alanine has been researched along with Canavan Disease in 2 studies
Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.
Canavan Disease: A rare neurodegenerative condition of infancy or childhood characterized by white matter vacuolization and demeylination that gives rise to a spongy appearance. Aspartoacylase deficiency leads to an accumulation of N-acetylaspartate in astrocytes. Inheritance may be autosomal recessive or the illness may occur sporadically. This illness occurs more frequently in individuals of Ashkenazic Jewish descent. The neonatal form features the onset of hypotonia and lethargy at birth, rapidly progressing to coma and death. The infantile form features developmental delay, DYSKINESIAS, hypotonia, spasticity, blindness, and megalencephaly. The juvenile form is characterized by ATAXIA; OPTIC ATROPHY; and DEMENTIA. (From Adams et al., Principles of Neurology, 6th ed, p944; Am J Med Genet 1988 Feb;29(2):463-71)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 2 (100.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Janson, CG | 1 |
Kolodny, EH | 1 |
Zeng, BJ | 1 |
Raghavan, S | 1 |
Pastores, G | 1 |
Torres, P | 1 |
Assadi, M | 1 |
McPhee, S | 1 |
Goldfarb, O | 1 |
Saslow, B | 1 |
Freese, A | 1 |
Wang, DJ | 1 |
Bilaniuk, L | 1 |
Shera, D | 1 |
Leone, P | 1 |
Velinov, M | 1 |
Zellers, N | 1 |
Styles, J | 1 |
Wisniewski, K | 1 |
2 other studies available for alanine and Canavan Disease
Article | Year |
---|---|
Mild-onset presentation of Canavan's disease associated with novel G212A point mutation in aspartoacylase gene.
Topics: Adult; Alanine; Amidohydrolases; Aspartic Acid; Canavan Disease; DNA Mutational Analysis; Female; Gl | 2006 |
Homozygosity for mutation G212A of the gene for aspartoacylase is associated with atypical form of Canavan's disease.
Topics: Alanine; Amidohydrolases; Amino Acid Substitution; Aspartic Acid; Canavan Disease; Child, Preschool; | 2008 |