alanine has been researched along with Brain Injuries in 9 studies
Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.
Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
| Excerpt | Relevance | Reference |
|---|---|---|
| " During long-term administration of thiopental and midazolam, pathologically elevated ventricular CSF glutamate levels were associated with significantly increased glutamine and alanine levels up to 14 days after trauma." | 2.69 | Thiopental and midazolam do not seem to impede metabolism of glutamate in brain-injured patients. ( Kempski, OS; Kossmann, T; Morganti-Kossmann, MC; Pleines, UE; Stocker, R; Stover, JF, 1999) |
| " In particular, these calpain inhibitors showed oral bioavailability in rats as demonstrated by N-(1-benzyl-2-carbamoyl-2-oxoethyl)-2-[E-2-(4-diethylaminomethylphenyl)ethen-1-yl]benzamide (5d)." | 1.32 | Benzoylalanine-derived ketoamides carrying vinylbenzyl amino residues: discovery of potent water-soluble calpain inhibitors with oral bioavailability. ( Beckenbach, E; Bopp, S; Hofmann, HP; Kartal, A; Kästel, C; Lindner, T; Lubisch, W; Metz-Garrecht, M; Möller, A; Reeb, J; Regner, F; Vierling, M, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 4 (44.44) | 29.6817 |
| 2010's | 2 (22.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Winston, CN | 1 |
| Chellappa, D | 1 |
| Wilkins, T | 1 |
| Barton, DJ | 1 |
| Washington, PM | 1 |
| Loane, DJ | 1 |
| Zapple, DN | 1 |
| Burns, MP | 1 |
| Nägeli, M | 1 |
| Fasshauer, M | 1 |
| Sommerfeld, J | 1 |
| Fendel, A | 1 |
| Brandi, G | 1 |
| Stover, JF | 2 |
| Lubisch, W | 1 |
| Beckenbach, E | 1 |
| Bopp, S | 1 |
| Hofmann, HP | 1 |
| Kartal, A | 1 |
| Kästel, C | 1 |
| Lindner, T | 1 |
| Metz-Garrecht, M | 1 |
| Reeb, J | 1 |
| Regner, F | 1 |
| Vierling, M | 1 |
| Möller, A | 1 |
| Guo, YW | 1 |
| Xu, RX | 1 |
| Yang, DL | 1 |
| Xu, JF | 1 |
| Casey, PA | 1 |
| McKenna, MC | 1 |
| Fiskum, G | 1 |
| Saraswati, M | 1 |
| Robertson, CL | 1 |
| Kuchiwaki, H | 1 |
| Inao, S | 1 |
| Yamamoto, M | 1 |
| Yoshida, K | 1 |
| Sugita, K | 1 |
| Pleines, UE | 1 |
| Morganti-Kossmann, MC | 1 |
| Stocker, R | 1 |
| Kempski, OS | 1 |
| Kossmann, T | 1 |
| Ruscák, M | 1 |
| Hager, H | 1 |
| Orlický, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Improvement of Therapy in Patients With Severe Traumatic Brain Injury: Differential Impact of Local and Systemic Changes and Routinely Applied Drugs[NCT02130674] | Phase 4 | 12 participants (Actual) | Interventional | 2005-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 trials available for alanine and Brain Injuries
| Article | Year |
|---|---|
Prolonged continuous intravenous infusion of the dipeptide L-alanine- L-glutamine significantly increases plasma glutamine and alanine without elevating brain glutamate in patients with severe traumatic brain injury.
Topics: Adolescent; Adult; Alanine; Brain Injuries; Dipeptides; Female; Glutamic Acid; Glutamine; Humans; In | 2014 |
Effect of dipeptide of glutamine and alanine on severe traumatic brain injury.
Topics: Adolescent; Adult; Aged; Alanine; Brain Injuries; Child; Dipeptides; Female; Glutamine; Humans; Male | 2007 |
Thiopental and midazolam do not seem to impede metabolism of glutamate in brain-injured patients.
Topics: Adolescent; Adult; Aged; Alanine; Brain Injuries; Cerebral Ventricles; Glutamic Acid; Glutamine; Hum | 1999 |
6 other studies available for alanine and Brain Injuries
| Article | Year |
|---|---|
Controlled cortical impact results in an extensive loss of dendritic spines that is not mediated by injury-induced amyloid-beta accumulation.
Topics: Alanine; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Azepines; Brain Injur | 2013 |
Benzoylalanine-derived ketoamides carrying vinylbenzyl amino residues: discovery of potent water-soluble calpain inhibitors with oral bioavailability.
Topics: Administration, Oral; Alanine; Animals; Benzene Derivatives; Biological Availability; Blood Platelet | 2003 |
[Detection of amino acid neurotransmitters in cerebrospinal fluid of patients in persistent vegetative state].
Topics: Adolescent; Adult; Alanine; Aspartic Acid; Brain Injuries; Child; Female; Glutamic Acid; Glycine; Hu | 2005 |
Early and sustained alterations in cerebral metabolism after traumatic brain injury in immature rats.
Topics: Aging; Alanine; Animals; Animals, Newborn; Aspartic Acid; Brain; Brain Injuries; Cell Respiration; C | 2008 |
An assessment of progression of brain edema with amino acid levels in cerebrospinal fluid and changes in electroencephalogram in an adult cat model of cold brain injury.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Blood-Brain Barrier; Brain Edema; Brain Injuries; Cats | 1994 |
Alanine formation and alanine aminotransferase activity in the nerve tissue with proliferating macroglia.
Topics: Alanine; Alanine Transaminase; Animals; Brain Injuries; Cricetinae; Glycolysis; Hydrogen-Ion Concent | 1976 |