Page last updated: 2024-11-08

alanine and Aura

alanine has been researched along with Aura in 31 studies

Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.

Research Excerpts

ExcerptRelevanceReference
"Merck Serono SA (formerly Serono), under license from Newron Pharmaceuticals SpA (following its acquisition of the rights from Pharmacia and Upjohn AB [now Pfizer Inc]), is developing the oral alpha-aminoamide derivative of milacemide, safinamide, a monoamine oxidase-B and glutamate release inhibitor, for the potential treatment of Parkinson's disease, epilepsy and restless legs syndrome."8.84Safinamide for the treatment of Parkinson's disease, epilepsy and restless legs syndrome. ( Chazot, PL, 2007)
"Amino acid analysis of plasma and urine obtained from 12 patients with epilepsy indicated that the plasma concentrations of taurine and glutamic acid were much higher than might have been expected."7.65Biochemical observations following administration of taurine to patients with epilepsy. ( Anderman, F; Sacks, C; Sherwin, AL; Van Gelder, NM, 1975)
"Epilepsy is often considered to be a progressive neurological disease, and the nature of this progression remains unclear."5.72Insights into the development of pentylenetetrazole-induced epileptic seizures from dynamic metabolomic changes. ( Cheng, P; Jia, P; Liao, S; Meng, K; Xiao, C; Xu, R; Zhao, X; Zheng, X, 2022)
"Merck Serono SA (formerly Serono), under license from Newron Pharmaceuticals SpA (following its acquisition of the rights from Pharmacia and Upjohn AB [now Pfizer Inc]), is developing the oral alpha-aminoamide derivative of milacemide, safinamide, a monoamine oxidase-B and glutamate release inhibitor, for the potential treatment of Parkinson's disease, epilepsy and restless legs syndrome."4.84Safinamide for the treatment of Parkinson's disease, epilepsy and restless legs syndrome. ( Chazot, PL, 2007)
"Safinamide (formerly PNU-151774E), a sodium and calcium channel modulator that also inhibits monoamine oxidase B (MAOB), is under development by Newron Pharmaceuticals for the potential treatment of epilepsy, Parkinson's disease (PD), pain and stroke [345222], [348351]."4.81Safinamide (Newron Pharmaceuticals). ( Chazot, PL, 2001)
"The association between the superoxide dismutase 2 (SOD2) Val16Ala polymorphism and the serum aminotransferase levels was retrospectively investigated in 207 valproic acid-treated patients with epilepsy."3.78Superoxide dismutase 2 Val16Ala polymorphism is a risk factor for the valproic acid-related elevation of serum aminotransferases. ( Deguchi, M; Ishitsu, T; Kaneko, S; Nakagawa, K; Noai, M; Ogusu, N; Oniki, K; Saruwatari, J; Yasui-Furukori, N; Yoshida, S; Yoshimori, Y, 2012)
"Amino acid analysis of plasma and urine obtained from 12 patients with epilepsy indicated that the plasma concentrations of taurine and glutamic acid were much higher than might have been expected."3.65Biochemical observations following administration of taurine to patients with epilepsy. ( Anderman, F; Sacks, C; Sherwin, AL; Van Gelder, NM, 1975)
" However, management of acute seizures in patients with COVID-19 as well as management of PWE and COVID-19 needs to consider potential drug-drug interactions between antiseizure drugs and candidate drugs currently assessed as therapeutic options for COVID-19."2.72Management of COVID-19 in patients with seizures: Mechanisms of action of potential COVID-19 drug treatments and consideration for potential drug-drug interactions with anti-seizure medications. ( Chandra, PP; Jain, S; Potschka, H; Tripathi, M; Vohora, D, 2021)
"Safinamide was originated by Farmitalia-CarloErba in Italy."2.42Safinamide: FCE 26743, NW 1015, PNU 151774, PNU 151774E. ( , 2004)
"Epilepsy is often considered to be a progressive neurological disease, and the nature of this progression remains unclear."1.72Insights into the development of pentylenetetrazole-induced epileptic seizures from dynamic metabolomic changes. ( Cheng, P; Jia, P; Liao, S; Meng, K; Xiao, C; Xu, R; Zhao, X; Zheng, X, 2022)

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-199015 (48.39)18.7374
1990's4 (12.90)18.2507
2000's6 (19.35)29.6817
2010's3 (9.68)24.3611
2020's3 (9.68)2.80

Authors

AuthorsStudies
Zhao, X1
Cheng, P1
Xu, R1
Meng, K1
Liao, S1
Jia, P1
Zheng, X1
Xiao, C1
Iwahashi, Y1
Toyama, Y1
Imai, S1
Itoh, H1
Osawa, M1
Inoue, M1
Shimada, I1
Jain, S1
Potschka, H1
Chandra, PP1
Tripathi, M1
Vohora, D1
Vien, TN1
Modgil, A1
Abramian, AM1
Jurd, R1
Walker, J1
Brandon, NJ1
Terunuma, M1
Rudolph, U1
Maguire, J1
Davies, PA1
Moss, SJ1
Maciejak, P1
Szyndler, J1
Turzyńska, D1
Sobolewska, A1
Taracha, E1
Skórzewska, A1
Lehner, M1
Bidziński, A1
Hamed, A1
Wisłowska-Stanek, A1
Płaźnik, A1
Lewis, RW1
Mabry, J1
Polisar, JG1
Eagen, KP1
Ganem, B1
Hess, GP1
Saruwatari, J1
Deguchi, M1
Yoshimori, Y1
Noai, M1
Yoshida, S2
Ogusu, N1
Oniki, K1
Yasui-Furukori, N1
Kaneko, S1
Ishitsu, T1
Nakagawa, K1
Fariello, RG2
Chazot, PL2
Sawa, M1
Kaji, S1
Izumi, T1
Baba, M1
Brandt, NJ1
Christensen, E1
Robitaille, Y1
Sherwin, A1
Bonhaus, DW1
Lippincott, SE1
Huxtable, RJ1
van Gelder, NM4
Janjua, NA1
Metrakos, K1
MacGibbon, B1
Metrakos, JD1
Abdul-Ghani, AS1
Attwell, PJ1
Singh Kent, N1
Bradford, HF1
Croucher, MJ1
Jane, DE1
Maj, R1
Ukmar, G1
Varasi, M1
Pevarello, P1
McArthur, RA1
Salvati, P1
Sakai, R1
Koike, T1
Sasaki, M1
Shimamoto, K1
Oiwa, C1
Yano, A1
Suzuki, K1
Tachibana, K1
Kamiya, H1
Sherwin, AL2
Sacks, C1
Anderman, F1
Schousboe, A1
Westergaard, N1
Sonnewald, U1
Petersen, SB1
Yu, AC1
Hertz, L1
Peeling, J1
Sutherland, G1
Schwartz, RM1
Boyes, S1
Aynsley-Green, A1
Allen, IC1
Grieve, A1
Griffiths, R1
Sills, MA1
Forsythe, WI1
Haidukewych, D1
Craig, CR1
Hartman, ER1
Rasmussen, T1
Courtois, A1
Palo, J1
Savolainen, H1
Iivanainen, M1
Kolpakov, VG1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Taurine as an Anti-Manic Agent: A Double-Blind, Placebo-Controlled Study in Adolescents With Bipolar Disorder[NCT00391001]Phase 14 participants (Actual)Interventional2006-02-28Terminated
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

6 reviews available for alanine and Aura

ArticleYear
Management of COVID-19 in patients with seizures: Mechanisms of action of potential COVID-19 drug treatments and consideration for potential drug-drug interactions with anti-seizure medications.
    Epilepsy research, 2021, Volume: 174

    Topics: Adenosine Monophosphate; Alanine; Amides; Anti-Inflammatory Agents; Antibodies, Monoclonal, Humanize

2021
Safinamide: FCE 26743, NW 1015, PNU 151774, PNU 151774E.
    Drugs in R&D, 2004, Volume: 5, Issue:6

    Topics: Alanine; Animals; Anticonvulsants; Antiparkinson Agents; Benzylamines; Clinical Trials, Phase I as T

2004
Safinamide.
    Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2007, Volume: 4, Issue:1

    Topics: Alanine; Animals; Anticonvulsants; Benzylamines; Brain; Clinical Trials as Topic; Epilepsy; Humans;

2007
Safinamide for the treatment of Parkinson's disease, epilepsy and restless legs syndrome.
    Current opinion in investigational drugs (London, England : 2000), 2007, Volume: 8, Issue:7

    Topics: Alanine; Animals; Benzylamines; Clinical Trials as Topic; Epilepsy; Humans; Molecular Structure; Mon

2007
Safinamide (Newron Pharmaceuticals).
    Current opinion in investigational drugs (London, England : 2000), 2001, Volume: 2, Issue:6

    Topics: Alanine; Animals; Anticonvulsants; Antiparkinson Agents; Benzylamines; Clinical Trials as Topic; Con

2001
Regulatory role of astrocytes for neuronal biosynthesis and homeostasis of glutamate and GABA.
    Progress in brain research, 1992, Volume: 94

    Topics: Alanine; Amino Acids; Animals; Astrocytes; Brain; Cell Communication; Epilepsy; gamma-Aminobutyric A

1992

Other Studies

25 other studies available for alanine and Aura

ArticleYear
Insights into the development of pentylenetetrazole-induced epileptic seizures from dynamic metabolomic changes.
    Metabolic brain disease, 2022, Volume: 37, Issue:7

    Topics: Alanine; Animals; Anticonvulsants; Asparagine; Citrates; Creatine; Creatinine; Disease Models, Anima

2022
Conformational equilibrium shift underlies altered K
    Nature communications, 2020, 10-14, Volume: 11, Issue:1

    Topics: Alanine; Ataxia; Bacterial Proteins; Epilepsy; Humans; Ion Channel Gating; Long QT Syndrome; Magneti

2020
Compromising the phosphodependent regulation of the GABAAR β3 subunit reproduces the core phenotypes of autism spectrum disorders.
    Proceedings of the National Academy of Sciences of the United States of America, 2015, Dec-01, Volume: 112, Issue:48

    Topics: Alanine; Animals; Autism Spectrum Disorder; Behavior, Animal; Biotinylation; Cell Membrane; Dendriti

2015
The effects of group III mGluR ligands on pentylenetetrazol-induced kindling of seizures and hippocampal amino acids concentration.
    Brain research, 2009, Jul-28, Volume: 1282

    Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Convulsants; Disease Models, Animal; Dose-Response Re

2009
Dihydropyrimidinone positive modulation of delta-subunit-containing gamma-aminobutyric acid type A receptors, including an epilepsy-linked mutant variant.
    Biochemistry, 2010, Jun-15, Volume: 49, Issue:23

    Topics: Alanine; Allosteric Regulation; Cell Line; Drug Synergism; Epilepsy; Genetic Variation; Glutamic Aci

2010
Superoxide dismutase 2 Val16Ala polymorphism is a risk factor for the valproic acid-related elevation of serum aminotransferases.
    Epilepsy research, 2012, Volume: 99, Issue:1-2

    Topics: Adolescent; Adult; Aged; Alanine; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Male; M

2012
[Effect of homopantothenic acid upon experimentally induced epileptiform waves].
    Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica, 1966, Volume: 68, Issue:11

    Topics: Alanine; Aminobutyrates; Animals; Cats; Electroencephalography; Epilepsy; Penicillins; Strychnine

1966
Omega-aminoaciduria induced by gamma-vinyl GABA.
    Lancet (London, England), 1984, Feb-25, Volume: 1, Issue:8374

    Topics: Adult; Alanine; Aminocaproates; Aminoisobutyric Acids; beta-Alanine; Child; Epilepsy; Female; gamma-

1984
gamma-vinyl GABA, and GABA and beta-alanine transamination.
    Lancet (London, England), 1984, Mar-31, Volume: 1, Issue:8379

    Topics: 4-Aminobutyrate Transaminase; Alanine; Aminocaproates; beta-Alanine; Epilepsy; gamma-Aminobutyric Ac

1984
High affinity (3H) beta-alanine uptake by scar margins of ferric chloride-induced epileptogenic foci in rat isocortex.
    Journal of neuropathology and experimental neurology, 1984, Volume: 43, Issue:4

    Topics: Alanine; Animals; Astrocytes; beta-Alanine; Cerebral Cortex; Chlorides; Epilepsy; Ferric Compounds;

1984
Subcellular distribution of neuroactive amino acids in brains of genetically epileptic rats.
    Epilepsia, 1984, Volume: 25, Issue:5

    Topics: Alanine; Amino Acids; Animals; Brain Chemistry; Epilepsy; gamma-Aminobutyric Acid; Glutamates; Gluta

1984
Plasma amino acids in 3/sec spike-wave epilepsy.
    Neurochemical research, 1980, Volume: 5, Issue:6

    Topics: Adolescent; Adult; Alanine; Amino Acids; Aspartic Acid; Child; Child, Preschool; Epilepsy; Female; G

1980
Anti-epileptogenic and anticonvulsant activity of L-2-amino-4-phosphonobutyrate, a presynaptic glutamate receptor agonist.
    Brain research, 1997, May-02, Volume: 755, Issue:2

    Topics: Alanine; Aminobutyrates; Amygdala; Analysis of Variance; Animals; Anticonvulsants; Calcium Radioisot

1997
PNU-151774E protects against kainate-induced status epilepticus and hippocampal lesions in the rat.
    European journal of pharmacology, 1998, Oct-16, Volume: 359, Issue:1

    Topics: Alanine; Animals; Anticonvulsants; Benzylamines; Diazepam; Epilepsy; Hippocampus; Kainic Acid; Lamot

1998
Isolation, structure determination, and synthesis of neodysiherbaine A, a new excitatory amino acid from a marine sponge.
    Organic letters, 2001, May-17, Volume: 3, Issue:10

    Topics: Alanine; Animals; Bridged Bicyclo Compounds, Heterocyclic; Convulsants; Dose-Response Relationship,

2001
Biochemical observations following administration of taurine to patients with epilepsy.
    Brain research, 1975, Aug-29, Volume: 94, Issue:2

    Topics: Adolescent; Adult; Alanine; Anticonvulsants; Aspartic Acid; Cerebral Cortex; Child; Child, Preschool

1975
High-resolution 1H NMR spectroscopy studies of extracts of human cerebral neoplasms.
    Magnetic resonance in medicine, 1992, Volume: 24, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alanine; Amino Acids; Astrocytoma; Brain; Brain Neoplasm

1992
Metabolic effects of three ketogenic diets in the treatment of severe epilepsy.
    Developmental medicine and child neurology, 1989, Volume: 31, Issue:2

    Topics: Adolescent; Adult; Alanine; Blood Glucose; Child; Child, Preschool; Dietary Fats; Energy Metabolism;

1989
Differential changes in the content of amino acid neurotransmitters in discrete regions of the rat brain prior to the onset and during the course of homocysteine-induced seizures.
    Journal of neurochemistry, 1986, Volume: 46, Issue:5

    Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Brain; Corpus Striatum; Epilepsy; gamma-Aminobutyric A

1986
Role of octanoic and decanoic acids in the control of seizures.
    Archives of disease in childhood, 1986, Volume: 61, Issue:12

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adolescent; Alanine; Caprylates; Child; Child, Preschool; Circ

1986
Concentration of amino acids in the brain of cobalt-epileptic rat.
    Epilepsia, 1973, Volume: 14, Issue:4

    Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Brain Chemistry; Cerebral Cortex; Cobalt; Disease Mode

1973
Amino acid content of epileptogenic human brain: focal versus surrounding regions.
    Brain research, 1972, May-26, Volume: 40, Issue:2

    Topics: Adolescent; Adult; Alanine; Amino Acids; Aminobutyrates; Aspartic Acid; Brain; Cerebral Cortex; Chil

1972
Close correlation between changing content of specific amino acids in epileptogenic cortex of cats, and severity of epilepsy.
    Brain research, 1972, Aug-25, Volume: 43, Issue:2

    Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Cats; Cerebral Cortex; Cobalt; Electro

1972
Free amino acids and carbohydrates in the cerebrospinal fluid of 305 mentally retarded patients: a screening study.
    Journal of mental deficiency research, 1973, Volume: 17, Issue:2

    Topics: Adolescent; Adult; Alanine; Amino Acids; Arginine; Carbohydrates; Child; Child, Preschool; Chromatog

1973
[On the probable pathogenetic mechanisms of epilepsy].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1967, Volume: 67, Issue:5

    Topics: 5-Hydroxytryptophan; Alanine; Ammonia; Animals; Asparagine; Carboxy-Lyases; Epilepsy; Glutamates; Li

1967