Compounds > alanine
Page last updated: 2024-11-08

alanine and Complication, Postoperative

alanine has been researched along with Complication, Postoperative in 17 studies

Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.

Research Excerpts

ExcerptRelevanceReference
"Intravenous infusion of L-glutamic acid results in the augmentation of the cardiac output and an improvement of the circulation in patients with postoperative cardiac failure."7.67Cardiac metabolism and performance during L-glutamic acid infusion in postoperative cardiac failure. ( Ivanov, VE; Lepilin, MG; Pisarenko, OI, 1986)
"In this prospective, randomized, multicenter, open-label, and comparative study, patients who had undergone ESD for EGC or gastric adenoma were randomized into groups receiving either rabeprazole monotherapy (10 mg/day, n=64) or a combination of rabeprazole plus rebamipide (300 mg/day, n=66)."5.22Limited Effect of Rebamipide in Addition to Proton Pump Inhibitor (PPI) in the Treatment of Post-Endoscopic Submucosal Dissection Gastric Ulcers: A Randomized Controlled Trial Comparing PPI Plus Rebamipide Combination Therapy with PPI Monotherapy. ( Akahoshi, K; Akiho, H; Aso, A; Harada, N; Iboshi, Y; Ihara, E; Iwasa, T; Nakamura, K; Nakamura, N; Ochiai, T; Ogino, H; Takayanagi, R, 2016)
"The effects of postoperative infusion of a hypertonic glucose solution on the blood glucose level, blood ketone body ratio (acetoacetate/beta-hydroxybutyrate), and plasma alanine and proline levels were studied in 70% hepatectomized rabbits (group A) and in rabbits 70% hepatectomized and, in addition, subjected to bile duct obstruction at 12 h after hepatectomy (group B)."3.67Changes in blood glucose levels in relation to blood ketone body ratio following hypertonic glucose infusion in 70% hepatectomized rabbits. ( Nakatani, T; Ozawa, K; Tobe, T; Yasuda, K, 1984)
"Intravenous infusion of L-glutamic acid results in the augmentation of the cardiac output and an improvement of the circulation in patients with postoperative cardiac failure."3.67Cardiac metabolism and performance during L-glutamic acid infusion in postoperative cardiac failure. ( Ivanov, VE; Lepilin, MG; Pisarenko, OI, 1986)
"This study enrolled 60 eyes of 30 dry eye patients undergoing corneal refractive surgery."2.80Effect of Rebamipide Ophthalmic Suspension on Intraocular Light Scattering for Dry Eye After Corneal Refractive Surgery. ( Igarashi, A; Kamiya, K; Kobashi, H; Shimizu, K, 2015)
" We conclude that the duration and dosage of glutamine administration (equivalent to 26 gm glutamine per day in a patient weighing 70 kg) used in this study are not sufficient to restore glutamine deficiency of the skeletal muscle in the depleted state."1.28Glutamine-containing dipeptides as infusion substrates in the septic state. ( Fürst, P; Karner, J; Ollenschläger, G; Roth, E; Simmel, A, 1989)

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19909 (52.94)18.7374
1990's1 (5.88)18.2507
2000's2 (11.76)29.6817
2010's3 (17.65)24.3611
2020's2 (11.76)2.80

Authors

AuthorsStudies
Ahluwalia, M1
Givertz, MM1
Mehra, MR1
Ma, R1
Zhang, Q1
Zhang, YS1
Xu, B1
Tong, ZW1
Zhao, CS1
Zhao, RG1
Faitot, F1
Ruhland, E1
Oncioiu, C1
Besch, C1
Addeo, P1
Cicek, AE1
Bachellier, P1
Namer, IJ1
Igarashi, A1
Kamiya, K1
Kobashi, H1
Shimizu, K1
Nakamura, K1
Ihara, E1
Akiho, H1
Akahoshi, K1
Harada, N1
Ochiai, T2
Nakamura, N1
Ogino, H1
Iwasa, T1
Aso, A1
Iboshi, Y1
Takayanagi, R1
Bendszus, M1
Martin-Schrader, I1
Schlake, HP1
Solymosi, L1
Nakatani, T1
Yasuda, K1
Ozawa, K1
Tobe, T1
Kingsland, PA1
Kingsnorth, A1
Royle, GT1
Kettlewell, MG1
Ross, BD1
Swaminathan, R1
Morgan, DB1
Hill, GL1
Bradley, JA1
Jacobi, CA1
Ordemann, J1
Zuckermann, H1
Döcke, W1
Volk, HD1
Müller, JM1
Kasuya, H1
Kikuchi, K1
Imamura, T1
Kawashima, A1
Aihara, Y1
Yamaguchi, K1
Fukamachi, K1
Hori, T1
Shiseki, M1
Tozuka, K1
Marchuk, JB1
Finley, RJ1
Groves, AC1
Wolfe, LI1
Holliday, RL1
Duff, JH1
Chesney, RW1
Kaplan, BS1
Freedom, RM1
Haller, JA1
Drummond, KN1
Nghiem, DD1
Conrad, GR1
Rezai, K1
Kirchner, PT1
Corry, RJ1
Kuni, CC1
du Cret, RP1
Boudreau, RJ1
Karner, J2
Roth, E1
Ollenschläger, G1
Fürst, P1
Simmel, A1
Pisarenko, OI1
Lepilin, MG1
Ivanov, VE1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Phase III Study of Metabolic Intervention With Glutamate in Coronary Surgery II[NCT02592824]Phase 3321 participants (Actual)Interventional2015-11-15Completed
Phase III Study of Intravenous Glutamate Infusion for Metabolic Protection of the Heart in Surgery for Unstable Coronary Artery Disease[NCT00489827]Phase 3865 participants (Actual)Interventional2005-10-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Incidence of Mortality

Postoperative mortality was defined as mortality within 30 days of surgery. (NCT02592824)
Timeframe: up to 30 days

InterventionParticipants (Count of Participants)
Intravenous Glutamate Infusion1
Intravenous Saline Infusion6

Incidence of Unexpected Adverse Events

suspected unexpected serious adverse reaction (NCT02592824)
Timeframe: within 24 hours from infusion

InterventionParticipants (Count of Participants)
Intravenous Glutamate Infusion0
Intravenous Saline Infusion0

Number of Participants With Incidence of Stroke

"Postoperative stroke was defined as neurological or cognitive deficit with a cerebral injury verified on (Computed Tomography) CT-scan. All suspected cases of stroke underwent CT-scan.~Stroke within 24 h of surgery was defined as a stroke that occurred within 24 h of surgery or signs of a stroke, when first assessable in deeply sedated patients on a ventilator." (NCT02592824)
Timeframe: within 24 hours from surgery

InterventionParticipants (Count of Participants)
Intravenous Glutamate Infusion0
Intravenous Saline Infusion4

Postoperative Increase of Plasma NT-proBNP

"Postoperative increase of NT-proBNP reflects postoperative myocardial dysfunction sustained in association with surgery. NT-proBNP usually peaks on the third to fourth postoperative day after coronary artery bypass surgery.~In the first GLUTAMICS trial a good agreement between hemodynamic criteria for postoperative heart failure and postoperative NT-proBNP was found." (NCT02592824)
Timeframe: from the day before surgery to the third postoperative day

Interventionng/L (Mean)
Intravenous Glutamate Infusion5390
Intravenous Saline Infusion6452

Postoperative Increase of Plasma NT-proBNP in Patients Without Diabetes

"Postoperative increase of NT-proBNP reflects postoperative myocardial dysfunction sustained in association with surgery. NT-proBNP usually peaks on the third to fourth postoperative day after coronary artery bypass surgery.~Previous observations suggest a blunted effect of glutamate in diabetic hearts." (NCT02592824)
Timeframe: from preoperative level to the third postoperative day

Interventionng/L (Mean)
Intravenous Glutamate Infusion4503
Intravenous Saline Infusion6825

Postoperative Plasma Level of NT-proBNP

Postoperative NT-proBNP reflects postoperative myocardial dysfunction. (NCT02592824)
Timeframe: first postoperative day

Interventionng/L (Mean)
Intravenous Glutamate Infusion4438
Intravenous Saline Infusion4420

Postoperative Plasma Level of NT-proBNP

Postoperative NT-proBNP reflects postoperative myocardial dysfunction. (NCT02592824)
Timeframe: third postoperative day

Interventionng/L (Mean)
Intravenous Glutamate Infusion8055
Intravenous Saline Infusion8804

Atrial Fibrillation

Number of patients with atrial fibrillation recorded postoperatively (NCT00489827)
Timeframe: Hospital stay

InterventionParticipants (Count of Participants)
Intravenous Glutamate147
Saline Infusion152

ICU Stay

ICU duration of stay (hours) (NCT00489827)
Timeframe: ICU stay

Interventionhours (Median)
Intravenous Glutamate21
Saline Infusion21

Number of Participants With Perioperative Myocardial Infarction, Postoperative Heart Failure or Postoperative Mortality

(NCT00489827)
Timeframe: 30 days

InterventionParticipants (Count of Participants)
Intravenous Glutamate31
Saline Infusion25

Number of Participants With Postoperative Stroke < 24 Hours

Incidence of Postoperative stroke < 24 hours of surgery verifed by CT-scan (NCT00489827)
Timeframe: 24 hours

InterventionParticipants (Count of Participants)
Intravenous Glutamate4
Saline Infusion6

Postoperative Hemodynamic State in Patients With Severely Reduced Left Ventricular Ejection Fraction (LVEF<0.40)

Hemodynamic instability despite inotropes or need for IABP at the end of surgery in patients with severely reduced left ventricular ejection fraction (LVEF<0.40) (NCT00489827)
Timeframe: End of surgery

InterventionParticipants (Count of Participants)
Intravenous Glutamate1
Saline Infusion5

Postoperative Renal Function

maximum p-creatinine value recorded postoperatively < 30 days (NCT00489827)
Timeframe: 30 days

Interventionµmol/L (Mean)
Intravenous Glutamate106
Saline Infusion106

Severe Circulatory Failure in CCS Class IV Patients

Severe circulatory failure according to prespecified criteria as judged by a blinded endpoints committee in CCS class IV patients (NCT00489827)
Timeframe: 30 days

InterventionParticipants (Count of Participants)
Intravenous Glutamate3
Saline Infusion16

Degree of Perioperative Myocardial Injury

p-CK-MB postoperative day 1, p-troponin-T postoperative day 3 (NCT00489827)
Timeframe: perioperative

,
Interventionµg/L (Median)
CK-MB day 1Troponin-T day 3
Intravenous Glutamate140.27
Saline Infusion140.24

Postoperative Hemodynamic State

Mixed venous oxygen saturation (SvO2) measured at weaning from cardiopulmonary bypass and on arrival to ICU (NCT00489827)
Timeframe: Until arrival to ICU

,
Interventionpercentage of saturated hemoglobin (Mean)
SvO2 at weaning from CPBSvO2 on arrival to ICU
Intravenous Glutamate72.065.0
Saline Infusion72.264.9

Trials

3 trials available for alanine and Complication, Postoperative

ArticleYear
Effect of Rebamipide Ophthalmic Suspension on Intraocular Light Scattering for Dry Eye After Corneal Refractive Surgery.
    Cornea, 2015, Volume: 34, Issue:8

    Topics: Administration, Topical; Adult; Alanine; Anti-Ulcer Agents; Dry Eye Syndromes; Female; Humans; Kerat

2015
Limited Effect of Rebamipide in Addition to Proton Pump Inhibitor (PPI) in the Treatment of Post-Endoscopic Submucosal Dissection Gastric Ulcers: A Randomized Controlled Trial Comparing PPI Plus Rebamipide Combination Therapy with PPI Monotherapy.
    Gut and liver, 2016, Nov-15, Volume: 10, Issue:6

    Topics: Adenoma; Aged; Alanine; Anti-Ulcer Agents; Drug Therapy, Combination; Endoscopic Mucosal Resection;

2016
[Effect of alanyl-glutamine in postoperative total parenteral nutrition on postoperative immunosuppression and morbidity. Preliminary results of a prospective randomized study].
    Langenbecks Archiv fur Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft fur Chirurgie. Kongress, 1998, Volume: 115

    Topics: Adult; Aged; Alanine; Dipeptides; Esophageal Diseases; Female; Glutamine; Humans; Immune Tolerance;

1998

Other Studies

14 other studies available for alanine and Complication, Postoperative

ArticleYear
A proposed strategy for management of immunosuppression in heart transplant patients with COVID-19.
    Clinical transplantation, 2020, Volume: 34, Issue:11

    Topics: Adenosine Monophosphate; Adult; Alanine; Algorithms; Antiviral Agents; Clinical Decision-Making; COV

2020
Preoperative rapid suppression of viral load by elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide regimen in human immunodeficiency virus-positive fracture patients significantly reduces postoperative complications.
    Chinese medical journal, 2020, Dec-05, Volume: 133, Issue:23

    Topics: Adenine; Alanine; Anti-HIV Agents; Cobicistat; Drug Combinations; Emtricitabine; HIV; HIV Infections

2020
Metabolomic profiling highlights the metabolic bases of acute-on-chronic and post-hepatectomy liver failure.
    HPB : the official journal of the International Hepato Pancreato Biliary Association, 2019, Volume: 21, Issue:10

    Topics: Acute-On-Chronic Liver Failure; Aged; Alanine; Biomarkers; Carcinoma, Hepatocellular; Female; Follow

2019
Embolisation of intracranial meningiomas without subsequent surgery.
    Neuroradiology, 2003, Volume: 45, Issue:7

    Topics: Adolescent; Adult; Aged; Alanine; Angiography; Child; Choline; Creatine; Embolization, Therapeutic;

2003
Changes in blood glucose levels in relation to blood ketone body ratio following hypertonic glucose infusion in 70% hepatectomized rabbits.
    European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 1984, Volume: 16, Issue:5

    Topics: Alanine; Animals; Bilirubin; Blood Glucose; Cholestasis; Citric Acid Cycle; Glucose; Glucose Solutio

1984
Glutamate metabolism in malnutrition and sepsis in man.
    The British journal of surgery, 1981, Volume: 68, Issue:4

    Topics: Adult; Aged; Alanine; Bacterial Infections; Blood Glucose; Glutamates; Half-Life; Humans; Insulin; M

1981
Blood concentration and disappearance of injected alanine and beta-hydroxybutyrate in surgical patients.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1981, Volume: 13, Issue:7

    Topics: 3-Hydroxybutyric Acid; Alanine; Fasting; Humans; Hydroxybutyrates; Ketone Bodies; Kinetics; Postoper

1981
[Two cases of methicillin-resistant Staphylococcus aureus (MRSA) sepsis following craniotomy].
    No shinkei geka. Neurological surgery, 2000, Volume: 28, Issue:5

    Topics: Adult; Aged; Alanine; Aminoglycosides; Ampicillin; Anti-Bacterial Agents; Craniotomy; Dibekacin; Dru

2000
Catabolic hormones and substrate patterns in septic patients.
    The Journal of surgical research, 1977, Volume: 23, Issue:3

    Topics: Adult; Alanine; Bacterial Infections; Blood Glucose; Catecholamines; Glucagon; Humans; Insulin; Male

1977
Acute renal failure: an important complication of cardiac surgery in infants.
    The Journal of pediatrics, 1975, Volume: 87, Issue:3

    Topics: Acute Kidney Injury; Alanine; Cardiac Surgical Procedures; Female; Heart Defects, Congenital; Humans

1975
Diagnosis of pancreatic rejection with Tc-99m DTPA scintigraphy.
    Transplantation proceedings, 1989, Volume: 21, Issue:1 Pt 3

    Topics: Alanine; beta-Alanine; Graft Rejection; Humans; Organometallic Compounds; Organotechnetium Compounds

1989
Pancreas transplants: evaluation using perfusion scintigraphy.
    AJR. American journal of roentgenology, 1989, Volume: 153, Issue:1

    Topics: Adult; Alanine; beta-Alanine; Female; Graft Rejection; Humans; Male; Middle Aged; Organometallic Com

1989
Glutamine-containing dipeptides as infusion substrates in the septic state.
    Surgery, 1989, Volume: 106, Issue:5

    Topics: Alanine; Amino Acids; Animals; Dipeptides; Dogs; Evaluation Studies as Topic; Fasting; Female; Gluta

1989
Cardiac metabolism and performance during L-glutamic acid infusion in postoperative cardiac failure.
    Clinical science (London, England : 1979), 1986, Volume: 70, Issue:1

    Topics: Alanine; Ammonia; Cardiac Output; Glutamates; Glutamic Acid; Glutamine; Heart; Heart Failure; Hemody

1986
Cardiac metabolism and performance during L-glutamic acid infusion in postoperative cardiac failure.
    Clinical science (London, England : 1979), 1986, Volume: 70, Issue:1

    Topics: Alanine; Ammonia; Cardiac Output; Glutamates; Glutamic Acid; Glutamine; Heart; Heart Failure; Hemody

1986
Cardiac metabolism and performance during L-glutamic acid infusion in postoperative cardiac failure.
    Clinical science (London, England : 1979), 1986, Volume: 70, Issue:1

    Topics: Alanine; Ammonia; Cardiac Output; Glutamates; Glutamic Acid; Glutamine; Heart; Heart Failure; Hemody

1986
Cardiac metabolism and performance during L-glutamic acid infusion in postoperative cardiac failure.
    Clinical science (London, England : 1979), 1986, Volume: 70, Issue:1

    Topics: Alanine; Ammonia; Cardiac Output; Glutamates; Glutamic Acid; Glutamine; Heart; Heart Failure; Hemody

1986