alanine has been researched along with Angiogenesis, Pathologic in 11 studies
Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Most toxic effects were mild." | 2.76 | A phase I study to determine the safety, pharmacokinetics and pharmacodynamics of a dual VEGFR and FGFR inhibitor, brivanib, in patients with advanced or metastatic solid tumors. ( de Braud, F; Feltquate, DM; Galbraith, S; Goss, G; Jayson, GC; Jonker, DJ; Kantor, J; Kollia, G; McArthur, GA; Mokliatchouk, O; Nuyten, DSA; Rosen, LS; Rustin, G; Sawyer, MB; Sweeney, CJ; Syed, S; Velasquez, L; Wilding, G, 2011) |
| " Developing efficient nanodrugs could reduce the dosage and greatly improve the therapeutic effects in cancer treatments." | 1.46 | Amino acid functionalized gadofullerene nanoparticles with superior antitumor activity via destruction of tumor vasculature in vivo. ( Deng, R; Guan, M; Guo, J; Jia, W; Li, J; Li, X; Lu, Z; Shu, C; Sun, L; Wang, C; Yu, T; Zhang, Y; Zhen, M; Zhou, Y; Zou, T, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (18.18) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 6 (54.55) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Xiu, M | 1 |
| Li, L | 1 |
| Li, Y | 1 |
| Gao, Y | 1 |
| Zhou, Y | 1 |
| Deng, R | 1 |
| Zhen, M | 1 |
| Li, J | 2 |
| Guan, M | 1 |
| Jia, W | 1 |
| Li, X | 1 |
| Zhang, Y | 1 |
| Yu, T | 1 |
| Zou, T | 1 |
| Lu, Z | 1 |
| Guo, J | 1 |
| Sun, L | 1 |
| Shu, C | 1 |
| Wang, C | 1 |
| Khochenkov, DA | 1 |
| Solomko, ES | 1 |
| Peretolchina, NM | 1 |
| Ryabaya, OO | 1 |
| Stepanova, EV | 1 |
| Huynh, H | 1 |
| Ngo, VC | 1 |
| Fargnoli, J | 1 |
| Ayers, M | 1 |
| Soo, KC | 1 |
| Koong, HN | 1 |
| Thng, CH | 1 |
| Ong, HS | 1 |
| Chung, A | 1 |
| Chow, P | 1 |
| Pollock, P | 1 |
| Byron, S | 1 |
| Tran, E | 1 |
| Li, HX | 1 |
| Zhao, XY | 1 |
| Wang, L | 1 |
| Wang, YS | 1 |
| Kan, B | 1 |
| Xu, JR | 1 |
| Wen, YJ | 1 |
| Peng, XC | 1 |
| Chen, X | 1 |
| Yan, F | 1 |
| Ye, B | 1 |
| Du, XB | 1 |
| Zhao, JM | 1 |
| Yi, T | 1 |
| Chen, XC | 1 |
| Du, XX | 1 |
| Wei, YQ | 1 |
| Zhao, X | 1 |
| Jonker, DJ | 1 |
| Rosen, LS | 1 |
| Sawyer, MB | 1 |
| de Braud, F | 1 |
| Wilding, G | 1 |
| Sweeney, CJ | 1 |
| Jayson, GC | 1 |
| McArthur, GA | 1 |
| Rustin, G | 1 |
| Goss, G | 1 |
| Kantor, J | 1 |
| Velasquez, L | 1 |
| Syed, S | 1 |
| Mokliatchouk, O | 1 |
| Feltquate, DM | 1 |
| Kollia, G | 1 |
| Nuyten, DSA | 1 |
| Galbraith, S | 1 |
| Cai, J | 1 |
| Chen, Z | 1 |
| Ruan, Q | 1 |
| Han, S | 1 |
| Liu, L | 1 |
| Qi, X | 1 |
| Boye, SL | 1 |
| Hauswirth, WW | 1 |
| Grant, MB | 1 |
| Boulton, ME | 1 |
| Dings, RP | 1 |
| Kumar, N | 1 |
| Miller, MC | 1 |
| Loren, M | 1 |
| Rangwala, H | 1 |
| Hoye, TR | 1 |
| Mayo, KH | 1 |
| He, Y | 1 |
| Zhou, H | 1 |
| Tang, H | 1 |
| Luo, Y | 1 |
| Harper, JW | 1 |
| Vallee, BL | 2 |
| Shapiro, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase I Dose Escalation Study to Determine the Safety, Pharmacokinetics and Pharmacodynamics of BMS-582664 in Combination With Full Dose Erbitux in Patients With Advanced Gastrointestinal Malignancies Who Have Failed Prior Therapy[NCT00207051] | Phase 1 | 62 participants (Actual) | Interventional | 2006-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for alanine and Angiogenesis, Pathologic
| Article | Year |
|---|---|
An update regarding the role of WNK kinases in cancer.
Topics: Alanine; Animals; Bicarbonates; Mammals; Neoplasms; Neovascularization, Pathologic; Proline; Serine; | 2022 |
1 trial available for alanine and Angiogenesis, Pathologic
| Article | Year |
|---|---|
A phase I study to determine the safety, pharmacokinetics and pharmacodynamics of a dual VEGFR and FGFR inhibitor, brivanib, in patients with advanced or metastatic solid tumors.
Topics: Adult; Aged; Aged, 80 and over; Alanine; Angiogenesis Inhibitors; Antineoplastic Agents; Dose-Respon | 2011 |
9 other studies available for alanine and Angiogenesis, Pathologic
| Article | Year |
|---|---|
Amino acid functionalized gadofullerene nanoparticles with superior antitumor activity via destruction of tumor vasculature in vivo.
Topics: Alanine; Animals; Antinematodal Agents; Cell Line, Tumor; Female; Fullerenes; Gadolinium; Liver Neop | 2017 |
Antiangiogenic Activity of Alofanib, an Allosteric Inhibitor of Fibroblast Growth Factor Receptor 2.
Topics: Alanine; Allosteric Regulation; Angiogenesis Inhibitors; Animals; Benzoates; Bevacizumab; Cell Line; | 2015 |
Brivanib alaninate, a dual inhibitor of vascular endothelial growth factor receptor and fibroblast growth factor receptor tyrosine kinases, induces growth inhibition in mouse models of human hepatocellular carcinoma.
Topics: Alanine; Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Humans | 2008 |
Antitumor effect of mSurvivinThr34→Ala in murine colon carcinoma when administered intravenously.
Topics: Adoptive Transfer; Alanine; Animals; Apoptosis; Blotting, Western; CD4-Positive T-Lymphocytes; CD8-P | 2010 |
γ-Secretase and presenilin mediate cleavage and phosphorylation of vascular endothelial growth factor receptor-1.
Topics: Alanine; Amino Acid Sequence; Amyloid Precursor Protein Secretases; Animals; Cattle; Eye Proteins; I | 2011 |
Structure-based optimization of angiostatic agent 6DBF7, an allosteric antagonist of galectin-1.
Topics: Alanine; Amino Acid Sequence; Angiogenesis Inhibitors; Animals; Benzofurans; Binding Sites; Cell Lin | 2013 |
Deficiency of disulfide bonds facilitating fibrillogenesis of endostatin.
Topics: Alanine; Alzheimer Disease; Animals; Benzothiazoles; Cell Survival; Circular Dichroism; Disulfides; | 2006 |
Mutagenesis of aspartic acid-116 enhances the ribonucleolytic activity and angiogenic potency of angiogenin.
Topics: Alanine; Animals; Asparagine; Aspartic Acid; Chick Embryo; Mutation; Neoplasm Proteins; Neovasculari | 1988 |
Site-directed mutagenesis of histidine-13 and histidine-114 of human angiogenin. Alanine derivatives inhibit angiogenin-induced angiogenesis.
Topics: Alanine; Amino Acids; Angiogenesis Inducing Agents; Animals; Chick Embryo; Chromatography, High Pres | 1989 |