alanine has been researched along with Critical Illness in 20 studies
Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.
Critical Illness: A disease or state in which death is possible or imminent.
| Excerpt | Relevance | Reference |
|---|---|---|
| "He developed severe sepsis and acute respiratory distress syndrome (ARDS) and received intravenous high dose corticosteroid and tocilizumab to counter SARS-CoV2 associated cytokine surge." | 2.72 | Severe acute myopathy following SARS-CoV-2 infection: a case report and review of recent literature. ( Ahmed, M; Begum, SM; Islam, B; Islam, Z, 2021) |
| "The novel coronavirus disease 2019 (COVID-19) with its early origin from Wuhan city in China has evolved into a global pandemic." | 2.66 | Clinical management of COVID-19. ( Abraham, OC; John, R; Karthik, R; Manesh, A; Varghese, GM, 2020) |
| " The outcomes of interest were mortality, progression to severe disease (severe pneumonia, admission to intensive care unit (ICU), and/or mechanical ventilation), viral clearance rate, QT prolongation, fatal cardiac complications, and noncardiac serious adverse events." | 2.66 | Comparative efficacy and safety of pharmacological interventions for the treatment of COVID-19: A systematic review and network meta-analysis. ( An, MH; Hwang, TH; Kim, MS; Kim, WJ, 2020) |
| " A prospective observational pharmacokinetic study was performed in non-critically ill hospitalized COVID-19 patients with hypoxemia." | 1.72 | Population Pharmacokinetics of Remdesivir and GS-441524 in Hospitalized COVID-19 Patients. ( Bosma, LBE; Leegwater, E; Moes, DJAR; Ottens, TH; van der Meer, IM; van Nieuwkoop, C; Wilms, EB, 2022) |
| "Hydroxychloroquine (HCQ) was used by 78." | 1.56 | Early impact of COVID-19 on transplant center practices and policies in the United States. ( Avery, RK; Boyarsky, BJ; Durand, CM; Garonzik-Wang, JM; Getsin, SN; Jackson, KR; Kernodle, AB; Massie, AB; Po-Yu Chiang, T; Segev, DL; Van Pilsum Rasmussen, SE; Werbel, WA, 2020) |
| "Severe sepsis and septic shock syndromes were observed in 7 (53." | 1.56 | Clinical Characteristics and Outcomes of Hospitalized and Critically Ill Children and Adolescents with Coronavirus Disease 2019 at a Tertiary Care Medical Center in New York City. ( Aldrich, M; Cabana, MD; Chao, JY; Derespina, KR; Goldman, DL; Herold, BC; Medar, SS; Ushay, HM; Weingarten, J, 2020) |
| "One patient experienced a torsade de pointes requiring cardiac resuscitation and one died due to multiple organ failure." | 1.56 | Early experience with remdesivir in SARS-CoV-2 pneumonia. ( Andini, R; Bertolino, L; Corcione, A; Durante-Mangoni, E; Florio, LL; Mele, F; Murino, P; Zampino, R, 2020) |
| "We report the first pharmacokinetic evaluation of remdesivir and GS-441524 in recovered COVID-19 patients." | 1.56 | Pharmacokinetics of remdesivir and GS-441524 in two critically ill patients who recovered from COVID-19. ( Agrati, C; Ascoli Bartoli, T; Avataneo, V; Capobianchi, MR; Caputi, P; Castilletti, C; D'Avolio, A; Forini, O; Ippolito, G; Lalle, E; Marchioni, L; Nicastri, E; Notari, S; Scorzolini, L; Tempestilli, M, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (10.00) | 18.2507 |
| 2000's | 1 (5.00) | 29.6817 |
| 2010's | 1 (5.00) | 24.3611 |
| 2020's | 16 (80.00) | 2.80 |
| Authors | Studies |
|---|---|
| De Pascale, G | 1 |
| Cutuli, SL | 1 |
| Carelli, S | 1 |
| Xhemalaj, R | 1 |
| Rosà, T | 1 |
| Bello, G | 1 |
| Vargas, J | 1 |
| Cesarano, M | 1 |
| Montini, L | 1 |
| Tanzarella, ES | 1 |
| Pintaudi, G | 1 |
| Di Muro, M | 1 |
| Grieco, DL | 1 |
| Antonelli, M | 1 |
| Drosos, AA | 1 |
| Pelechas, E | 1 |
| Voulgari, PV | 1 |
| Leegwater, E | 1 |
| Moes, DJAR | 1 |
| Bosma, LBE | 1 |
| Ottens, TH | 1 |
| van der Meer, IM | 1 |
| van Nieuwkoop, C | 1 |
| Wilms, EB | 1 |
| Wilkinson, D | 1 |
| Gallagher, IJ | 1 |
| McNelly, A | 1 |
| Bear, DE | 1 |
| Hart, N | 1 |
| Montgomery, HE | 1 |
| Le Guennec, A | 1 |
| Conte, MR | 1 |
| Francis, T | 1 |
| Harridge, SDR | 1 |
| Atherton, PJ | 1 |
| Puthucheary, ZA | 1 |
| Atluri, S | 1 |
| Manchikanti, L | 1 |
| Hirsch, JA | 1 |
| Boyarsky, BJ | 1 |
| Po-Yu Chiang, T | 1 |
| Werbel, WA | 1 |
| Durand, CM | 1 |
| Avery, RK | 1 |
| Getsin, SN | 1 |
| Jackson, KR | 1 |
| Kernodle, AB | 1 |
| Van Pilsum Rasmussen, SE | 1 |
| Massie, AB | 1 |
| Segev, DL | 1 |
| Garonzik-Wang, JM | 1 |
| Chao, JY | 1 |
| Derespina, KR | 1 |
| Herold, BC | 1 |
| Goldman, DL | 1 |
| Aldrich, M | 1 |
| Weingarten, J | 1 |
| Ushay, HM | 1 |
| Cabana, MD | 1 |
| Medar, SS | 1 |
| Durante-Mangoni, E | 2 |
| Andini, R | 2 |
| Bertolino, L | 2 |
| Mele, F | 2 |
| Florio, LL | 2 |
| Murino, P | 1 |
| Corcione, A | 2 |
| Zampino, R | 2 |
| Ledford, H | 1 |
| Tempestilli, M | 1 |
| Caputi, P | 1 |
| Avataneo, V | 1 |
| Notari, S | 1 |
| Forini, O | 1 |
| Scorzolini, L | 1 |
| Marchioni, L | 1 |
| Ascoli Bartoli, T | 1 |
| Castilletti, C | 1 |
| Lalle, E | 1 |
| Capobianchi, MR | 1 |
| Nicastri, E | 1 |
| D'Avolio, A | 1 |
| Ippolito, G | 1 |
| Agrati, C | 1 |
| Varghese, GM | 1 |
| John, R | 1 |
| Manesh, A | 1 |
| Karthik, R | 1 |
| Abraham, OC | 1 |
| Galdo, M | 1 |
| De Rosa, R | 1 |
| Méndez-Echevarría, A | 1 |
| Pérez-Martínez, A | 1 |
| Gonzalez Del Valle, L | 1 |
| Ara, MF | 1 |
| Melendo, S | 1 |
| Ruiz de Valbuena, M | 1 |
| Vazquez-Martinez, JL | 1 |
| Morales-Martínez, A | 1 |
| Remesal, A | 1 |
| Sándor-Bajusz, KA | 1 |
| Cabañas, F | 1 |
| Calvo, C | 1 |
| Kim, MS | 1 |
| An, MH | 1 |
| Kim, WJ | 1 |
| Hwang, TH | 1 |
| Islam, B | 1 |
| Ahmed, M | 1 |
| Islam, Z | 1 |
| Begum, SM | 1 |
| Mahendra, M | 1 |
| Nuchin, A | 1 |
| Kumar, R | 1 |
| Shreedhar, S | 1 |
| Mahesh, PA | 1 |
| Cohen, J | 1 |
| Chin, DN | 1 |
| Ensinger, H | 1 |
| Träger, K | 1 |
| Geisser, W | 1 |
| Anhäupl, T | 1 |
| Ahnefeld, FW | 1 |
| Vogt, J | 1 |
| Georgieff, M | 1 |
| Holecek, M | 1 |
| Yamaguchi, T | 1 |
| Shimahara, Y | 1 |
| Takada, Y | 1 |
| Ino, K | 1 |
| Mori, K | 1 |
| Kobayashi, N | 1 |
| Yamaoka, Y | 1 |
| Ozawa, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy and Safety of Normoxic Allogenic Umbilical Cord Mesenchymal Stem Cells Administered as Adjuntive Treatment to Standard Treatment in Severe Patients With COVID-19[NCT05132972] | Phase 2/Phase 3 | 42 participants (Anticipated) | Interventional | 2021-01-17 | Recruiting | ||
| Efficacy of Intravenous Infusions of Stem Cells in the Treatment of COVID-19 Patients[NCT04437823] | Phase 2 | 5 participants (Actual) | Interventional | 2020-06-01 | Completed | ||
| Describing Chinese Herbal Medicine Telehealth Care for Symptoms Related to Infectious Diseases Such as COVID-19: A Descriptive, Longitudinal, Pragmatic Cohort Study[NCT04380870] | 500 participants (Anticipated) | Observational | 2020-05-11 | Recruiting | |||
| First-in-Human Evaluation of the Safety, Tolerability, and Pharmacokinetics of Orally Administered GS-441524 in a Healthy Human Volunteer[NCT04859244] | Phase 1 | 1 participants (Actual) | Interventional | 2021-01-01 | Completed | ||
| "Conducting Clinical Trials of the Medicine Rutan Tablets 0.1g No. 10 in the Complex Therapy of the Viral Disease COVID-19"[NCT05859919] | Phase 2 | 57 participants (Actual) | Interventional | 2020-10-12 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for alanine and Critical Illness
| Article | Year |
|---|---|
Treatment strategies of COVID-19: A rheumatology perspective.
Topics: Adenosine Monophosphate; Adrenal Cortex Hormones; Alanine; Antibodies, Monoclonal; COVID-19 Drug Tre | 2022 |
Clinical management of COVID-19.
Topics: Adenosine Monophosphate; Adrenal Cortex Hormones; Airway Management; Alanine; Antibodies, Monoclonal | 2020 |
Comparative efficacy and safety of pharmacological interventions for the treatment of COVID-19: A systematic review and network meta-analysis.
Topics: Adenosine Monophosphate; Alanine; Anti-Inflammatory Agents; Azithromycin; COVID-19; COVID-19 Drug Tr | 2020 |
Severe acute myopathy following SARS-CoV-2 infection: a case report and review of recent literature.
Topics: Adenosine Monophosphate; Adult; Alanine; Antibodies, Monoclonal, Humanized; Anticoagulants; Antivira | 2021 |
Nutrition and sepsis.
Topics: Alanine; Antioxidants; Arginine; Critical Illness; Cross Infection; Dietary Supplements; Emulsions; | 2013 |
Relation between glutamine, branched-chain amino acids, and protein metabolism.
Topics: Alanine; Amino Acids, Branched-Chain; Animals; Critical Illness; Glutamine; Humans; Liver; Muscle, S | 2002 |
1 trial available for alanine and Critical Illness
| Article | Year |
|---|---|
The metabolic effects of intermittent versus continuous feeding in critically ill patients.
Topics: Alanine; Amino Acids; Carnitine; Critical Illness; Humans; Ketones | 2023 |
13 other studies available for alanine and Critical Illness
| Article | Year |
|---|---|
Remdesivir plus Dexamethasone in COVID-19: A cohort study of severe patients requiring high flow oxygen therapy or non-invasive ventilation.
Topics: Adenosine Monophosphate; Alanine; Cohort Studies; COVID-19 Drug Treatment; Critical Illness; Dexamet | 2022 |
Population Pharmacokinetics of Remdesivir and GS-441524 in Hospitalized COVID-19 Patients.
Topics: Adenosine; Adenosine Monophosphate; Alanine; Anti-Bacterial Agents; COVID-19 Drug Treatment; Critica | 2022 |
Expanded Umbilical Cord Mesenchymal Stem Cells (UC-MSCs) as a Therapeutic Strategy in Managing Critically Ill COVID-19 Patients: The Case for Compassionate Use.
Topics: Adenosine Monophosphate; Alanine; Analgesia; Antiviral Agents; Betacoronavirus; China; Compassionate | 2020 |
Expanded Umbilical Cord Mesenchymal Stem Cells (UC-MSCs) as a Therapeutic Strategy in Managing Critically Ill COVID-19 Patients: The Case for Compassionate Use.
Topics: Adenosine Monophosphate; Alanine; Analgesia; Antiviral Agents; Betacoronavirus; China; Compassionate | 2020 |
Expanded Umbilical Cord Mesenchymal Stem Cells (UC-MSCs) as a Therapeutic Strategy in Managing Critically Ill COVID-19 Patients: The Case for Compassionate Use.
Topics: Adenosine Monophosphate; Alanine; Analgesia; Antiviral Agents; Betacoronavirus; China; Compassionate | 2020 |
Expanded Umbilical Cord Mesenchymal Stem Cells (UC-MSCs) as a Therapeutic Strategy in Managing Critically Ill COVID-19 Patients: The Case for Compassionate Use.
Topics: Adenosine Monophosphate; Alanine; Analgesia; Antiviral Agents; Betacoronavirus; China; Compassionate | 2020 |
Expanded Umbilical Cord Mesenchymal Stem Cells (UC-MSCs) as a Therapeutic Strategy in Managing Critically Ill COVID-19 Patients: The Case for Compassionate Use.
Topics: Adenosine Monophosphate; Alanine; Analgesia; Antiviral Agents; Betacoronavirus; China; Compassionate | 2020 |
Expanded Umbilical Cord Mesenchymal Stem Cells (UC-MSCs) as a Therapeutic Strategy in Managing Critically Ill COVID-19 Patients: The Case for Compassionate Use.
Topics: Adenosine Monophosphate; Alanine; Analgesia; Antiviral Agents; Betacoronavirus; China; Compassionate | 2020 |
Expanded Umbilical Cord Mesenchymal Stem Cells (UC-MSCs) as a Therapeutic Strategy in Managing Critically Ill COVID-19 Patients: The Case for Compassionate Use.
Topics: Adenosine Monophosphate; Alanine; Analgesia; Antiviral Agents; Betacoronavirus; China; Compassionate | 2020 |
Expanded Umbilical Cord Mesenchymal Stem Cells (UC-MSCs) as a Therapeutic Strategy in Managing Critically Ill COVID-19 Patients: The Case for Compassionate Use.
Topics: Adenosine Monophosphate; Alanine; Analgesia; Antiviral Agents; Betacoronavirus; China; Compassionate | 2020 |
Expanded Umbilical Cord Mesenchymal Stem Cells (UC-MSCs) as a Therapeutic Strategy in Managing Critically Ill COVID-19 Patients: The Case for Compassionate Use.
Topics: Adenosine Monophosphate; Alanine; Analgesia; Antiviral Agents; Betacoronavirus; China; Compassionate | 2020 |
Early impact of COVID-19 on transplant center practices and policies in the United States.
Topics: Adenosine Monophosphate; Alanine; Antibodies, Monoclonal, Humanized; Betacoronavirus; Clinical Labor | 2020 |
Clinical Characteristics and Outcomes of Hospitalized and Critically Ill Children and Adolescents with Coronavirus Disease 2019 at a Tertiary Care Medical Center in New York City.
Topics: Adenosine Monophosphate; Adolescent; Alanine; Antiviral Agents; Asthma; Betacoronavirus; Blood Urea | 2020 |
Early experience with remdesivir in SARS-CoV-2 pneumonia.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Chemical and Drug Induced Liver | 2020 |
Coronavirus breakthrough: dexamethasone is first drug shown to save lives.
Topics: Adenosine Monophosphate; Alanine; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Critica | 2020 |
Pharmacokinetics of remdesivir and GS-441524 in two critically ill patients who recovered from COVID-19.
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Aged; Alanine; Antiviral Agents; Betacoronavirus; C | 2020 |
Pharmacokinetics of remdesivir and GS-441524 in two critically ill patients who recovered from COVID-19.
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Aged; Alanine; Antiviral Agents; Betacoronavirus; C | 2020 |
Pharmacokinetics of remdesivir and GS-441524 in two critically ill patients who recovered from COVID-19.
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Aged; Alanine; Antiviral Agents; Betacoronavirus; C | 2020 |
Pharmacokinetics of remdesivir and GS-441524 in two critically ill patients who recovered from COVID-19.
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Aged; Alanine; Antiviral Agents; Betacoronavirus; C | 2020 |
Liver injury in remdesivir-treated COVID-19 patients.
Topics: Adenosine Monophosphate; Administration, Intravenous; Adult; Aged; Alanine; Antiviral Agents; Betaco | 2020 |
Compassionate use of remdesivir in children with COVID-19.
Topics: Adenosine Monophosphate; Adolescent; Alanine; Antiviral Agents; Child; Child, Preschool; Compassiona | 2021 |
Predictors of mortality in patients with severe COVID-19 pneumonia - a retrospective study.
Topics: Adenosine Monophosphate; Adult; Aged; Alanine; COVID-19; Critical Illness; Female; Hospital Mortalit | 2021 |
Glucose and urea production and leucine, ketoisocaproate and alanine fluxes at supraphysiological plasma adrenaline concentrations in volunteers.
Topics: Adult; Alanine; Amino Acids; Blood Glucose; C-Peptide; Caproates; Critical Illness; Epinephrine; Gas | 1994 |
Evaluation of ketogenesis in seriously reduced hepatic mitochondrial redox state. An analysis of survivors and non-survivors in critically ill hepatectomized patients.
Topics: Adult; Aged; Alanine; Critical Illness; Female; Hepatectomy; Humans; Ketone Bodies; Lactates; Male; | 1992 |