alanine has been researched along with Cancer of Colon in 26 studies
Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We hypothesized that this polymorphism may modulate the cytotoxic effect of 5-fluorouracil (5FU) and methotrexate (MTX), two commonly used chemotherapeutic agents for colon and breast cancers, because the modes of action of 5FU and MTX are critically dependent on cellular composition of folates." | 7.72 | Effect of the methylenetetrahydrofolate reductase C677T polymorphism on chemosensitivity of colon and breast cancer cells to 5-fluorouracil and methotrexate. ( Croxford, R; Kim, YI; Lucock, M; Sohn, KJ; Yates, Z, 2004) |
| "The human colon carcinoma cell line HT-29, when grown to confluence, was found to take up taurine and accumulate it against a concentration gradient from a NaCl-containing uptake medium." | 7.68 | Constitutive expression of the taurine transporter in a human colon carcinoma cell line. ( Brandsch, M; Ganapathy, V; Leibach, FH; Miyamoto, Y; Tiruppathi, C, 1992) |
| "The results of our study indicate that there is an inverse correlation between alanine and the risk of colon adenocarcinoma." | 4.31 | Amino acids and risk of colon adenocarcinoma: a Mendelian randomization study. ( Jia, Z; Wang, Q; Wang, Y; Zhu, Z, 2023) |
| " We hypothesized that this polymorphism may modulate the cytotoxic effect of 5-fluorouracil (5FU) and methotrexate (MTX), two commonly used chemotherapeutic agents for colon and breast cancers, because the modes of action of 5FU and MTX are critically dependent on cellular composition of folates." | 3.72 | Effect of the methylenetetrahydrofolate reductase C677T polymorphism on chemosensitivity of colon and breast cancer cells to 5-fluorouracil and methotrexate. ( Croxford, R; Kim, YI; Lucock, M; Sohn, KJ; Yates, Z, 2004) |
| "The human colon carcinoma cell line HT-29, when grown to confluence, was found to take up taurine and accumulate it against a concentration gradient from a NaCl-containing uptake medium." | 3.68 | Constitutive expression of the taurine transporter in a human colon carcinoma cell line. ( Brandsch, M; Ganapathy, V; Leibach, FH; Miyamoto, Y; Tiruppathi, C, 1992) |
| "Thirty patients with advanced metastatic colorectal adenocarcinoma were treated with alanosine at a dose of 160 mg/m2 daily for 5 days every 4 weeks." | 3.66 | A phase II study of alanosine in advanced large bowel carcinoma. ( Hahn, RG; Hineman, V; Moertel, CG; Rubin, J; Schutt, AJ, 1983) |
| "Obesity is associated with increased incidence and worse prognosis of more than one dozen tumor types; however, the molecular mechanisms for this association remain under debate." | 1.51 | Obesity-associated, but not obesity-independent, tumors respond to insulin by increasing mitochondrial glucose oxidation. ( Perry, RJ; Rabin-Court, A; Rodrigues, MR; Zhang, XM, 2019) |
| "Transduction of colon cancer cells with rAAV-Sur-Mut(Cys84Ala) inhibited cell proliferation and induced apoptosis and mitotic catastrophe in vitro." | 1.33 | Gene therapy for colon cancer by adeno-associated viral vector-mediated transfer of survivin Cys84Ala mutant. ( Chan, AO; Cui, JT; Huajiang, X; Jiang, SH; Kung, HF; Lam, SK; Lin, MC; Liston, P; Ng, SS; Tu, SP; Wong, BC; Wong, WM; Xia, HH; Xu, R; Yuen, MF; Zhu, YB; Zou, B, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (26.92) | 18.7374 |
| 1990's | 6 (23.08) | 18.2507 |
| 2000's | 8 (30.77) | 29.6817 |
| 2010's | 4 (15.38) | 24.3611 |
| 2020's | 1 (3.85) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, Y | 1 |
| Jia, Z | 1 |
| Wang, Q | 1 |
| Zhu, Z | 1 |
| Rabin-Court, A | 1 |
| Rodrigues, MR | 1 |
| Zhang, XM | 1 |
| Perry, RJ | 1 |
| Häggblad Sahlberg, S | 1 |
| Mortensen, AC | 1 |
| Haglöf, J | 1 |
| Engskog, MK | 1 |
| Arvidsson, T | 1 |
| Pettersson, C | 1 |
| Glimelius, B | 1 |
| Stenerlöw, B | 1 |
| Nestor, M | 1 |
| Corpet, DE | 1 |
| Taché, S | 1 |
| Archer, MC | 1 |
| Bruce, WR | 1 |
| Li, HX | 1 |
| Zhao, XY | 1 |
| Wang, L | 1 |
| Wang, YS | 1 |
| Kan, B | 1 |
| Xu, JR | 1 |
| Li, J | 1 |
| Wen, YJ | 1 |
| Peng, XC | 1 |
| Chen, X | 1 |
| Yan, F | 1 |
| Ye, B | 1 |
| Du, XB | 1 |
| Zhao, JM | 1 |
| Yi, T | 1 |
| Chen, XC | 1 |
| Du, XX | 1 |
| Wei, YQ | 1 |
| Zhao, X | 1 |
| Kabeya, M | 1 |
| Ina, K | 1 |
| Yuasa, S | 1 |
| Kikuchi, F | 1 |
| Tajiri, C | 1 |
| Kato, T | 1 |
| Hibi, S | 1 |
| Minagawa, Y | 1 |
| Furuta, R | 1 |
| Kayukawa, S | 1 |
| Kataoka, T | 1 |
| Kawai, M | 1 |
| Sohn, KJ | 1 |
| Croxford, R | 1 |
| Yates, Z | 1 |
| Lucock, M | 1 |
| Kim, YI | 1 |
| Tu, SP | 1 |
| Cui, JT | 1 |
| Liston, P | 1 |
| Huajiang, X | 1 |
| Xu, R | 1 |
| Lin, MC | 1 |
| Zhu, YB | 1 |
| Zou, B | 1 |
| Ng, SS | 1 |
| Jiang, SH | 1 |
| Xia, HH | 1 |
| Wong, WM | 1 |
| Chan, AO | 1 |
| Yuen, MF | 1 |
| Lam, SK | 1 |
| Kung, HF | 1 |
| Wong, BC | 1 |
| Gross, I | 1 |
| Lhermitte, B | 1 |
| Domon-Dell, C | 1 |
| Duluc, I | 1 |
| Martin, E | 1 |
| Gaiddon, C | 1 |
| Kedinger, M | 1 |
| Freund, JN | 1 |
| Jiang, J | 1 |
| Gajalakshmi, V | 1 |
| Wang, J | 1 |
| Kuriki, K | 1 |
| Suzuki, S | 1 |
| Nakamura, S | 1 |
| Akasaka, S | 1 |
| Ishikawa, H | 1 |
| Tokudome, S | 1 |
| Niwa, Y | 1 |
| Nakamura, M | 1 |
| Omiya, N | 1 |
| Itoh, A | 1 |
| Hirooka, Y | 1 |
| Goto, H | 1 |
| O'Connell, MJ | 1 |
| Rubin, J | 2 |
| Schutt, AJ | 2 |
| Moertel, CG | 2 |
| Kvols, LK | 1 |
| Grasset, E | 1 |
| Pinto, M | 1 |
| Dussaulx, E | 1 |
| Zweibaum, A | 1 |
| Desjeux, JF | 1 |
| Hineman, V | 1 |
| Hahn, RG | 1 |
| Hashimoto, K | 1 |
| Shimizu, M | 1 |
| Pocard, M | 1 |
| Chevillard, S | 1 |
| Villaudy, J | 1 |
| Poupon, MF | 1 |
| Dutrillaux, B | 1 |
| Remvikos, Y | 1 |
| Pasche, B | 1 |
| Luo, Y | 1 |
| Rao, PH | 1 |
| Nimer, SD | 1 |
| Dmitrovsky, E | 1 |
| Caron, P | 1 |
| Luzzatto, L | 1 |
| Offit, K | 1 |
| Cordon-Cardo, C | 1 |
| Renault, B | 1 |
| Satagopan, JM | 1 |
| Murty, VV | 1 |
| Massagué, J | 1 |
| Paranavitana, CM | 1 |
| Ogier-Denis, E | 1 |
| Pattingre, S | 1 |
| El Benna, J | 1 |
| Codogno, P | 1 |
| Wenzel, U | 1 |
| Meissner, B | 1 |
| Döring, F | 1 |
| Daniel, H | 1 |
| Royle, G | 1 |
| Gill, PG | 1 |
| Tiruppathi, C | 1 |
| Brandsch, M | 1 |
| Miyamoto, Y | 1 |
| Ganapathy, V | 1 |
| Leibach, FH | 1 |
| Souba, WW | 1 |
| Pan, M | 1 |
| Stevens, BR | 1 |
| Bibby, MC | 1 |
| Double, JA | 1 |
| Burns, R | 1 |
| Thomas, DW | 1 |
| Barron, VJ | 1 |
| Kellen, JA | 1 |
| Lustig, V | 1 |
2 trials available for alanine and Cancer of Colon
| Article | Year |
|---|---|
[Pilot study on clinical effects of rebamipide gargle against oral mucositis induced by fluoropyrimidines].
Topics: Alanine; Antimetabolites, Antineoplastic; Colonic Neoplasms; Fluorouracil; Humans; Mouthwashes; Pilo | 2011 |
Clinical trial of PALA and L-Alanosine in advanced colorectal carcinoma.
Topics: Adult; Aged; Alanine; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Clinical Trials | 1983 |
24 other studies available for alanine and Cancer of Colon
| Article | Year |
|---|---|
Amino acids and risk of colon adenocarcinoma: a Mendelian randomization study.
Topics: Adenocarcinoma; Alanine; Amino Acids; Colonic Neoplasms; Genome-Wide Association Study; Humans; Mend | 2023 |
Obesity-associated, but not obesity-independent, tumors respond to insulin by increasing mitochondrial glucose oxidation.
Topics: Alanine; Breast Neoplasms; Cell Line, Tumor; Citrate (si)-Synthase; Colonic Neoplasms; Female; Gene | 2019 |
Different functions of AKT1 and AKT2 in molecular pathways, cell migration and metabolism in colon cancer cells.
Topics: Alanine; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Colonic Neoplasms; Fatty Ac | 2017 |
Dehydroalanine and lysinoalanine in thermolyzed casein do not promote colon cancer in the rat.
Topics: Alanine; Animals; Azoxymethane; Carcinogenicity Tests; Caseins; Cheese; Colonic Neoplasms; Diet; Fec | 2008 |
Antitumor effect of mSurvivinThr34→Ala in murine colon carcinoma when administered intravenously.
Topics: Adoptive Transfer; Alanine; Animals; Apoptosis; Blotting, Western; CD4-Positive T-Lymphocytes; CD8-P | 2010 |
Effect of the methylenetetrahydrofolate reductase C677T polymorphism on chemosensitivity of colon and breast cancer cells to 5-fluorouracil and methotrexate.
Topics: Alanine; Animals; Antimetabolites, Antineoplastic; Blotting, Western; Breast Neoplasms; Cell Line, T | 2004 |
Gene therapy for colon cancer by adeno-associated viral vector-mediated transfer of survivin Cys84Ala mutant.
Topics: Alanine; Amino Acid Substitution; Apoptosis; Cell Division; Cell Line, Tumor; Colonic Neoplasms; Cys | 2005 |
Phosphorylation of the homeotic tumor suppressor Cdx2 mediates its ubiquitin-dependent proteasome degradation.
Topics: Adenocarcinoma; Alanine; Alkaline Phosphatase; Amino Acid Sequence; Amino Acid Substitution; Animals | 2005 |
Influence of the C161T but not Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma on colorectal cancer in an Indian population.
Topics: Adult; Aged; Alanine; Colonic Neoplasms; Colorectal Neoplasms; Cytosine; Gene Frequency; Haplotypes; | 2005 |
Ileal cancer and erosions in the small intestine revealed by capsule endoscopy.
Topics: Adenocarcinoma; Adenoma; Aged, 80 and over; Alanine; Anti-Ulcer Agents; Capsule Endoscopy; Colonic N | 2007 |
Epithelial properties of human colonic carcinoma cell line Caco-2: electrical parameters.
Topics: Adenocarcinoma; Alanine; Aldosterone; Amiloride; Amphotericin B; Cell Differentiation; Cell Division | 1984 |
A phase II study of alanosine in advanced large bowel carcinoma.
Topics: Adenocarcinoma; Adult; Aged; Alanine; Antibiotics, Antineoplastic; Colonic Neoplasms; Drug Evaluatio | 1983 |
Epithelial properties of human intestinal Caco-2 cells cultured in a serum-free medium.
Topics: Adenocarcinoma; Alanine; Animals; Biological Transport; Cattle; Cell Division; Cell Line; Colonic Ne | 1993 |
Different p53 mutations produce distinct effects on the ability of colon carcinoma cells to become blocked at the G1/S boundary after irradiation.
Topics: Alanine; Base Sequence; Blotting, Western; Cell Cycle; Cell Line; Colonic Neoplasms; Cyclin-Dependen | 1996 |
Type I transforming growth factor beta receptor maps to 9q22 and exhibits a polymorphism and a rare variant within a polyalanine tract.
Topics: Acute Disease; Alanine; Amino Acid Sequence; Blood Donors; Chromosome Mapping; Chromosomes, Human, P | 1998 |
Non-radioactive detection of K-ras mutations by nested allele specific PCR and oligonucleotide hybridization.
Topics: Alanine; Amino Acid Substitution; Animals; Aspartic Acid; Breast Neoplasms; Codon; Colonic Neoplasms | 1998 |
Erk1/2-dependent phosphorylation of Galpha-interacting protein stimulates its GTPase accelerating activity and autophagy in human colon cancer cells.
Topics: Alanine; Casein Kinase II; Colonic Neoplasms; Enzyme Inhibitors; Flavonoids; GTP Phosphohydrolases; | 2000 |
PEPT1-mediated uptake of dipeptides enhances the intestinal absorption of amino acids via transport system b(0,+).
Topics: Alanine; Amino Acids; Arginine; Biological Transport; Carrier Proteins; Colonic Neoplasms; Dipeptide | 2001 |
Metabolic changes following the intravenous infusion of Corynebacterium parvum in man.
Topics: Aged; Alanine; Bacterial Vaccines; Blood Glucose; Colonic Neoplasms; Female; Humans; Injections, Int | 1979 |
Constitutive expression of the taurine transporter in a human colon carcinoma cell line.
Topics: Alanine; Biological Transport; Carcinoma; Carrier Proteins; Chlorides; Colonic Neoplasms; Culture Me | 1992 |
Kinetics of the sodium-dependent glutamine transporter in human intestinal cell confluent monolayers.
Topics: Adenocarcinoma; Alanine; Amino Acid Transport Systems, Basic; Amino Acids; Analysis of Variance; Bio | 1992 |
Activity of N-[N'-(2-chloroethyl)-N'-nitrosocarbamoyl]-alanine and derivatives against transplantable adenocarcinomata of the mouse colon (MAC).
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Alanine; Animals; Antineoplastic Agents; Colonic Neoplasms; D | 1986 |
Reversible encephalopathy possibly associated with bismuth subgallate ingestion.
Topics: Adult; Aged; Alanine; Arginine; Bismuth; Brain Diseases; Cerebellum; Chromatography; Cognition Disor | 1974 |
Patterns of amino-acid inhibition of alkaline phosphatases as an aid in cancer diagnosis.
Topics: Adenocarcinoma; Alanine; Alkaline Phosphatase; Amino Acids; Animals; Arginine; Colonic Neoplasms; Fe | 1971 |