Page last updated: 2024-11-08

alanine and Ataxia

alanine has been researched along with Ataxia in 13 studies

Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.

Ataxia: Impairment of the ability to perform smoothly coordinated voluntary movements. This condition may affect the limbs, trunk, eyes, pharynx, larynx, and other structures. Ataxia may result from impaired sensory or motor function. Sensory ataxia may result from posterior column injury or PERIPHERAL NERVE DISEASES. Motor ataxia may be associated with CEREBELLAR DISEASES; CEREBRAL CORTEX diseases; THALAMIC DISEASES; BASAL GANGLIA DISEASES; injury to the RED NUCLEUS; and other conditions.

Research Excerpts

ExcerptRelevanceReference
"A mutation of alanine to threonine in the III S4-S5 linker of the mouse Scn8a sodium channel has previously been identified as causing the ataxia in med(jo) mice."3.70A mutation that causes ataxia shifts the voltage-dependence of the Scn8a sodium channel. ( Goldin, AL; Smith, MR, 1999)
"Episodic ataxia type 1 (EA1) is an autosomal dominant neurological disorder characterized by myokymia and attacks of ataxic gait often precipitated by stress."1.38Kv1.1 knock-in ataxic mice exhibit spontaneous myokymic activity exacerbated by fatigue, ischemia and low temperature. ( Botti, FM; Brunetti, O; D'Adamo, MC; Di Giovanni, G; Gibertini, S; Imbrici, P; Mora, M; Muscat, R; Pessia, M; Pettorossi, VE; Valentino, M; Zammit, C, 2012)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19905 (38.46)18.7374
1990's2 (15.38)18.2507
2000's1 (7.69)29.6817
2010's4 (30.77)24.3611
2020's1 (7.69)2.80

Authors

AuthorsStudies
Iwahashi, Y1
Toyama, Y1
Imai, S1
Itoh, H1
Osawa, M1
Inoue, M1
Shimada, I1
Yoshinaga, T1
Sekijima, Y1
Koyama, S1
Maruyama, K1
Yoshida, T1
Kato, T1
Ikeda, S1
Johannesen, KM1
Miranda, MJ1
Lerche, H1
Møller, RS1
Brunetti, O1
Imbrici, P1
Botti, FM1
Pettorossi, VE1
D'Adamo, MC1
Valentino, M1
Zammit, C1
Mora, M1
Gibertini, S1
Di Giovanni, G1
Muscat, R1
Pessia, M1
Pelayo-Negro, AL1
Sánchez-Quintana, C1
Rodríguez-Oroz, MC1
Volpini, V1
Zeviani, M1
Tola-Arribas, MA1
Berciano, J1
Infante, J1
Mantuano, E1
Veneziano, L1
Evans, OB1
Tanii, Y1
Nishikawa, T1
Hashimoto, A1
Takahashi, K1
Smith, MR1
Goldin, AL1
Blass, JP2
Lonsdale, D1
Uhlendorf, BW2
Hom, E1
Dunn, HG1
Dolman, CL1
Avigan, J1
Guibaud, P1

Other Studies

13 other studies available for alanine and Ataxia

ArticleYear
Conformational equilibrium shift underlies altered K
    Nature communications, 2020, 10-14, Volume: 11, Issue:1

    Topics: Alanine; Ataxia; Bacterial Proteins; Epilepsy; Humans; Ion Channel Gating; Long QT Syndrome; Magneti

2020
Clinical and radiological findings of a cerebrotendinous xanthomatosis patient with a novel p.A335V mutation in the CYP27A1 gene.
    Internal medicine (Tokyo, Japan), 2014, Volume: 53, Issue:23

    Topics: Achilles Tendon; Alanine; Ataxia; Brain; Cataract; Chenodeoxycholic Acid; Cholestanetriol 26-Monooxy

2014
Letter to the editor: confirming neonatal seizure and late onset ataxia in SCN2A Ala263Val.
    Journal of neurology, 2016, Volume: 263, Issue:7

    Topics: Alanine; Ataxia; Epilepsy, Benign Neonatal; Female; Humans; Infant; Male; NAV1.2 Voltage-Gated Sodiu

2016
Kv1.1 knock-in ataxic mice exhibit spontaneous myokymic activity exacerbated by fatigue, ischemia and low temperature.
    Neurobiology of disease, 2012, Volume: 47, Issue:3

    Topics: Alanine; Animals; Ataxia; Calcium; Calcium Signaling; Cold Temperature; Disease Models, Animal; Elec

2012
Screening for POLG W748S and A467T mutations in ataxia patients from Spain.
    Movement disorders : official journal of the Movement Disorder Society, 2012, Sep-01, Volume: 27, Issue:10

    Topics: Adult; Age of Onset; Aged; Alanine; Ataxia; DNA Polymerase gamma; DNA-Directed DNA Polymerase; Femal

2012
Early onset progressive ataxia associated with the first CACNA1A mutation identified within the I-II loop.
    Journal of the neurological sciences, 2007, Dec-15, Volume: 263, Issue:1-2

    Topics: Alanine; Ataxia; Calcium Channels; Disease Progression; Humans; Mutation; Protein Structure, Tertiar

2007
Pyruvate decarboxylase deficiency in subacute necrotizing encephalomyelopathy.
    Archives of neurology, 1981, Volume: 38, Issue:8

    Topics: Alanine; Ataxia; Brain; Brain Diseases; Carbohydrate Metabolism, Inborn Errors; Carboxy-Lyases; Huma

1981
Stereoselective antagonism by enantiomers of alanine and serine of phencyclidine-induced hyperactivity, stereotypy and ataxia in the rat.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 269, Issue:3

    Topics: Alanine; Animals; Ataxia; Injections, Intraventricular; Male; Motor Activity; Phencyclidine; Rats; R

1994
A mutation that causes ataxia shifts the voltage-dependence of the Scn8a sodium channel.
    Neuroreport, 1999, Sep-29, Volume: 10, Issue:14

    Topics: Alanine; Amino Acid Substitution; Animals; Ataxia; Electrophysiology; Kinetics; Mice; Mutation; NAV1

1999
Intermittent ataxia with pyruvate-decarboxylase deficiency.
    Lancet (London, England), 1971, Jun-19, Volume: 1, Issue:7712

    Topics: Alanine; Ataxia; Carboxy-Lyases; Hartnup Disease; Humans; Male; Metabolism, Inborn Errors; Pyruvates

1971
Necrotizing encephalomyelopathy. Report of a case with relapsing polyneuropathy and hyperalaninemia and with manifestations resembling Friedreich's ataxia.
    Neurology, 1969, Volume: 19, Issue:6

    Topics: Alanine; Ataxia; Blindness; Brain; Brain Diseases; Bronchopneumonia; Cerebellar Ataxia; Child; Child

1969
A defect in pyruvate decarboxylase in a child with an intermittent movement disorder.
    The Journal of clinical investigation, 1970, Volume: 49, Issue:3

    Topics: Alanine; Ataxia; Carbon Isotopes; Carboxy-Lyases; Child; Female; Fibroblasts; Humans; Lactates; Leuk

1970
[Intermittent ataxia with hyperpyruvicemia and hyperalaninuria (pyruvate decarboxylase deficiency)].
    Pediatrie, 1971, Volume: 26, Issue:4

    Topics: Alanine; Amino Acid Metabolism, Inborn Errors; Ataxia; Carboxy-Lyases; Child; Humans; Pyruvates

1971