alanine has been researched along with Chemical and Drug Induced Liver Injury in 32 studies
Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.
Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In view of the adverse toxic effects of both on the mammalian liver, it is necessary to conduct a cumulative risk assessment of their dietary exposure to consumers." | 1.72 | Dissipation and Residue of Metalaxyl-M and Azoxystrobin in Scallions and Cumulative Risk Assessment of Dietary Exposure to Hepatotoxicity. ( Chai, Y; Du, X; Liu, R; Yuan, L, 2022) |
| "Naringin (Nar) has been reported to exert potential hepatoprotective effects against acetaminophen (APAP)-induced injury." | 1.72 | Naringin regulates mitochondrial dynamics to protect against acetaminophen-induced hepatotoxicity by activating the AMPK/Nrf2 signaling pathway in vitro. ( Bi, Y; Chen, Y; Duan, Z; Guo, W; Li, Z; Wu, Q; Yu, P, 2022) |
| "One patient experienced a torsade de pointes requiring cardiac resuscitation and one died due to multiple organ failure." | 1.56 | Early experience with remdesivir in SARS-CoV-2 pneumonia. ( Andini, R; Bertolino, L; Corcione, A; Durante-Mangoni, E; Florio, LL; Mele, F; Murino, P; Zampino, R, 2020) |
| " The contributions of the metabolites to the separation of control from dosed liver tissues varied depending on the type of spectral editing method used." | 1.32 | Spectral editing and pattern recognition methods applied to high-resolution magic-angle spinning 1H nuclear magnetic resonance spectroscopy of liver tissues. ( Antti, H; Beckonert, O; Bollard, ME; Ebbels, TM; Holmes, E; Keun, H; Lindon, JC; Nicholson, JK; Tang, H; Wang, Y, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (25.00) | 18.7374 |
| 1990's | 2 (6.25) | 18.2507 |
| 2000's | 3 (9.38) | 29.6817 |
| 2010's | 3 (9.38) | 24.3611 |
| 2020's | 16 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhu, Y | 1 |
| Zhang, Y | 1 |
| Li, Y | 2 |
| Guo, C | 1 |
| Fan, Z | 1 |
| Yang, M | 1 |
| Zhou, X | 1 |
| Sun, Z | 1 |
| Wang, J | 1 |
| Mahdavifard, S | 1 |
| Sekhavatmand, N | 1 |
| Zhou, Z | 1 |
| Wu, Y | 2 |
| Hua, W | 1 |
| Yan, X | 1 |
| Li, L | 1 |
| Zhu, A | 1 |
| Qi, J | 1 |
| Chai, Y | 1 |
| Liu, R | 1 |
| Du, X | 1 |
| Yuan, L | 1 |
| Wu, Q | 1 |
| Yu, P | 1 |
| Bi, Y | 1 |
| Li, Z | 1 |
| Guo, W | 1 |
| Chen, Y | 1 |
| Duan, Z | 1 |
| Reznik, EV | 1 |
| Yudin, DV | 1 |
| Gudilova, YY | 1 |
| Baikova, IE | 1 |
| Karmanova, SE | 1 |
| Nikitin, IG | 1 |
| Durante-Mangoni, E | 2 |
| Andini, R | 2 |
| Bertolino, L | 2 |
| Mele, F | 2 |
| Florio, LL | 2 |
| Murino, P | 1 |
| Corcione, A | 2 |
| Zampino, R | 2 |
| Leegwater, E | 1 |
| Strik, A | 1 |
| Wilms, EB | 1 |
| Bosma, LBE | 1 |
| Burger, DM | 1 |
| Ottens, TH | 1 |
| van Nieuwkoop, C | 1 |
| Montastruc, F | 1 |
| Thuriot, S | 1 |
| Durrieu, G | 1 |
| Galdo, M | 1 |
| De Rosa, R | 1 |
| Téllez, L | 1 |
| Martín Mateos, RM | 1 |
| Abdel-Wahab, BA | 1 |
| Ali, FEM | 1 |
| Alkahtani, SA | 1 |
| Alshabi, AM | 1 |
| Mahnashi, MH | 1 |
| Hassanein, EHM | 1 |
| Zekarias, A | 1 |
| Watson, S | 1 |
| Vidlin, SH | 1 |
| Grundmark, B | 1 |
| Wu, PE | 2 |
| Morris, AM | 2 |
| Bahçecíoğlu, ÖF | 1 |
| Gök, S | 1 |
| Durmuş, M | 1 |
| Soares, AA | 1 |
| de Oliveira, AL | 1 |
| Sá-Nakanishi, AB | 1 |
| Comar, JF | 1 |
| Rampazzo, AP | 1 |
| Vicentini, FA | 1 |
| Natali, MR | 1 |
| Gomes da Costa, SM | 1 |
| Bracht, A | 1 |
| Peralta, RM | 1 |
| Josan, S | 1 |
| Billingsley, K | 1 |
| Orduna, J | 1 |
| Park, JM | 1 |
| Luong, R | 1 |
| Yu, L | 1 |
| Hurd, R | 1 |
| Pfefferbaum, A | 1 |
| Spielman, D | 1 |
| Mayer, D | 1 |
| Kim, GW | 1 |
| Oh, CH | 1 |
| Kim, JC | 1 |
| Yoon, W | 1 |
| Jeong, YY | 1 |
| Kim, YH | 1 |
| Kim, JK | 1 |
| Park, JG | 1 |
| Kang, HK | 1 |
| Jeong, GW | 1 |
| MONDEN, M | 1 |
| OJI, N | 1 |
| SHIGETA, Y | 1 |
| Wang, Y | 1 |
| Bollard, ME | 1 |
| Keun, H | 1 |
| Antti, H | 1 |
| Beckonert, O | 1 |
| Ebbels, TM | 1 |
| Lindon, JC | 1 |
| Holmes, E | 1 |
| Tang, H | 1 |
| Nicholson, JK | 1 |
| Kume, H | 1 |
| Okazaki, K | 1 |
| Sasaki, H | 1 |
| Liao, P | 1 |
| Wei, L | 1 |
| Zhang, X | 1 |
| Li, X | 1 |
| Wu, H | 1 |
| Ni, J | 1 |
| Pei, F | 1 |
| Dudley, RE | 1 |
| Klaassen, CD | 2 |
| Katayama, T | 1 |
| Cheng, CC | 1 |
| Egashira, Y | 1 |
| Ohta, T | 1 |
| Sanada, H | 1 |
| Kurysheva, NG | 1 |
| Ekshtat, BIa | 1 |
| Kazanina, SS | 1 |
| Kossmann, S | 1 |
| Magner-Krezel, Z | 1 |
| Price, VF | 1 |
| Jollow, DJ | 1 |
| Hazelton, GA | 1 |
| Hjelle, JJ | 1 |
| Usui, H | 1 |
| Ukida, M | 1 |
| Nagashima, H | 1 |
| Record, CO | 1 |
| Alberti, KG | 1 |
| Williamson, DH | 1 |
1 review available for alanine and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
COVID-19 and liver disease: An update.
Topics: Adenosine Monophosphate; Age Factors; Alanine; Antiviral Agents; Betacoronavirus; Bile Ducts; Chemic | 2020 |
31 other studies available for alanine and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Integrative proteomics and metabolomics approach to elucidate metabolic dysfunction induced by silica nanoparticles in hepatocytes.
Topics: Alanine; Chemical and Drug Induced Liver Injury; Hepatocytes; Humans; Metabolomics; Nanoparticles; P | 2022 |
Glutamine Is a Superior Protector Against Lead-Induced Hepatotoxicity in Rats via Antioxidant, Anti-inflammatory, and Chelating Properties.
Topics: Alanine; Albumins; Alkaline Phosphatase; Animals; Anti-Inflammatory Agents; Antioxidants; Aspartate | 2022 |
Sappanone A ameliorates acetaminophen-induced acute liver injury in mice.
Topics: Acetaminophen; Alanine; Animals; Anti-Inflammatory Agents; Antioxidants; Aspartate Aminotransferases | 2022 |
Dissipation and Residue of Metalaxyl-M and Azoxystrobin in Scallions and Cumulative Risk Assessment of Dietary Exposure to Hepatotoxicity.
Topics: Adolescent; Alanine; Chemical and Drug Induced Liver Injury; Child; Chromatography, Liquid; Dietary | 2022 |
Naringin regulates mitochondrial dynamics to protect against acetaminophen-induced hepatotoxicity by activating the AMPK/Nrf2 signaling pathway in vitro.
Topics: Acetaminophen; Alanine; Alanine Transaminase; AMP-Activated Protein Kinases; Animals; Aspartate Amin | 2022 |
[A medicinal liver injury with an immunomodulatory drug of natural origin. Case report].
Topics: Adjuvants, Immunologic; Adult; Alanine; Alkaline Phosphatase; Aspartic Acid; Bilirubin; Chemical and | 2021 |
Early experience with remdesivir in SARS-CoV-2 pneumonia.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Chemical and Drug Induced Liver | 2020 |
Drug-induced Liver Injury in a Patient With Coronavirus Disease 2019: Potential Interaction of Remdesivir With P-Glycoprotein Inhibitors.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; C | 2021 |
Hepatic Disorders With the Use of Remdesivir for Coronavirus 2019.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Chemical and Drug Induced Liver | 2020 |
Liver injury in remdesivir-treated COVID-19 patients.
Topics: Adenosine Monophosphate; Administration, Intravenous; Adult; Aged; Alanine; Antiviral Agents; Betaco | 2020 |
Hepatoprotective effect of rebamipide against methotrexate-induced hepatic intoxication: role of Nrf2/GSK-3β, NF-κβ-p65/JAK1/STAT3, and PUMA/Bax/Bcl-2 signaling pathways.
Topics: Alanine; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; | 2020 |
Sex Differences in Reported Adverse Drug Reactions to COVID-19 Drugs in a Global Database of Individual Case Safety Reports.
Topics: Abdominal Pain; Adenosine Monophosphate; Alanine; Antibodies, Monoclonal, Humanized; Antiviral Agent | 2020 |
Remdesivir for patients with COVID-19.
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Chemical and Drug Induced Liver Injury; COVID-19 | 2021 |
Is it safe to use remdesivir in combination with a combined p-glycoprotein and CYP3A4 inhibitor?
Topics: Adenosine Monophosphate; Alanine; ATP Binding Cassette Transporter, Subfamily B; Chemical and Drug I | 2021 |
Topics: Adenosine Monophosphate; Alanine; Antiviral Agents; Chemical and Drug Induced Liver Injury; COVID-19 | 2021 |
Effects of an Agaricus blazei aqueous extract pretreatment on paracetamol-induced brain and liver injury in rats.
Topics: Acetaminophen; Administration, Oral; Agaricus; Alanine; Animals; Antioxidants; Biomarkers; Brain; Br | 2013 |
Assessing inflammatory liver injury in an acute CCl4 model using dynamic 3D metabolic imaging of hyperpolarized [1-(13)C]pyruvate.
Topics: Alanine; Animals; Carbon Tetrachloride; Carbon-13 Magnetic Resonance Spectroscopy; Chemical and Drug | 2015 |
Noninvasive biomarkers for acute hepatotoxicity induced by 1,3-dichloro-2-propanol: hyperpolarized 13C dynamic MR spectroscopy.
Topics: Alanine; Algorithms; alpha-Chlorohydrin; Animals; Biomarkers; Carbon-13 Magnetic Resonance Spectrosc | 2016 |
[A STUDY OF THE FREE AMINO ACIDS IN THE SERUM OF LIVER DISEASES].
Topics: Alanine; Amino Acids; Ammonia; Animals; Arginine; Blood; Carbon Tetrachloride; Chemical and Drug Ind | 1964 |
THE EFFECT OF GLUCOCORTICOID ON GLUCONEOGENESIS IN RATS WITH LIVER DAMAGE.
Topics: Alanine; Blood Glucose; Carbohydrate Metabolism; Carbon Isotopes; Carbon Tetrachloride Poisoning; Ch | 1964 |
Spectral editing and pattern recognition methods applied to high-resolution magic-angle spinning 1H nuclear magnetic resonance spectroscopy of liver tissues.
Topics: Alanine; Animals; Chemical and Drug Induced Liver Injury; Choline; Glucose; Glycogen; Hydrazines; Li | 2003 |
Hepatoprotective effects of whey protein on D-galactosamine-induced hepatitis and liver fibrosis in rats.
Topics: Alanine; Animals; Aspartate Aminotransferases; Bilirubin; Chemical and Drug Induced Liver Injury; Di | 2006 |
Metabolic profiling of serum from gadolinium chloride-treated rats by 1H NMR spectroscopy.
Topics: Alanine; Amino Acids; Animals; Biomarkers; Blood Glucose; Chemical and Drug Induced Liver Injury; Cr | 2007 |
Changes in hepatic glutathione concentration modify cadmium-induced hepatotoxicity.
Topics: Alanine; Animals; Aspartic Acid; Cadmium Poisoning; Chemical and Drug Induced Liver Injury; Cysteine | 1984 |
Effect of dietary L-glutamine on the hepatotoxic action of D-galactosamine in rats.
Topics: Alanine; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver | 1996 |
[Mechanism of the hepatotropic action of 1,1,2,3-tetrachlorpropene].
Topics: Alanine; Alanine Transaminase; Animals; Aspartate Aminotransferases; Aspartic Acid; Chemical and Dru | 1977 |
[Biochemical indices of liver function in workers from repair brigades in chemical plants "Organika-Azot" in Jaworz].
Topics: Adult; Alanine; Albumins; alpha-Macroglobulins; Aspartate Aminotransferases; Blood Proteins; Chemica | 1992 |
Effect of glucose and gluconeogenic substrates on fasting-induced suppression of acetaminophen glucuronidation in the rat.
Topics: Acetaminophen; Alanine; Animals; Biotransformation; Blood Glucose; Chemical and Drug Induced Liver I | 1989 |
Effects of butylated hydroxyanisole on acetaminophen hepatotoxicity and glucuronidation in vivo.
Topics: Acetaminophen; Alanine; Animals; Anisoles; Aspartate Aminotransferases; Biotransformation; Butylated | 1986 |
Metabolism of branched-chain amino acids in rats with acute hepatic failure: a tracer study using 15N-leucine.
Topics: Alanine; Amino Acids, Branched-Chain; Animals; Chemical and Drug Induced Liver Injury; Galactosamine | 1985 |
Metabolic studies in experimental liver disease resulting from D(+)-galactosamine administration.
Topics: Acetoacetates; Alanine; Alanine Transaminase; Animals; Aspartate Aminotransferases; Aspartic Acid; C | 1972 |