Page last updated: 2024-11-08

alanine and Anxiety

alanine has been researched along with Anxiety in 10 studies

Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.

Anxiety: Feelings or emotions of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.

Research Excerpts

ExcerptRelevanceReference
" Here, we compared the efficacy of DZP with that of UBP302 [(S)-3-(2-carboxybenzyl)willardiine; an antagonist of the kainate receptors that contain the GluK1 subunit] against seizures, neuropathology, and behavioral deficits induced by soman in rats."7.80The limitations of diazepam as a treatment for nerve agent-induced seizures and neuropathology in rats: comparison with UBP302. ( Apland, JP; Aroniadou-Anderjaska, V; Braga, MF; Figueiredo, TH; Miller, SL; Rossetti, F, 2014)
" Mice treated with PGW5 (25 and 50mg/kg/d) for 28 days did not show toxic effects in terms of weight gain and blood-chemistry analysis."5.40A novel analog of olanzapine linked to sarcosinyl moiety (PGW5) demonstrates high efficacy and good safety profile in mouse models of schizophrenia. ( Bidder, M; Gil-Ad, I; Kramer, M; Portnoy, M; Taler, M; Tarasenko, I; Weizman, A, 2014)
" Here, we compared the efficacy of DZP with that of UBP302 [(S)-3-(2-carboxybenzyl)willardiine; an antagonist of the kainate receptors that contain the GluK1 subunit] against seizures, neuropathology, and behavioral deficits induced by soman in rats."3.80The limitations of diazepam as a treatment for nerve agent-induced seizures and neuropathology in rats: comparison with UBP302. ( Apland, JP; Aroniadou-Anderjaska, V; Braga, MF; Figueiredo, TH; Miller, SL; Rossetti, F, 2014)
"The α(2)δ auxiliary subunits (α(2)δ-1 and α(2)δ-2) of voltage-sensitive calcium channels are thought to be the site of action of pregabalin (Lyrica), a drug that has been shown to be anxiolytic in clinical trials for generalized anxiety disorder."3.77Anxiolytic-like activity of pregabalin in the Vogel conflict test in α2δ-1 (R217A) and α2δ-2 (R279A) mouse mutants. ( Donevan, S; El-Kattan, A; Lotarski, SM; Offord, J; Osgood, S; Poe, J; Taylor, CP, 2011)
" Mice treated with PGW5 (25 and 50mg/kg/d) for 28 days did not show toxic effects in terms of weight gain and blood-chemistry analysis."1.40A novel analog of olanzapine linked to sarcosinyl moiety (PGW5) demonstrates high efficacy and good safety profile in mouse models of schizophrenia. ( Bidder, M; Gil-Ad, I; Kramer, M; Portnoy, M; Taler, M; Tarasenko, I; Weizman, A, 2014)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (10.00)18.2507
2000's2 (20.00)29.6817
2010's6 (60.00)24.3611
2020's1 (10.00)2.80

Authors

AuthorsStudies
Lu, L1
Zheng, X1
Wang, S1
Tang, C1
Zhang, Y1
Yao, G1
Zeng, J1
Ge, S1
Wen, H1
Xu, M1
Guyatt, G1
Xu, N1
Marxreiter, F1
Ettle, B1
May, VE1
Esmer, H1
Patrick, C1
Kragh, CL1
Klucken, J1
Winner, B1
Riess, O1
Winkler, J1
Masliah, E1
Nuber, S1
Gil-Ad, I1
Portnoy, M1
Tarasenko, I1
Bidder, M1
Kramer, M1
Taler, M1
Weizman, A1
Apland, JP1
Aroniadou-Anderjaska, V1
Figueiredo, TH1
Rossetti, F1
Miller, SL1
Braga, MF1
Francisco, Eda S1
Guedes, RC1
Lo Iacono, L1
Gross, C1
Graham, DR1
Sidhu, A1
Lotarski, SM1
Donevan, S1
El-Kattan, A1
Osgood, S1
Poe, J1
Taylor, CP1
Offord, J1
Danysz, W1
Acosta, GB1

Reviews

2 reviews available for alanine and Anxiety

ArticleYear
Anti-Aβ agents for mild to moderate Alzheimer's disease: systematic review and meta-analysis.
    Journal of neurology, neurosurgery, and psychiatry, 2020, Volume: 91, Issue:12

    Topics: Acitretin; Alanine; Alzheimer Disease; Amyloid beta-Peptides; Antibodies, Monoclonal, Humanized; Anx

2020
LY-544344. Eli Lilly.
    IDrugs : the investigational drugs journal, 2005, Volume: 8, Issue:9

    Topics: Alanine; Animals; Anti-Anxiety Agents; Anxiety; Bridged Bicyclo Compounds; Clinical Trials as Topic;

2005

Other Studies

8 other studies available for alanine and Anxiety

ArticleYear
Glial A30P alpha-synuclein pathology segregates neurogenesis from anxiety-related behavior in conditional transgenic mice.
    Neurobiology of disease, 2013, Volume: 59

    Topics: Alanine; alpha-Synuclein; Animals; Anxiety; Avoidance Learning; Cell Count; Disease Models, Animal;

2013
A novel analog of olanzapine linked to sarcosinyl moiety (PGW5) demonstrates high efficacy and good safety profile in mouse models of schizophrenia.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2014, Volume: 24, Issue:3

    Topics: Alanine; Amphetamine; Animals; Antipsychotic Agents; Anxiety; Benzodiazepines; Brain; Central Nervou

2014
The limitations of diazepam as a treatment for nerve agent-induced seizures and neuropathology in rats: comparison with UBP302.
    The Journal of pharmacology and experimental therapeutics, 2014, Volume: 351, Issue:2

    Topics: Alanine; Amygdala; Animals; Anticonvulsants; Anxiety; Diazepam; Hippocampus; Male; Nerve Degeneratio

2014
Neonatal taurine and alanine modulate anxiety-like behavior and decelerate cortical spreading depression in rats previously suckled under different litter sizes.
    Amino acids, 2015, Volume: 47, Issue:11

    Topics: Alanine; Animals; Animals, Newborn; Anxiety; Behavior, Animal; Cortical Spreading Depression; Litter

2015
Alpha-Ca2+/calmodulin-dependent protein kinase II contributes to the developmental programming of anxiety in serotonin receptor 1A knock-out mice.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008, Jun-11, Volume: 28, Issue:24

    Topics: Actins; Alanine; Analysis of Variance; Animals; Animals, Newborn; Anxiety; Behavior, Animal; Calcium

2008
Mice expressing the A53T mutant form of human alpha-synuclein exhibit hyperactivity and reduced anxiety-like behavior.
    Journal of neuroscience research, 2010, Volume: 88, Issue:8

    Topics: Age Factors; Alanine; alpha-Synuclein; Analysis of Variance; Animals; Anxiety; Disease Models, Anima

2010
Anxiolytic-like activity of pregabalin in the Vogel conflict test in α2δ-1 (R217A) and α2δ-2 (R279A) mouse mutants.
    The Journal of pharmacology and experimental therapeutics, 2011, Volume: 338, Issue:2

    Topics: Alanine; Animals; Anti-Anxiety Agents; Anxiety; Arginine; Calcium Channels; Conflict, Psychological;

2011
Administration of cholecystokinin sulphated octapeptide (CCK-8S) induces changes on rat amino acid tissue levels and on a behavioral test for anxiety.
    General pharmacology, 1998, Volume: 31, Issue:4

    Topics: Alanine; Amino Acids; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Brain; Cerebral Corte

1998