alanine has been researched along with Cell Transformation, Neoplastic in 34 studies
Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.
Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Three androgen-independent human prostate cancer cell lines (TSU-Prl, DU-145, and PC-3) were cultured in the presence of azatyrosine and their growth rates were determined over a 7-day period." | 1.29 | Reversion of human prostate tumorigenic growth by azatyrosine. ( Benoit, RM; Eiseman, J; Jacobs, SC; Kyprianou, N, 1995) |
| "Zineb was completely detoxified when the exogenous metabolizing system was added to the target cells to increase their inherent metabolic capacity." | 1.29 | In vitro transforming effect of the fungicides metalaxyl and zineb. ( Bonora, B; Colacci, A; Grilli, S; Perocco, P, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (14.71) | 18.7374 |
| 1990's | 16 (47.06) | 18.2507 |
| 2000's | 10 (29.41) | 29.6817 |
| 2010's | 2 (5.88) | 24.3611 |
| 2020's | 1 (2.94) | 2.80 |
| Authors | Studies |
|---|---|
| Yadav, N | 1 |
| Gogada, R | 1 |
| O'Malley, J | 1 |
| Gundampati, RK | 1 |
| Jayanthi, S | 1 |
| Hashmi, S | 1 |
| Lella, R | 1 |
| Zhang, D | 1 |
| Wang, J | 1 |
| Kumar, R | 2 |
| Suresh Kumar, TK | 1 |
| Chandra, D | 1 |
| Marostica, LL | 1 |
| de Barros, AL | 1 |
| Silva, JO | 1 |
| Lopes, SC | 1 |
| Salgado, BS | 1 |
| Chondrogiannis, S | 1 |
| Rubello, D | 1 |
| Cassali, GD | 1 |
| Schenkel, EP | 1 |
| Cardoso, VN | 1 |
| Simões, CM | 1 |
| Oliveira, MC | 1 |
| Ngan, ES | 1 |
| Lang, BH | 1 |
| Liu, T | 1 |
| Shum, CK | 1 |
| So, MT | 1 |
| Lau, DK | 1 |
| Leon, TY | 1 |
| Cherny, SS | 1 |
| Tsai, SY | 1 |
| Lo, CY | 1 |
| Khoo, US | 1 |
| Tam, PK | 1 |
| Garcia-Barceló, MM | 1 |
| Smith, KM | 1 |
| Yacobi, R | 1 |
| Van Etten, RA | 1 |
| Galés, C | 1 |
| Sanchez, D | 1 |
| Poirot, M | 1 |
| Pyronnet, S | 1 |
| Buscail, L | 1 |
| Cussac, D | 1 |
| Pradayrol, L | 1 |
| Fourmy, D | 1 |
| Silvente-Poirot, S | 1 |
| Vadlamudi, RK | 1 |
| Bagheri-Yarmand, R | 1 |
| Yang, Z | 1 |
| Balasenthil, S | 1 |
| Nguyen, D | 1 |
| Sahin, AA | 1 |
| den Hollander, P | 1 |
| Tanaka, M | 1 |
| Nagano-Fujii, M | 1 |
| Deng, L | 1 |
| Ishido, S | 1 |
| Sada, K | 1 |
| Hotta, H | 1 |
| Turturro, F | 1 |
| Driscoll, M | 1 |
| Friday, E | 1 |
| Welbourne, T | 1 |
| van Veelen, CW | 1 |
| Verbiest, H | 1 |
| Zülch, KJ | 1 |
| van Ketel, B | 1 |
| van der Vlist, MJ | 1 |
| Vlug, AM | 1 |
| Rijksen, G | 1 |
| Staal, GE | 1 |
| Benoit, RM | 1 |
| Eiseman, J | 1 |
| Jacobs, SC | 1 |
| Kyprianou, N | 1 |
| Cowley, S | 1 |
| Paterson, H | 1 |
| Kemp, P | 1 |
| Marshall, CJ | 1 |
| Romero, P | 1 |
| Humphries, EH | 1 |
| Chen, J | 1 |
| Hanafusa, T | 1 |
| Wang, LH | 1 |
| Maher, DW | 1 |
| Strawn, LM | 1 |
| Donoghue, DJ | 1 |
| Perocco, P | 1 |
| Colacci, A | 1 |
| Bonora, B | 1 |
| Grilli, S | 1 |
| Koering, CE | 1 |
| Vennin-Fikry, M | 1 |
| Dupressoir, T | 1 |
| Schlehofer, JR | 1 |
| Rommelaere, J | 1 |
| Stehelin, D | 1 |
| Austen, M | 1 |
| Cerni, C | 1 |
| Lüscher-Firzlaff, JM | 1 |
| Lüscher, B | 1 |
| Adduci, AJ | 1 |
| Schlegel, R | 1 |
| Unger, T | 1 |
| Sionov, RV | 1 |
| Moallem, E | 1 |
| Yee, CL | 1 |
| Howley, PM | 1 |
| Oren, M | 1 |
| Haupt, Y | 1 |
| Monden, Y | 1 |
| Hamano Takaku, F | 1 |
| Shindo Okada, N | 1 |
| Nishimura, S | 6 |
| Turkson, J | 1 |
| Ryan, D | 1 |
| Kim, JS | 1 |
| Zhang, Y | 1 |
| Chen, Z | 1 |
| Haura, E | 1 |
| Laudano, A | 1 |
| Sebti, S | 1 |
| Hamilton, AD | 1 |
| Jove, R | 1 |
| Bost, F | 1 |
| Caron, L | 1 |
| Vial, E | 1 |
| Montreau, N | 1 |
| Marchetti, I | 1 |
| Dejong, V | 1 |
| Defize, L | 1 |
| Castellazzi, M | 1 |
| Binétruy, B | 1 |
| Danielsen, AJ | 1 |
| Maihle, NJ | 1 |
| Suzuki, T | 1 |
| K-Tsuzuku, J | 1 |
| Ajima, R | 1 |
| Nakamura, T | 1 |
| Yoshida, Y | 1 |
| Yamamoto, T | 1 |
| Quash, G | 1 |
| Calogero, H | 1 |
| Fossar, N | 1 |
| Ferdinand, A | 1 |
| Taylor, D | 1 |
| Theroux, SJ | 1 |
| Taglienti-Sian, C | 1 |
| Nair, N | 1 |
| Countaway, JL | 1 |
| Robinson, HL | 1 |
| Davis, RJ | 1 |
| Nomura, T | 1 |
| Ryoyama, K | 1 |
| Okada, G | 1 |
| Matano, S | 1 |
| Nakamura, S | 1 |
| Kameyama, T | 1 |
| Krzyzosiak, WJ | 1 |
| Shindo-Okada, N | 4 |
| Teshima, H | 1 |
| Nakajima, K | 1 |
| Okada, N | 1 |
| Makabe, O | 3 |
| Nagahara, H | 3 |
| Yamaizumi, Z | 1 |
| Mercier, J | 1 |
| Befort, N | 1 |
| Beck, JP | 1 |
| Ebel, JP | 1 |
1 review available for alanine and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Azatyrosine. Mechanism of action for conversion of transformed phenotype to normal.
Topics: Alanine; Animals; Antibiotics, Antineoplastic; Cell Transformation, Neoplastic; Genes, erbB-2; Human | 1999 |
33 other studies available for alanine and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Molecular insights on cytochrome c and nucleotide regulation of apoptosome function and its implication in cancer.
Topics: Alanine; Amino Acid Substitution; Apoptosomes; Apoptotic Protease-Activating Factor 1; Case-Control | 2020 |
[In Process Citation].
Topics: Alanine; Amino Acid Substitution; Cell Transformation, Neoplastic; DNA Mutational Analysis; Glycine; | 2015 |
Feasibility study with 99mTc-HYNIC-βAla-Bombesin(7-14) as an agent to early visualization of lung tumour cells in nude mice.
Topics: A549 Cells; Alanine; Animals; Bombesin; Cell Transformation, Neoplastic; Feasibility Studies; Female | 2016 |
A germline mutation (A339V) in thyroid transcription factor-1 (TITF-1/NKX2.1) in patients with multinodular goiter and papillary thyroid carcinoma.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alanine; Animals; Carcinoma, Papillary; Case-Control Stu | 2009 |
Autoinhibition of Bcr-Abl through its SH3 domain.
Topics: 3T3 Cells; Alanine; Amino Acid Sequence; Animals; Binding Sites; Catalytic Domain; Cell Transformati | 2003 |
High tumorigenic potential of a constitutively active mutant of the cholecystokinin 2 receptor.
Topics: 3T3 Cells; Alanine; Amino Acid Motifs; Animals; Carcinogenicity Tests; Cell Division; Cell Transform | 2003 |
Dynein light chain 1, a p21-activated kinase 1-interacting substrate, promotes cancerous phenotypes.
Topics: Alanine; Apoptosis; Blotting, Western; Breast Neoplasms; Carrier Proteins; Cell Cycle; Cell Division | 2004 |
Single-point mutations of hepatitis C virus NS3 that impair p53 interaction and anti-apoptotic activity of NS3.
Topics: Alanine; Animals; Apoptosis; Cell Line; Cell Transformation, Neoplastic; DNA Primers; Genes, p53; He | 2006 |
ALK-mediated Na+/H+ exchanger-dependent intracellular alkalinization: does it matter for oncogenesis?
Topics: Alanine; Ammonia; Animals; Cell Division; Cell Line, Tumor; Cell Transformation, Neoplastic; Chroman | 2007 |
Pyruvate kinase in human brain tumours. Its significance in the treatment of gliomas.
Topics: Adolescent; Adult; Aged; Alanine; Brain; Brain Neoplasms; Cell Transformation, Neoplastic; Child; Ch | 1982 |
Reversion of human prostate tumorigenic growth by azatyrosine.
Topics: Adenocarcinoma; Alanine; Animals; Antibiotics, Antineoplastic; Cell Division; Cell Transformation, N | 1995 |
Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells.
Topics: 3T3 Cells; Alanine; Animals; Cell Differentiation; Cell Division; Cell Line; Cell Transformation, Ne | 1994 |
A mutant v-rel with increased ability to transform B lymphocytes.
Topics: Alanine; Amino Acid Sequence; Animals; B-Lymphocytes; Base Sequence; Cell Line; Cell Transformation, | 1995 |
Ala-->Gly mutation in the putative catalytic loop confers temperature sensitivity on Ros, insulin receptor, and insulin-like growth factor I receptor protein-tyrosine kinases.
Topics: Alanine; Amino Acid Sequence; Base Sequence; Cell Transformation, Neoplastic; DNA Primers; Glycine; | 1994 |
Alanine mutagenesis of conserved residues in the platelet-derived growth factor family: identification of residues necessary for dimerization and transformation.
Topics: Alanine; Amino Acid Sequence; Cell Transformation, Neoplastic; Conserved Sequence; Humans; Molecular | 1993 |
In vitro transforming effect of the fungicides metalaxyl and zineb.
Topics: 3T3 Cells; Alanine; Animals; Benzo(a)pyrene; Biotransformation; Carcinogens; Cell Survival; Cell Tra | 1995 |
Sensitivity to the parvovirus minute virus of mice as a probe for azatyrosine-mediated phenotypic reversion of spontaneously transformed cells.
Topics: 3T3 Cells; Alanine; Animals; Antibiotics, Antineoplastic; Cell Transformation, Neoplastic; Female; M | 1996 |
YY1 can inhibit c-Myc function through a mechanism requiring DNA binding of YY1 but neither its transactivation domain nor direct interaction with c-Myc.
Topics: Alanine; Animals; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Basic-Leucine Zipper | 1998 |
The transmembrane domain of the E5 oncoprotein contains functionally discrete helical faces.
Topics: 3T3 Cells; Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; Cattle; Cell Membrane; Ce | 1999 |
Mutations in serines 15 and 20 of human p53 impair its apoptotic activity.
Topics: Alanine; Animals; Apoptosis; Binding Sites; Cell Transformation, Neoplastic; DNA; Gene Expression; H | 1999 |
Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation.
Topics: 3T3 Cells; Alanine; Animals; Baculoviridae; Cell Line; Cell Nucleus; Cell Transformation, Neoplastic | 2001 |
The defective transforming phenotype of c-Jun Ala(63/73) is rescued by mutation of the C-terminal phosphorylation site.
Topics: Alanine; Animals; Cell Line, Transformed; Cell Transformation, Neoplastic; Cyclic AMP Response Eleme | 2001 |
Ligand-independent oncogenic transformation by the EGF receptor requires kinase domain catalytic activity.
Topics: Alanine; Animals; Aspartic Acid; Catalysis; Cell Line, Transformed; Cell Nucleus; Cell Transformatio | 2002 |
Phosphorylation of three regulatory serines of Tob by Erk1 and Erk2 is required for Ras-mediated cell proliferation and transformation.
Topics: 3T3 Cells; Alanine; Animals; Carrier Proteins; Cell Cycle; Cell Division; Cell Transformation, Neopl | 2002 |
Modification of diamine oxidase activity in vitro by metabolites of asparagine and differences in asparagine decarboxylation in normal and virus-transformed baby hamster kidney cells.
Topics: Alanine; Amides; Amine Oxidase (Copper-Containing); Asparagine; Cell Line; Cell Transformation, Neop | 1976 |
Increased oncogenic potential of ErbB is associated with the loss of a COOH-terminal domain serine phosphorylation site.
Topics: 3T3 Cells; Alanine; Animals; Cell Transformation, Neoplastic; Chick Embryo; Glutamates; Glutamic Aci | 1992 |
Non-transformed, but not ras/myc-transformed, serum-free mouse embryo cells recover from growth suppression by azatyrosine.
Topics: Alanine; Animals; Antibiotics, Antineoplastic; Blotting, Northern; Cell Division; Cell Line; Cell Li | 1992 |
Isolation of genes specifically expressed in flat revertant cells derived from activated ras-transformed NIH 3T3 cells by treatment with azatyrosine.
Topics: 3T3 Cells; Alanine; Animals; Base Sequence; Cell Transformation, Neoplastic; Cloning, Molecular; Col | 1992 |
[Characteristics of revertant cells induced from transformed cells by the treatment with an antibiotic, azatyrosine].
Topics: Alanine; Antibiotics, Antineoplastic; Cell Transformation, Neoplastic; Gene Expression Regulation, N | 1990 |
Permanent conversion of NIH3T3 cells transformed by activated c-Ha-ras, c-Ki-ras, N-ras, or c-raf, and of human pancreatic adenocarcinoma containing activated c-Ki-ras to apparently normal cells by treatment with the antibiotic azatyrosine.
Topics: Adenocarcinoma; Alanine; Animals; Antibiotics, Antineoplastic; Cell Division; Cell Line, Transformed | 1990 |
Permanent conversion of mouse and human cells transformed by activated ras or raf genes to apparently normal cells by treatment with the antibiotic azatyrosine.
Topics: Alanine; Animals; Antibiotics, Antineoplastic; Blotting, Southern; Cell Division; Cell Line; Cell Tr | 1989 |
The antibiotic, L-beta-(5-hydroxy-2-pyridyl)-alanine specifically inhibits growth of the NIH3T3 cells transformed by activated human c-Ha-ras and induces formation of flat revertant cells.
Topics: Alanine; Animals; Antibiotics, Antineoplastic; Cell Division; Cell Transformation, Neoplastic; Cells | 1988 |
[Comparative study of transfer ribonucleic acids extracted from rat liver and Zajdela hepatoma. I. Study of the acceptor properties of tRNA].
Topics: Acylation; Alanine; Animals; Arginine; Ascites; Carcinoma, Hepatocellular; Cell Differentiation; Cel | 1972 |