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alanine and Amyloidosis

alanine has been researched along with Amyloidosis in 17 studies

Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.

Amyloidosis: A group of sporadic, familial and/or inherited, degenerative, and infectious disease processes, linked by the common theme of abnormal protein folding and deposition of AMYLOID. As the amyloid deposits enlarge they displace normal tissue structures, causing disruption of function. Various signs and symptoms depend on the location and size of the deposits.

Research Excerpts

ExcerptRelevanceReference
"Oculopharyngeal muscular dystrophy is a late-onset disease caused by an elongation of a natural 10-alanine segment within the N-terminal domain of the nuclear poly(A)-binding protein 1 (PABPN1) to maximally 17 alanines."1.38Polyalanine-independent conformational conversion of nuclear poly(A)-binding protein 1 (PABPN1). ( Hause, G; Kühn, U; Schwarz, E; Winter, R, 2012)

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19902 (11.76)18.7374
1990's5 (29.41)18.2507
2000's5 (29.41)29.6817
2010's5 (29.41)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Sant'Anna, R1
Almeida, MR1
Varejāo, N1
Gallego, P1
Esperante, S1
Ferreira, P1
Pereira-Henriques, A1
Palhano, FL1
de Carvalho, M1
Foguel, D1
Reverter, D1
Saraiva, MJ1
Ventura, S1
Morgan, GJ1
Usher, GA1
Kelly, JW1
Podoly, E1
Hanin, G1
Soreq, H1
Dey, BR1
Chung, SS1
Spitzer, TR1
Zheng, H1
Macgillivray, TE1
Seldin, DC1
McAfee, S1
Ballen, K1
Attar, E1
Wang, T1
Shin, J1
Newton-Cheh, C1
Moore, S1
Sanchorawala, V1
Skinner, M3
Madsen, JC1
Semigran, MJ1
Winter, R1
Kühn, U1
Hause, G1
Schwarz, E1
Aldave, AJ1
Gutmark, JG1
Yellore, VS1
Affeldt, JA1
Meallet, MA1
Udar, N1
Rao, NA1
Small, KW1
Klintworth, GK1
Zambarakji, HJ1
Charteris, DG1
Ayliffe, W1
Luthert, PJ1
Schon, F1
Hawkins, PN1
Shimizu, Y1
Takeuchi, M1
Matsumura, M1
Tokuda, T1
Iwata, M1
Kristen, AV1
Ehlermann, P1
Helmke, B1
Hund, E1
Haberkorn, U1
Linke, RP1
Katus, HA1
Winter, P1
Altland, K2
Dengler, TJ1
Salvi, F1
Salvi, G1
Volpe, R1
Mencucci, R1
Plasmati, R1
Michelucci, R1
Gobbi, P1
Santangelo, M1
Ferlini, A1
Forabosco, A1
Théberge, R1
Connors, L1
Skare, J1
Falk, RH1
Costello, CE1
Akar, E1
Yalcinkaya, F1
Akar, N1
Baba, S1
Takahashi, T1
Kasama, T1
Shirasawa, H1
Jones, LA1
Skare, JC1
Cohen, AS1
Harding, JA1
Milunsky, A1
Koeppen, AH1
Wallace, MR2
Benson, MD2
Clerici, E1

Reviews

2 reviews available for alanine and Amyloidosis

ArticleYear
Alanine-to-threonine substitutions and amyloid diseases: butyrylcholinesterase as a case study.
    Chemico-biological interactions, 2010, Sep-06, Volume: 187, Issue:1-3

    Topics: Alanine; Amino Acid Substitution; Amyloidosis; Animals; Butyrylcholinesterase; Disease; Humans; Thre

2010
Genetic amyloidosis: recent advances.
    Advances in nephrology from the Necker Hospital, 1989, Volume: 18

    Topics: Alanine; Amyloidosis; DNA Mutational Analysis; Humans; Methionine; Polymorphism, Restriction Fragmen

1989

Other Studies

15 other studies available for alanine and Amyloidosis

ArticleYear
Cavity filling mutations at the thyroxine-binding site dramatically increase transthyretin stability and prevent its aggregation.
    Scientific reports, 2017, 03-24, Volume: 7

    Topics: Aged; Alanine; Amino Acid Substitution; Amyloidosis; Asymptomatic Diseases; Binding Sites; Crystallo

2017
Incomplete Refolding of Antibody Light Chains to Non-Native, Protease-Sensitive Conformations Leads to Aggregation: A Mechanism of Amyloidogenesis in Patients?
    Biochemistry, 2017, Dec-19, Volume: 56, Issue:50

    Topics: Alanine; Amyloid; Amyloidosis; Circular Dichroism; Endopeptidases; Humans; Immunoglobulin Light Chai

2017
Cardiac transplantation followed by dose-intensive melphalan and autologous stem-cell transplantation for light chain amyloidosis and heart failure.
    Transplantation, 2010, Oct-27, Volume: 90, Issue:8

    Topics: Adult; Aged; Alanine; Amyloidosis; Aspartate Aminotransferases; Cardiotonic Agents; Female; Heart Fa

2010
Polyalanine-independent conformational conversion of nuclear poly(A)-binding protein 1 (PABPN1).
    The Journal of biological chemistry, 2012, Jun-29, Volume: 287, Issue:27

    Topics: Alanine; Amyloidosis; Escherichia coli; Humans; Muscular Dystrophy, Oculopharyngeal; Poly(A)-Binding

2012
Lattice corneal dystrophy associated with the Ala546Asp and Pro551Gln missense changes in the TGFBI gene.
    American journal of ophthalmology, 2004, Volume: 138, Issue:5

    Topics: Adult; Alanine; Amyloid; Amyloidosis; Aspartic Acid; Cornea; Corneal Dystrophies, Hereditary; DNA Mu

2004
Vitreous amyloidosis in alanine 71 transthyretin mutation.
    The British journal of ophthalmology, 2005, Volume: 89, Issue:6

    Topics: Alanine; Amyloidosis; Eye Diseases; Female; Humans; Infant; Middle Aged; Mutation; Prealbumin; Vitre

2005
A case of biopsy-proven leptomeningeal amyloidosis and intravenous Ig-responsive polyneuropathy associated with the Ala25Thr transthyretin gene mutation.
    Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, 2006, Volume: 13, Issue:1

    Topics: Alanine; Amino Acid Substitution; Amyloid Neuropathies; Amyloidosis; Brain; Brain Stem; Cerebellum;

2006
Transthyretin valine-94-alanine, a novel variant associated with late-onset systemic amyloidosis with cardiac involvement.
    Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, 2007, Volume: 14, Issue:4

    Topics: Alanine; Amino Acid Substitution; Amyloidosis; Base Sequence; Cardiomyopathy, Dilated; DNA Mutationa

2007
Transthyretin-related TTR hereditary amyloidosis of the vitreous body. Clinical and molecular characterization in two Italian families.
    Ophthalmic paediatrics and genetics, 1993, Volume: 14, Issue:1

    Topics: Adult; Aged; Alanine; Amyloidosis; Eye Diseases; Female; Humans; Lens Diseases; Male; Middle Aged; M

1993
A new amyloidogenic transthyretin variant (Val122Ala) found in a compound heterozygous patient.
    Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, 1999, Volume: 6, Issue:1

    Topics: Alanine; Amyloid; Amyloidosis; Female; Heterozygote; Humans; Isoelectric Focusing; Male; Mass Spectr

1999
Is the Ala138Gly alteration of MEFV gene important for amyloidosis?
    Human mutation, 2001, Volume: 17, Issue:1

    Topics: Alanine; Amino Acid Substitution; Amyloidosis; Cytoskeletal Proteins; Familial Mediterranean Fever;

2001
Identification of two novel amyloid A protein subsets coexisting in an individual patient of AA-amyloidosis.
    Biochimica et biophysica acta, 1992, Dec-10, Volume: 1180, Issue:2

    Topics: Alanine; Amino Acid Sequence; Amyloid; Amyloidosis; Arthritis, Rheumatoid; Female; Humans; Middle Ag

1992
Familial amyloidotic polyneuropathy: a new transthyretin position 30 mutation (alanine for valine) in a family of German descent.
    Clinical genetics, 1992, Volume: 41, Issue:2

    Topics: Adult; Alanine; Amyloid; Amyloidosis; Base Sequence; DNA; Female; Germany; Humans; Male; Molecular S

1992
Familial amyloid polyneuropathy: alanine-for-threonine substitution in the transthyretin (prealbumin) molecule.
    Muscle & nerve, 1990, Volume: 13, Issue:11

    Topics: Adult; Aged; Alanine; Amyloidosis; Blotting, Southern; DNA; Female; Humans; Isoelectric Focusing; Ma

1990
Induction of amyloidosis in mice upon treatment with polypeptidyl-caseins and DNP-casein. Relation to antigenicity.
    Acta pathologica et microbiologica Scandinavica. Supplement, 1972, Volume: 233

    Topics: Alanine; Amyloidosis; Animals; Antigens; Caseins; Female; Hemagglutination Tests; Male; Mice; Nitrob

1972