alanine has been researched along with Cytomegalovirus in 13 studies
Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.
Cytomegalovirus: A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, infecting the salivary glands, liver, spleen, lungs, eyes, and other organs, in which they produce characteristically enlarged cells with intranuclear inclusions. Infection with Cytomegalovirus is also seen as an opportunistic infection in AIDS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Three human immunodeficiency virus-infected subjects with progressive cytomegalovirus (CMV) retinitis despite prolonged antiviral therapy had buffy coat CMV isolates that were resistant to both ganciclovir and foscarnet." | 7.70 | Mutation in region III of the DNA polymerase gene conferring foscarnet resistance in cytomegalovirus isolates from 3 subjects receiving prolonged antiviral therapy. ( Chou, S; Drew, WL; Gordon, SM; LaVoy, AG; Marousek, G; Miner, RC; Parenti, DM; Ross, JG, 1998) |
| "Human cytomegalovirus (HCMV) isolates resistant to ganciclovir were found in patients undergoing therapy." | 7.69 | Value of a ligase chain reaction assay for detection of ganciclovir resistance-related mutation 594 in UL97 gene of human cytomegalovirus. ( Bour, JB; Bourgeois, C; Pothier, P; Sixt, N, 1997) |
| "Starting from the structure of known beta-lactam covalent human cytomegalovirus (HCMV) protease inhibitors and from the knowledge of the residues implicated in the active site of this enzyme, we designed a series of phenylalanine-derived 2-azetidinones bearing a 4-carboxylate moiety that could be apt for additional interactions with the guanidine group of the Arg165/Arg166 residues of the viral protease." | 3.73 | From 1-acyl-beta-lactam human cytomegalovirus protease inhibitors to 1-benzyloxycarbonylazetidines with improved antiviral activity. A straightforward approach to convert covalent to noncovalent inhibitors. ( Andrei, G; Balzarini, J; De Clercq, E; García-López, MT; Gerona-Navarro, G; González-Muñiz, R; Pérez de Vega, MJ; Snoeck, R, 2005) |
| "Three human immunodeficiency virus-infected subjects with progressive cytomegalovirus (CMV) retinitis despite prolonged antiviral therapy had buffy coat CMV isolates that were resistant to both ganciclovir and foscarnet." | 3.70 | Mutation in region III of the DNA polymerase gene conferring foscarnet resistance in cytomegalovirus isolates from 3 subjects receiving prolonged antiviral therapy. ( Chou, S; Drew, WL; Gordon, SM; LaVoy, AG; Marousek, G; Miner, RC; Parenti, DM; Ross, JG, 1998) |
| "Human cytomegalovirus (HCMV) isolates resistant to ganciclovir were found in patients undergoing therapy." | 3.69 | Value of a ligase chain reaction assay for detection of ganciclovir resistance-related mutation 594 in UL97 gene of human cytomegalovirus. ( Bour, JB; Bourgeois, C; Pothier, P; Sixt, N, 1997) |
| " The results demonstrated that the tricin-alanine-glutamic acid conjugate exhibited enhanced permeability, stability in MDCK cells, and excellent bioavailability after oral administration in Crl:CD (SD) male rats." | 1.37 | Increased bioavailability of tricin-amino acid derivatives via a prodrug approach. ( Koketsu, M; Muto, Y; Ninomiya, M; Tanaka, K; Tsuchida, Y; Watanabe, K, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (38.46) | 18.2507 |
| 2000's | 5 (38.46) | 29.6817 |
| 2010's | 3 (23.08) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Stegmann, C | 1 |
| Rothemund, F | 1 |
| Laib Sampaio, K | 1 |
| Adler, B | 1 |
| Sinzger, C | 1 |
| Ninomiya, M | 1 |
| Tanaka, K | 1 |
| Tsuchida, Y | 1 |
| Muto, Y | 1 |
| Koketsu, M | 1 |
| Watanabe, K | 1 |
| Peterson, LW | 1 |
| Kim, JS | 1 |
| Kijek, P | 1 |
| Mitchell, S | 1 |
| Hilfinger, J | 1 |
| Breitenbach, J | 1 |
| Borysko, K | 1 |
| Drach, JC | 2 |
| Kashemirov, BA | 1 |
| McKenna, CE | 1 |
| Khayat, R | 2 |
| Batra, R | 2 |
| Qian, C | 1 |
| Halmos, T | 1 |
| Bailey, M | 1 |
| Tong, L | 2 |
| Gerona-Navarro, G | 1 |
| Pérez de Vega, MJ | 1 |
| García-López, MT | 1 |
| Andrei, G | 1 |
| Snoeck, R | 1 |
| De Clercq, E | 1 |
| Balzarini, J | 1 |
| González-Muñiz, R | 1 |
| McCartney, SA | 1 |
| Brignole, EJ | 1 |
| Kolegraff, KN | 1 |
| Loveland, AN | 1 |
| Ussin, LM | 1 |
| Gibson, W | 1 |
| Gautier, N | 1 |
| Chavant, E | 1 |
| Prieur, E | 1 |
| Monsarrat, B | 1 |
| Mazarguil, H | 1 |
| Davrinche, C | 1 |
| Gairin, JE | 1 |
| Davignon, JL | 1 |
| Bourgeois, C | 1 |
| Sixt, N | 1 |
| Bour, JB | 1 |
| Pothier, P | 1 |
| Liang, PH | 1 |
| Brun, KA | 1 |
| Feild, JA | 1 |
| O'Donnell, K | 1 |
| Doyle, ML | 1 |
| Green, SM | 1 |
| Baker, AE | 1 |
| Blackburn, MN | 1 |
| Abdel-Meguid, SS | 1 |
| Fish, KN | 1 |
| Soderberg-Naucler, C | 1 |
| Nelson, JA | 1 |
| Chou, S | 1 |
| Marousek, G | 1 |
| Parenti, DM | 1 |
| Gordon, SM | 1 |
| LaVoy, AG | 1 |
| Ross, JG | 1 |
| Miner, RC | 1 |
| Drew, WL | 1 |
| Qiu, YL | 1 |
| Geiser, F | 1 |
| Kira, T | 1 |
| Gullen, E | 1 |
| Cheng, YC | 1 |
| Ptak, RG | 1 |
| Breitenbach, JM | 1 |
| Hartline, CB | 1 |
| Kern, ER | 1 |
| Zemlicka, J | 1 |
| Massariol, MJ | 1 |
| Lagacé, L | 1 |
13 other studies available for alanine and Cytomegalovirus
| Article | Year |
|---|---|
The N Terminus of Human Cytomegalovirus Glycoprotein O Is Important for Binding to the Cellular Receptor PDGFRα.
Topics: Alanine; Cell Line; Cells, Cultured; Cytomegalovirus; Cytomegalovirus Infections; Endocytosis; Endot | 2019 |
Increased bioavailability of tricin-amino acid derivatives via a prodrug approach.
Topics: Administration, Oral; Alanine; Animals; Antiviral Agents; Biological Availability; Cell Line; Cell M | 2011 |
Synthesis, transport and antiviral activity of Ala-Ser and Val-Ser prodrugs of cidofovir.
Topics: Administration, Oral; Alanine; Animals; Antiviral Agents; Cells, Cultured; Cidofovir; Cytomegaloviru | 2011 |
Structural and biochemical studies of inhibitor binding to human cytomegalovirus protease.
Topics: Alanine; Arginine; Binding, Competitive; Crystallization; Crystallography, X-Ray; Cytomegalovirus; G | 2003 |
From 1-acyl-beta-lactam human cytomegalovirus protease inhibitors to 1-benzyloxycarbonylazetidines with improved antiviral activity. A straightforward approach to convert covalent to noncovalent inhibitors.
Topics: Alanine; Antiviral Agents; Azetidines; Cells, Cultured; Cytomegalovirus; Humans; Lactams; Protease I | 2005 |
Chemical rescue of I-site cleavage in living cells and in vitro discriminates between the cytomegalovirus protease, assemblin, and its precursor, pUL80a.
Topics: Alanine; Amino Acid Substitution; Cell Line; Cell Line, Transformed; Cell Transformation, Viral; Clo | 2005 |
Characterization of an epitope of the human cytomegalovirus protein IE1 recognized by a CD4+ T cell clone.
Topics: Alanine; Amino Acid Sequence; CD4-Positive T-Lymphocytes; Clone Cells; Cytokines; Cytomegalovirus; C | 1996 |
Value of a ligase chain reaction assay for detection of ganciclovir resistance-related mutation 594 in UL97 gene of human cytomegalovirus.
Topics: Alanine; Cytomegalovirus; Drug Resistance, Microbial; Electrophoresis, Polyacrylamide Gel; Ganciclov | 1997 |
Site-directed mutagenesis probing the catalytic role of arginines 165 and 166 of human cytomegalovirus protease.
Topics: Alanine; Arginine; Catalysis; Cytomegalovirus; Dimerization; Endopeptidases; Humans; Kinetics; Model | 1998 |
Steady-state plasma membrane expression of human cytomegalovirus gB is determined by the phosphorylation state of Ser900.
Topics: Alanine; Animals; Antibodies, Monoclonal; Antifungal Agents; Aspartic Acid; Biological Transport; Ce | 1998 |
Mutation in region III of the DNA polymerase gene conferring foscarnet resistance in cytomegalovirus isolates from 3 subjects receiving prolonged antiviral therapy.
Topics: Adult; AIDS-Related Opportunistic Infections; Alanine; Antiviral Agents; Cytomegalovirus; Cytomegalo | 1998 |
Synthesis and enantioselectivity of the antiviral effects of (R,Z)-,(S,Z)-methylenecyclopropane analogues of purine nucleosides and phosphoralaninate prodrugs: influence of heterocyclic base, type of virus and host cells.
Topics: Adenosine; Alanine; Animals; Antiviral Agents; Chromatography, High Pressure Liquid; Cyclopropanes; | 2000 |
Investigating the role of histidine 157 in the catalytic activity of human cytomegalovirus protease.
Topics: Alanine; Binding Sites; Catalytic Domain; Conserved Sequence; Crystallization; Crystallography, X-Ra | 2001 |