alanine has been researched along with Adenocarcinoma in 37 studies
Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.
Adenocarcinoma: A malignant epithelial tumor with a glandular organization.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Using PCR based restriction fragment length polymorphism and single strand conformational polymorphism, we determined single nucleotide exchanges in the p16 and cyclin D1 genes among 56 esophageal adenocarcinomas (ADC) arising in Barrett's esophagus, 95 cardiac gastric ADC, and in 191 distal gastric ADC." | 7.73 | Polymorphism of p16 INK4A and cyclin D1 in adenocarcinomas of the upper gastrointestinal tract. ( Gabbert, HE; Geddert, H; Kiel, S; Sarbia, M; Willers, R; Zhang, J; Zotz, RB, 2005) |
| "The results of our study indicate that there is an inverse correlation between alanine and the risk of colon adenocarcinoma." | 4.31 | Amino acids and risk of colon adenocarcinoma: a Mendelian randomization study. ( Jia, Z; Wang, Q; Wang, Y; Zhu, Z, 2023) |
| "Using PCR based restriction fragment length polymorphism and single strand conformational polymorphism, we determined single nucleotide exchanges in the p16 and cyclin D1 genes among 56 esophageal adenocarcinomas (ADC) arising in Barrett's esophagus, 95 cardiac gastric ADC, and in 191 distal gastric ADC." | 3.73 | Polymorphism of p16 INK4A and cyclin D1 in adenocarcinomas of the upper gastrointestinal tract. ( Gabbert, HE; Geddert, H; Kiel, S; Sarbia, M; Willers, R; Zhang, J; Zotz, RB, 2005) |
| "Thirty patients with advanced metastatic colorectal adenocarcinoma were treated with alanosine at a dose of 160 mg/m2 daily for 5 days every 4 weeks." | 3.66 | A phase II study of alanosine in advanced large bowel carcinoma. ( Hahn, RG; Hineman, V; Moertel, CG; Rubin, J; Schutt, AJ, 1983) |
| "We examined 90 patients with early gastric cancer who had undergone ESD." | 2.78 | Efficacy of treatment with rebamipide for endoscopic submucosal dissection-induced ulcers. ( Asakuma, Y; Kashida, H; Kawasaki, M; Kudo, M; Matsui, S; Sakurai, T; Takayama, M, 2013) |
| "MNNG-induced carcinogenesis and may also inhibit progression of cancer in rats." | 1.42 | Preventive effect of rebamipide on N-methyl-N'-nitro-N-nitrosoguanidine-induced gastric carcinogenesis in rats. ( Ebi, M; Hayashi, N; Joh, T; Katano, T; Kataoka, H; Mizoshita, T; Mori, Y; Ozeki, K; Shimura, T; Tanida, S; Tatematsu, M; Tsukamoto, H; Tsukamoto, T, 2015) |
| "In specimens (Borrmann type III) with tubular adenocarcinoma, resonance peaks were observed at 1." | 1.32 | Ex vivo proton MR spectroscopy (1H-MRS) for evaluation of human gastric carcinoma. ( Cha, SS; Cho, JY; Choi, KS; Eun, CK; Kim, J; Lee, J; Lee, SY; Mun, CW; Nam, SH; Shin, WJ; Yang, YI, 2004) |
| "Three androgen-independent human prostate cancer cell lines (TSU-Prl, DU-145, and PC-3) were cultured in the presence of azatyrosine and their growth rates were determined over a 7-day period." | 1.29 | Reversion of human prostate tumorigenic growth by azatyrosine. ( Benoit, RM; Eiseman, J; Jacobs, SC; Kyprianou, N, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (21.62) | 18.7374 |
| 1990's | 12 (32.43) | 18.2507 |
| 2000's | 9 (24.32) | 29.6817 |
| 2010's | 6 (16.22) | 24.3611 |
| 2020's | 2 (5.41) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, Y | 1 |
| Jia, Z | 1 |
| Wang, Q | 1 |
| Zhu, Z | 2 |
| Parker, SJ | 1 |
| Amendola, CR | 1 |
| Hollinshead, KER | 1 |
| Yu, Q | 1 |
| Yamamoto, K | 1 |
| Encarnación-Rosado, J | 1 |
| Rose, RE | 1 |
| LaRue, MM | 1 |
| Sohn, ASW | 1 |
| Biancur, DE | 2 |
| Paulo, JA | 1 |
| Gygi, SP | 1 |
| Jones, DR | 1 |
| Wang, H | 1 |
| Philips, MR | 1 |
| Bar-Sagi, D | 1 |
| Mancias, JD | 1 |
| Kimmelman, AC | 2 |
| Milshteyn, E | 1 |
| von Morze, C | 1 |
| Gordon, JW | 1 |
| Larson, PEZ | 1 |
| Vigneron, DB | 2 |
| Takayama, M | 1 |
| Matsui, S | 1 |
| Kawasaki, M | 1 |
| Asakuma, Y | 1 |
| Sakurai, T | 1 |
| Kashida, H | 1 |
| Kudo, M | 1 |
| An, YJ | 1 |
| Cho, HR | 1 |
| Kim, TM | 1 |
| Keam, B | 1 |
| Kim, JW | 1 |
| Wen, H | 1 |
| Park, CK | 1 |
| Lee, SH | 1 |
| Im, SA | 1 |
| Kim, JE | 1 |
| Choi, SH | 1 |
| Park, S | 1 |
| Tsukamoto, H | 1 |
| Mizoshita, T | 1 |
| Katano, T | 1 |
| Hayashi, N | 1 |
| Ozeki, K | 1 |
| Ebi, M | 1 |
| Shimura, T | 1 |
| Mori, Y | 1 |
| Tanida, S | 1 |
| Kataoka, H | 1 |
| Tsukamoto, T | 1 |
| Tatematsu, M | 1 |
| Joh, T | 1 |
| Sousa, CM | 1 |
| Wang, X | 1 |
| Halbrook, CJ | 1 |
| Sherman, MH | 1 |
| Zhang, L | 1 |
| Kremer, D | 1 |
| Hwang, RF | 1 |
| Witkiewicz, AK | 1 |
| Ying, H | 1 |
| Asara, JM | 1 |
| Evans, RM | 1 |
| Cantley, LC | 1 |
| Lyssiotis, CA | 1 |
| Calabrese, C | 1 |
| Pisi, A | 1 |
| Di Febo, G | 1 |
| Liguori, G | 1 |
| Filippini, G | 1 |
| Cervellera, M | 1 |
| Righi, V | 1 |
| Lucchi, P | 1 |
| Mucci, A | 1 |
| Schenetti, L | 1 |
| Tonini, V | 1 |
| Tosi, MR | 1 |
| Tugnoli, V | 1 |
| Albers, MJ | 1 |
| Bok, R | 1 |
| Chen, AP | 1 |
| Cunningham, CH | 1 |
| Zierhut, ML | 1 |
| Zhang, VY | 1 |
| Kohler, SJ | 1 |
| Tropp, J | 1 |
| Hurd, RE | 1 |
| Yen, YF | 1 |
| Nelson, SJ | 1 |
| Kurhanewicz, J | 1 |
| Boleij, A | 1 |
| Dutilh, BE | 1 |
| Kortman, GA | 1 |
| Roelofs, R | 1 |
| Laarakkers, CM | 1 |
| Engelke, UF | 1 |
| Tjalsma, H | 1 |
| Li, Y | 1 |
| Raffo, AJ | 1 |
| Drew, L | 1 |
| Mao, Y | 1 |
| Tran, A | 1 |
| Petrylak, DP | 1 |
| Fine, RL | 1 |
| Hu, YJ | 1 |
| Diamond, AM | 1 |
| Fornaro, M | 1 |
| Plescia, J | 1 |
| Chheang, S | 1 |
| Tallini, G | 1 |
| Zhu, YM | 1 |
| King, M | 1 |
| Altieri, DC | 1 |
| Languino, LR | 1 |
| Mun, CW | 1 |
| Cho, JY | 1 |
| Shin, WJ | 1 |
| Choi, KS | 1 |
| Eun, CK | 1 |
| Cha, SS | 1 |
| Lee, J | 1 |
| Yang, YI | 1 |
| Nam, SH | 1 |
| Kim, J | 1 |
| Lee, SY | 1 |
| Gross, I | 1 |
| Lhermitte, B | 1 |
| Domon-Dell, C | 1 |
| Duluc, I | 1 |
| Martin, E | 1 |
| Gaiddon, C | 1 |
| Kedinger, M | 1 |
| Freund, JN | 1 |
| Geddert, H | 1 |
| Kiel, S | 1 |
| Zotz, RB | 1 |
| Zhang, J | 1 |
| Willers, R | 1 |
| Gabbert, HE | 1 |
| Sarbia, M | 1 |
| Niwa, Y | 1 |
| Nakamura, M | 1 |
| Omiya, N | 1 |
| Itoh, A | 1 |
| Hirooka, Y | 1 |
| Goto, H | 1 |
| Grasset, E | 1 |
| Pinto, M | 1 |
| Dussaulx, E | 1 |
| Zweibaum, A | 1 |
| Desjeux, JF | 1 |
| Hotate, T | 1 |
| Rubin, J | 1 |
| Hineman, V | 1 |
| Moertel, CG | 1 |
| Schutt, AJ | 1 |
| Hahn, RG | 1 |
| Benoit, RM | 1 |
| Eiseman, J | 1 |
| Jacobs, SC | 1 |
| Kyprianou, N | 1 |
| Hashimoto, K | 1 |
| Shimizu, M | 1 |
| Finkelstein, SD | 1 |
| Przygodzki, R | 1 |
| Pricolo, VE | 1 |
| Sayegh, R | 1 |
| Bakker, A | 1 |
| Swalsky, PA | 1 |
| Keller, G | 1 |
| Berrevoets, CA | 1 |
| Veldscholte, J | 1 |
| Mulder, E | 1 |
| Suzuki, H | 1 |
| Sato, N | 1 |
| Watabe, Y | 1 |
| Masai, M | 1 |
| Seino, S | 1 |
| Shimazaki, J | 1 |
| Yoshida, T | 1 |
| Sato, R | 1 |
| Mahmood, S | 1 |
| Kawasaki, S | 1 |
| Futai, M | 1 |
| Maeda, M | 1 |
| Marceau, M | 1 |
| Forest, K | 1 |
| Béretti, JL | 1 |
| Tainer, J | 1 |
| Nassif, X | 1 |
| Paul, B | 1 |
| Korytnyk, W | 1 |
| Souba, WW | 1 |
| Pan, M | 1 |
| Stevens, BR | 1 |
| Kubota, A | 1 |
| Meguid, MM | 1 |
| Hitch, DC | 1 |
| Omura, F | 1 |
| Otsu, M | 1 |
| Kikuchi, M | 1 |
| Von Hoff, DD | 1 |
| Green, SJ | 1 |
| Neidhart, JA | 1 |
| Fabian, C | 1 |
| Budd, T | 1 |
| Boyd, JF | 1 |
| Osborne, CK | 1 |
| Shindo-Okada, N | 1 |
| Makabe, O | 1 |
| Nagahara, H | 1 |
| Nishimura, S | 1 |
| Bibby, MC | 1 |
| Double, JA | 1 |
| Del Prato, S | 1 |
| Vigili de Kreutzenberg, S | 1 |
| Trevisan, R | 1 |
| Duner, E | 1 |
| Avogaro, A | 1 |
| Nosadini, R | 1 |
| Baccaglini, U | 1 |
| Tremolada, C | 1 |
| Tiengo, A | 1 |
| Kopelovich, L | 1 |
| Kellen, JA | 1 |
| Lustig, V | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Hyperpolarized 13-C Pyruvate MRI Surveillance of Multiple Cancers[NCT05697406] | Phase 1/Phase 2 | 25 participants (Anticipated) | Interventional | 2024-02-01 | Not yet recruiting | ||
| A Phase 1 Ascending-dose Study to Assess the Safety and Tolerability and Imaging Potential of Hyperpolarized Pyruvate (13C) Injection in Subjects With Prostate Cancer[NCT01229618] | Phase 1 | 31 participants (Actual) | Interventional | 2010-10-31 | Completed | ||
| A Pilot Study to Determine the Effect of Dietary Intervention on Novel Biomarkers of Breast Cancer Risk.[NCT00555386] | 27 participants (Actual) | Interventional | 2007-04-30 | Completed | |||
| Selenoproteins as Prognostic Markers and Therapeutic Targets in Breast Cancer.[NCT05817227] | 300 participants (Anticipated) | Observational | 2022-05-19 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for alanine and Adenocarcinoma
| Article | Year |
|---|---|
Efficacy of treatment with rebamipide for endoscopic submucosal dissection-induced ulcers.
Topics: Adenocarcinoma; Aged; Alanine; Anti-Ulcer Agents; Dissection; Female; Gastroscopy; Humans; Iatrogeni | 2013 |
Phase II study of L-alanosine (NSC 153353) in patients with advanced breast cancer. A Southwest Oncology Group study.
Topics: Adenocarcinoma; Adult; Aged; Alanine; Antibiotics, Antineoplastic; Breast Neoplasms; Drug Evaluation | 1991 |
35 other studies available for alanine and Adenocarcinoma
| Article | Year |
|---|---|
Amino acids and risk of colon adenocarcinoma: a Mendelian randomization study.
Topics: Adenocarcinoma; Alanine; Amino Acids; Colonic Neoplasms; Genome-Wide Association Study; Humans; Mend | 2023 |
Selective Alanine Transporter Utilization Creates a Targetable Metabolic Niche in Pancreatic Cancer.
Topics: Adenocarcinoma; Alanine; Carcinoma, Pancreatic Ductal; Humans; Metabolic Networks and Pathways; Sign | 2020 |
High spatiotemporal resolution bSSFP imaging of hyperpolarized [1-
Topics: Adenocarcinoma; Alanine; Animals; Carbon Isotopes; Image Processing, Computer-Assisted; Lactic Acid; | 2018 |
An NMR metabolomics approach for the diagnosis of leptomeningeal carcinomatosis in lung adenocarcinoma cancer patients.
Topics: Adenocarcinoma; Alanine; Area Under Curve; Biomarkers, Tumor; Case-Control Studies; Citric Acid; Cre | 2015 |
Preventive effect of rebamipide on N-methyl-N'-nitro-N-nitrosoguanidine-induced gastric carcinogenesis in rats.
Topics: Adenocarcinoma; Alanine; Animals; Antioxidants; Carcinogenesis; Carcinogens; Disease Models, Animal; | 2015 |
Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion.
Topics: Adenocarcinoma; Alanine; Animals; Autophagy; Biosynthetic Pathways; Carbon; Carcinoma, Pancreatic Du | 2016 |
Biochemical alterations from normal mucosa to gastric cancer by ex vivo magnetic resonance spectroscopy.
Topics: Adenocarcinoma; Aged; Alanine; Biomarkers, Tumor; Choline; Endoscopy, Gastrointestinal; Female; Gast | 2008 |
Hyperpolarized 13C lactate, pyruvate, and alanine: noninvasive biomarkers for prostate cancer detection and grading.
Topics: Adenocarcinoma; Alanine; Animals; Biomarkers, Tumor; Carbon Isotopes; Disease Models, Animal; Lactic | 2008 |
Hyperpolarized 13C lactate, pyruvate, and alanine: noninvasive biomarkers for prostate cancer detection and grading.
Topics: Adenocarcinoma; Alanine; Animals; Biomarkers, Tumor; Carbon Isotopes; Disease Models, Animal; Lactic | 2008 |
Hyperpolarized 13C lactate, pyruvate, and alanine: noninvasive biomarkers for prostate cancer detection and grading.
Topics: Adenocarcinoma; Alanine; Animals; Biomarkers, Tumor; Carbon Isotopes; Disease Models, Animal; Lactic | 2008 |
Hyperpolarized 13C lactate, pyruvate, and alanine: noninvasive biomarkers for prostate cancer detection and grading.
Topics: Adenocarcinoma; Alanine; Animals; Biomarkers, Tumor; Carbon Isotopes; Disease Models, Animal; Lactic | 2008 |
Bacterial responses to a simulated colon tumor microenvironment.
Topics: Adenocarcinoma; Alanine; Bacterial Proteins; Cell Line, Tumor; Colon; Colorectal Neoplasms; Culture | 2012 |
Fas-mediated apoptosis is dependent on wild-type p53 status in human cancer cells expressing a temperature-sensitive p53 mutant alanine-143.
Topics: Adenocarcinoma; Alanine; Antibodies, Monoclonal; Apoptosis; Caspase 3; Caspase 8; Caspase 9; Caspase | 2003 |
Role of glutathione peroxidase 1 in breast cancer: loss of heterozygosity and allelic differences in the response to selenium.
Topics: Adenocarcinoma; Alanine; Alleles; Amino Acid Substitution; Breast Neoplasms; Codon; DNA, Neoplasm; E | 2003 |
Role of glutathione peroxidase 1 in breast cancer: loss of heterozygosity and allelic differences in the response to selenium.
Topics: Adenocarcinoma; Alanine; Alleles; Amino Acid Substitution; Breast Neoplasms; Codon; DNA, Neoplasm; E | 2003 |
Role of glutathione peroxidase 1 in breast cancer: loss of heterozygosity and allelic differences in the response to selenium.
Topics: Adenocarcinoma; Alanine; Alleles; Amino Acid Substitution; Breast Neoplasms; Codon; DNA, Neoplasm; E | 2003 |
Role of glutathione peroxidase 1 in breast cancer: loss of heterozygosity and allelic differences in the response to selenium.
Topics: Adenocarcinoma; Alanine; Alleles; Amino Acid Substitution; Breast Neoplasms; Codon; DNA, Neoplasm; E | 2003 |
Fibronectin protects prostate cancer cells from tumor necrosis factor-alpha-induced apoptosis via the AKT/survivin pathway.
Topics: Adenocarcinoma; Adenoviridae; Alanine; Apoptosis; Caspases; Cell Adhesion; Cell Death; Cell Line; Ce | 2003 |
Ex vivo proton MR spectroscopy (1H-MRS) for evaluation of human gastric carcinoma.
Topics: Adenocarcinoma; Alanine; Choline; Feasibility Studies; Humans; Lipid Metabolism; Magnetic Resonance | 2004 |
Phosphorylation of the homeotic tumor suppressor Cdx2 mediates its ubiquitin-dependent proteasome degradation.
Topics: Adenocarcinoma; Alanine; Alkaline Phosphatase; Amino Acid Sequence; Amino Acid Substitution; Animals | 2005 |
Polymorphism of p16 INK4A and cyclin D1 in adenocarcinomas of the upper gastrointestinal tract.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Alanine; Barrett Esophagus; Cardia; Case-Control Stu | 2005 |
Ileal cancer and erosions in the small intestine revealed by capsule endoscopy.
Topics: Adenocarcinoma; Adenoma; Aged, 80 and over; Alanine; Anti-Ulcer Agents; Capsule Endoscopy; Colonic N | 2007 |
Epithelial properties of human colonic carcinoma cell line Caco-2: electrical parameters.
Topics: Adenocarcinoma; Alanine; Aldosterone; Amiloride; Amphotericin B; Cell Differentiation; Cell Division | 1984 |
[Studies on urinary biochemical markers in patients with head and neck cancer: especially on polyamines, beta-aminoisobutyric acid and beta-alanine (author's transl)].
Topics: Adenocarcinoma; Alanine; Aminoisobutyric Acids; beta-Alanine; Carcinoma, Squamous Cell; Head and Nec | 1981 |
A phase II study of alanosine in advanced large bowel carcinoma.
Topics: Adenocarcinoma; Adult; Aged; Alanine; Antibiotics, Antineoplastic; Colonic Neoplasms; Drug Evaluatio | 1983 |
Reversion of human prostate tumorigenic growth by azatyrosine.
Topics: Adenocarcinoma; Alanine; Animals; Antibiotics, Antineoplastic; Cell Division; Cell Transformation, N | 1995 |
Epithelial properties of human intestinal Caco-2 cells cultured in a serum-free medium.
Topics: Adenocarcinoma; Alanine; Animals; Biological Transport; Cattle; Cell Division; Cell Line; Colonic Ne | 1993 |
K-ras-2 topographic genotyping of pancreatic adenocarcinoma.
Topics: Adenocarcinoma; Alanine; Arginine; Aspartic Acid; Codon; Cysteine; DNA, Neoplasm; Exons; Forecasting | 1994 |
Effects of antiandrogens on transformation and transcription activation of wild-type and mutated (LNCaP) androgen receptors.
Topics: Adenocarcinoma; Alanine; Amino Acid Sequence; Androgen Antagonists; Anilides; Animals; Blotting, Wes | 1993 |
Androgen receptor gene mutations in human prostate cancer.
Topics: Adenocarcinoma; Alanine; Amino Acid Sequence; Base Sequence; DNA Primers; DNA-Binding Proteins; DNA, | 1993 |
GATA-6 DNA binding protein expressed in human gastric adenocarcinoma MKN45 cells.
Topics: Adenocarcinoma; Alanine; Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Conserved Seque | 1997 |
Consequences of the loss of O-linked glycosylation of meningococcal type IV pilin on piliation and pilus-mediated adhesion.
Topics: Adenocarcinoma; Alanine; Amino Acid Sequence; Bacterial Adhesion; Bacterial Outer Membrane Proteins; | 1998 |
Alanine derivatives with reactive groups.
Topics: Adenocarcinoma; Alanine; Animals; Antimetabolites, Antineoplastic; Cells, Cultured; Mammary Neoplasm | 1978 |
Kinetics of the sodium-dependent glutamine transporter in human intestinal cell confluent monolayers.
Topics: Adenocarcinoma; Alanine; Amino Acid Transport Systems, Basic; Amino Acids; Analysis of Variance; Bio | 1992 |
Amino acid profiles correlate diagnostically with organ site in three kinds of malignant tumors.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Alanine; Amino Acids; Arginine; Breast Neoplasms; Ca | 1992 |
Accelerated secretion of human lysozyme with a disulfide bond mutation.
Topics: Adenocarcinoma; Alanine; Amino Acid Sequence; Animals; Base Sequence; Cell Line; Cloning, Molecular; | 1992 |
Permanent conversion of NIH3T3 cells transformed by activated c-Ha-ras, c-Ki-ras, N-ras, or c-raf, and of human pancreatic adenocarcinoma containing activated c-Ki-ras to apparently normal cells by treatment with the antibiotic azatyrosine.
Topics: Adenocarcinoma; Alanine; Animals; Antibiotics, Antineoplastic; Cell Division; Cell Line, Transformed | 1990 |
Activity of N-[N'-(2-chloroethyl)-N'-nitrosocarbamoyl]-alanine and derivatives against transplantable adenocarcinomata of the mouse colon (MAC).
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Alanine; Animals; Antineoplastic Agents; Colonic Neoplasms; D | 1986 |
Hyperalaninaemia is an early feature of diabetes secondary to total pancreatectomy.
Topics: Adenocarcinoma; Adult; Aged; Alanine; C-Peptide; Diabetes Mellitus, Type 1; Female; Glucagon; Humans | 1985 |
Pyruvate dehydrogenase, the citrate condensing enzyme and the utilization of 14 C-labeled lactate, pyruvate and alanine by slices of lactating mammary gland and adenocarcinoma of mouse mammary gland.
Topics: Adenocarcinoma; Alanine; Amino Acids; Animals; Carbon Dioxide; Carbon Isotopes; Citrate (si)-Synthas | 1973 |
Patterns of amino-acid inhibition of alkaline phosphatases as an aid in cancer diagnosis.
Topics: Adenocarcinoma; Alanine; Alkaline Phosphatase; Amino Acids; Animals; Arginine; Colonic Neoplasms; Fe | 1971 |