alanine has been researched along with Cerebral Ischemia in 34 studies
Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Safinamide is a newly approved add-on drug to treat Parkinson's disease, and previously studies suggest safinamide could have a potential role on neuroprotection." | 5.56 | The Protective Effect of Safinamide in Ischemic Stroke Mice and a Brain Endothelial Cell Line. ( Kong, S; Sun, R; Wei, G; Xu, T, 2020) |
| " We show that modulation of the eNOS serine 1179 (S1179) phosphorylation site affects vascular reactivity and determines stroke size in vivo." | 3.74 | The phosphorylation state of eNOS modulates vascular reactivity and outcome of cerebral ischemia in vivo. ( Atochin, DN; Ayata, C; Critchlow, JD; Dantas, AP; Huang, PL; Liu, VW; Looft-Wilson, R; Michel, T; Moskowitz, MA; Murata, T; Salomone, S; Sessa, WC; Shin, HK; Wang, A, 2007) |
| "Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C mutations, being considered unfavourable genetic factors by causing elevated serum homocysteine levels, may be risk factors for cardiovascular disorders, including ischaemic stroke." | 3.73 | [Interactions between the MTHFR C677T and MTHFR A1298C mutations in ischaemic stroke]. ( Fodor, L; Kondacs, A; Melegh, B; Somogyvári, F; Szabó, M; Szolnoki, Z, 2006) |
| "Safinamide has neuroprotective and neurorescuing effects in MPTP-treated mice, in the rat kainic acid, and in the gerbil ischemia model." | 2.43 | Safinamide: from molecular targets to a new anti-Parkinson drug. ( Caccia, C; Calabresi, M; Curatolo, L; Faravelli, L; Fariello, RG; Maestroni, S; Maj, R; Salvati, P, 2006) |
| "Safinamide is a newly approved add-on drug to treat Parkinson's disease, and previously studies suggest safinamide could have a potential role on neuroprotection." | 1.56 | The Protective Effect of Safinamide in Ischemic Stroke Mice and a Brain Endothelial Cell Line. ( Kong, S; Sun, R; Wei, G; Xu, T, 2020) |
| "The MELAS has been related to mutation A3243G in most cases, but some other mitochondrial DNA mutations were described in the background of this syndrome as well." | 1.37 | A8344G mutation of the mitochondrial DNA with typical mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes syndrome. ( Gál, A; Lukács, T; Molnár, MJ; Reményi, V; Semjén, J; Valikovics, A; Vastagh, I, 2011) |
| "Mice resistant to cerebral malaria were infected with P." | 1.34 | Magnetic resonance spectroscopy reveals an impaired brain metabolic profile in mice resistant to cerebral malaria infected with Plasmodium berghei ANKA. ( Coltel, N; Confort-Gouny, S; Cozzone, PJ; Dalmasso, C; Grau, GE; Gulian, JM; Kober, F; Le Fur, Y; Liprandi, A; Penet, MF; Viola, A, 2007) |
| " Agonists of the glycine recognition site of NMDA receptors (D-serine and D-alanine) did not have any toxic effect in hippocampal cultures, whereas competitive blockade of the glycine site by 7-chlorokynurenic acid was neuroprotective." | 1.33 | Glycine-induced neurotoxicity in organotypic hippocampal slice cultures. ( Barth, A; Barth, L; Newell, DW; Nguyen, LB, 2005) |
| " In order to examine dosage dependency in the effect of MTPG, 4 dosages of MTPG (0." | 1.32 | [Effects of alpha-methyl-(4-tetrazolyl-phenyl) glycine on the induction of hippocampal ischemic tolerance in the rat]. ( Ai, J; Chen, XL; Feng, RF; Li, QJ; Li, WB; Liu, HQ; Zhao, HG; Zhou, AM, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (5.88) | 18.7374 |
| 1990's | 9 (26.47) | 18.2507 |
| 2000's | 18 (52.94) | 29.6817 |
| 2010's | 4 (11.76) | 24.3611 |
| 2020's | 1 (2.94) | 2.80 |
| Authors | Studies |
|---|---|
| Xu, T | 1 |
| Sun, R | 1 |
| Wei, G | 1 |
| Kong, S | 1 |
| Yang, R | 1 |
| Chen, K | 1 |
| Zhao, Y | 1 |
| Tian, P | 1 |
| Duan, F | 1 |
| Sun, W | 1 |
| Liu, Y | 1 |
| Yan, Z | 1 |
| Li, S | 1 |
| Vaslin, A | 1 |
| Puyal, J | 1 |
| Clarke, PG | 1 |
| Oja, SS | 1 |
| Saransaari, P | 1 |
| Feng, RF | 2 |
| Hu, YY | 1 |
| Li, WB | 2 |
| Liu, HQ | 2 |
| Li, QJ | 2 |
| Zhang, M | 1 |
| Zhou, A | 1 |
| Simon, RP | 1 |
| David, L | 1 |
| Markoula, S | 1 |
| Milionis, H | 1 |
| Lazaros, L | 1 |
| Spengos, K | 1 |
| Vassilopoulou, S | 1 |
| Chatzistefanidis, D | 1 |
| Kargiotis, O | 1 |
| Georgiou, I | 1 |
| Kyritsis, AP | 1 |
| Vastagh, I | 1 |
| Gál, A | 1 |
| Reményi, V | 1 |
| Semjén, J | 1 |
| Lukács, T | 1 |
| Valikovics, A | 1 |
| Molnár, MJ | 1 |
| Carpenedo, R | 3 |
| Meli, E | 1 |
| Peruginelli, F | 2 |
| Pellegrini-Giampietro, DE | 2 |
| Moroni, F | 3 |
| Chen, XL | 1 |
| Zhou, AM | 1 |
| Zhao, HG | 1 |
| Ai, J | 1 |
| Pongrácz, E | 1 |
| Tordai, A | 1 |
| Csornai, M | 1 |
| Béla, Z | 1 |
| Nagy, Z | 1 |
| Serres, S | 1 |
| Bezancon, E | 1 |
| Franconi, JM | 1 |
| Merle, M | 1 |
| Barth, A | 1 |
| Nguyen, LB | 1 |
| Barth, L | 1 |
| Newell, DW | 1 |
| Szolnoki, Z | 1 |
| Somogyvári, F | 1 |
| Szabó, M | 1 |
| Kondacs, A | 1 |
| Fodor, L | 1 |
| Melegh, B | 1 |
| Caccia, C | 1 |
| Maj, R | 1 |
| Calabresi, M | 1 |
| Maestroni, S | 1 |
| Faravelli, L | 1 |
| Curatolo, L | 1 |
| Salvati, P | 1 |
| Fariello, RG | 1 |
| Penet, MF | 1 |
| Kober, F | 1 |
| Confort-Gouny, S | 1 |
| Le Fur, Y | 1 |
| Dalmasso, C | 1 |
| Coltel, N | 1 |
| Liprandi, A | 1 |
| Gulian, JM | 1 |
| Grau, GE | 1 |
| Cozzone, PJ | 1 |
| Viola, A | 1 |
| Oda, M | 1 |
| Kure, S | 1 |
| Sugawara, T | 1 |
| Yamaguchi, S | 1 |
| Kojima, K | 1 |
| Shinka, T | 1 |
| Sato, K | 1 |
| Narisawa, A | 1 |
| Aoki, Y | 1 |
| Matsubara, Y | 1 |
| Omae, T | 1 |
| Mizoi, K | 1 |
| Kinouchi, H | 1 |
| Atochin, DN | 1 |
| Wang, A | 1 |
| Liu, VW | 1 |
| Critchlow, JD | 1 |
| Dantas, AP | 1 |
| Looft-Wilson, R | 1 |
| Murata, T | 1 |
| Salomone, S | 1 |
| Shin, HK | 1 |
| Ayata, C | 1 |
| Moskowitz, MA | 2 |
| Michel, T | 1 |
| Sessa, WC | 1 |
| Huang, PL | 2 |
| Pruissen, DM | 1 |
| Rosendaal, FR | 1 |
| Gorter, JW | 1 |
| Garcia, AA | 1 |
| Kappelle, LJ | 1 |
| Algra, A | 1 |
| Erecińska, M | 1 |
| Nelson, D | 1 |
| Wilson, DF | 1 |
| Silver, IA | 1 |
| Benzi, G | 1 |
| Arrigoni, E | 1 |
| Pastoris, O | 1 |
| Raimondo, S | 1 |
| Dossena, M | 1 |
| Fulle, D | 1 |
| Tumminello, MC | 1 |
| Villa, RF | 1 |
| Maginn, M | 1 |
| Caldwell, M | 1 |
| Kelly, JP | 1 |
| Leonard, BE | 1 |
| Obrenovitch, TP | 1 |
| Urenjak, J | 1 |
| Richards, DA | 1 |
| Ueda, Y | 1 |
| Curzon, G | 1 |
| Symon, L | 1 |
| Maiese, K | 1 |
| Swiriduk, M | 1 |
| TenBroeke, M | 1 |
| Rhodes, PG | 1 |
| Cai, Z | 1 |
| Higuchi, T | 1 |
| Graham, SH | 1 |
| Fernandez, EJ | 1 |
| Rooney, WD | 1 |
| Gaspary, HL | 1 |
| Weiner, MW | 1 |
| Maudsley, AA | 1 |
| Nonaka, M | 1 |
| Yoshimine, T | 1 |
| Kohmura, E | 1 |
| Wakayama, A | 1 |
| Yamashita, T | 1 |
| Hayakawa, T | 1 |
| Shimizu-Sasamata, M | 1 |
| Bosque-Hamilton, P | 1 |
| Lo, EH | 1 |
| Cozzi, A | 2 |
| Li, PA | 1 |
| Shuaib, A | 1 |
| Miyashita, H | 1 |
| He, QP | 1 |
| Siesjö, BK | 1 |
| Warner, DS | 1 |
| Ooboshi, H | 1 |
| Ibayashi, S | 1 |
| Takano, K | 1 |
| Sadoshima, S | 1 |
| Kondo, A | 1 |
| Uchimura, H | 1 |
| Fujishima, M | 1 |
| Uchino, S | 1 |
| Nakamura, T | 1 |
| Nakamura, K | 1 |
| Nakajima-Iijima, S | 1 |
| Mishina, M | 1 |
| Kohsaka, S | 1 |
| Kudo, Y | 1 |
| Sanni, LA | 1 |
| Rae, C | 1 |
| Maitland, A | 1 |
| Stocker, R | 1 |
| Hunt, NH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| "An Observational, Prospective, Multinational, Multicentre Study Comparing the Effectiveness of Safinamide, Rasagiline and Other Standard Of Care as Add-On Therapy to Levodopa (L-Dopa) in Parkinson's Disease (Pd) Fluctuating Patients"[NCT03994328] | 1,235 participants (Actual) | Observational | 2019-12-03 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for alanine and Cerebral Ischemia
| Article | Year |
|---|---|
Safinamide: from molecular targets to a new anti-Parkinson drug.
Topics: Alanine; Animals; Antiparkinson Agents; Benzylamines; Brain Ischemia; Disease Models, Animal; Gerbil | 2006 |
33 other studies available for alanine and Cerebral Ischemia
| Article | Year |
|---|---|
The Protective Effect of Safinamide in Ischemic Stroke Mice and a Brain Endothelial Cell Line.
Topics: Alanine; Animals; Benzylamines; Blood-Brain Barrier; Brain; Brain Ischemia; Cells, Cultured; Endothe | 2020 |
Analysis of Potential Amino Acid Biomarkers in Brain Tissue and the Effect of Galangin on Cerebral Ischemia.
Topics: Alanine; Amino Acid Transport Systems, Neutral; Animals; Aspartic Acid; Biomarkers; Brain; Brain Isc | 2016 |
Excitotoxicity-induced endocytosis confers drug targeting in cerebral ischemia.
Topics: Alanine; Animals; Animals, Newborn; Brain Ischemia; Cells, Cultured; Cerebral Cortex; Dextrans; Dise | 2009 |
Release of endogenous amino acids from the hippocampus and brain stem from developing and adult mice in ischemia.
Topics: Aging; Alanine; Animals; Aspartic Acid; Brain Ischemia; Brain Stem; Female; gamma-Aminobutyric Acid; | 2009 |
[The role of NO resulted from neuronal nitric oxide synthase in the metabotropic glutamate receptor2/3 mediated-brain ischemic tolerance].
Topics: Alanine; Animals; Brain Ischemia; Ischemic Preconditioning; Male; Nitric Oxide; Nitric Oxide Synthas | 2009 |
Nascent proteomes of ischemic-injured and ischemic-tolerant neuronal cells.
Topics: Alanine; Animals; Brain; Brain Ischemia; Cells, Cultured; Click Chemistry; Down-Regulation; Gene Exp | 2011 |
Associations of ESR2 AluI (G/A) polymorphism with ischemic stroke in Caucasians.
Topics: Aged; Aged, 80 and over; Alanine; Alu Elements; Brain Ischemia; Estrogen Receptor beta; Female; Gene | 2012 |
A8344G mutation of the mitochondrial DNA with typical mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes syndrome.
Topics: Acidosis, Lactic; Adult; Alanine; Brain Ischemia; DNA, Mitochondrial; Glycine; Humans; Male; MELAS S | 2011 |
Kynurenine 3-mono-oxygenase inhibitors attenuate post-ischemic neuronal death in organotypic hippocampal slice cultures.
Topics: Alanine; Animals; Brain Ischemia; Cell Death; Cell Hypoxia; Culture Media, Conditioned; Enzyme Inhib | 2002 |
[Effects of alpha-methyl-(4-tetrazolyl-phenyl) glycine on the induction of hippocampal ischemic tolerance in the rat].
Topics: Alanine; Animals; Brain Ischemia; Hippocampus; Ischemic Preconditioning; Male; Rats; Rats, Sprague-D | 2003 |
[Significance of Factor V gene A506G mutation (Leiden) in the pathogenesis of ischemic stroke].
Topics: Adult; Age of Onset; Alanine; Brain Ischemia; DNA Mutational Analysis; Factor V; Female; Genetic Pre | 2003 |
Ex vivo analysis of lactate and glucose metabolism in the rat brain under different states of depressed activity.
Topics: Alanine; Analgesics, Opioid; Animals; Brain; Brain Chemistry; Brain Ischemia; Cerebrovascular Circul | 2004 |
Glycine-induced neurotoxicity in organotypic hippocampal slice cultures.
Topics: Alanine; Animals; Animals, Newborn; Brain Ischemia; Dose-Response Relationship, Drug; Drug Resistanc | 2005 |
[Interactions between the MTHFR C677T and MTHFR A1298C mutations in ischaemic stroke].
Topics: Adult; Aged; Alanine; Alleles; Brain Ischemia; Cysteine; Female; Humans; Male; Methylenetetrahydrofo | 2006 |
Magnetic resonance spectroscopy reveals an impaired brain metabolic profile in mice resistant to cerebral malaria infected with Plasmodium berghei ANKA.
Topics: Alanine; Anemia; Animals; Brain; Brain Diseases; Brain Edema; Brain Ischemia; Cell Proliferation; Ce | 2007 |
Direct correlation between ischemic injury and extracellular glycine concentration in mice with genetically altered activities of the glycine cleavage multienzyme system.
Topics: Alanine; Amino Acid Oxidoreductases; Animals; Brain Ischemia; Carrier Proteins; Cerebrovascular Circ | 2007 |
The phosphorylation state of eNOS modulates vascular reactivity and outcome of cerebral ischemia in vivo.
Topics: Alanine; Animals; Aspartic Acid; Brain Ischemia; Cerebral Arteries; Disease Models, Animal; Gene Exp | 2007 |
Haemostatic genetic variants, ABO blood group and bleeding risk during oral anticoagulant treatment after cerebral ischaemia of arterial origin.
Topics: ABO Blood-Group System; Administration, Oral; Aged; Alanine; Anticoagulants; Arteries; Blood Protein | 2007 |
Neurotransmitter amino acids in the CNS. I. Regional changes in amino acid levels in rat brain during ischemia and reperfusion.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Brain; Brain Ischemia; Cerebrovascular Circulation; ga | 1984 |
Drug interference on some biochemical parameters of rat cerebral cortex during post-ischemic recovery.
Topics: Alanine; Amino Acids; Animals; Brain Ischemia; Cerebral Cortex; Dihydroergotoxine; Energy Transfer; | 1980 |
The effect of 2-amino-3-phosphonopropionic acid (AP-3) in the gerbil model of cerebral ischaemia.
Topics: Alanine; Animals; Brain Ischemia; Gerbillinae; Male; Motor Activity; Nerve Degeneration; Neurons; Re | 1995 |
Extracellular neuroactive amino acids in the rat striatum during ischaemia: comparison between penumbral conditions and ischaemia with sustained anoxic depolarisation.
Topics: Alanine; Amino Acids; Animals; Brain Ischemia; Corpus Striatum; Dialysis; Electroencephalography; El | 1993 |
Cellular mechanisms of protection by metabotropic glutamate receptors during anoxia and nitric oxide toxicity.
Topics: Alanine; Aminobutyrates; Animals; Brain Ischemia; Cell Death; Cell Hypoxia; Cell Survival; Cyclic AM | 1996 |
Intrauterine hypoxia-ischemia reduces phosphoinositide hydrolysis stimulated by metabotropic glutamate receptor agonists in cultured rat cerebellar granule cells.
Topics: Alanine; Animals; Brain Ischemia; Cell Count; Cells, Cultured; Cerebellum; Cycloleucine; Enzyme Inhi | 1996 |
Effects of severe global ischemia on N-acetylaspartate and other metabolites in the rat brain.
Topics: Alanine; Animals; Aspartic Acid; Brain; Brain Ischemia; Creatine; Lactic Acid; Magnetic Resonance Im | 1997 |
Changes in brain organic osmolytes in experimental cerebral ischemia.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Brain Chemistry; Brain Ischemia; Creatine; Disease Mod | 1998 |
Attenuated neurotransmitter release and spreading depression-like depolarizations after focal ischemia in mutant mice with disrupted type I nitric oxide synthase gene.
Topics: Alanine; Animals; Brain; Brain Ischemia; Cerebral Infarction; Cerebrovascular Circulation; Cortical | 1998 |
Kynurenine hydroxylase inhibitors reduce ischemic brain damage: studies with (m-nitrobenzoyl)-alanine (mNBA) and 3,4-dimethoxy-[-N-4-(nitrophenyl)thiazol-2yl]-benzenesulfonamide (Ro 61-8048) in models of focal or global brain ischemia.
Topics: Alanine; Animals; Brain Ischemia; Enzyme Inhibitors; Gerbillinae; Kynurenine 3-Monooxygenase; Male; | 1999 |
Hyperglycemia enhances extracellular glutamate accumulation in rats subjected to forebrain ischemia.
Topics: Alanine; Animals; Brain Ischemia; Glutamic Acid; Glutamine; Glycine; Hyperglycemia; Male; Prosenceph | 2000 |
Neuroprotective effects of kynurenine-3-hydroxylase inhibitors in models of brain ischemia.
Topics: Alanine; Animals; Brain Ischemia; Cerebral Infarction; Disease Models, Animal; Enzyme Inhibitors; Ge | 1999 |
Hypothermia inhibits ischemia-induced efflux of amino acids and neuronal damage in the hippocampus of aged rats.
Topics: Aging; Alanine; Amino Acids; Animals; Aspartic Acid; Brain Ischemia; Cerebrovascular Circulation; Ex | 2000 |
Real-time, two-dimensional visualization of ischaemia-induced glutamate release from hippocampal slices.
Topics: Alanine; Aspartic Acid; Brain Ischemia; Calcium Signaling; Cell Line; Computer Systems; Dentate Gyru | 2001 |
Is ischemia involved in the pathogenesis of murine cerebral malaria?
Topics: Adenosine Triphosphate; Alanine; Amino Acids; Animals; Brain; Brain Ischemia; Chromatography, High P | 2001 |