Page last updated: 2024-11-08

alanine and Celiac Sprue

alanine has been researched along with Celiac Sprue in 7 studies

Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19904 (57.14)18.7374
1990's0 (0.00)18.2507
2000's1 (14.29)29.6817
2010's1 (14.29)24.3611
2020's1 (14.29)2.80

Authors

AuthorsStudies
Qiu, L1
Song, J1
Zhang, JZH1
Nurminen, S1
Kivelä, L1
Taavela, J1
Huhtala, H1
Mäki, M1
Kaukinen, K1
Kurppa, K1
Ellis, HJ1
Pollock, EL1
Engel, W1
Fraser, JS1
Rosen-Bronson, S1
Wieser, H1
Ciclitira, PJ1
Rutgeerts, L1
Tytgat, G1
Eggermont, E1
Silk, DB1
Kumar, PJ1
Perrett, D1
Clark, ML1
Dawson, AM1
Desjeux, JF1
Sandler, L1
Sassier, P1
Lestradet, H1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Acute Glycine Pharmacodynamic Study[NCT01610011]21 participants (Actual)Interventional2010-07-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Brain Glycine Increments After Oral Glycine Administration Measured With MRS as Glycine/Total Creatine, Normalized to the Glycine Dose Administered (g/kg).

Brain and plasma glycine levels are measured with proton magnetic resonance spectroscopy at 4T and analytically, respectively. Because glycine doses were limited to 30 g to avoid nausea and vomiting, some subjects with higher weights were administered lower doses per body weight of glycine (g/kg). Therefore, we corrected MRS data by the actual glycine dose administered (g/kg) to account for dosing differences. (NCT01610011)
Timeframe: For up to 2 hours

InterventionPercent brain glycine/creatine increase (Mean)
Glycine Administration Controls393
Glycine Administration GLDC Mutation Subjects677

Other Studies

7 other studies available for alanine and Celiac Sprue

ArticleYear
Computational Alanine Scanning Reveals Common Features of TCR/pMHC Recognition in HLA-DQ8-Associated Celiac Disease.
    Methods in molecular biology (Clifton, N.J.), 2022, Volume: 2385

    Topics: Alanine; Celiac Disease; Gliadin; Histocompatibility Antigens; HLA-DQ Antigens; Humans; Models, Mole

2022
Factors associated with growth disturbance at celiac disease diagnosis in children: a retrospective cohort study.
    BMC gastroenterology, 2015, Oct-06, Volume: 15

    Topics: Abdominal Pain; Age Factors; Age of Onset; Alanine; Antibodies; Atrophy; Celiac Disease; Child; Chil

2015
Investigation of the putative immunodominant T cell epitopes in coeliac disease.
    Gut, 2003, Volume: 52, Issue:2

    Topics: Adult; Aged; Alanine; Amino Acid Sequence; Celiac Disease; Cell Line; Clone Cells; Cytokines; Down-R

2003
Glucagon-induced increase of enterokinase activity in human duodenal mucosa.
    Digestion, 1973, Volume: 8, Issue:5

    Topics: Alanine; Alkaline Phosphatase; Biliary Tract Diseases; Celiac Disease; Duodenum; Endopeptidases; Glu

1973
Amino acid, dipeptide, and protein absorption in human beings.
    Nutrition reviews, 1973, Volume: 31, Issue:9

    Topics: Adult; Alanine; Amino Acids; Antibody Formation; Arginine; Biological Transport; Celiac Disease; Chi

1973
Amino acid and peptide absorption in patients with coeliac disease and dermatitis herpetiformis.
    Gut, 1974, Volume: 15, Issue:1

    Topics: Adult; Aged; Alanine; Amino Acids; Celiac Disease; Dermatitis Herpetiformis; Dipeptides; Glycine; Hu

1974
Acquired and congenital disorders of intestinal transport of D. glucose in children.
    Revue europeenne d'etudes cliniques et biologiques. European journal of clinical and biological research, 1971, Volume: 16, Issue:4

    Topics: Alanine; Biological Transport; Biopsy; Celiac Disease; Child, Preschool; Female; Galactose; Glucose;

1971