alanine and Ataxia
alanine has been researched along with Ataxia in 13 studies
Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.
Ataxia: Impairment of the ability to perform smoothly coordinated voluntary movements. This condition may affect the limbs, trunk, eyes, pharynx, larynx, and other structures. Ataxia may result from impaired sensory or motor function. Sensory ataxia may result from posterior column injury or PERIPHERAL NERVE DISEASES. Motor ataxia may be associated with CEREBELLAR DISEASES; CEREBRAL CORTEX diseases; THALAMIC DISEASES; BASAL GANGLIA DISEASES; injury to the RED NUCLEUS; and other conditions.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "A mutation of alanine to threonine in the III S4-S5 linker of the mouse Scn8a sodium channel has previously been identified as causing the ataxia in med(jo) mice." | 3.70 | A mutation that causes ataxia shifts the voltage-dependence of the Scn8a sodium channel. ( Goldin, AL; Smith, MR, 1999) |
| "Episodic ataxia type 1 (EA1) is an autosomal dominant neurological disorder characterized by myokymia and attacks of ataxic gait often precipitated by stress." | 1.38 | Kv1.1 knock-in ataxic mice exhibit spontaneous myokymic activity exacerbated by fatigue, ischemia and low temperature. ( Botti, FM; Brunetti, O; D'Adamo, MC; Di Giovanni, G; Gibertini, S; Imbrici, P; Mora, M; Muscat, R; Pessia, M; Pettorossi, VE; Valentino, M; Zammit, C, 2012) |
Research
Studies (13)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (38.46) | 18.7374 |
| 1990's | 2 (15.38) | 18.2507 |
| 2000's | 1 (7.69) | 29.6817 |
| 2010's | 4 (30.77) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Iwahashi, Y | 1 |
| Toyama, Y | 1 |
| Imai, S | 1 |
| Itoh, H | 1 |
| Osawa, M | 1 |
| Inoue, M | 1 |
| Shimada, I | 1 |
| Yoshinaga, T | 1 |
| Sekijima, Y | 1 |
| Koyama, S | 1 |
| Maruyama, K | 1 |
| Yoshida, T | 1 |
| Kato, T | 1 |
| Ikeda, S | 1 |
| Johannesen, KM | 1 |
| Miranda, MJ | 1 |
| Lerche, H | 1 |
| Møller, RS | 1 |
| Brunetti, O | 1 |
| Imbrici, P | 1 |
| Botti, FM | 1 |
| Pettorossi, VE | 1 |
| D'Adamo, MC | 1 |
| Valentino, M | 1 |
| Zammit, C | 1 |
| Mora, M | 1 |
| Gibertini, S | 1 |
| Di Giovanni, G | 1 |
| Muscat, R | 1 |
| Pessia, M | 1 |
| Pelayo-Negro, AL | 1 |
| Sánchez-Quintana, C | 1 |
| Rodríguez-Oroz, MC | 1 |
| Volpini, V | 1 |
| Zeviani, M | 1 |
| Tola-Arribas, MA | 1 |
| Berciano, J | 1 |
| Infante, J | 1 |
| Mantuano, E | 1 |
| Veneziano, L | 1 |
| Evans, OB | 1 |
| Tanii, Y | 1 |
| Nishikawa, T | 1 |
| Hashimoto, A | 1 |
| Takahashi, K | 1 |
| Smith, MR | 1 |
| Goldin, AL | 1 |
| Blass, JP | 2 |
| Lonsdale, D | 1 |
| Uhlendorf, BW | 2 |
| Hom, E | 1 |
| Dunn, HG | 1 |
| Dolman, CL | 1 |
| Avigan, J | 1 |
| Guibaud, P | 1 |
Other Studies
13 other studies available for alanine and Ataxia
| Article | Year |
|---|---|
Conformational equilibrium shift underlies altered K
Topics: Alanine; Ataxia; Bacterial Proteins; Epilepsy; Humans; Ion Channel Gating; Long QT Syndrome; Magneti | 2020 |
Clinical and radiological findings of a cerebrotendinous xanthomatosis patient with a novel p.A335V mutation in the CYP27A1 gene.
Topics: Achilles Tendon; Alanine; Ataxia; Brain; Cataract; Chenodeoxycholic Acid; Cholestanetriol 26-Monooxy | 2014 |
Letter to the editor: confirming neonatal seizure and late onset ataxia in SCN2A Ala263Val.
Topics: Alanine; Ataxia; Epilepsy, Benign Neonatal; Female; Humans; Infant; Male; NAV1.2 Voltage-Gated Sodiu | 2016 |
Kv1.1 knock-in ataxic mice exhibit spontaneous myokymic activity exacerbated by fatigue, ischemia and low temperature.
Topics: Alanine; Animals; Ataxia; Calcium; Calcium Signaling; Cold Temperature; Disease Models, Animal; Elec | 2012 |
Screening for POLG W748S and A467T mutations in ataxia patients from Spain.
Topics: Adult; Age of Onset; Aged; Alanine; Ataxia; DNA Polymerase gamma; DNA-Directed DNA Polymerase; Femal | 2012 |
Early onset progressive ataxia associated with the first CACNA1A mutation identified within the I-II loop.
Topics: Alanine; Ataxia; Calcium Channels; Disease Progression; Humans; Mutation; Protein Structure, Tertiar | 2007 |
Pyruvate decarboxylase deficiency in subacute necrotizing encephalomyelopathy.
Topics: Alanine; Ataxia; Brain; Brain Diseases; Carbohydrate Metabolism, Inborn Errors; Carboxy-Lyases; Huma | 1981 |
Stereoselective antagonism by enantiomers of alanine and serine of phencyclidine-induced hyperactivity, stereotypy and ataxia in the rat.
Topics: Alanine; Animals; Ataxia; Injections, Intraventricular; Male; Motor Activity; Phencyclidine; Rats; R | 1994 |
A mutation that causes ataxia shifts the voltage-dependence of the Scn8a sodium channel.
Topics: Alanine; Amino Acid Substitution; Animals; Ataxia; Electrophysiology; Kinetics; Mice; Mutation; NAV1 | 1999 |
Intermittent ataxia with pyruvate-decarboxylase deficiency.
Topics: Alanine; Ataxia; Carboxy-Lyases; Hartnup Disease; Humans; Male; Metabolism, Inborn Errors; Pyruvates | 1971 |
Necrotizing encephalomyelopathy. Report of a case with relapsing polyneuropathy and hyperalaninemia and with manifestations resembling Friedreich's ataxia.
Topics: Alanine; Ataxia; Blindness; Brain; Brain Diseases; Bronchopneumonia; Cerebellar Ataxia; Child; Child | 1969 |
A defect in pyruvate decarboxylase in a child with an intermittent movement disorder.
Topics: Alanine; Ataxia; Carbon Isotopes; Carboxy-Lyases; Child; Female; Fibroblasts; Humans; Lactates; Leuk | 1970 |
[Intermittent ataxia with hyperpyruvicemia and hyperalaninuria (pyruvate decarboxylase deficiency)].
Topics: Alanine; Amino Acid Metabolism, Inborn Errors; Ataxia; Carboxy-Lyases; Child; Humans; Pyruvates | 1971 |