57 of their beta chain respectively." | 1.30 | The P9 pocket of HLA-DQ2 (non-Aspbeta57) has no particular preference for negatively charged anchor residues found in other type 1 diabetes-predisposing non-Aspbeta57 MHC class II molecules. ( Buus, S; Holm, A; Johansen, BH; Paulsen, G; Quarsten, H; Sollid, LM; Thorpe, CJ, 1998) |
| "We conclude that IDDM subjects adapt normally to dietary protein restriction." | 1.29 | Effects of dietary protein restriction on regional amino acid metabolism in insulin-dependent diabetes mellitus. ( Brodsky, IG; Devlin, JT, 1996) |
| "From 1981 to 1994, 112 IDDM patients were on IT." | 1.29 | Long-term intensive insulin therapy in IDDM: effects on HbA1c, risk for severe and mild hypoglycaemia, status of counterregulation and awareness of hypoglycaemia. ( Annibale, B; Bartocci, L; Bolli, GB; Brunetti, P; Ciofetta, M; Di Vincenzo, A; Epifano, L; Fanelli, C; Lalli, C; Lepore, M; Modarelli, F; Pampanelli, S; Rambotti, AM; Sindaco, PD, 1996) |
| "In two groups of juvenile onset diabetics similar in age, weight, diet and daily insulin dosage (eight without C-peptide, group I; eight with C-peptide, group II) the serum levels of free and antibody bound insulin, C-peptide, glucose, lactate, alanine and FFA were determined over 24 h." | 1.26 | Free insulin, bound insulin, C-peptide and the metabolic control in juvenile onset diabetics: comparison of C-peptide secretors and non-secretors during 24 hours conventional insulin therapy. ( Edelmann, A; Gerbitz, KD; Kemmler, W; Mehnert, H; Summer, J; Wieland, OH, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 28 (32.56) | 18.7374 |
| 1990's | 30 (34.88) | 18.2507 |
| 2000's | 19 (22.09) | 29.6817 |
| 2010's | 8 (9.30) | 24.3611 |
| 2020's | 1 (1.16) | 2.80 |
| Authors | Studies |
|---|---|
| Li, Q | 1 |
| Parikh, H | 1 |
| Butterworth, MD | 1 |
| Lernmark, Å | 1 |
| Hagopian, W | 1 |
| Rewers, M | 1 |
| She, JX | 1 |
| Toppari, J | 1 |
| Ziegler, AG | 1 |
| Akolkar, B | 1 |
| Fiehn, O | 1 |
| Fan, S | 1 |
| Krischer, JP | 1 |
| Gerasimou, P | 1 |
| Nicolaidou, V | 1 |
| Skordis, N | 1 |
| Picolos, M | 1 |
| Monos, D | 1 |
| Costeas, PA | 1 |
| Khan, F | 1 |
| Parikh, MP | 1 |
| McCullough, AJ | 1 |
| Kuipers, A | 1 |
| Moll, GN | 1 |
| Wagner, E | 1 |
| Franklin, R | 1 |
| Kraus, AU | 1 |
| Penna-Martinez, M | 1 |
| Shoghi, F | 1 |
| Seidl, C | 1 |
| Meyer, G | 1 |
| Badenhoop, K | 2 |
| Pellicano, R | 1 |
| Saracco, GM | 1 |
| Comar, JF | 1 |
| de Oliveira, DS | 1 |
| Bracht, L | 1 |
| Kemmelmeier, FS | 1 |
| Peralta, RM | 1 |
| Bracht, A | 1 |
| Jensen-Waern, M | 1 |
| Andersson, M | 1 |
| Kruse, R | 1 |
| Nilsson, B | 1 |
| Larsson, R | 1 |
| Korsgren, O | 1 |
| Essén-Gustavsson, B | 1 |
| Jermendy, A | 1 |
| Szatmári, I | 1 |
| Laine, AP | 1 |
| Lukács, K | 1 |
| Horváth, KH | 1 |
| Körner, A | 1 |
| Madácsy, L | 1 |
| Veijola, R | 1 |
| Simell, O | 1 |
| Knip, M | 2 |
| Ilonen, J | 1 |
| Hermann, R | 1 |
| Mochida, T | 1 |
| Tanaka, T | 2 |
| Shiraki, Y | 1 |
| Tajiri, H | 1 |
| Matsumoto, S | 1 |
| Shimbo, K | 1 |
| Ando, T | 1 |
| Nakamura, K | 1 |
| Okamoto, M | 1 |
| Endo, F | 1 |
| Cinek, O | 1 |
| Drevínek, P | 1 |
| Sumník, Z | 1 |
| Bendlová, B | 1 |
| Sedláková, P | 1 |
| Kolousková, S | 1 |
| Snajderová, M | 1 |
| Vavrinec, J | 1 |
| Malecki, MT | 1 |
| Klupa, T | 1 |
| Moczulski, DK | 1 |
| Rogus, JJ | 1 |
| Hartemann-Heurtier, A | 1 |
| Mars, LT | 1 |
| Bercovici, N | 1 |
| Desbois, S | 1 |
| Cambouris, C | 1 |
| Piaggio, E | 1 |
| Zappulla, J | 1 |
| Saoudi, A | 1 |
| Liblau, RS | 1 |
| Nakayama, M | 2 |
| Babaya, N | 2 |
| Miao, D | 2 |
| Sikora, K | 1 |
| Elliott, JF | 2 |
| Eisenbarth, GS | 2 |
| Oliveira, CS | 1 |
| Hauache, OM | 1 |
| Vieira, JG | 1 |
| Maciel, RM | 1 |
| Sjöroos, M | 1 |
| Canani, LH | 1 |
| Velho, G | 1 |
| Gross, JL | 1 |
| Reis, AF | 1 |
| Gianani, R | 1 |
| Liu, E | 1 |
| Porcellati, F | 1 |
| Pampanelli, S | 5 |
| Rossetti, P | 1 |
| Busciantella Ricci, N | 1 |
| Marzotti, S | 1 |
| Lucidi, P | 1 |
| Santeusanio, F | 2 |
| Bolli, GB | 4 |
| Fanelli, CG | 1 |
| Möllsten, A | 1 |
| Marklund, SL | 1 |
| Wessman, M | 2 |
| Svensson, M | 1 |
| Forsblom, C | 2 |
| Parkkonen, M | 2 |
| Brismar, K | 1 |
| Groop, PH | 2 |
| Dahlquist, G | 1 |
| Wadén, J | 1 |
| Thorn, LM | 1 |
| Lakka, T | 1 |
| Saraheimo, M | 1 |
| Rosengård-Bärlund, M | 1 |
| Heikkilä, O | 1 |
| Turunen, JA | 1 |
| Tikkanen, H | 1 |
| Stene, LC | 1 |
| Thorsby, PM | 1 |
| Berg, JP | 1 |
| Rønningen, KS | 1 |
| Joner, G | 1 |
| Viberti, GC | 1 |
| Home, PD | 4 |
| Bilous, RW | 1 |
| Alberti, KG | 6 |
| Dalton, N | 1 |
| Keen, H | 1 |
| Pickup, JC | 1 |
| Brunetti, P | 5 |
| Bueti, A | 1 |
| Antonella, MA | 1 |
| Calabrese, G | 1 |
| Fabietti, PG | 1 |
| Massi Benedetti, M | 1 |
| Capaldo, B | 1 |
| Massi-Benedetti, M | 1 |
| Worth, R | 1 |
| Cook, DB | 1 |
| Heaton, A | 1 |
| Freyse, EJ | 3 |
| Fischer, U | 3 |
| Albrecht, G | 1 |
| Vannini, P | 1 |
| Marchesini, G | 1 |
| Forlani, G | 1 |
| Angiolini, A | 1 |
| Ciavarella, A | 1 |
| Zoli, M | 1 |
| Pisi, E | 1 |
| Soltész, G | 1 |
| Molnár, D | 1 |
| Mestyán, J | 1 |
| Giugliano, D | 1 |
| Luyckx, AS | 1 |
| Lefebvre, PJ | 1 |
| Turk, D | 1 |
| Alzaid, A | 1 |
| Dinneen, S | 1 |
| Nair, KS | 1 |
| Rizza, R | 1 |
| Rattarasarn, C | 1 |
| Dagogo-Jack, S | 1 |
| Zachwieja, JJ | 1 |
| Cryer, PE | 7 |
| Fanelli, C | 2 |
| Di Vincenzo, A | 3 |
| Modarelli, F | 3 |
| Lepore, M | 3 |
| Ciofetta, M | 3 |
| Epifano, L | 3 |
| Wiethop, BV | 2 |
| Bae, YS | 1 |
| Yoon, JW | 2 |
| Torlone, E | 2 |
| Ialli, C | 1 |
| Del Sindaco, P | 2 |
| Bartocci, L | 2 |
| Brodsky, IG | 1 |
| Devlin, JT | 1 |
| Lalli, C | 2 |
| Sindaco, PD | 1 |
| Rambotti, AM | 2 |
| Annibale, B | 1 |
| Kassi, G | 1 |
| Perriello, G | 1 |
| Bolli, G | 1 |
| Donner, H | 1 |
| Rau, H | 1 |
| Walfish, PG | 1 |
| Braun, J | 1 |
| Siegmund, T | 1 |
| Finke, R | 1 |
| Herwig, J | 1 |
| Usadel, KH | 1 |
| Becher, T | 1 |
| El-Hag, O | 1 |
| Knospe, S | 1 |
| Göke, B | 1 |
| Terentyeva, EA | 1 |
| Hayakawa, K | 1 |
| Tanae, A | 1 |
| Katsumata, N | 1 |
| Hibi, I | 1 |
| Chiasson, JL | 1 |
| el Achkar, GG | 1 |
| Ducros, F | 1 |
| Bourque, J | 1 |
| Maheux, P | 1 |
| Saleh, TY | 1 |
| Jun, HS | 1 |
| Kang, Y | 1 |
| Notkins, AL | 1 |
| Quarsten, H | 1 |
| Paulsen, G | 1 |
| Johansen, BH | 1 |
| Thorpe, CJ | 1 |
| Holm, A | 1 |
| Buus, S | 1 |
| Sollid, LM | 1 |
| Ringel, J | 1 |
| Engeli, S | 1 |
| Distler, A | 1 |
| Sharma, AM | 1 |
| McGowan, PE | 1 |
| Lawrie, WC | 1 |
| Reglinski, J | 1 |
| Spickett, CM | 1 |
| Wilson, R | 1 |
| Walker, JJ | 1 |
| Wisdom, S | 1 |
| Maclean, MA | 1 |
| Takara, M | 1 |
| Komiya, I | 1 |
| Kinjo, Y | 1 |
| Tomoyose, T | 1 |
| Yamashiro, S | 1 |
| Akamine, H | 1 |
| Masuda, M | 1 |
| Takasu, N | 1 |
| Fisher, SJ | 1 |
| Shi, ZQ | 1 |
| Lickley, HL | 1 |
| Efendic, S | 1 |
| Vranic, M | 1 |
| Giacca, A | 1 |
| Bruttomesso, D | 1 |
| Fongher, C | 1 |
| Silvestri, B | 1 |
| Barberio, S | 1 |
| Marescotti, MC | 1 |
| Iori, E | 1 |
| Valerio, A | 1 |
| Crazzolara, D | 1 |
| Pianta, A | 1 |
| Tiengo, A | 3 |
| Del Prato, S | 3 |
| Fritsche, A | 1 |
| Madaus, A | 1 |
| Tschritter, O | 1 |
| Ozeker, M | 1 |
| Wulle, EL | 1 |
| Machicao, F | 1 |
| Häring, H | 1 |
| Stumvoll, M | 1 |
| Hamadeh, MJ | 2 |
| Schiffrin, A | 1 |
| Hoffer, LJ | 2 |
| Mochizuki, M | 1 |
| Amemiya, S | 1 |
| Kobayashi, K | 2 |
| Ishihara, T | 1 |
| Aya, M | 1 |
| Kato, K | 1 |
| Kasuga, A | 1 |
| Nakazawa, S | 1 |
| Zuppi, C | 1 |
| Messana, I | 1 |
| Tapanainen, P | 1 |
| Vincenzoni, F | 1 |
| Giardina, B | 1 |
| Nuutinen, M | 1 |
| Gerbitz, KD | 1 |
| Kemmler, W | 1 |
| Edelmann, A | 1 |
| Summer, J | 1 |
| Mehnert, H | 1 |
| Wieland, OH | 1 |
| Unger, RH | 1 |
| Hansen, AP | 1 |
| Hansen, HE | 1 |
| Orskov, H | 1 |
| Nosadini, R | 2 |
| Noy, G | 1 |
| Beccaria, L | 1 |
| Chiumello, G | 1 |
| Gianazza, E | 1 |
| Luppis, B | 1 |
| Righetti, PG | 1 |
| Gerich, JE | 2 |
| Lorenzi, M | 2 |
| Bier, DM | 3 |
| Schneider, V | 1 |
| Tsalikian, E | 2 |
| Karam, JH | 2 |
| Forsham, PH | 1 |
| Assan, R | 1 |
| Heuclin, C | 1 |
| Girard, JR | 1 |
| Basdevant, A | 1 |
| Predine, J | 1 |
| Husson, JM | 1 |
| Krentz, AJ | 1 |
| Ellis, SH | 1 |
| Hardman, M | 1 |
| Nattrass, M | 3 |
| Shishko, PI | 1 |
| Kovalev, PA | 1 |
| Goncharov, VG | 1 |
| Zajarny, IU | 1 |
| Boyle, PJ | 1 |
| Avogaro, A | 2 |
| Smith, L | 1 |
| Shah, SD | 3 |
| Santiago, JV | 1 |
| Wilczek, H | 1 |
| Gunnarsson, R | 1 |
| Felig, P | 1 |
| Ostman, J | 1 |
| Groth, CG | 1 |
| Wahren, J | 1 |
| Kalhan, SC | 1 |
| Hertz, RH | 1 |
| Rossi, KQ | 1 |
| Savin, SM | 1 |
| Orskov, L | 1 |
| Mengel, A | 1 |
| Møller, N | 1 |
| Pedersen, O | 1 |
| Rasmussen, O | 1 |
| Seefeldt, T | 1 |
| Schmitz, O | 1 |
| Almdal, TP | 1 |
| Jensen, T | 1 |
| Vilstrup, H | 1 |
| Vigili de Kreutzenberg, S | 2 |
| Maifreni, L | 1 |
| Lisato, G | 1 |
| Riccio, A | 1 |
| Trevisan, R | 2 |
| Fritze, K | 1 |
| Hirsch, IB | 1 |
| Smith, LJ | 1 |
| Havlin, CE | 1 |
| Clutter, WE | 2 |
| Vallet-Colom, I | 1 |
| Lévy-Marchal, C | 1 |
| Zarrouk, D | 1 |
| Tichet, J | 1 |
| Krishnamoorthy, R | 1 |
| Czernichow, P | 1 |
| Elion, J | 1 |
| Grossman, LD | 1 |
| Shumak, SL | 1 |
| George, SR | 1 |
| Singer, W | 1 |
| Zinman, B | 2 |
| Selam, JL | 1 |
| Kashyap, M | 1 |
| Lozano, J | 1 |
| Hanna, M | 1 |
| Turner, D | 1 |
| Jeandidier, N | 1 |
| Chan, E | 1 |
| Charles, MA | 1 |
| Benn, JJ | 1 |
| Bozzard, SJ | 1 |
| Kelley, D | 1 |
| Mitrakou, A | 1 |
| Aoki, T | 1 |
| Sorensen, J | 1 |
| Gerich, J | 1 |
| Sonksen, PH | 1 |
| Tuttle, KR | 1 |
| Marker, JC | 1 |
| Dalsky, GP | 1 |
| Schwartz, NS | 1 |
| Holloszy, JO | 1 |
| Hale, PJ | 1 |
| Black, E | 1 |
| de Beaufort, CE | 1 |
| Bruining, GJ | 1 |
| Houtzagers, CM | 1 |
| van Strik, R | 1 |
| Singh, BM | 1 |
| Palma, MA | 1 |
| Robert, JJ | 1 |
| Beaufrere, B | 1 |
| Koziet, J | 1 |
| Desjeux, JF | 1 |
| Young, VR | 1 |
| Lestradet, H | 1 |
| Duner, E | 1 |
| Baccaglini, U | 1 |
| Tremolada, C | 1 |
| Zuniga-Guajardo, S | 1 |
| Jimenez, JT | 1 |
| Walford, S | 1 |
| Hanning, I | 1 |
| Gabr, M | 1 |
| Ghaleb, HO | 1 |
| Mahfouz, M | 1 |
| Niemeyer, G | 1 |
| Marquardt, JL | 1 |
| Stimmler, L | 1 |
| Jensen, N | 1 |
| Toseland, P | 1 |
1 review available for alanine and Diabetes Mellitus, Type 1
| Article | Year |
|---|---|
Role of glucagon in the pathogenesis of diabetes: the status of the controversy.
Topics: Alanine; Animals; Antigens; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Type 1; Dietary Pro | 1978 |
9 trials available for alanine and Diabetes Mellitus, Type 1
| Article | Year |
|---|---|
The effects of non-insulin-dependent diabetes mellitus on the kinetics of onset of insulin action in hepatic and extrahepatic tissues.
Topics: Alanine; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 1; Female; Gluconeogenesis; Glucose; Gluc | 1995 |
Glycemic actions of alanine and terbutaline in IDDM.
Topics: Administration, Oral; Alanine; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 1; Epinephrine; Fat | 1993 |
Alanine and terbutaline in treatment of hypoglycemia in IDDM.
Topics: 3-Hydroxybutyric Acid; Administration, Oral; Alanine; Blood Glucose; C-Peptide; Diabetes Mellitus, T | 1993 |
Alanine and terbutaline in the prevention of nocturnal hypoglycemia in IDDM.
Topics: Adrenergic beta-Agonists; Adult; Alanine; Blood Glucose; Circadian Rhythm; Diabetes Mellitus, Type 1 | 1997 |
Combination of continuous subcutaneous infusion of insulin and octreotide in Type 1 diabetic patients.
Topics: Adult; Alanine; Blood Glucose; Calorimetry, Indirect; Circadian Rhythm; Diabetes Mellitus, Type 1; D | 2001 |
Sulfate production depicts fed-state adaptation to protein restriction in humans.
Topics: Adult; Alanine; Blood Glucose; Carbon Isotopes; Diabetes Mellitus, Type 1; Diet, Protein-Restricted; | 2001 |
Effect of protein restriction on (15)N transfer from dietary [(15)N]alanine and [(15)N]Spirulina platensis into urea.
Topics: Alanine; Aspartic Acid; Bacterial Proteins; Diabetes Mellitus, Type 1; Diet, Protein-Restricted; Fem | 2001 |
Metabolic effects of aldose reductase inhibition in diabetic man.
Topics: Alanine; Aldehyde Reductase; Blood Glucose; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Di | 1992 |
Comparison of peripheral and portal (via the umbilical vein) routes of insulin infusion in IDDM patients.
Topics: Adolescent; Adult; Alanine; Diabetes Mellitus, Type 1; Growth Hormone; Humans; Hydrocortisone; Infus | 1992 |
76 other studies available for alanine and Diabetes Mellitus, Type 1
| Article | Year |
|---|---|
Longitudinal Metabolome-Wide Signals Prior to the Appearance of a First Islet Autoantibody in Children Participating in the TEDDY Study.
Topics: Alanine; Amino Acids, Branched-Chain; Autoantibodies; Child, Preschool; Dehydroascorbic Acid; Diabet | 2020 |
Combined effect of glutamine at position 70 of HLA-DRB1 and alanine at position 57 of HLA-DQB1 in type 1 diabetes: An epitope analysis.
Topics: Age of Onset; Alanine; Binding Sites; Cohort Studies; Cyprus; Diabetes Mellitus, Type 1; Epitope Map | 2018 |
Hepatobiliary and Pancreatic: Mauriac syndrome: A rare cause of elevated liver enzymes.
Topics: Adolescent; Alanine; Alanine Transaminase; Aspartate Aminotransferases; Diabetes Mellitus, Type 1; F | 2019 |
Efficacy of lanthionine-stabilized angiotensin-(1-7) in type I and type II diabetes mouse models.
Topics: Alanine; Angiotensin I; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, | 2019 |
HLA-DQB1 Position 57 Defines Susceptibility to Isolated and Polyglandular Autoimmunity in Adults: Interaction With Gender.
Topics: Addison Disease; Adult; Alanine; Amino Acid Substitution; Asparagine; Case-Control Studies; Diabetes | 2019 |
On elevated alanine aminotransferase in type 1 diabetes mellitus.
Topics: Alanine; Alanine Transaminase; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Humans | 2016 |
The Metabolic Responses to L-Glutamine of Livers from Rats with Diabetes Types 1 and 2.
Topics: Alanine; Ammonia; Animals; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Gluconeogenesis; Gl | 2016 |
Effects of streptozotocin-induced diabetes in domestic pigs with focus on the amino acid metabolism.
Topics: Alanine; Amino Acids; Amino Acids, Branched-Chain; Animals; Blood Glucose; Body Weight; C-Peptide; D | 2009 |
The interferon-induced helicase IFIH1 Ala946Thr polymorphism is associated with type 1 diabetes in both the high-incidence Finnish and the medium-incidence Hungarian populations.
Topics: Age of Onset; Alanine; Amino Acid Substitution; Child; DEAD-box RNA Helicases; Diabetes Mellitus, Ty | 2010 |
Time-dependent changes in the plasma amino acid concentration in diabetes mellitus.
Topics: Alanine; Amino Acids; Amino Acids, Branched-Chain; Animals; Blood Glucose; Diabetes Mellitus, Type 1 | 2011 |
NEUROD polymorphism Ala45Thr is associated with Type 1 diabetes mellitus in Czech children.
Topics: Adolescent; Age of Onset; Alanine; Base Sequence; Basic Helix-Loop-Helix Transcription Factors; Chil | 2003 |
The Ala45Thr polymorphism of BETA2/NeuroD1 gene and susceptibility to type 1 diabetes mellitus in caucasians.
Topics: Adult; Age of Onset; Alanine; Amino Acid Substitution; Base Sequence; Basic Helix-Loop-Helix Transcr | 2003 |
An altered self-peptide with superagonist activity blocks a CD8-mediated mouse model of type 1 diabetes.
Topics: Adoptive Transfer; Alanine; Amino Acid Substitution; Animals; Autoantigens; CD8-Positive T-Lymphocyt | 2004 |
Thymic expression of mutated B16:A preproinsulin messenger RNA does not reverse acceleration of NOD diabetes associated with insulin 2 (thymic expressed insulin) knockout.
Topics: Alanine; Amino Acid Substitution; Animals; Autoantibodies; Blood Glucose; Diabetes Mellitus, Type 1; | 2005 |
The Ala45Thr polymorphism of NEUROD1 is associated with type 1 diabetes in Brazilian women.
Topics: Alanine; Amino Acid Substitution; Basic Helix-Loop-Helix Transcription Factors; Brazil; Confidence I | 2005 |
Long-term prevention of diabetes and marked suppression of insulin autoantibodies and insulitis in mice lacking native insulin B9-23 sequence.
Topics: Alanine; Amino Acid Substitution; Animals; Autoantibodies; Cell Transplantation; Diabetes Mellitus, | 2006 |
Effect of the amino acid alanine on glucagon secretion in non-diabetic and type 1 diabetic subjects during hyperinsulinaemic euglycaemia, hypoglycaemia and post-hypoglycaemic hyperglycaemia.
Topics: Adolescent; Adult; Alanine; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 1; Epinephrine; Female | 2007 |
A functional polymorphism in the manganese superoxide dismutase gene and diabetic nephropathy.
Topics: Adult; Age of Onset; Alanine; Blood Pressure; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Fem | 2007 |
Leisure-time physical activity is associated with the metabolic syndrome in type 1 diabetes: effect of the PPARgamma Pro12Ala polymorphism: the FinnDiane Study.
Topics: Adult; Alanine; Amino Acid Substitution; Cross-Sectional Studies; Diabetes Mellitus, Type 1; Humans; | 2007 |
Peroxisome proliferator-activated receptor-gamma2 Pro12Ala polymorphism, cod liver oil and risk of type 1 diabetes.
Topics: Alanine; Amino Acid Substitution; Case-Control Studies; Child; Cod Liver Oil; Diabetes Mellitus, Typ | 2008 |
Metabolic effects of physical exercise in insulin-dependent diabetics controlled by continuous subcutaneous insulin infusion or conventional injection therapy.
Topics: Adult; Alanine; Blood Glucose; Diabetes Mellitus, Type 1; Energy Metabolism; Fatty Acids, Nonesterif | 1984 |
Metabolic effects of intensified insulin therapy.
Topics: Alanine; Blood Glucose; Diabetes Mellitus, Type 1; Drug Administration Schedule; Fatty Acids, Nonest | 1984 |
The response of blood intermediary metabolite levels to 24 hours treatment with a blood glucose-controlled insulin infusion system in type 1 diabetes.
Topics: 3-Hydroxybutyric Acid; Adult; Alanine; Blood Glucose; Diabetes Mellitus, Type 1; Female; Glycerol; H | 1984 |
Tracer kinetic studies of glucose and alanine metabolism in diabetic dogs on the artificial beta cell.
Topics: Alanine; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Dogs; I | 1984 |
Branched-chain amino acids and alanine as indices of the metabolic control in type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetic patients.
Topics: Alanine; Amino Acids, Branched-Chain; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Type 1; F | 1982 |
Effect of intravenous alanine on blood glucose, glucagon and growth hormone levels in diabetic children.
Topics: Adolescent; Alanine; Blood Glucose; Diabetes Mellitus, Type 1; Diabetic Ketoacidosis; Glucagon; Grow | 1982 |
Effects of acetylsalicylic acid on blood glucose, plasma FFA, glycerol, 3-hydroxybutyrate, alanine, C-peptide, glucagon and growth hormone responses to arginine in insulin-dependent diabetics.
Topics: Adolescent; Adult; Alanine; Arginine; Aspirin; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 1; | 1980 |
Hypoglycemia-induced autonomic failure in IDDM is specific for stimulus of hypoglycemia and is not attributable to prior autonomic activation.
Topics: 3-Hydroxybutyric Acid; Adult; Alanine; Analysis of Variance; Autonomic Nervous System; Blood Glucose | 1994 |
Post-hypoglycaemic hyperketonaemia does not contribute to brain metabolism during insulin-induced hypoglycaemia in humans.
Topics: 3-Hydroxybutyric Acid; Adult; Alanine; Brain; Cognition; Diabetes Mellitus, Type 1; Female; Glycerol | 1993 |
Determination of diabetogenicity attributable to a single amino acid, Ala776, on the polyprotein of encephalomyocarditis virus.
Topics: Alanine; Animals; Base Sequence; Capsid; Capsid Proteins; Diabetes Mellitus, Type 1; DNA, Viral; Enc | 1993 |
Improved postprandial metabolic control after subcutaneous injection of a short-acting insulin analog in IDDM of short duration with residual pancreatic beta-cell function.
Topics: 3-Hydroxybutyric Acid; Adult; Alanine; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 1; Drug Adm | 1995 |
Effects of dietary protein restriction on regional amino acid metabolism in insulin-dependent diabetes mellitus.
Topics: Alanine; Amino Acids; Blood Glucose; Diabetes Mellitus, Type 1; Dietary Proteins; Dose-Response Rela | 1996 |
Long-term intensive insulin therapy in IDDM: effects on HbA1c, risk for severe and mild hypoglycaemia, status of counterregulation and awareness of hypoglycaemia.
Topics: 3-Hydroxybutyric Acid; Adult; Alanine; Blood Glucose; Diabetes Mellitus, Type 1; Epinephrine; Fatty | 1996 |
Effects of the short-acting insulin analog [Lys(B28),Pro(B29)] on postprandial blood glucose control in IDDM.
Topics: 3-Hydroxybutyric Acid; Adult; Alanine; Analysis of Variance; Blood Glucose; C-Peptide; Diabetes Mell | 1996 |
CTLA4 alanine-17 confers genetic susceptibility to Graves' disease and to type 1 diabetes mellitus.
Topics: Abatacept; Adolescent; Adult; Alanine; Alleles; Antigens, CD; Antigens, Differentiation; Child; Chil | 1997 |
Blood glucose lowering and glucagonostatic effects of glucagon-like peptide I in insulin-deprived diabetic dogs.
Topics: Alanine; Animals; Blood Glucose; Diabetes Mellitus, Type 1; Dogs; Female; Glucagon; Glucagon-Like Pe | 1997 |
Urinary biotinidase and alanine excretion in patients with insulin-dependent diabetes mellitus.
Topics: Acetylglucosaminidase; Adolescent; Adult; Alanine; Albuminuria; Amidohydrolases; Biotinidase; Case-C | 1997 |
Glucose turnover and gluconeogenesis during pregnancy in women with and without insulin-dependent diabetes mellitus.
Topics: Alanine; Carbon Isotopes; Deuterium; Diabetes Mellitus, Type 1; Estradiol; Fasting; Female; Glucagon | 1997 |
Gain or loss of diabetogenicity resulting from a single point mutation in recombinant encephalomyocarditis virus.
Topics: Alanine; Animals; Antibodies, Viral; Blood Glucose; Cardiovirus Infections; Diabetes Mellitus, Type | 1997 |
The P9 pocket of HLA-DQ2 (non-Aspbeta57) has no particular preference for negatively charged anchor residues found in other type 1 diabetes-predisposing non-Aspbeta57 MHC class II molecules.
Topics: Alanine; Alleles; Aspartic Acid; B-Lymphocytes; Binding Sites; Cell Line; Computer Simulation; Diabe | 1998 |
Pro12Ala missense mutation of the peroxisome proliferator activated receptor gamma and diabetes mellitus.
Topics: Adult; Alanine; Amino Acid Substitution; Cholesterol; Codon; Coronary Disease; Diabetes Mellitus; Di | 1999 |
1H NMR as a non-invasive probe of amniotic fluid in insulin dependent diabetes mellitus.
Topics: Acetates; Alanine; Amniotic Fluid; Citric Acid; Diabetes Mellitus, Type 1; Female; Glucose; Humans; | 1999 |
Association of CTLA-4 gene A/G polymorphism in Japanese type 1 diabetic patients with younger age of onset and autoimmune thyroid disease.
Topics: Abatacept; Adolescent; Adult; Age of Onset; Aged; Alanine; Antigens, CD; Antigens, Differentiation; | 2000 |
Low-dose IGF-I has no selective advantage over insulin in regulating glucose metabolism in hyperglycemic depancreatized dogs.
Topics: 3-Hydroxybutyric Acid; Alanine; Analysis of Variance; Animals; Blood Glucose; Diabetes Mellitus, Typ | 2001 |
[Polymorphism of pro12Ala in peroxisome proliferator activated receptor gamma 2 (PPAgamma2): beta cell function and insulin sensitivity].
Topics: Adult; Alanine; Alleles; Diabetes Mellitus, Type 1; Female; Gene Expression Regulation; Genotype; Gl | 2001 |
The association of Ala45Thr polymorphism in NeuroD with child-onset Type 1a diabetes in Japanese.
Topics: Adolescent; Age of Onset; Alanine; Alleles; Asian People; Basic Helix-Loop-Helix Transcription Facto | 2002 |
Proton nuclear magnetic resonance spectral profiles of urine from children and adolescents with type 1 diabetes.
Topics: Adolescent; Alanine; Child; Citric Acid; Diabetes Mellitus, Type 1; Female; Glycated Hemoglobin; Hip | 2002 |
Free insulin, bound insulin, C-peptide and the metabolic control in juvenile onset diabetics: comparison of C-peptide secretors and non-secretors during 24 hours conventional insulin therapy.
Topics: Adolescent; Adult; Alanine; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 1; Fatty Acids, Nonest | 1979 |
Normalisation of growth hormone hypersecretion in uraemic diabetics and non-diabetics. Studies with artificial pancreas and artificial kidney.
Topics: Alanine; Artificial Organs; Blood Glucose; Diabetes Mellitus, Type 1; Fatty Acids, Nonesterified; Fe | 1979 |
Hemoglobin A1C separation by isoelectric focusing.
Topics: Alanine; Aminocaproic Acid; Diabetes Mellitus, Type 1; Glycine; Hemoglobin A; Histidine; Humans; Iso | 1978 |
Prevention of human diabetic ketoacidosis by somatostatin. Evidence for an essential role of glucagon.
Topics: Adult; Alanine; Blood Glucose; Depression, Chemical; Diabetes Mellitus, Type 1; Diabetic Ketoacidosi | 1975 |
Hormonal and metabolic effects of somatostatin in diabetic patients submitted to an i.v. arginine infusion.
Topics: Adult; Alanine; Arginine; Blood Glucose; Diabetes Mellitus, Type 1; Dose-Response Relationship, Drug | 1977 |
Plasma glucagon and alanine responses to acute insulin deficiency in man.
Topics: Adult; Alanine; Blood Glucose; Diabetes Mellitus, Type 1; Fatty Acids, Nonesterified; Glucagon; Glyc | 1975 |
Absence of the dawn phenomenon and abnormal lipolysis in type 1 (insulin-dependent) diabetic patients with chronic growth hormone deficiency.
Topics: 3-Hydroxybutyric Acid; Adult; Alanine; Blood Glucose; Circadian Rhythm; Diabetes Mellitus, Type 1; E | 1992 |
Normalization of hepatic glucose regulation despite systemic insulin delivery. Studies in patients with pancreatic transplantation for type 1 (insulin-dependent) diabetes mellitus.
Topics: Adult; Alanine; Blood Glucose; Diabetes Mellitus, Type 1; Fatty Acids, Nonesterified; Glucose; Glyce | 1991 |
Glucose-alanine relationship in diabetes in human pregnancy.
Topics: Adult; Alanine; Blood Glucose; Carbon Dioxide; Diabetes Mellitus, Type 1; Female; Humans; Oxygen Con | 1991 |
Decreased hepatic glucagon responses in type 1 (insulin-dependent) diabetes mellitus.
Topics: 3-Hydroxybutyric Acid; Adult; Alanine; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 1; Fatty Ac | 1991 |
Increased hepatic efficacy of urea synthesis from alanine in insulin-dependent diabetes mellitus.
Topics: Adult; Alanine; Blood Glucose; Diabetes Mellitus, Type 1; Female; Glucagon; Humans; Insulin; Kinetic | 1990 |
Glucose turnover and recycling in diabetes secondary to total pancreatectomy: effect of glucagon infusion.
Topics: Adult; Alanine; Blood Glucose; Diabetes Mellitus, Type 1; Female; Glucagon; Gluconeogenesis; Glucose | 1990 |
Insulin therapy on the peritoneal route: effects on glucose control in experimental insulin dependent diabetes.
Topics: Alanine; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Dogs; Fatty Acids; Glu | 1990 |
Failure of nocturnal hypoglycemia to cause daytime hyperglycemia in patients with IDDM.
Topics: 3-Hydroxybutyric Acid; Adult; Alanine; Blood Glucose; Circadian Rhythm; Diabetes Mellitus, Type 1; E | 1990 |
HLA-DQB 1 codon 57 and genetic susceptibility to type 1 (insulin-dependent) diabetes mellitus in French children.
Topics: Alanine; Alleles; Aspartic Acid; Child; Codon; Diabetes Mellitus, Type 1; France; Gene Frequency; Ge | 1990 |
The effects of SMS 201-995 (sandostatin) on metabolic profiles in insulin-dependent diabetes mellitus.
Topics: Adult; Alanine; Blood Glucose; Diabetes Mellitus, Type 1; Female; Glucagon; Glycerol; Growth Hormone | 1989 |
Comparison of intraperitoneal and subcutaneous insulin administration on lipids, apolipoproteins, fuel metabolites, and hormones in type I diabetes mellitus.
Topics: Adult; Alanine; Apolipoproteins; Blood Glucose; Diabetes Mellitus, Type 1; Drug Administration Route | 1989 |
Persistent abnormalities of the metabolism of an oral glucose load in insulin-treated type I diabetics.
Topics: Administration, Oral; Alanine; Blood Glucose; Calorimetry, Indirect; Diabetes Mellitus, Type 1; Fore | 1989 |
Glucagon, not insulin, may play a secondary role in defense against hypoglycemia during exercise.
Topics: 3-Hydroxybutyric Acid; Adult; Alanine; Blood Glucose; Blood Pressure; Diabetes Mellitus, Type 1; Epi | 1988 |
Metabolic effects of low-dose incremental insulin infusion in diabetic man.
Topics: Adult; Alanine; Blood Glucose; Diabetes Mellitus, Type 1; Fatty Acids, Nonesterified; Glycerol; Huma | 1986 |
Overnight metabolic profiles in very young insulin-dependent diabetic children.
Topics: Age Factors; Alanine; Blood Glucose; Child; Child, Preschool; Delayed-Action Preparations; Diabetes | 1986 |
Multiple aspects of insulin resistance. Comparison of glucose and intermediary metabolite response to incremental insulin infusion in IDDM subjects of short and long duration.
Topics: Adult; Alanine; Blood Glucose; Diabetes Mellitus, Type 1; Fatty Acids, Nonesterified; Glucose; Glyce | 1987 |
Whole body de novo amino acid synthesis in type I (insulin-dependent) diabetes studied with stable isotope-labeled leucine, alanine, and glycine.
Topics: Adolescent; Adult; Alanine; Amino Acids; Diabetes Mellitus, Type 1; Glucose; Glycine; Humans; Hyperg | 1985 |
Hyperalaninaemia is an early feature of diabetes secondary to total pancreatectomy.
Topics: Adenocarcinoma; Adult; Aged; Alanine; C-Peptide; Diabetes Mellitus, Type 1; Female; Glucagon; Humans | 1985 |
The metabolic response to the euglycemic insulin clamp in type I diabetes and normal humans.
Topics: 3-Hydroxybutyric Acid; Adult; Alanine; Blood Glucose; Diabetes Mellitus, Type 1; Fasting; Fatty Acid | 1985 |
Free insulin levels and metabolic effects of meal-time bolus and square-wave intraperitoneal insulin infusion in insulin-dependent diabetic patients.
Topics: 3-Hydroxybutyric Acid; Adult; Alanine; Blood Glucose; Diabetes Mellitus, Type 1; Fatty Acids, Nonest | 1985 |
Serum and urinary aminoacid pattern in juvenile diabetes.
Topics: Adolescent; Alanine; Amino Acids; Child; Chromatography; Diabetes Mellitus, Type 1; Electrophoresis, | 1973 |
Retinal function in an unique syndrome of optic atrophy, juvenile diabetes mellitus, diabetes insipidus, neurosensory hearing loss, autonomic dysfunction, and hyperalanineuria.
Topics: Adaptation, Ocular; Adult; Alanine; Amino Acid Metabolism, Inborn Errors; Diabetes Insipidus; Diabet | 1972 |
Alaninuria, associated with microcephaly, dwarfism, enamel hypoplasia, and diabetes mellitus in two sisters.
Topics: Alanine; Amino Acid Metabolism, Inborn Errors; Birth Weight; Child, Preschool; Dental Enamel Hypopla | 1970 |