alanine has been researched along with Amyloid Deposits in 6 studies
Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.
| Excerpt | Relevance | Reference |
|---|---|---|
| "An unresolved debate in Alzheimer's disease (AD) is whether amyloid plaques are pathogenic, causing overt physical disruption of neural circuits, or protective, sequestering soluble forms of amyloid-β (Aβ) that initiate synaptic damage and cognitive decline." | 1.40 | Genetic modulation of soluble Aβ rescues cognitive and synaptic impairment in a mouse model of Alzheimer's disease. ( Chiang, AC; Cirrito, JR; Fowler, SW; Jankowsky, JL; Larson, ME; Lesné, SE; Savjani, RR; Schuler, DR; Sherman, MA, 2014) |
| "Atherosclerosis is a chronic inflammatory disease resulting from interactions between lipids, macrophages and arterial wall cells." | 1.35 | gamma-Secretase inhibitor reduces diet-induced atherosclerosis in apolipoprotein E-deficient mice. ( Aoyama, T; Cheng, XW; Kikuchi, R; Liao, JK; Murohara, T; Takeshita, K; Yamamoto, K, 2009) |
| " The differential time courses in the three compartments do not seem to be due to pharmacokinetic factors." | 1.32 | Studies of Abeta pharmacodynamics in the brain, cerebrospinal fluid, and plasma in young (plaque-free) Tg2576 mice using the gamma-secretase inhibitor N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]az ( Adams, WJ; Hosley, JD; Lanz, TA; Merchant, KM, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fowler, SW | 1 |
| Chiang, AC | 1 |
| Savjani, RR | 1 |
| Larson, ME | 1 |
| Sherman, MA | 1 |
| Schuler, DR | 1 |
| Cirrito, JR | 1 |
| Lesné, SE | 1 |
| Jankowsky, JL | 1 |
| Aoyama, T | 1 |
| Takeshita, K | 1 |
| Kikuchi, R | 1 |
| Yamamoto, K | 1 |
| Cheng, XW | 1 |
| Liao, JK | 1 |
| Murohara, T | 1 |
| Li, T | 1 |
| Huang, Y | 1 |
| Jin, S | 1 |
| Ye, L | 1 |
| Rong, N | 1 |
| Yang, X | 1 |
| Ding, Y | 1 |
| Cheng, Z | 1 |
| Zhang, J | 1 |
| Wan, Z | 1 |
| Harrison, DC | 1 |
| Hussain, I | 1 |
| Hall, A | 1 |
| Lee, DH | 1 |
| Lau, LF | 1 |
| Matsuoka, Y | 1 |
| Busche, MA | 1 |
| Chen, X | 1 |
| Henning, HA | 1 |
| Reichwald, J | 1 |
| Staufenbiel, M | 1 |
| Sakmann, B | 1 |
| Konnerth, A | 1 |
| Lanz, TA | 1 |
| Hosley, JD | 1 |
| Adams, WJ | 1 |
| Merchant, KM | 1 |
| Manea, M | 1 |
| Kalászi, A | 1 |
| Mezo, G | 1 |
| Horváti, K | 1 |
| Bodor, A | 1 |
| Horváth, A | 1 |
| Farkas, O | 1 |
| Perczel, A | 1 |
| Przybylski, M | 1 |
| Hudecz, F | 1 |
6 other studies available for alanine and Amyloid Deposits
| Article | Year |
|---|---|
Genetic modulation of soluble Aβ rescues cognitive and synaptic impairment in a mouse model of Alzheimer's disease.
Topics: Alanine; Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; An | 2014 |
gamma-Secretase inhibitor reduces diet-induced atherosclerosis in apolipoprotein E-deficient mice.
Topics: Alanine; Amyloid Precursor Protein Secretases; Animals; Apolipoproteins E; Atherosclerosis; Azepines | 2009 |
Γ-secretase modulators do not induce Aβ-rebound and accumulation of β-C-terminal fragment.
Topics: Alanine; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Area Under Curve; Aze | 2012 |
Critical role of soluble amyloid-β for early hippocampal hyperactivity in a mouse model of Alzheimer's disease.
Topics: Age Factors; Alanine; Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases | 2012 |
Studies of Abeta pharmacodynamics in the brain, cerebrospinal fluid, and plasma in young (plaque-free) Tg2576 mice using the gamma-secretase inhibitor N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]az
Topics: Alanine; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopep | 2004 |
Antibody recognition and conformational flexibility of a plaque-specific beta-amyloid epitope modulated by non-native peptide flanking regions.
Topics: Alanine; Amyloid beta-Peptides; Antibodies, Monoclonal; Enzyme-Linked Immunosorbent Assay; Epitopes; | 2008 |