alanine has been researched along with Breast Cancer in 59 studies
Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We hypothesized that this polymorphism may modulate the cytotoxic effect of 5-fluorouracil (5FU) and methotrexate (MTX), two commonly used chemotherapeutic agents for colon and breast cancers, because the modes of action of 5FU and MTX are critically dependent on cellular composition of folates." | 7.72 | Effect of the methylenetetrahydrofolate reductase C677T polymorphism on chemosensitivity of colon and breast cancer cells to 5-fluorouracil and methotrexate. ( Croxford, R; Kim, YI; Lucock, M; Sohn, KJ; Yates, Z, 2004) |
| " We retrospectively examined the progression of oral mucositis in 91 patients with breast cancer who received the 5-fluorouracil, epirubicin, and cyclophosphamide (FEC)-100 regimen between September 2007 and August 2008." | 3.80 | [Therapeutic effect of rebamipide for oral mucositis associated with FEC therapy for breast cancer]. ( Abe, M; Bamba, N; Enami, A; Makihara, K; Masaoka, M; Masuda, N; Mizutani, M; Shikata, A; Takada, S; Yamamoto, M; Yamamura, J; Yasojima, H, 2014) |
| " Transduction of p27(T187A) in breast cancer cells with a doxycycline-regulated adenovirus led to greater inhibition of proliferation, more extensive apoptosis, with a markedly reduced protein levels of cyclin E and increased accumulation of cyclin D1, compared with wild-type p27." | 3.73 | Inducible expression of a degradation-resistant form of p27Kip1 causes growth arrest and apoptosis in breast cancer cells. ( Claret, FX; Johnson, TJ; Korapati, AL; Mansouri, A; Tian, L; Zhang, Q, 2005) |
| "A functional polymorphism at codon 16 (Alanine-to-Valine) of manganese superoxide dismutase (MnSOD) has been hypothesized to increase the risk of breast cancer and to modify the effects of oxidative stress." | 3.73 | Manganese superoxide dismutase Ala-9Val polymorphism, environmental modifiers, and risk of breast cancer in a German population. ( Chang-Claude, J; Slanger, TE; Wang-Gohrke, S, 2006) |
| " We hypothesized that this polymorphism may modulate the cytotoxic effect of 5-fluorouracil (5FU) and methotrexate (MTX), two commonly used chemotherapeutic agents for colon and breast cancers, because the modes of action of 5FU and MTX are critically dependent on cellular composition of folates." | 3.72 | Effect of the methylenetetrahydrofolate reductase C677T polymorphism on chemosensitivity of colon and breast cancer cells to 5-fluorouracil and methotrexate. ( Croxford, R; Kim, YI; Lucock, M; Sohn, KJ; Yates, Z, 2004) |
| " MDA-MB-435 human breast carcinoma cells were transfected with a control expression vector (pCMVBamneo), the vector containing the wild type nm23-H1, or the nm23-H1 vector encoding mutations at the following amino acids: serine 44, a phosphorylation site; proline 96, the k-pn mutation in the Drosophila nm23 homolog that causes developmental defects; histidine 118, involved in Nm23's nucleoside diphosphate kinase activity; and serine 120, a site of mutation in human neuroblastomas and phosphorylation." | 3.69 | Site-directed mutagenesis of nm23-H1. Mutation of proline 96 or serine 120 abrogates its motility inhibitory activity upon transfection into human breast carcinoma cells. ( Freije, JM; MacDonald, NJ; Manrow, RE; Steeg, PS; Stracke, ML, 1996) |
| "Our meta-analysis on total of 7,366 cancer cases and 9,102 controls from 13 published case-control studies showed no overall association of this polymorphism either with breast cancer risk or for cancer risk as such (for Ala homozygous odds ratio, 0." | 2.44 | Target sequence polymorphism of human manganese superoxide dismutase gene and its association with cancer risk: a review. ( Bag, A; Bag, N, 2008) |
| "Breast cancer is a heterogeneous disease and there are only limited known relations of plasma metabolomic signatures with the tumour characteristics in early BC and knowing them would be of great advantage in noninvasive diagnostics." | 1.72 | Circulating metabolites in the early stage of breast cancer were not related to cancer stage or subtypes but associated with ki67 level. Promising statistical discrimination from controls. ( Baranovicova, E; Dankova, Z; Dvorska, D; Halasova, E; Kudelova, E; Racay, P; Smolar, M; Zubor, P, 2022) |
| "Obesity is associated with increased incidence and worse prognosis of more than one dozen tumor types; however, the molecular mechanisms for this association remain under debate." | 1.51 | Obesity-associated, but not obesity-independent, tumors respond to insulin by increasing mitochondrial glucose oxidation. ( Perry, RJ; Rabin-Court, A; Rodrigues, MR; Zhang, XM, 2019) |
| "This study showed that breast cancer cells tolerate and use lactate at clinically relevant concentrations in vitro (± glucose) and in vivo." | 1.39 | Catabolism of exogenous lactate reveals it as a legitimate metabolic substrate in breast cancer. ( Chi, JT; Dewhirst, MW; Kennedy, KM; Landon, CD; Pizzo, S; Ribeiro, A; Richardson, R; Scarbrough, PM; Schroeder, T; Sonveaux, P; Yuan, H, 2013) |
| "Different Bcl-2 protein levels in breast cancer cell lines were determined using western blot." | 1.37 | BCL-2 (-938C > A) polymorphism is associated with breast cancer susceptibility. ( Haffty, BG; Jiang, L; Li, X; Liang, F; Ma, T; Moran, MS; Tao, K; Yan, S; Yang, Q; Yuan, C; Zhang, N, 2011) |
| "The effect of tamoxifen on breast cancer growth may, in part, be related to perturbations in cell volume regulation." | 1.37 | Specificity of the volume-activated amino acid efflux pathway in cultured human breast cancer cells. ( Shennan, DB; Thomson, J, 2011) |
| "In conclusion, in both human breast carcinoma cell lines and MEF cell lines stably transfected with human MnSOD, the MnSOD-ala allele was associated with increased production of MnSOD protein per unit mRNA indicating a possible imbalance in MnSOD protein production from the MnSOD-val mRNA." | 1.36 | Manganese superoxide dismutase: effect of the ala16val polymorphism on protein, activity, and mRNA levels in human breast cancer cell lines and stably transfected mouse embryonic fibroblasts. ( McAtee, BL; Yager, JD, 2010) |
| "Subjects with LN+ breast cancer (LN+ group) showed a higher incidence of VV genotype carriers associated with positive Ki-67 marker." | 1.36 | Polymorphism (ALA16VAL) correlates with regional lymph node status in breast cancer. ( Alexandre, CO; Bica, CG; da Silva, LL; Gottlieb, MG; Graudenz, MS; Mânica da Cruz, IB; Toscani, NV; Zettler, CG, 2010) |
| "We matched 361 female breast cancer cases with 361 controls, nested within the prospective 'Diet, Cancer and Health' study." | 1.34 | Peroxisome proliferator-activated [corrected] receptor-gamma2 [corrected] Pro12Ala, interaction with alcohol intake and NSAID use, in relation to risk of breast cancer in a prospective study of Danes. ( Christensen, J; Friis, S; Nexø, BA; Tjønneland, A; Vogel, U; Wallin, H, 2007) |
| "A nonsignificant increased risk of breast cancer among current smokers was limited to women homozygous for the Ala alleles compared with Val/Val never smokers (multivariate odds ratio, 1." | 1.32 | Manganese superoxide dismutase polymorphism, plasma antioxidants, cigarette smoking, and risk of breast cancer. ( Colditz, GA; Hankinson, SE; Hunter, DJ; Spiegelman, D; Tamimi, RM, 2004) |
| "MCF-7 hormone-dependent breast cancer cells were transfected with an expression vector for the wild-type RIalpha or mutant RIalpha-p." | 1.30 | Ala99ser mutation in RI alpha regulatory subunit of protein kinase A causes reduced kinase activation by cAMP and arrest of hormone-dependent breast cancer cell growth. ( Cho-Chung, YS; Hong, SH; Kim, SN; Lee, GR; Noguchi, K; Park, SD, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (3.39) | 18.7374 |
| 1990's | 7 (11.86) | 18.2507 |
| 2000's | 33 (55.93) | 29.6817 |
| 2010's | 13 (22.03) | 24.3611 |
| 2020's | 4 (6.78) | 2.80 |
| Authors | Studies |
|---|---|
| Mi, X | 1 |
| Guo, X | 1 |
| Du, H | 1 |
| Han, M | 1 |
| Liu, H | 1 |
| Luo, Y | 1 |
| Wang, D | 2 |
| Xiang, R | 1 |
| Yue, S | 1 |
| Zhang, Y | 1 |
| Tan, X | 1 |
| Baranovicova, E | 1 |
| Racay, P | 1 |
| Zubor, P | 1 |
| Smolar, M | 1 |
| Kudelova, E | 1 |
| Halasova, E | 1 |
| Dvorska, D | 1 |
| Dankova, Z | 1 |
| Rogado, J | 1 |
| Gullón, P | 1 |
| Obispo, B | 1 |
| Serrano, G | 1 |
| Lara, MÁ | 1 |
| Hu, B | 1 |
| Song, N | 1 |
| Cao, Y | 1 |
| Li, M | 1 |
| Liu, X | 1 |
| Zhou, Z | 1 |
| Shi, L | 1 |
| Yu, Z | 1 |
| Rabin-Court, A | 1 |
| Rodrigues, MR | 1 |
| Zhang, XM | 1 |
| Perry, RJ | 1 |
| Wang, H | 2 |
| Liu, L | 1 |
| Lang, Z | 1 |
| Guo, S | 1 |
| Gong, H | 1 |
| Guan, H | 1 |
| Zhang, J | 1 |
| Liu, B | 1 |
| Kennedy, KM | 1 |
| Scarbrough, PM | 1 |
| Ribeiro, A | 1 |
| Richardson, R | 1 |
| Yuan, H | 1 |
| Sonveaux, P | 1 |
| Landon, CD | 1 |
| Chi, JT | 1 |
| Pizzo, S | 1 |
| Schroeder, T | 1 |
| Dewhirst, MW | 1 |
| Enami, A | 1 |
| Masuda, N | 1 |
| Yamamura, J | 1 |
| Mizutani, M | 1 |
| Yasojima, H | 1 |
| Shikata, A | 1 |
| Masaoka, M | 1 |
| Takada, S | 1 |
| Bamba, N | 1 |
| Yamamoto, M | 1 |
| Abe, M | 1 |
| Makihara, K | 1 |
| Zhang, P | 1 |
| Zhu, W | 1 |
| Yan, J | 1 |
| Wang, Y | 2 |
| He, L | 1 |
| Li, J | 1 |
| Shen, Y | 1 |
| Liu, A | 1 |
| Wang, X | 3 |
| Zhao, C | 1 |
| Bag, A | 1 |
| Bag, N | 1 |
| Sun, W | 1 |
| Nikolovska-Coleska, Z | 1 |
| Qin, D | 1 |
| Sun, H | 1 |
| Yang, CY | 1 |
| Bai, L | 1 |
| Qiu, S | 1 |
| Ma, D | 1 |
| Wang, S | 2 |
| Kotsopoulos, J | 1 |
| Tworoger, SS | 1 |
| De Vivo, I | 1 |
| DeVivo, I | 1 |
| Hankinson, SE | 2 |
| Hunter, DJ | 2 |
| Willett, WC | 1 |
| Chen, WY | 1 |
| Mull, BB | 1 |
| Cox, J | 1 |
| Bui, T | 1 |
| Keyomarsi, K | 1 |
| McAtee, BL | 1 |
| Yager, JD | 1 |
| Zhuo, P | 1 |
| Goldberg, M | 1 |
| Herman, L | 1 |
| Lee, BS | 1 |
| Brown, RL | 1 |
| Foster, CB | 1 |
| Peters, U | 1 |
| Diamond, AM | 2 |
| Shiang, CY | 1 |
| Qi, Y | 1 |
| Wang, B | 1 |
| Lazar, V | 1 |
| Wang, J | 1 |
| Fraser Symmans, W | 1 |
| Hortobagyi, GN | 1 |
| Andre, F | 1 |
| Pusztai, L | 1 |
| Bica, CG | 1 |
| da Silva, LL | 1 |
| Toscani, NV | 1 |
| Zettler, CG | 1 |
| Gottlieb, MG | 1 |
| Alexandre, CO | 1 |
| Graudenz, MS | 1 |
| Mânica da Cruz, IB | 1 |
| Patel, RR | 1 |
| Sengupta, S | 1 |
| Kim, HR | 1 |
| Klein-Szanto, AJ | 1 |
| Pyle, JR | 1 |
| Zhu, F | 1 |
| Li, T | 1 |
| Ross, EA | 1 |
| Oseni, S | 1 |
| Fargnoli, J | 1 |
| Jordan, VC | 1 |
| Zhang, N | 1 |
| Li, X | 2 |
| Tao, K | 1 |
| Jiang, L | 1 |
| Ma, T | 1 |
| Yan, S | 1 |
| Yuan, C | 1 |
| Moran, MS | 1 |
| Liang, F | 1 |
| Haffty, BG | 1 |
| Yang, Q | 1 |
| Shennan, DB | 2 |
| Thomson, J | 2 |
| Grinde, MT | 1 |
| Moestue, SA | 1 |
| Borgan, E | 1 |
| Risa, Ø | 1 |
| Engebraaten, O | 1 |
| Gribbestad, IS | 1 |
| Donini, CF | 1 |
| Di Zazzo, E | 1 |
| Zuchegna, C | 1 |
| Di Domenico, M | 1 |
| D'Inzeo, S | 1 |
| Nicolussi, A | 1 |
| Avvedimento, EV | 1 |
| Coppa, A | 1 |
| Porcellini, A | 1 |
| Hu, YJ | 1 |
| Egan, KM | 1 |
| Thompson, PA | 1 |
| Titus-Ernstoff, L | 2 |
| Moore, JH | 1 |
| Ambrosone, CB | 1 |
| Sohn, KJ | 1 |
| Croxford, R | 1 |
| Yates, Z | 1 |
| Lucock, M | 1 |
| Kim, YI | 1 |
| Kittiniyom, K | 1 |
| Mastronardi, M | 1 |
| Roemer, M | 1 |
| Wells, WA | 1 |
| Greenberg, ER | 1 |
| Newsham, IF | 1 |
| Tamimi, RM | 1 |
| Spiegelman, D | 1 |
| Colditz, GA | 1 |
| Vadlamudi, RK | 1 |
| Bagheri-Yarmand, R | 1 |
| Yang, Z | 1 |
| Balasenthil, S | 1 |
| Nguyen, D | 1 |
| Sahin, AA | 1 |
| den Hollander, P | 1 |
| Kumar, R | 1 |
| Millikan, RC | 1 |
| Player, J | 1 |
| de Cotret, AR | 1 |
| Moorman, P | 1 |
| Pittman, G | 1 |
| Vannappagari, V | 1 |
| Tse, CK | 1 |
| Keku, T | 1 |
| Cai, Q | 1 |
| Shu, XO | 1 |
| Wen, W | 1 |
| Cheng, JR | 1 |
| Dai, Q | 1 |
| Gao, YT | 1 |
| Zheng, W | 1 |
| Pierson-Mullany, LK | 1 |
| Lange, CA | 1 |
| Herédi-Szabó, K | 1 |
| Lubke, J | 1 |
| Toth, G | 1 |
| Murphy, RF | 1 |
| Lovas, S | 1 |
| Taufer, M | 1 |
| Peres, A | 1 |
| de Andrade, VM | 1 |
| de Oliveira, G | 1 |
| Sá, G | 1 |
| do Canto, ME | 1 |
| dos Santos, AR | 1 |
| Bauer, ME | 1 |
| da Cruz, IB | 1 |
| Zhang, Q | 1 |
| Tian, L | 1 |
| Mansouri, A | 1 |
| Korapati, AL | 1 |
| Johnson, TJ | 1 |
| Claret, FX | 1 |
| Yin, S | 1 |
| Meng, Y | 1 |
| Finley, RL | 1 |
| Sakr, W | 1 |
| Yang, H | 1 |
| Reddy, N | 1 |
| Sheng, S | 1 |
| Li, Y | 1 |
| Yang, X | 1 |
| van Breemen, RB | 1 |
| Bolton, JL | 1 |
| Zhai, X | 1 |
| Liu, J | 1 |
| Hu, Z | 1 |
| Qing, J | 1 |
| Jin, G | 1 |
| Gao, J | 1 |
| Shen, H | 1 |
| Azuma, H | 1 |
| Ehata, S | 1 |
| Miyazaki, H | 1 |
| Watabe, T | 1 |
| Maruyama, O | 1 |
| Imamura, T | 1 |
| Sakamoto, T | 1 |
| Kiyama, S | 1 |
| Kiyama, Y | 1 |
| Ubai, T | 1 |
| Inamoto, T | 1 |
| Takahara, S | 1 |
| Itoh, Y | 1 |
| Otsuki, Y | 1 |
| Katsuoka, Y | 1 |
| Miyazono, K | 1 |
| Horie, S | 1 |
| Slanger, TE | 1 |
| Chang-Claude, J | 1 |
| Wang-Gohrke, S | 1 |
| Vogel, U | 1 |
| Christensen, J | 1 |
| Nexø, BA | 1 |
| Wallin, H | 1 |
| Friis, S | 1 |
| Tjønneland, A | 1 |
| Silva, SN | 1 |
| Cabral, MN | 1 |
| Bezerra de Castro, G | 1 |
| Pires, M | 1 |
| Azevedo, AP | 1 |
| Manita, I | 1 |
| Pina, JE | 1 |
| Rueff, J | 1 |
| Gaspar, J | 1 |
| Davidson, J | 1 |
| Gow, IF | 1 |
| Greger, JG | 1 |
| Fursov, N | 1 |
| Cooch, N | 1 |
| McLarney, S | 1 |
| Freedman, LP | 1 |
| Edwards, DP | 1 |
| Cheskis, BJ | 1 |
| Wu, Y | 1 |
| Shen, D | 1 |
| Chen, Z | 1 |
| Clayton, S | 1 |
| Vadgama, JV | 1 |
| Ko, H | 1 |
| Kim, HS | 1 |
| Kim, NH | 1 |
| Lee, SH | 1 |
| Kim, KH | 1 |
| Hong, SH | 2 |
| Yook, JI | 1 |
| Lovelock, PK | 1 |
| Spurdle, AB | 1 |
| Mok, MT | 1 |
| Farrugia, DJ | 1 |
| Lakhani, SR | 1 |
| Healey, S | 1 |
| Arnold, S | 1 |
| Buchanan, D | 1 |
| Couch, FJ | 1 |
| Henderson, BR | 1 |
| Goldgar, DE | 1 |
| Tavtigian, SV | 1 |
| Chenevix-Trench, G | 1 |
| Brown, MA | 1 |
| MacDonald, NJ | 1 |
| Freije, JM | 1 |
| Stracke, ML | 1 |
| Manrow, RE | 1 |
| Steeg, PS | 2 |
| Weis, KE | 1 |
| Ekena, K | 1 |
| Thomas, JA | 1 |
| Lazennec, G | 1 |
| Katzenellenbogen, BS | 1 |
| Paranavitana, CM | 1 |
| Srivastava, RK | 1 |
| Mi, QS | 1 |
| Hardwick, JM | 1 |
| Longo, DL | 1 |
| Lee, GR | 1 |
| Kim, SN | 1 |
| Noguchi, K | 1 |
| Park, SD | 1 |
| Cho-Chung, YS | 1 |
| Woo, LL | 1 |
| Purohit, A | 1 |
| Malini, B | 1 |
| Reed, MJ | 1 |
| Potter, BV | 1 |
| Baxter, SW | 1 |
| Choong, DY | 1 |
| Eccles, DM | 1 |
| Campbell, IG | 1 |
| Hartsough, MT | 1 |
| Morrison, DK | 1 |
| Salerno, M | 1 |
| Palmieri, D | 1 |
| Ouatas, T | 1 |
| Mair, M | 1 |
| Patrick, J | 1 |
| Kubota, A | 1 |
| Meguid, MM | 1 |
| Hitch, DC | 1 |
| Von Hoff, DD | 1 |
| Green, SJ | 1 |
| Neidhart, JA | 1 |
| Fabian, C | 1 |
| Budd, T | 1 |
| Boyd, JF | 1 |
| Osborne, CK | 1 |
| Ohno, R | 1 |
| Hersh, EM | 1 |
| Bojan, O | 1 |
| Mustea, I | 1 |
| Preda, N | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Pilot Study to Determine the Effect of Dietary Intervention on Novel Biomarkers of Breast Cancer Risk.[NCT00555386] | 27 participants (Actual) | Interventional | 2007-04-30 | Completed | |||
| Selenoproteins as Prognostic Markers and Therapeutic Targets in Breast Cancer.[NCT05817227] | 300 participants (Anticipated) | Observational | 2022-05-19 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for alanine and Breast Cancer
| Article | Year |
|---|---|
Polymorphisms of ERBB2 and breast cancer risk: a meta-analysis of 26 studies involving 35,088 subjects.
Topics: Adult; Aged; Alanine; Alleles; Asian People; Black People; Breast Neoplasms; Case-Control Studies; F | 2013 |
Target sequence polymorphism of human manganese superoxide dismutase gene and its association with cancer risk: a review.
Topics: Alanine; Alleles; Antioxidants; Breast Neoplasms; Genetic Predisposition to Disease; Humans; Neoplas | 2008 |
1 trial available for alanine and Breast Cancer
| Article | Year |
|---|---|
Phase II study of L-alanosine (NSC 153353) in patients with advanced breast cancer. A Southwest Oncology Group study.
Topics: Adenocarcinoma; Adult; Aged; Alanine; Antibiotics, Antineoplastic; Breast Neoplasms; Drug Evaluation | 1991 |
56 other studies available for alanine and Breast Cancer
| Article | Year |
|---|---|
Combined legumain- and integrin-targeted nanobubbles for molecular ultrasound imaging of breast cancer.
Topics: Alanine; Animals; Breast Neoplasms; Cell Line, Tumor; Contrast Media; Cysteine Endopeptidases; Endot | 2022 |
Circulating metabolites in the early stage of breast cancer were not related to cancer stage or subtypes but associated with ki67 level. Promising statistical discrimination from controls.
Topics: Alanine; Biomarkers, Tumor; Breast Neoplasms; Female; Histidine; Humans; Ki-67 Antigen; Metabolomics | 2022 |
Prolonged SARS-CoV-2 viral shedding in patients with solid tumours and associated factors.
Topics: Adenosine Monophosphate; Aged; Alanine; Antineoplastic Agents; Antiviral Agents; Breast Neoplasms; C | 2021 |
Noncanonical Amino Acids for Hypoxia-Responsive Peptide Self-Assembly and Fluorescence.
Topics: Alanine; Amino Acids; Animals; Breast Neoplasms; Cell Line, Tumor; Female; Fluorescent Dyes; Mice; M | 2021 |
Obesity-associated, but not obesity-independent, tumors respond to insulin by increasing mitochondrial glucose oxidation.
Topics: Alanine; Breast Neoplasms; Cell Line, Tumor; Citrate (si)-Synthase; Colonic Neoplasms; Female; Gene | 2019 |
Catabolism of exogenous lactate reveals it as a legitimate metabolic substrate in breast cancer.
Topics: Adult; Aged; Alanine; Animals; Breast Neoplasms; Cell Death; Cell Hypoxia; Cell Line, Tumor; Coumari | 2013 |
[Therapeutic effect of rebamipide for oral mucositis associated with FEC therapy for breast cancer].
Topics: Adult; Aged; Alanine; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophospha | 2014 |
Enantioselective Effects of Metalaxyl Enantiomers on Breast Cancer Cells Metabolic Profiling Using HPLC-QTOF-Based Metabolomics.
Topics: Alanine; Breast Neoplasms; Chromatography, High Pressure Liquid; Discriminant Analysis; Energy Metab | 2017 |
Transfection of the DAAO gene and subsequent induction of cytotoxic oxidative stress by D-alanine in 9L cells.
Topics: Alanine; Animals; Apoptosis; Blotting, Western; Brain Neoplasms; Breast Neoplasms; Carcinoma, Squamo | 2008 |
Design, synthesis, and evaluation of potent, nonpeptidic mimetics of second mitochondria-derived activator of caspases.
Topics: Alanine; Apoptosis; Apoptosis Regulatory Proteins; Breast Neoplasms; Bridged Bicyclo Compounds, Hete | 2009 |
+331G/A variant in the progesterone receptor gene, postmenopausal hormone use and risk of breast cancer.
Topics: Adult; Alanine; Breast Neoplasms; Case-Control Studies; Confidence Intervals; Estrogen Replacement T | 2009 |
Post-translational modification and stability of low molecular weight cyclin E.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Breast Neoplasms; Cell Line; Cell Line, Tumor | 2009 |
Manganese superoxide dismutase: effect of the ala16val polymorphism on protein, activity, and mRNA levels in human breast cancer cell lines and stably transfected mouse embryonic fibroblasts.
Topics: Alanine; Animals; Breast Neoplasms; Cell Line, Tumor; Female; Fibroblasts; Humans; Mice; Mice, Knock | 2010 |
Molecular consequences of genetic variations in the glutathione peroxidase 1 selenoenzyme.
Topics: Alanine; Alleles; Antioxidants; Breast Neoplasms; Codon; DNA Damage; Gene Expression Regulation, Enz | 2009 |
Amplification of fibroblast growth factor receptor-1 in breast cancer and the effects of brivanib alaninate.
Topics: Alanine; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Comparative | 2010 |
Polymorphism (ALA16VAL) correlates with regional lymph node status in breast cancer.
Topics: Alanine; Breast Neoplasms; Female; Gene Frequency; Genotype; Humans; Lymph Nodes; Middle Aged; Polym | 2010 |
Experimental treatment of oestrogen receptor (ER) positive breast cancer with tamoxifen and brivanib alaninate, a VEGFR-2/FGFR-1 kinase inhibitor: a potential clinical application of angiogenesis inhibitors.
Topics: Alanine; Angiogenesis Inhibitors; Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Ne | 2010 |
BCL-2 (-938C > A) polymorphism is associated with breast cancer susceptibility.
Topics: Adult; Aged; Alanine; Biomarkers, Tumor; Blotting, Western; Breast Neoplasms; Case-Control Studies; | 2011 |
Specificity of the volume-activated amino acid efflux pathway in cultured human breast cancer cells.
Topics: Adenosine Triphosphate; Alanine; Amino Acids; Aminoisobutyric Acids; Biological Transport; Breast Ne | 2011 |
13C high-resolution-magic angle spinning MRS reveals differences in glucose metabolism between two breast cancer xenograft models with different gene expression patterns.
Topics: Alanine; Animals; Breast Neoplasms; Carbon Isotopes; Female; Gene Expression Regulation, Neoplastic; | 2011 |
The p85α regulatory subunit of PI3K mediates cAMP-PKA and retinoic acid biological effects on MCF7 cell growth and migration.
Topics: Alanine; Animals; Antineoplastic Agents; Aspartic Acid; Breast Neoplasms; Cattle; Cell Cycle Checkpo | 2012 |
Role of glutathione peroxidase 1 in breast cancer: loss of heterozygosity and allelic differences in the response to selenium.
Topics: Adenocarcinoma; Alanine; Alleles; Amino Acid Substitution; Breast Neoplasms; Codon; DNA, Neoplasm; E | 2003 |
Role of glutathione peroxidase 1 in breast cancer: loss of heterozygosity and allelic differences in the response to selenium.
Topics: Adenocarcinoma; Alanine; Alleles; Amino Acid Substitution; Breast Neoplasms; Codon; DNA, Neoplasm; E | 2003 |
Role of glutathione peroxidase 1 in breast cancer: loss of heterozygosity and allelic differences in the response to selenium.
Topics: Adenocarcinoma; Alanine; Alleles; Amino Acid Substitution; Breast Neoplasms; Codon; DNA, Neoplasm; E | 2003 |
Role of glutathione peroxidase 1 in breast cancer: loss of heterozygosity and allelic differences in the response to selenium.
Topics: Adenocarcinoma; Alanine; Alleles; Amino Acid Substitution; Breast Neoplasms; Codon; DNA, Neoplasm; E | 2003 |
MnSOD polymorphism and breast cancer in a population-based case-control study.
Topics: Alanine; Alleles; Amino Acid Substitution; Breast Neoplasms; Case-Control Studies; Diet; Female; Hum | 2003 |
Effect of the methylenetetrahydrofolate reductase C677T polymorphism on chemosensitivity of colon and breast cancer cells to 5-fluorouracil and methotrexate.
Topics: Alanine; Animals; Antimetabolites, Antineoplastic; Blotting, Western; Breast Neoplasms; Cell Line, T | 2004 |
Allele-specific loss of heterozygosity at the DAL-1/4.1B (EPB41L3) tumor-suppressor gene locus in the absence of mutation.
Topics: Adult; Alanine; Alleles; Amino Acid Sequence; Amino Acid Substitution; Animals; Base Sequence; Breas | 2004 |
Manganese superoxide dismutase polymorphism, plasma antioxidants, cigarette smoking, and risk of breast cancer.
Topics: Adult; Alanine; Antioxidants; Breast Neoplasms; Case-Control Studies; Cohort Studies; Female; Genoty | 2004 |
Dynein light chain 1, a p21-activated kinase 1-interacting substrate, promotes cancerous phenotypes.
Topics: Alanine; Apoptosis; Blotting, Western; Breast Neoplasms; Carrier Proteins; Cell Cycle; Cell Division | 2004 |
Manganese superoxide dismutase Ala-9Val polymorphism and risk of breast cancer in a population-based case-control study of African Americans and whites.
Topics: Adult; Alanine; Alleles; Amino Acid Substitution; Black or African American; Breast Neoplasms; Case- | 2004 |
Genetic polymorphism in the manganese superoxide dismutase gene, antioxidant intake, and breast cancer risk: results from the Shanghai Breast Cancer Study.
Topics: Adult; Alanine; Alleles; Antioxidants; Breast Neoplasms; Case-Control Studies; Cocarcinogenesis; Die | 2004 |
Phosphorylation of progesterone receptor serine 400 mediates ligand-independent transcriptional activity in response to activation of cyclin-dependent protein kinase 2.
Topics: Alanine; Amino Acid Substitution; Animals; Blotting, Western; Breast Neoplasms; CDC2-CDC28 Kinases; | 2004 |
Importance of the central region of lamprey gonadotropin-releasing hormone III in the inhibition of breast cancer cell growth.
Topics: Alanine; Animals; Breast Neoplasms; Cell Line, Tumor; Cell Membrane; Cell Proliferation; Dose-Respon | 2005 |
Is the Val16Ala manganese superoxide dismutase polymorphism associated with the aging process?
Topics: Adult; Aged; Aged, 80 and over; Aging; Alanine; Antigens, CD; Breast Neoplasms; Cause of Death; DNA | 2005 |
Inducible expression of a degradation-resistant form of p27Kip1 causes growth arrest and apoptosis in breast cancer cells.
Topics: Adenoviridae; Alanine; Annexin A5; Apoptosis; Biomarkers, Tumor; Breast Neoplasms; CDC2-CDC28 Kinase | 2005 |
Tumor-suppressive maspin regulates cell response to oxidative stress by direct interaction with glutathione S-transferase.
Topics: Alanine; Arginine; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Separation; DNA, Comp | 2005 |
Characterization of two new variants of human catechol O-methyltransferase in vitro.
Topics: Alanine; Breast Neoplasms; Catechol O-Methyltransferase; DNA Methylation; Equilenin; Escherichia col | 2005 |
Polymorphisms of ADPRT Val762Ala and XRCC1 Arg399Glu and risk of breast cancer in Chinese women: a case control analysis.
Topics: Adult; Alanine; Amino Acid Substitution; Arginine; Asian People; Breast Neoplasms; Case-Control Stud | 2006 |
Effect of Smad7 expression on metastasis of mouse mammary carcinoma JygMC(A) cells.
Topics: Adenoviridae; Alanine; Animals; Arginine; Blotting, Western; Breast Neoplasms; Cell Adhesion; Cell L | 2005 |
Manganese superoxide dismutase Ala-9Val polymorphism, environmental modifiers, and risk of breast cancer in a German population.
Topics: Alanine; Breast Neoplasms; Environment; Female; Genotype; Germany; Humans; Middle Aged; Polymorphism | 2006 |
Peroxisome proliferator-activated [corrected] receptor-gamma2 [corrected] Pro12Ala, interaction with alcohol intake and NSAID use, in relation to risk of breast cancer in a prospective study of Danes.
Topics: Alanine; Alcohol Drinking; Anti-Inflammatory Agents, Non-Steroidal; Base Sequence; Breast Neoplasms; | 2007 |
Breast cancer risk and polymorphisms in genes involved in metabolism of estrogens (CYP17, HSD17beta1, COMT and MnSOD): possible protective role of MnSOD gene polymorphism Val/Ala and Ala/Ala in women that never breast fed.
Topics: Alanine; Breast Feeding; Breast Neoplasms; Case-Control Studies; Catechol O-Methyltransferase; Estra | 2006 |
Properties of volume-activated taurine efflux from human breast cancer cells.
Topics: Alanine; Breast Neoplasms; Calcium; Cell Line, Tumor; Cell Size; Chlorides; Female; Humans; Iodides; | 2006 |
Phosphorylation of MNAR promotes estrogen activation of phosphatidylinositol 3-kinase.
Topics: Alanine; Amino Acid Substitution; Animals; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Chlorocebu | 2007 |
Taxol induced apoptosis regulates amino acid transport in breast cancer cells.
Topics: Alanine; Amino Acid Transport Systems; Amino Acids; Antibiotics, Antineoplastic; Antineoplastic Agen | 2007 |
Nuclear localization signals of the E-cadherin transcriptional repressor Snail.
Topics: Active Transport, Cell Nucleus; Alanine; Amino Acid Motifs; Amino Acid Sequence; Amino Acid Substitu | 2007 |
Identification of BRCA1 missense substitutions that confer partial functional activity: potential moderate risk variants?
Topics: Alanine; Arginine; Biomarkers, Tumor; Breast Neoplasms; Centrosome; DNA, Complementary; Factor Analy | 2007 |
Site-directed mutagenesis of nm23-H1. Mutation of proline 96 or serine 120 abrogates its motility inhibitory activity upon transfection into human breast carcinoma cells.
Topics: Alanine; Amino Acid Sequence; Animals; Breast Neoplasms; Cell Division; Chemotaxis; Drosophila; Fema | 1996 |
Constitutively active human estrogen receptors containing amino acid substitutions for tyrosine 537 in the receptor protein.
Topics: Alanine; Amino Acid Sequence; Amino Acids; Animals; Binding Sites; Breast Neoplasms; CHO Cells; Cric | 1996 |
Non-radioactive detection of K-ras mutations by nested allele specific PCR and oligonucleotide hybridization.
Topics: Alanine; Amino Acid Substitution; Animals; Aspartic Acid; Breast Neoplasms; Codon; Colonic Neoplasms | 1998 |
Deletion of the loop region of Bcl-2 completely blocks paclitaxel-induced apoptosis.
Topics: Alanine; Amino Acid Substitution; Apoptosis; Breast Neoplasms; Calcium-Calmodulin-Dependent Protein | 1999 |
Ala99ser mutation in RI alpha regulatory subunit of protein kinase A causes reduced kinase activation by cAMP and arrest of hormone-dependent breast cancer cell growth.
Topics: Alanine; Amino Acid Substitution; Apoptosis; Breast Neoplasms; Cell Division; Cyclic AMP; Cyclic AMP | 1999 |
Potent active site-directed inhibition of steroid sulphatase by tricyclic coumarin-based sulphamates.
Topics: Alanine; Antineoplastic Agents; Arylsulfatases; Binding Sites; Breast Neoplasms; Coumarins; Dehydroe | 2000 |
Transforming growth factor beta receptor 1 polyalanine polymorphism and exon 5 mutation analysis in breast and ovarian cancer.
Topics: Adult; Aged; Aged, 80 and over; Alanine; Breast Neoplasms; DNA Mutational Analysis; Endometriosis; E | 2002 |
Nm23-H1 metastasis suppressor phosphorylation of kinase suppressor of Ras via a histidine protein kinase pathway.
Topics: Alanine; Amino Acid Substitution; Antigens, Neoplasm; Base Sequence; Breast Neoplasms; Cell Line; DN | 2002 |
Amino acid profiles correlate diagnostically with organ site in three kinds of malignant tumors.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Alanine; Amino Acids; Arginine; Breast Neoplasms; Ca | 1992 |
Immunosuppressive effects of L-asparaginase.
Topics: Adrenal Gland Neoplasms; Adult; Aged; Alanine; Antibody Formation; Antigens; Asparaginase; Asparagin | 1970 |
[Modification of some free amino acids in the serum of cancer patients under the influence of glucose on tumoral metabolism].
Topics: Alanine; Amino Acids; Breast Neoplasms; Chromatography, Paper; Dietary Carbohydrates; Dietary Protei | 1969 |