alanine has been researched along with Brittle Bone Disease in 7 studies
Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The features of a child with osteogenesis imperfecta type III (OI III) resulting from the heterozygous substitution of glycine 1006 by alanine in the pro alpha 2(I) chain of type I procollagen were studied." | 7.69 | Arachnoid cyst and chronic subdural haematoma in a child with osteogenesis imperfecta type III resulting from the substitution of glycine 1006 by alanine in the pro alpha 2(I) chain of type I procollagen. ( Cole, WG; Lam, TP, 1996) |
| "The features of a child with osteogenesis imperfecta type III (OI III) resulting from the heterozygous substitution of glycine 1006 by alanine in the pro alpha 2(I) chain of type I procollagen were studied." | 3.69 | Arachnoid cyst and chronic subdural haematoma in a child with osteogenesis imperfecta type III resulting from the substitution of glycine 1006 by alanine in the pro alpha 2(I) chain of type I procollagen. ( Cole, WG; Lam, TP, 1996) |
| "Substitution of a glycine residue in the triple helix of the alpha 1(I) chain by either arginine, valine or alanine was associated with the type II lethal perinatal osteogenesis imperfecta phenotype." | 3.67 | Correlation of clinical and molecular biological abnormalities in osteogenesis imperfecta. ( Bateman, J; Chan, D; Cole, W; Lamande, S; Mascara, T; Rogers, J, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (28.57) | 18.7374 |
| 1990's | 3 (42.86) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Xiao, J | 1 |
| Cheng, H | 1 |
| Silva, T | 1 |
| Baum, J | 1 |
| Brodsky, B | 1 |
| Valli, M | 1 |
| Sangalli, A | 1 |
| Rossi, A | 1 |
| Mottes, M | 1 |
| Forlino, A | 1 |
| Tenni, R | 1 |
| Pignatti, PF | 1 |
| Cetta, G | 1 |
| Lu, J | 1 |
| Costa, T | 1 |
| Cole, WG | 2 |
| Lam, TP | 1 |
| Campbell, BG | 1 |
| Wootton, JA | 1 |
| MacLeod, JN | 1 |
| Minor, RR | 1 |
| Cole, W | 1 |
| Chan, D | 1 |
| Lamande, S | 1 |
| Mascara, T | 1 |
| Rogers, J | 1 |
| Bateman, J | 1 |
| Eastoe, JE | 1 |
| Martens, P | 1 |
| Thomas, NR | 1 |
7 other studies available for alanine and Brittle Bone Disease
| Article | Year |
|---|---|
Osteogenesis imperfecta missense mutations in collagen: structural consequences of a glycine to alanine replacement at a highly charged site.
Topics: Alanine; Amino Acid Substitution; Calorimetry, Differential Scanning; Circular Dichroism; Collagen T | 2011 |
Osteogenesis imperfecta and type-I collagen mutations. A lethal variant caused by a Gly910-->Ala substitution in the alpha 1 (I) chain.
Topics: Alanine; Collagen; Cyanogen Bromide; Deoxyribonuclease HpaII; Deoxyribonucleases, Type II Site-Speci | 1993 |
A novel G1006A substitution in the alpha 2(I) chain of type I collagen produces osteogenesis imperfecta type III.
Topics: Alanine; Base Sequence; Collagen; Female; Glycine; Heterozygote; Humans; Male; Molecular Sequence Da | 1995 |
Arachnoid cyst and chronic subdural haematoma in a child with osteogenesis imperfecta type III resulting from the substitution of glycine 1006 by alanine in the pro alpha 2(I) chain of type I procollagen.
Topics: Adult; Alanine; Arachnoid Cysts; Female; Genetic Carrier Screening; Glycine; Hematoma, Subdural; Hum | 1996 |
Sequence of normal canine COL1A1 cDNA and identification of a heterozygous alpha1(I) collagen Gly208Ala mutation in a severe case of canine osteogenesis imperfecta.
Topics: Alanine; Amino Acid Sequence; Animals; Base Sequence; Collagen; Collagen Type I; Collagen Type I, al | 2000 |
Correlation of clinical and molecular biological abnormalities in osteogenesis imperfecta.
Topics: Alanine; Arginine; Genotype; Glycine; Humans; Infant; Mutation; Osteogenesis Imperfecta; Phenotype; | 1989 |
The amino-acid composition of human hard tissue collagens in osteogenesis imperfecta and dentinogenesis imperfecta.
Topics: Alanine; Amino Acids; Bone and Bones; Child; Collagen; Dentin; Dentinogenesis Imperfecta; Glycine; H | 1973 |