alanine has been researched along with Alloxan Diabetes in 95 studies
Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The following evidence suggests that diabetes mellitus may not be the simple consequence of relative or absolute insulin deficiency by itself, but may require the presence of glucagon: (1) relative or absolute hyperglucogonaemia has been identified in every form of endogenous hyperglycaemia, including total pancreatectomy in dogs; (2) insulin lack in the absence of glucagon does not cause endogenous hyperglycaemia, but when endogenous or exogenous glucagon is present, it quickly appears, irrespective of insulin levels at the time." | 7.65 | The essential role of glucagon in the pathogenesis of diabetes mellitus. ( Orci, L; Unger, RH, 1975) |
| "The following evidence suggests that diabetes mellitus may not be the simple consequence of relative or absolute insulin deficiency by itself, but may require the presence of glucagon: (1) relative or absolute hyperglucogonaemia has been identified in every form of endogenous hyperglycaemia, including total pancreatectomy in dogs; (2) insulin lack in the absence of glucagon does not cause endogenous hyperglycaemia, but when endogenous or exogenous glucagon is present, it quickly appears, irrespective of insulin levels at the time." | 3.65 | The essential role of glucagon in the pathogenesis of diabetes mellitus. ( Orci, L; Unger, RH, 1975) |
| " Various phosphonate prodrugs were explored without success, until a novel phosphonic diamide prodrug approach was implemented, which delivered compound 30j with good oral bioavailability (OBAV) (22-47%)." | 1.37 | Discovery of a series of phosphonic acid-containing thiazoles and orally bioavailable diamide prodrugs that lower glucose in diabetic animals through inhibition of fructose-1,6-bisphosphatase. ( Cashion, DK; Dang, Q; DaRe, J; Erion, MD; Fan, Y; Gibson, T; Jacintho, JD; Jiang, T; Kasibhatla, SR; Lemus, R; Li, H; Li, W; Liu, Y; Potter, SC; Sun, Z; Taplin, F; Tian, F; van Poelje, PD, 2011) |
| "Amlodipine did not affect cardiac hypertrophy." | 1.32 | Cardiovascular hypertrophy in diabetic spontaneously hypertensive rats: optimizing blockade of the renin-angiotensin system. ( Allen, TJ; Burrell, LM; Cao, Z; Cooper, ME; Davis, BJ; Lassila, M, 2003) |
| " Chronic administration of rebamipide (100 mg/kg/day, p." | 1.30 | Effects of rebamipide in a model of experimental diabetes and on the synthesis of transforming growth factor-beta and fibronectin, and lipid peroxidation induced by high glucose in cultured mesangial cells. ( Ha, H; Kim, KH; Lee, SH, 1997) |
| " In conclusion, this study suggests that short-term administration of LA at high dosage to normal and diabetic rats causes an inhibition of gluconeogenesis secondary to an interference with hepatic fatty acid oxidation." | 1.30 | Lipoic acid acutely induces hypoglycemia in fasting nondiabetic and diabetic rats. ( Bashan, N; Gutman, A; Khamaisi, M; Potashnik, R; Rudich, A; Tritschler, HJ, 1999) |
| "3." | 1.25 | Concentrations of free glucogenic amino acids in livers of rats subjected to various metabolic stresses. ( Lopes-Vieira, O; Walker, B; Williamson, DH, 1967) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 64 (67.37) | 18.7374 |
| 1990's | 16 (16.84) | 18.2507 |
| 2000's | 6 (6.32) | 29.6817 |
| 2010's | 7 (7.37) | 24.3611 |
| 2020's | 2 (2.11) | 2.80 |
| Authors | Studies |
|---|---|
| Ezeonwumelu, IJ | 2 |
| Mode, AM | 1 |
| Magaji, UF | 2 |
| Nzoniwu, NA | 1 |
| Tangaza, MH | 1 |
| Tanimu, FI | 1 |
| Dandare, SU | 2 |
| Shinkafi, TS | 1 |
| Adio, AA | 1 |
| Ahmad, K | 1 |
| Morze, CV | 1 |
| Allu, PKR | 1 |
| Chang, GY | 1 |
| Marco-Rius, I | 1 |
| Milshteyn, E | 1 |
| Wang, ZJ | 1 |
| Ohliger, MA | 1 |
| Gleason, CE | 1 |
| Kurhanewicz, J | 1 |
| Vigneron, DB | 1 |
| Pearce, D | 1 |
| Wang, B | 1 |
| Smyl, C | 1 |
| Chen, CY | 1 |
| Li, XY | 1 |
| Huang, W | 1 |
| Zhang, HM | 1 |
| Pai, VJ | 1 |
| Kang, JX | 1 |
| El-Bahy, AAZ | 1 |
| Aboulmagd, YM | 1 |
| Zaki, M | 1 |
| Kuipers, A | 1 |
| Moll, GN | 1 |
| Wagner, E | 1 |
| Franklin, R | 1 |
| Szkudelska, K | 1 |
| Nogowski, L | 1 |
| Szkudelski, T | 1 |
| McCommis, KS | 1 |
| Chen, Z | 1 |
| Fu, X | 1 |
| McDonald, WG | 1 |
| Colca, JR | 1 |
| Kletzien, RF | 1 |
| Burgess, SC | 1 |
| Finck, BN | 1 |
| Jensen-Waern, M | 1 |
| Andersson, M | 1 |
| Kruse, R | 1 |
| Nilsson, B | 1 |
| Larsson, R | 1 |
| Korsgren, O | 1 |
| Essén-Gustavsson, B | 1 |
| Dang, Q | 1 |
| Liu, Y | 1 |
| Cashion, DK | 1 |
| Kasibhatla, SR | 1 |
| Jiang, T | 1 |
| Taplin, F | 1 |
| Jacintho, JD | 1 |
| Li, H | 1 |
| Sun, Z | 1 |
| Fan, Y | 1 |
| DaRe, J | 1 |
| Tian, F | 1 |
| Li, W | 1 |
| Gibson, T | 1 |
| Lemus, R | 1 |
| van Poelje, PD | 1 |
| Potter, SC | 1 |
| Erion, MD | 1 |
| Lassila, M | 1 |
| Davis, BJ | 1 |
| Allen, TJ | 1 |
| Burrell, LM | 1 |
| Cooper, ME | 1 |
| Cao, Z | 1 |
| OJI, N | 1 |
| SAID, A | 1 |
| EL-HAWARY, MF | 1 |
| WAGLE, SR | 3 |
| ROSEN, F | 1 |
| HARDING, HR | 1 |
| MILHOLLAND, RJ | 1 |
| NICHOL, CA | 1 |
| BENTOR, V | 1 |
| WERTHEIMER, HE | 1 |
| ASHMORE, J | 1 |
| Kohli, R | 1 |
| Meininger, CJ | 1 |
| Haynes, TE | 1 |
| Yan, W | 1 |
| Self, JT | 1 |
| Wu, G | 1 |
| Malaisse, WJ | 1 |
| Willem, R | 1 |
| Williamson, DH | 1 |
| Lopes-Vieira, O | 1 |
| Walker, B | 1 |
| Lindsay, DB | 1 |
| Gonzalez, AM | 1 |
| Sochor, M | 1 |
| McLean, P | 1 |
| Stevenson, RW | 2 |
| Orskov, H | 1 |
| Parsons, JA | 2 |
| Alberti, KG | 3 |
| Past, MR | 1 |
| Cook, DE | 1 |
| Hetenyi, G | 3 |
| Anderson, PJ | 1 |
| Kinson, GA | 1 |
| Freyse, EJ | 3 |
| Fischer, U | 4 |
| Albrecht, G | 4 |
| Nosadini, R | 1 |
| Datta, H | 1 |
| Hodson, A | 1 |
| Tischler, ME | 1 |
| Kojima, H | 1 |
| Rizza, RA | 1 |
| Hall, LD | 1 |
| Westland, RE | 1 |
| Haymond, MW | 1 |
| Clemens, AH | 1 |
| Gerich, JE | 1 |
| Service, FJ | 1 |
| Barber, EF | 1 |
| Handlogten, ME | 1 |
| Vida, TA | 1 |
| Kilberg, MS | 1 |
| Zaleski, J | 1 |
| Zabłocki, K | 1 |
| Bryła, J | 1 |
| Buse, MG | 1 |
| Weigand, DA | 1 |
| Peeler, D | 1 |
| Hedden, MP | 1 |
| Layberry, RA | 1 |
| Foster, DM | 1 |
| Berman, M | 1 |
| Martin, RJ | 1 |
| Makula, A | 1 |
| Kasser, TR | 1 |
| Hotta, N | 2 |
| Komori, T | 2 |
| Kobayashi, M | 1 |
| Sakakibara, F | 2 |
| Koh, N | 2 |
| Sakamoto, N | 1 |
| Tormo, MA | 1 |
| Gómez-Zubeldia, MA | 1 |
| Ropero, F | 1 |
| Muñoz-Casillas, M | 1 |
| Moreno, JC | 1 |
| Campillo, JE | 1 |
| Chakir, M | 1 |
| D'Orléans-Juste, P | 1 |
| Plante, GE | 1 |
| Ferraz, M | 1 |
| Brunaldi, K | 1 |
| Oliveira, CE | 1 |
| Bazotte, RB | 1 |
| Mori, K | 1 |
| Nakamura, J | 1 |
| Hamada, Y | 1 |
| Hara, T | 1 |
| Nakashima, E | 1 |
| Naruse, K | 1 |
| Takeuchi, N | 1 |
| Ha, H | 1 |
| Lee, SH | 1 |
| Kim, KH | 1 |
| Meynial-Denis, D | 2 |
| Chavaroux, A | 2 |
| Foucat, L | 2 |
| Mignon, M | 2 |
| Prugnaud, J | 2 |
| Bayle, G | 2 |
| Renou, JP | 2 |
| Arnal, M | 2 |
| Gray, AM | 2 |
| Flatt, PR | 2 |
| Giacca, A | 1 |
| McCall, R | 1 |
| Chan, B | 1 |
| Shi, ZQ | 1 |
| Khamaisi, M | 1 |
| Rudich, A | 1 |
| Potashnik, R | 1 |
| Tritschler, HJ | 1 |
| Gutman, A | 2 |
| Bashan, N | 1 |
| Abdel-Wahab, YH | 1 |
| Chatham, JC | 1 |
| Des Rosiers, C | 1 |
| Forder, JR | 1 |
| Unger, RH | 3 |
| Orci, L | 1 |
| Cherrington, AD | 1 |
| Lacy, WW | 1 |
| Chiasson, JL | 1 |
| Goodman, MN | 2 |
| Ruderman, NB | 2 |
| Aoki, TT | 1 |
| Schmahl, FW | 1 |
| Snell, K | 1 |
| Duff, DA | 1 |
| Brockman, RP | 1 |
| Bergman, EN | 1 |
| Mondon, CE | 1 |
| Jones, IR | 1 |
| Azhar, S | 1 |
| Hollenbeck, CB | 1 |
| Reaven, GM | 1 |
| Bae, YS | 1 |
| Eun, HM | 1 |
| Pon, RT | 1 |
| Giron, D | 1 |
| Yoon, JW | 1 |
| Almdal, TP | 3 |
| Holst, JJ | 1 |
| Heindorff, H | 1 |
| Vilstrup, H | 3 |
| Grandini, SA | 1 |
| Brentegani, LG | 1 |
| Novaes, AB | 1 |
| Migliorini, RH | 1 |
| Fritze, K | 1 |
| Dunbar, JC | 1 |
| Schultz, S | 1 |
| Houser, F | 1 |
| Walker, J | 1 |
| Ardawi, MS | 1 |
| Fedorak, RN | 1 |
| Chang, EB | 1 |
| Madara, JL | 1 |
| Field, M | 2 |
| Cohen, SM | 2 |
| Barrett, EJ | 2 |
| Schwartz, RG | 1 |
| Young, LH | 1 |
| Jacob, R | 3 |
| Zaret, BL | 1 |
| Marx, S | 1 |
| Keilacker, H | 1 |
| Albisser, AM | 1 |
| Nomura, M | 1 |
| McPhedran, NT | 1 |
| Couderc, R | 1 |
| Durand, G | 1 |
| Feger, J | 1 |
| Agneray, J | 1 |
| Kalderon, B | 1 |
| Levy, E | 1 |
| Shafrir, E | 1 |
| Adler, JH | 1 |
| Nissim, I | 1 |
| Lapidot, A | 1 |
| Rosenthal, N | 1 |
| Rosenthal, NR | 1 |
| Barrett, E | 1 |
| Ribes, G | 1 |
| Valette, G | 1 |
| Dalstein, JM | 1 |
| Loubatieres-Mariani, MM | 1 |
| Balasse, EO | 1 |
| De Graef, J | 1 |
| Neef, MA | 1 |
| Exton, JH | 1 |
| Mallette, LE | 1 |
| Jefferson, LS | 1 |
| Wong, EH | 1 |
| Friedmann, N | 1 |
| Miller, TB | 1 |
| Park, CR | 1 |
| Ingebretsen, WR | 1 |
| Moxley, MA | 1 |
| Allen, DO | 1 |
| Sakurai, H | 1 |
| Dobbs, R | 1 |
| Rasio, EA | 1 |
| Huchzermeyer, H | 1 |
| Rudorff, KH | 3 |
| Staib, W | 3 |
| Harris, RA | 1 |
| Leland, MC | 1 |
| Mahoney, JM | 1 |
| Mapes, JP | 1 |
| Scheynius, A | 1 |
| Täljedal, IB | 1 |
| Eaton, RP | 1 |
| Kipnis, DM | 1 |
| Nakagawa, H | 1 |
| Miura, S | 1 |
| Kimura, H | 1 |
| Kanatsuna, T | 1 |
| Fromm, D | 1 |
| Silen, W | 1 |
| Bauman, N | 1 |
| Pease, BS | 1 |
| Flock, EV | 1 |
| Tyce, GM | 1 |
| Owen, CA | 1 |
| Friedmann, B | 1 |
| Goodman, EH | 1 |
| Weinhouse, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Involvement of Steatosis-induced Glucagon Resistance in Hyperglucagonaemia[NCT02337660] | 30 participants (Actual) | Interventional | 2015-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for alanine and Alloxan Diabetes
| Article | Year |
|---|---|
Hormonal regulation of protein degradation in skeletal and cardiac muscle.
Topics: Adrenalectomy; Alanine; Animals; Corticosterone; Diabetes Mellitus, Experimental; Epinephrine; Fasti | 1981 |
The hormonal control of hepatic gluconeogenesis.
Topics: Adrenal Glands; Adrenalectomy; Alanine; Amino Acids; Animals; Carbon Isotopes; Cyclic AMP; Dexametha | 1970 |
The control of glucagon secretion.
Topics: Adaptation, Physiological; Alanine; Animals; Diabetes Mellitus, Experimental; Diazoxide; Dogs; Fasti | 1972 |
Glucagon physiology and pathophysiology.
Topics: Alanine; Amino Acids; Animals; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Experimental; Di | 1971 |
91 other studies available for alanine and Alloxan Diabetes
| Article | Year |
|---|---|
Coadministration of L-alanine and L-glutamine ameliorate blood glucose levels, biochemical indices and histological features in alloxan-induced diabetic rats.
Topics: Alanine; Alloxan; Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Glutamine; | 2022 |
L-alanine supplementation improves blood glucose level and biochemical indices in alloxan-induced diabetic rats.
Topics: Alanine; Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dietary Supplements; Huma | 2021 |
Non-invasive detection of divergent metabolic signals in insulin deficiency vs. insulin resistance in vivo.
Topics: Alanine; Animals; Diabetes Mellitus, Experimental; Gluconeogenesis; Insulin; Insulin Resistance; Kid | 2018 |
Suppression of Postprandial Blood Glucose Fluctuations by a Low-Carbohydrate, High-Protein, and High-Omega-3 Diet via Inhibition of Gluconeogenesis.
Topics: Alanine; Alanine Transaminase; Animals; Blood Glucose; Carbon Isotopes; Diabetes Mellitus, Experimen | 2018 |
Diabetex: A novel approach for diabetic wound healing.
Topics: Alanine; Animals; Ascorbic Acid; Blood Coagulation; Blood Glucose; Collagen; Diabetes Mellitus, Expe | 2018 |
Efficacy of lanthionine-stabilized angiotensin-(1-7) in type I and type II diabetes mouse models.
Topics: Alanine; Angiotensin I; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, | 2019 |
Adipocyte dysfunction in rats with streptozotocin-nicotinamide-induced diabetes.
Topics: Adipocytes; Adipose Tissue; Alanine; Animals; Diabetes Mellitus, Experimental; Glucose; Lipogenesis; | 2014 |
Loss of Mitochondrial Pyruvate Carrier 2 in the Liver Leads to Defects in Gluconeogenesis and Compensation via Pyruvate-Alanine Cycling.
Topics: Alanine; Animals; Blood Glucose; Cell Line; Citric Acid Cycle; Diabetes Mellitus, Experimental; Gluc | 2015 |
Effects of streptozotocin-induced diabetes in domestic pigs with focus on the amino acid metabolism.
Topics: Alanine; Amino Acids; Amino Acids, Branched-Chain; Animals; Blood Glucose; Body Weight; C-Peptide; D | 2009 |
Discovery of a series of phosphonic acid-containing thiazoles and orally bioavailable diamide prodrugs that lower glucose in diabetic animals through inhibition of fructose-1,6-bisphosphatase.
Topics: Administration, Oral; Alanine; Amides; Animals; Biological Availability; Blood Proteins; Diabetes Me | 2011 |
Cardiovascular hypertrophy in diabetic spontaneously hypertensive rats: optimizing blockade of the renin-angiotensin system.
Topics: Alanine; Amiodarone; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Ani | 2003 |
The influence of steroid hormones on gluconeogenesis in rats with experimental diabetes.
Topics: Alanine; Animals; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Experimental; Gluconeogenesis | 1963 |
Role of the Strecker degradation of alpha-amino acid in alloxan diabetes.
Topics: Alanine; Amino Acids; Animals; Diabetes Mellitus, Experimental; Glycine | 1962 |
THE INFLUENCE OF GROWTH HORMONE, CORTISOL AND INSULIN ON THE INCORPORATION OF AMINO ACIDS INTO PROTEIN.
Topics: Adrenal Glands; Alanine; Amino Acids; Animals; Carbon Isotopes; Diabetes Mellitus, Experimental; Glu | 1963 |
GLUCOCORTICOIDS AND TRANSAMINASE ACTIVITY. VI. COMPARISON OF THE ADAPTIVE INCREASES OF ALANINE- AND TYROSINE-ALPHA-KETOGLUTARATE TRANSAMINASES.
Topics: Adrenalectomy; Alanine; Alanine Transaminase; Animals; Carcinoma 256, Walker; Desoxycorticosterone; | 1963 |
TRANSPORT AND INCORPORATION OF AMINO ACIDS INTO THE AORTIC WALL: INFLUENCE OF AGE AND HORMONES.
Topics: Aging; Alanine; Amino Acids; Aminobutyrates; Animals; Aorta; Carbon Isotopes; Diabetes Mellitus, Exp | 1964 |
STUDIES ON EXPERIMENTAL DIABETES. 3. EFFECTS OF ACUTE INSULIN INSUFFICIENCY ON 14C-GLUCOSE FORMATION FROM LABELED SUBSTRATES.
Topics: Alanine; Animals; Carbohydrate Metabolism; Carbon Dioxide; Carbon Isotopes; Diabetes Mellitus, Exper | 1964 |
Dietary L-arginine supplementation enhances endothelial nitric oxide synthesis in streptozotocin-induced diabetic rats.
Topics: Alanine; Amino Acids; Animals; Arginine; Blood Glucose; Body Weight; Coronary Vessels; Diabetes Mell | 2004 |
Isotopic discrimination between D-[1-(13)C]fructose and D-[2-(13)C]fructose in rat liver cells.
Topics: Alanine; Animals; Carbon Isotopes; Cell Separation; Deuterium; Diabetes Mellitus, Experimental; Fruc | 2004 |
Concentrations of free glucogenic amino acids in livers of rats subjected to various metabolic stresses.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Diabetes Mellitus, Experimental; Gluconeogenesis; Glut | 1967 |
Relationships between amino acid catabolism and protein anabolism in the ruminant.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Cattle; Diabetes Mellitus, Experimental; Gluconeogenes | 1982 |
Effect of experimental diabetes on glycolytic intermediates and regulation of phosphofructokinase in rat lens.
Topics: Adenine Nucleotides; Alanine; Animals; Cyclic AMP; Diabetes Mellitus, Experimental; Fructosediphosph | 1980 |
Metabolic responses to intraduodenal glucose loading in insulin-infused diabetic dogs.
Topics: 3-Hydroxybutyric Acid; Alanine; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Fatty | 1983 |
Catalytic activities of cytochrome P-450 from female rat liver: correlation with sex differences in drug metabolism in diabetic liver.
Topics: Alanine; Animals; Catalysis; Cytochrome P-450 Enzyme System; Diabetes Mellitus, Experimental; Ethylm | 1983 |
Gluconeogenesis from threonine in normal and diabetic rats.
Topics: Alanine; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Gluconeogenesis; Kinetics; Male; R | 1984 |
Tracer kinetic studies of glucose and alanine metabolism in diabetic dogs on the artificial beta cell.
Topics: Alanine; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Dogs; I | 1984 |
A possible mechanism for the anti-ketogenic action of alanine in the rat.
Topics: Alanine; Animals; Asparagine; Aspartic Acid; Depression, Chemical; Diabetes Mellitus, Experimental; | 1980 |
Comparison of the metabolic responses to portal and peripheral infusions of insulin in diabetic dogs.
Topics: 3-Hydroxybutyric Acid; Alanine; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Gluca | 1981 |
Correction for the metabolic exchange of 14C for 12C atoms in the pathway of gluconeogenesis in vivo.
Topics: Alanine; Animals; Bicarbonates; Blood Glucose; Carbon; Carbon Radioisotopes; Citric Acid Cycle; Diab | 1982 |
Biochemical changes after surgical stress in rabbits.
Topics: Alanine; Animals; Blood Glucose; Blood Proteins; Blood Urea Nitrogen; Diabetes Mellitus, Experimenta | 1982 |
Comparison of peripheral and portal venous insulin administration on postprandial metabolic responses in alloxan-diabetic dogs. Effects of identical preprogrammed complex insulin infusion waveforms.
Topics: Alanine; Amino Acids, Branched-Chain; Animals; Diabetes Mellitus, Experimental; Dogs; Glucagon; Infu | 1982 |
Neutral amino acid transport in hepatocytes isolated from streptozotocin-induced diabetic rats.
Topics: Adrenalectomy; Alanine; Amino Acids; Aminoisobutyric Acids; Animals; Biological Transport; Cells, Cu | 1982 |
The stimulatory effect of alloxan-diabetes on the gluconeogenesis from alanine and glutamine in rabbit hepatocytes.
Topics: Alanine; Animals; Biological Transport; Diabetes Mellitus, Experimental; Food; Gluconeogenesis; Glut | 1981 |
The effect of diabetes and the redox potential on amino acid content and release by isolated rat hemidiaphragms.
Topics: Alanine; Amino Acids; Animals; Cycloheximide; Diabetes Mellitus, Experimental; Diaphragm; Electron T | 1980 |
Transfer of carbon atoms among circulating glucose, alanine, and lactate in pancreatectomized dogs.
Topics: Alanine; Animals; Blood Glucose; Carbon; Carbon Radioisotopes; Diabetes Mellitus, Experimental; Dogs | 1980 |
Placental metabolism and enzyme activities in diabetic pigs.
Topics: Alanine; Alanine Transaminase; Alloxan; Animals; Aspartate Aminotransferases; Diabetes Mellitus, Exp | 1980 |
The inhibitory action of buformin, a biguanide on gluconeogenesis from alanine and its transport system in rat livers.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Alanine; Animals; Biological Transport, Active; Buformin; Cell | 1993 |
Experimental streptozotocin-reduced diabetes and intestinal glucose metabolism in the rat, in vivo and in vitro.
Topics: Alanine; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucose; Glycolysis; In Vitro Tech | 1995 |
Neutral endopeptidase inhibition, a new approach in the exploration of diabetic vasculopathy in rats.
Topics: Alanine; Animals; Blood Pressure; Capillary Permeability; Captopril; Diabetes Mellitus, Experimental | 1995 |
Hepatic glucose production from L-alanine is absent in perfused liver of diabetic rats.
Topics: Alanine; Alloxan; Animals; Anti-Bacterial Agents; Diabetes Mellitus, Experimental; Gluconeogenesis; | 1997 |
Increased alanine uptake and lipid synthesis from alanine in isolated hepatocytes of Wistar-Kyoto fatty rats: an inhibitory effect of biguanides.
Topics: Aging; Alanine; Animals; Body Weight; Buformin; Cells, Cultured; Diabetes Mellitus, Experimental; Di | 1997 |
Effects of rebamipide in a model of experimental diabetes and on the synthesis of transforming growth factor-beta and fibronectin, and lipid peroxidation induced by high glucose in cultured mesangial cells.
Topics: Alanine; Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Fibronectins; | 1997 |
Contribution of proteolysis and de novo synthesis to alanine production in diabetic rat skeletal muscle: a 15N/1H nuclear magnetic resonance study.
Topics: Alanine; Animals; Diabetes Mellitus, Experimental; Female; Gas Chromatography-Mass Spectrometry; Leu | 1997 |
Despite similar rates of alanine release, fasting and diabetes affect de novo alanine synthesis differently.
Topics: Alanine; Animals; Diabetes Mellitus, Experimental; Fasting; Rats | 1998 |
Insulin-releasing and insulin-like activity of Agaricus campestris (mushroom).
Topics: 1-Methyl-3-isobutylxanthine; Abdominal Muscles; Agaricus; Alanine; Animals; Biological Transport; Bl | 1998 |
Increased dependence of glucose production on peripheral insulin in diabetic depancreatized dogs.
Topics: Alanine; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Fatty Acids, Nonesterified; | 1999 |
Lipoic acid acutely induces hypoglycemia in fasting nondiabetic and diabetic rats.
Topics: 3-Hydroxybutyric Acid; Alanine; Animals; Blood Glucose; Carnitine; Diabetes Mellitus, Experimental; | 1999 |
The traditional plant treatment, Sambucus nigra (elder), exhibits insulin-like and insulin-releasing actions in vitro.
Topics: 1-Methyl-3-isobutylxanthine; Alanine; Animals; Diabetes Mellitus, Experimental; Gluconeogenesis; Glu | 2000 |
Evidence of separate pathways for lactate uptake and release by the perfused rat heart.
Topics: Alanine; Animals; Carbon Isotopes; Diabetes Mellitus, Experimental; Glucose; Heart; Lactates; Magnet | 2001 |
The essential role of glucagon in the pathogenesis of diabetes mellitus.
Topics: Alanine; Animals; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Experimental; Dogs; Glucagon; | 1975 |
Effect of glucagon on glucose production during insulin deficiency in the dog.
Topics: Alanine; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Female; Glucagon; Gluconeoge | 1978 |
Glucose and amino acid metabolism in perfused skeletal muscle. Effect of dichloroacetate.
Topics: Acetates; Alanine; Amino Acids; Animals; Diabetes Mellitus, Experimental; Dichloroacetic Acid; Femal | 1978 |
Regulation of alanine formation and release in rat muscle in vivo: effect of starvation and diabetes.
Topics: Alanine; Animals; Biological Transport, Active; Blood Glucose; Diabetes Mellitus, Experimental; Fema | 1977 |
Alanine release by rat adipose tissue in vitro.
Topics: Adipose Tissue; Alanine; Animals; Diabetes Mellitus, Experimental; Glucose; Glutamates; Lactates; Le | 1977 |
Effect of glucagon on plasma alanine and glutamine metabolism and hepatic gluconeogenesis in sheep.
Topics: Alanine; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Female; Glucagon; Gluconeogenesis; | 1975 |
Lactate production and pyruvate dehydrogenase activity in fat and skeletal muscle from diabetic rats.
Topics: Adipose Tissue; Alanine; Animals; Biological Transport; Blood Glucose; Cells, Cultured; Diabetes Mel | 1992 |
Two amino acids, Phe 16 and Ala 776, on the polyprotein are most likely to be responsible for the diabetogenicity of encephalomyocarditis virus.
Topics: Alanine; Amino Acid Sequence; Animals; Base Sequence; Cloning, Molecular; Codon; Diabetes Mellitus, | 1990 |
Glucagon immunoneutralization in diabetic rats normalizes urea synthesis and decreases nitrogen wasting.
Topics: Alanine; Animals; Antibodies; Blood Glucose; Diabetes Mellitus, Experimental; Female; Glucagon; Nitr | 1992 |
Protein synthesis in wound after tooth extraction in pancreatectomized diabetic rats.
Topics: Alanine; Alveolar Process; Animals; Bone Regeneration; Diabetes Mellitus, Experimental; Male; Pancre | 1990 |
Insulin therapy on the peritoneal route: effects on glucose control in experimental insulin dependent diabetes.
Topics: Alanine; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Dogs; Fatty Acids; Glu | 1990 |
Regulation of the hepatic response to glucagon: role of insulin, growth hormone and cortisol.
Topics: Alanine; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Female; Glucagon; Gluconeogenesis; | 1989 |
Glutamine and ketone-body metabolism in the gut of streptozotocin-diabetic rats.
Topics: Alanine; Ammonia; Animals; Blood Glucose; Cell Separation; Colon; Diabetes Mellitus, Experimental; G | 1988 |
Intestinal adaptation to diabetes. Altered Na-dependent nutrient absorption in streptozocin-treated chronically diabetic rats.
Topics: 3-O-Methylglucose; Alanine; Animals; Carrier Proteins; Diabetes Mellitus, Experimental; Hydroxydopam | 1987 |
Effects of insulin on perfused liver from streptozotocin-diabetic and untreated rats: 13C NMR assay of pyruvate kinase flux.
Topics: Alanine; Animals; Carbon Isotopes; Diabetes Mellitus, Experimental; Fasting; Female; Gluconeogenesis | 1987 |
13C and 31P NMR study of gluconeogenesis: utilization of 13C-labeled substrates by perfused liver from streptozotocin-diabetic and untreated rats.
Topics: Alanine; Animals; Carbon Isotopes; Diabetes Mellitus, Experimental; Fasting; Female; Gluconeogenesis | 1987 |
Exogenous hyperglucagonaemia in insulin controlled diabetic rats increases urea excretion and nitrogen loss from organs.
Topics: Alanine; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Female; Glucagon; Insulin; Nitroge | 1988 |
Strict insulin therapy normalises organ nitrogen contents and the capacity of urea nitrogen synthesis in experimental diabetes in rats.
Topics: Alanine; Animals; Body Composition; Body Weight; Diabetes Mellitus, Experimental; Energy Metabolism; | 1988 |
Effect of chronic diabetes on myocardial fuel metabolism and insulin sensitivity.
Topics: Alanine; Amino Acids; Amino Acids, Branched-Chain; Animals; Blood Glucose; Diabetes Mellitus, Experi | 1988 |
The effect of prehepatic insulin administration on alanine flux rates in diabetic dogs.
Topics: Alanine; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Insulin; Insulin Infusion Sy | 1987 |
Intermediary metabolism in diabetic dogs treated with pancreatic autotransplants and insulin pumps.
Topics: 3-Hydroxybutyric Acid; Alanine; Animals; Diabetes Mellitus, Experimental; Dogs; Fatty Acids, Noneste | 1986 |
[Gluconeogenesis, ketogenesis, and ureogenesis in isolated hepatocytes from diabetic rats: effects of insulin].
Topics: Alanine; Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Gluconeogenesis; Glucose; Insuli | 1986 |
Characterization of stages in development of obesity-diabetes syndrome in sand rat (Psammomys obesus).
Topics: Adipose Tissue; Age Factors; Alanine; Animals; Arvicolinae; Blood Glucose; Carbon Radioisotopes; Dia | 1986 |
Dynamic aspects of amino acid metabolism in alloxan-induced diabetes and insulin-treated rabbits: in vivo studies with 15N and gas chromatography-mass spectrometry.
Topics: Alanine; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Food; Gas Chromatography-Mass Spec | 1986 |
Characterization of glutamine transport by liver plasma membrane vesicles.
Topics: Alanine; Animals; Biological Transport; Cell Membrane; Diabetes Mellitus, Experimental; Glutamine; K | 1986 |
Diabetes enhances activity of alanine transport in liver plasma membrane vesicles.
Topics: Alanine; Amino Acids; Animals; Biological Transport; Cell Membrane; Diabetes Mellitus, Experimental; | 1985 |
Effect of sodium 2-chloropropionate on glucagon secretion in the rat.
Topics: Alanine; Animals; Arginine; Diabetes Mellitus, Experimental; Glucagon; Glycosuria; Hydrocarbons, Chl | 1985 |
Alanine turnover in normal and diabetic dogs.
Topics: Alanine; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Female; Glutamine; Glycerol; | 1985 |
Studies on gluconeogenesis, protein synthesis and cyclic AMP levels in isolated parenchymal cells following insulin withdrawal from alloxan diabetic rats.
Topics: Alanine; Amino Acids; Animals; Carbon Isotopes; Cyclic AMP; Diabetes Mellitus, Experimental; Fructos | 1972 |
Somatostatin-induced changes in insulin and glucagon secretion in normal and diabetic dogs.
Topics: Alanine; Animals; Blood Glucose; Caseins; Diabetes Mellitus, Experimental; Dogs; Duodenum; Glucagon; | 1974 |
Glucose metabolism in an isolated blood capillary preparation.
Topics: Air Sacs; Alanine; Animals; Capillaries; Carbon Dioxide; Carbon Isotopes; Cattle; Cell Membrane Perm | 1973 |
[Experimental studies on the problem of insulin resistance in adipositas and diabetes mellitus, with the aid of New Zealand obese mice. Pathogenesis of the obese-hyperglycaemic syndrome (author's transl)].
Topics: Adipose Tissue; Aging; Alanine; Animals; Body Weight; Carbon Radioisotopes; Diabetes Mellitus, Exper | 1973 |
Regulatory function of mitochondria in lipogenesis.
Topics: Alanine; Animals; Carbon Dioxide; Carbon Radioisotopes; Cell-Free System; Cytoplasm; Diabetes Mellit | 1973 |
On the mechanism of glucose protection against alloxan toxicity.
Topics: Alanine; Alloxan; Animals; Binding Sites; Cell Membrane; Diabetes Mellitus, Experimental; Female; Ga | 1971 |
Effect of glucose feeding on lipoprotein synthesis in the rat.
Topics: Alanine; Amino Acids; Animals; Blood Protein Electrophoresis; Carbon Isotopes; Diabetes Mellitus, Ex | 1969 |
Studies on substrate induction of serine dehydratase of rat liver.
Topics: Adrenalectomy; Alanine; Amino Acids; Ammonia; Animals; Antibodies; Blood Glucose; Carbon Isotopes; D | 1969 |
[Influence of insulin and proinsulin on gluconeogenesis from alanine in the isolated perfused liver of normal and alloxan diabetic rats].
Topics: Alanine; Animals; Carbon Dioxide; Carbon Isotopes; Depression, Chemical; Diabetes Mellitus, Experime | 1970 |
Effect of insulin and proinsulin on the metabolism of alanine in the rat liver.
Topics: Alanine; Animals; Blood Proteins; Carbon Dioxide; Carbon Isotopes; Depression, Chemical; Diabetes Me | 1970 |
Effect of insulin on sugar and amino acid transport cross isolated small intestine.
Topics: Alanine; Amino Acids; Animals; Biological Transport; Carbon Isotopes; Diabetes Mellitus, Experimenta | 1969 |
Effects of 5-methoxyindole-2-carboxylic acid on carbohydrate metabolism.
Topics: Acids; Alanine; Animals; Blood Glucose; Carbohydrate Metabolism; Carbon Isotopes; Diabetes Mellitus, | 1969 |
Glucose metabolism in brains of diabetic rats.
Topics: Alanine; Aminobutyrates; Animals; Aspartic Acid; Brain; Carbon Isotopes; Diabetes Mellitus; Diabetes | 1969 |
Dietary and hormonal effects on gluconeogenesis in the rat.
Topics: Adrenalectomy; Alanine; Animals; Blood Glucose; Carbon Isotopes; Diabetes Mellitus, Experimental; Fa | 1965 |