alanine has been researched along with Absence Seizure in 68 studies
Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here, we compared the efficacy of DZP with that of UBP302 [(S)-3-(2-carboxybenzyl)willardiine; an antagonist of the kainate receptors that contain the GluK1 subunit] against seizures, neuropathology, and behavioral deficits induced by soman in rats." | 7.80 | The limitations of diazepam as a treatment for nerve agent-induced seizures and neuropathology in rats: comparison with UBP302. ( Apland, JP; Aroniadou-Anderjaska, V; Braga, MF; Figueiredo, TH; Miller, SL; Rossetti, F, 2014) |
| "Epilepsy is often considered to be a progressive neurological disease, and the nature of this progression remains unclear." | 5.72 | Insights into the development of pentylenetetrazole-induced epileptic seizures from dynamic metabolomic changes. ( Cheng, P; Jia, P; Liao, S; Meng, K; Xiao, C; Xu, R; Zhao, X; Zheng, X, 2022) |
| "Penicillin seizures do not cause a change in levels of GABA, but result in a decrease in glutamate within the focus." | 5.26 | Effect of amino-oxyacetic acid (AOAA) on focal penicillin seizures. ( Collins, RC; Mehta, S, 1978) |
| " Here, we compared the efficacy of DZP with that of UBP302 [(S)-3-(2-carboxybenzyl)willardiine; an antagonist of the kainate receptors that contain the GluK1 subunit] against seizures, neuropathology, and behavioral deficits induced by soman in rats." | 3.80 | The limitations of diazepam as a treatment for nerve agent-induced seizures and neuropathology in rats: comparison with UBP302. ( Apland, JP; Aroniadou-Anderjaska, V; Braga, MF; Figueiredo, TH; Miller, SL; Rossetti, F, 2014) |
| "The aim of the present study was to analyze biochemical effects of a neurosteroid, pregnenolone sulfate (PS), which accompany changes in the threshold of seizures, and to establish the contribution of local, hippocampal monoaminergic and amino acid systems, to the control of convulsive activity." | 3.72 | Pregnenolone sulfate potentiates the effects of NMDA on hippocampal alanine and dopamine. ( Bidziński, A; Członkowska, AI; Krzaścik, P; Lehner, M; Maciejak, P; Płaźnik, A; Skórzewska, A; Szyndler, J; Taracha, E; Turzyńska, D; Walkowiak, J; Wisłowska, A; Zienowicz, M, 2004) |
| "Dysiherbaine (DH) is a marine sponge-derived amino acid that causes seizures upon injection into mice." | 3.71 | Pharmacological properties of the potent epileptogenic amino acid dysiherbaine, a novel glutamate receptor agonist isolated from the marine sponge Dysidea herbacea. ( Contractor, A; Ghetti, A; Green, T; Kamiya, H; Oiwa, C; Sakai, R; Shimamoto, K; Swanson, GT; Tamura-Horikawa, Y, 2001) |
| "The metabotropic Group III agonist, (1S,3R,4S)-1-aminocyclopentane-1,2,4-tricarboxylic acid (ACPT-1), selective for the mGlu(4alpha) receptor, suppresses sound-induced seizures in DBA/2 mice following its intracerebroventricular (i." | 3.71 | Anticonvulsant activity of a mGlu(4alpha) receptor selective agonist, (1S,3R,4S)-1-aminocyclopentane-1,2,4-tricarboxylic acid. ( Chapman, AG; Meldrum, BS; Talebi, A; Yip, PK, 2001) |
| "n-Alkyl esters of nipecotic acid were prepared by Fischer esterification, and the esters were evaluated against bicuculline-induced seizures in mice." | 3.67 | gamma-Aminobutyric acid uptake inhibition and anticonvulsant activity of nipecotic acid esters. ( Crider, AM; Hinko, CN; Seibert, K; Tschappat, KD; Wood, JD, 1984) |
| "Fetal mice treated on days 10, 11, and 12 of gestation by injecting the mothers with (i) 50 milligrams of beta-2-thienylalanine, (ii) solvent, or (iii) sham injection had identical frequencies of audiogenic seizures when tested 23 days after birth; these frequencies were significantly higher than those of an unhandled control group." | 3.65 | Suceptibility of mice to audiogenic seizures is increased by handling their dams during gestation. ( Beck, SL; Gavin, DL, 1976) |
| " Increases in the concentrations of alanine, ammonia and lactic acid in rat brain accompany picrotoxin-induced seizures; there is no increase in the concentration of glutamine." | 3.64 | EFFECTS OF DIELDRIN, PICROTOXIN AND TELODRIN ON THE METABOLISM OF AMMONIA IN BRAIN. ( AKINTONWA, DA; HATHWAY, DE; MALLINSON, A, 1965) |
| "Epilepsy is often considered to be a progressive neurological disease, and the nature of this progression remains unclear." | 1.72 | Insights into the development of pentylenetetrazole-induced epileptic seizures from dynamic metabolomic changes. ( Cheng, P; Jia, P; Liao, S; Meng, K; Xiao, C; Xu, R; Zhao, X; Zheng, X, 2022) |
| "We highlight the value of considering seizures and encephalopathy as one of the presenting features of COVID-19 disease." | 1.62 | A young man presenting with encephalopathy and seizures secondary to SARS-CoV-2. ( Ijaz, M; Jalil, BA; Khan, AM; Ledbetter, TG, 2021) |
| "Doripenem and meropenem did not induce convulsions at up to 100 microg/mouse." | 1.33 | Absence of convulsive liability of doripenem, a new carbapenem antibiotic, in comparison with beta-lactam antibiotics. ( Abe, K; Arai, T; Hasebe, N; Horiuchi, M; Kimura, M; Tokumura, M, 2006) |
| "Cerebral focal lesions in MELAS might have a metabolic nature and several pathogenetic mechanisms might be involved in the genesis of stroke-like episodes when there is a local increased ATP demand." | 1.32 | MELAS: clinical phenotype and morphological brain abnormalities. ( Bartolomei, L; Cavallaro, T; Grauso, M; Morelli, L; Piscioli, F; Rizzuto, N; Simonati, A; Sparaco, M, 2003) |
| "Alaproclate and GEA-857 antagonized seizures induced by NMDA, 200 mg/kg subcutaneously at doses similar to those antagonizing the harmaline- and NMDA-induced elevation of cerebellar cGMP." | 1.30 | NMDA receptor-mediated increase in cyclic GMP in the rat cerebellum in vivo is blocked by alaproclate and GEA-857. ( Hu, PS; Ross, SB, 1997) |
| "To clarify the biochemical mechanism of convulsions from a view point of the amino acid metabolism, the free amino acid patterns in brains of El mice were investigated." | 1.27 | Amino acid metabolism in the brain with convulsive disorders. Part I: Free amino acid patterns in the brain of E1 mouse with convulsive seizure. ( Honda, T, 1984) |
| "Strychnine induced two types of motor seizures: (1) falling over with tail whipping and (2) convulsions." | 1.27 | Prevention of the convulsant and hyperalgesic action of strychnine by intrathecal glycine and related amino acids. ( Banas, C; Beyer, C; Gomora, P; Komisaruk, BR, 1988) |
| "Diazepam, known to produce its anticonvulsant, sedative and muscle relaxant effects through its interaction either with central GABA or glycine receptors was found to be the most potent (48." | 1.27 | Effects of glycine and other inhibitory amino acid neurotransmitters on strychnine convulsive threshold in mice. ( Sangiah, S, 1985) |
| "Penicillin seizures do not cause a change in levels of GABA, but result in a decrease in glutamate within the focus." | 1.26 | Effect of amino-oxyacetic acid (AOAA) on focal penicillin seizures. ( Collins, RC; Mehta, S, 1978) |
| "Orotic aciduria was present (max: 693 mg/day) and was related to NH4 levels." | 1.25 | [Chronic hyperammonemia with orotic aciduria: evidence of pyrimidine pathway stimulation (author's transl)]. ( Beaudry, MA; Collu, R; Dallairf, L; Ducharme, JR; Leboeuf, G; Letarte, J; Melancon, SB, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 41 (60.29) | 18.7374 |
| 1990's | 7 (10.29) | 18.2507 |
| 2000's | 12 (17.65) | 29.6817 |
| 2010's | 6 (8.82) | 24.3611 |
| 2020's | 2 (2.94) | 2.80 |
| Authors | Studies |
|---|---|
| Zhao, X | 1 |
| Cheng, P | 1 |
| Xu, R | 1 |
| Meng, K | 1 |
| Liao, S | 1 |
| Jia, P | 1 |
| Zheng, X | 1 |
| Xiao, C | 1 |
| Jalil, BA | 1 |
| Ijaz, M | 1 |
| Khan, AM | 1 |
| Ledbetter, TG | 1 |
| McDonald, TS | 1 |
| Borges, K | 1 |
| Grosenbaugh, DK | 1 |
| Ross, BM | 1 |
| Wagley, P | 1 |
| Zanelli, SA | 1 |
| Parrock, S | 1 |
| Hussain, S | 1 |
| Issler, N | 1 |
| Differ, AM | 1 |
| Lench, N | 1 |
| Guarino, S | 1 |
| Oosterveld, MJ | 1 |
| Keijzer-Veen, M | 1 |
| Brilstra, E | 1 |
| van Wieringen, H | 1 |
| Konijnenberg, AY | 1 |
| Amin-Rasip, S | 1 |
| Dumitriu, S | 1 |
| Klootwijk, E | 1 |
| Knoers, N | 1 |
| Bockenhauer, D | 1 |
| Kleta, R | 1 |
| Zdebik, AA | 1 |
| Apland, JP | 2 |
| Aroniadou-Anderjaska, V | 2 |
| Figueiredo, TH | 1 |
| Rossetti, F | 1 |
| Miller, SL | 1 |
| Braga, MF | 2 |
| Park, KD | 1 |
| Yang, XF | 1 |
| Dustrude, ET | 1 |
| Wang, Y | 1 |
| Ripsch, MS | 1 |
| White, FA | 1 |
| Khanna, R | 1 |
| Kohn, H | 2 |
| Salomé, C | 1 |
| Salomé-Grosjean, E | 1 |
| Stables, JP | 2 |
| Kingston, AE | 1 |
| Griffey, K | 1 |
| Johnson, MP | 1 |
| Chamberlain, MJ | 1 |
| Kelly, G | 1 |
| Tomlinson, R | 1 |
| Wright, RA | 1 |
| Johnson, BG | 1 |
| Schoepp, DD | 1 |
| Harris, JR | 1 |
| Clark, BP | 1 |
| Baker, RS | 1 |
| Tizzano, JT | 1 |
| Yudkoff, M | 1 |
| Daikhin, Y | 1 |
| Nissim, I | 2 |
| Horyn, O | 1 |
| Lazarow, A | 1 |
| Sparaco, M | 1 |
| Simonati, A | 1 |
| Cavallaro, T | 1 |
| Bartolomei, L | 1 |
| Grauso, M | 1 |
| Piscioli, F | 1 |
| Morelli, L | 1 |
| Rizzuto, N | 1 |
| MASSIEU, GH | 2 |
| TAPIA, R | 2 |
| PASANTES, H | 2 |
| ORTEGA, BG | 2 |
| WIECHERT, P | 2 |
| KNAAPE, HH | 1 |
| ROA, PD | 1 |
| TEWS, JK | 3 |
| STONE, WE | 2 |
| CREMER, JE | 1 |
| WOOD, JD | 2 |
| WATSON, WJ | 1 |
| HATHWAY, DE | 1 |
| MALLINSON, A | 1 |
| AKINTONWA, DA | 1 |
| Preuss, UW | 1 |
| Koller, G | 1 |
| Zill, P | 1 |
| Bondy, B | 1 |
| Soyka, M | 1 |
| Maciejak, P | 1 |
| Członkowska, AI | 1 |
| Bidziński, A | 1 |
| Walkowiak, J | 1 |
| Szyndler, J | 1 |
| Lehner, M | 1 |
| Skórzewska, A | 1 |
| Turzyńska, D | 1 |
| Zienowicz, M | 1 |
| Wisłowska, A | 1 |
| Taracha, E | 1 |
| Krzaścik, P | 1 |
| Płaźnik, A | 1 |
| Horiuchi, M | 1 |
| Kimura, M | 1 |
| Tokumura, M | 1 |
| Hasebe, N | 1 |
| Arai, T | 1 |
| Abe, K | 1 |
| Shoji, M | 2 |
| Akiyama, N | 2 |
| Tsubone, K | 2 |
| Lash, LL | 1 |
| Sanders, JM | 1 |
| Swanson, GT | 2 |
| Sakai, R | 3 |
| Shimamoto, K | 3 |
| Oikawa, M | 2 |
| Sasaki, M | 2 |
| Aoki, K | 1 |
| Pérez de la Mora, M | 1 |
| DeFeudis, FV | 2 |
| Elliott, KA | 4 |
| Ressler, C | 1 |
| Nelson, J | 1 |
| Pfeffer, M | 1 |
| Nishizawa, Y | 1 |
| Honda, T | 1 |
| Crider, AM | 1 |
| Tschappat, KD | 1 |
| Hinko, CN | 1 |
| Seibert, K | 1 |
| Pellicciari, R | 1 |
| Natalini, B | 1 |
| Costantino, G | 1 |
| Mahmoud, MR | 1 |
| Mattoli, L | 1 |
| Sadeghpour, BM | 1 |
| Moroni, F | 1 |
| Chiarugi, A | 1 |
| Carpenedo, R | 1 |
| Paruszewski, R | 1 |
| Rostafinska-Suchar, G | 1 |
| Strupinska, M | 1 |
| Jaworski, P | 1 |
| Hu, PS | 1 |
| Ross, SB | 1 |
| Sejima, H | 1 |
| Ito, M | 1 |
| Kishi, K | 1 |
| Tsuda, H | 1 |
| Shiraishi, H | 1 |
| Pevarello, P | 1 |
| Bonsignori, A | 1 |
| Dostert, P | 1 |
| Heidempergher, F | 1 |
| Pinciroli, V | 1 |
| Colombo, M | 1 |
| McArthur, RA | 1 |
| Salvati, P | 2 |
| Post, C | 1 |
| Fariello, RG | 2 |
| Varasi, M | 1 |
| Maj, R | 1 |
| Marrari, P | 1 |
| Beard, D | 1 |
| Algate, C | 1 |
| Green, T | 1 |
| Contractor, A | 1 |
| Ghetti, A | 1 |
| Tamura-Horikawa, Y | 1 |
| Oiwa, C | 1 |
| Kamiya, H | 1 |
| Chapman, AG | 1 |
| Talebi, A | 1 |
| Yip, PK | 1 |
| Meldrum, BS | 1 |
| Collins, RC | 1 |
| Mehta, S | 1 |
| Maclaren, NK | 1 |
| Cowles, C | 1 |
| Ozand, PT | 1 |
| Shuttee, R | 1 |
| Cornblath, M | 1 |
| Aynsley-Green, A | 1 |
| Moncrieff, MW | 1 |
| Ratter, S | 1 |
| Benedict, CR | 1 |
| Storrs, CN | 1 |
| Maxson, SC | 1 |
| Towle, AC | 1 |
| Sze, PY | 1 |
| Cosmatos, A | 1 |
| Cheng, K | 1 |
| Okada, Y | 1 |
| Katsoyannis, PG | 1 |
| Lodge, D | 1 |
| Johnston, GA | 1 |
| Curtis, DR | 1 |
| Brand, SJ | 1 |
| Beck, SL | 1 |
| Gavin, DL | 1 |
| Battistin, L | 1 |
| Varotto, M | 1 |
| Lorenzi, AD | 1 |
| Beaudry, MA | 1 |
| Letarte, J | 1 |
| Collu, R | 1 |
| Leboeuf, G | 1 |
| Ducharme, JR | 1 |
| Melancon, SB | 1 |
| Dallairf, L | 1 |
| Connick, JH | 1 |
| Heywood, GC | 1 |
| Sills, GJ | 1 |
| Thompson, GG | 1 |
| Brodie, MJ | 1 |
| Stone, TW | 1 |
| Croucher, MJ | 1 |
| Bradford, HF | 1 |
| Ryzhov, IV | 1 |
| Slepokurov, MV | 1 |
| Lapin, IP | 1 |
| Mandel'shtam, IuE | 1 |
| Aleksandrov, VG | 1 |
| Beyer, C | 1 |
| Banas, C | 1 |
| Gomora, P | 1 |
| Komisaruk, BR | 1 |
| Sangiah, S | 1 |
| Donelli, MG | 1 |
| Rosso, R | 1 |
| Garattini, S | 1 |
| Alimov, IIu | 1 |
| Iur'eva, EA | 1 |
| Marchenko, ZM | 1 |
| Nordmann, R | 1 |
| Petit, MA | 1 |
| Nordmann, J | 1 |
| Reynolds, AP | 1 |
| Gallagher, BB | 1 |
| King, LJ | 1 |
| Carl, JL | 1 |
| Lao, L | 1 |
| Mison-Crighel, N | 1 |
| Pintilie, C | 1 |
| Kreindler, A | 1 |
| Crighel, E | 1 |
| Whisler, KE | 1 |
| Brown, DJ | 1 |
| Yoshino, Y | 2 |
| Africa, B | 1 |
| Carpenter, FH | 1 |
| Koenig, H | 2 |
| Patel, A | 2 |
| Richter, JJ | 1 |
| Wainer, A | 1 |
| Baumgartner, R | 1 |
| Scheidegger, S | 1 |
| Stalder, G | 1 |
| Hottinger, A | 1 |
| Göllnitz, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| STTEPP: Safety, Tolerability and Dose Limiting Toxicity of Lacosamide in Patients With Painful Chronic Pancreatitis[NCT05603702] | Phase 1 | 24 participants (Anticipated) | Interventional | 2023-03-17 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for alanine and Absence Seizure
| Article | Year |
|---|---|
Studies on homopantothenic acid.
Topics: Alanine; Animals; Biological Availability; Blood-Brain Barrier; Brain; gamma-Aminobutyric Acid; Ison | 1984 |
67 other studies available for alanine and Absence Seizure
| Article | Year |
|---|---|
Insights into the development of pentylenetetrazole-induced epileptic seizures from dynamic metabolomic changes.
Topics: Alanine; Animals; Anticonvulsants; Asparagine; Citrates; Creatine; Creatinine; Disease Models, Anima | 2022 |
A young man presenting with encephalopathy and seizures secondary to SARS-CoV-2.
Topics: Adenosine Monophosphate; Adult; Alanine; Anticonvulsants; Antiviral Agents; Brain Diseases; Confusio | 2021 |
Impaired hippocampal glucose metabolism during and after flurothyl-induced seizures in mice: Reduced phosphorylation coincides with reduced activity of pyruvate dehydrogenase.
Topics: Alanine; Amino Acids; Animals; Antioxidants; Blood Glucose; Citric Acid Cycle; Flurothyl; Gas Chroma | 2017 |
The Role of Kainate Receptors in the Pathophysiology of Hypoxia-Induced Seizures in the Neonatal Mouse.
Topics: Alanine; Animals; Animals, Newborn; Disease Models, Animal; Disease Susceptibility; Electroencephalo | 2018 |
KCNJ10 mutations display differential sensitivity to heteromerisation with KCNJ16.
Topics: Alanine; Animals; Female; Genotype; Hearing Loss, Sensorineural; Humans; Intellectual Disability; Oo | 2013 |
The limitations of diazepam as a treatment for nerve agent-induced seizures and neuropathology in rats: comparison with UBP302.
Topics: Alanine; Amygdala; Animals; Anticonvulsants; Anxiety; Diazepam; Hippocampus; Male; Nerve Degeneratio | 2014 |
Chimeric agents derived from the functionalized amino acid, lacosamide, and the α-aminoamide, safinamide: evaluation of their inhibitory actions on voltage-gated sodium channels, and antiseizure and antinociception activities and comparison with lacosamid
Topics: Acetamides; Alanine; Analgesics; Animals; Anticonvulsants; Benzylamines; Cells, Cultured; Cerebral C | 2015 |
Soman induces ictogenesis in the amygdala and interictal activity in the hippocampus that are blocked by a GluR5 kainate receptor antagonist in vitro.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Alanine; Amygdala; Animals; Calcium; Evoked Potentials; Hippoc | 2009 |
Merging the structural motifs of functionalized amino acids and alpha-aminoamides: compounds with significant anticonvulsant activities.
Topics: Acetamides; Alanine; Amides; Amino Acids; Animals; Anticonvulsants; Benzylamines; Drug Evaluation, P | 2010 |
Inhibition of group I metabotropic glutamate receptor responses in vivo in rats by a new generation of carboxyphenylglycine-like amino acid antagonists.
Topics: Alanine; Animals; Benzoates; Cerebellum; Dose-Response Relationship, Drug; Drug Interactions; Excita | 2002 |
Metabolism of brain amino acids following pentylenetetrazole treatment.
Topics: Alanine; Amino Acids; Animals; Brain Chemistry; Convulsants; Gas Chromatography-Mass Spectrometry; G | 2003 |
MELAS: clinical phenotype and morphological brain abnormalities.
Topics: Adenosine Triphosphatases; Adult; Alanine; Brain; Carboxylic Ester Hydrolases; Child; DNA, Mitochond | 2003 |
CONVULSANT EFFECT OF L-GLUTAMIC ACID-GAMMA-HYDRAZIDE BY SIMULTANEOUS TREATMENT WITH PYRIDOXAL PHOSPHATE.
Topics: Alanine; Aminobutyrates; Animals; Aspartic Acid; Brain; Carboxy-Lyases; Convulsants; Glutamates; Glu | 1964 |
[ON THE EFFECT OF EXPERIMENTALLY INDUCED CONVULSIONS ON THE PERMEABILITY OF THE HEMATOENCEPHALIC BARRIER TO VARIOUS AMINO ACIDS].
Topics: Alanine; Amino Acids; Blood Chemical Analysis; Blood-Brain Barrier; Cerebrospinal Fluid; Chemical Ph | 1963 |
A NEUROCHEMICAL STUDY OF THIOSEMICARBAZIDE SEIZURES AND THEIR INHIBITION BY AMINO-OXYACETIC ACID.
Topics: Acetates; Alanine; Amino Acids; Aminobutyrates; Ammonia; Animals; Aspartic Acid; Azides; Brain; Dogs | 1964 |
AMINO ACID METABOLISM IN RAT BRAIN STUDIED WITH 14C-LABELLED GLUCOSE.
Topics: Alanine; Amino Acids; Aminobutyrates; Aspartic Acid; Brain; Carbon Isotopes; Glucose; Glutamates; Gl | 1964 |
MOLECULAR STRUCTURE-ACTIVITY RELATIONSHIPS OF COMPOUNDS PROTECTING RATS AGAINST OXYGEN POISONING.
Topics: Acetates; Alanine; Amino Acids; Aminobutyrates; Antidotes; Arginine; Aspartic Acid; Blood-Brain Barr | 1964 |
EFFECTS OF DIELDRIN, PICROTOXIN AND TELODRIN ON THE METABOLISM OF AMMONIA IN BRAIN.
Topics: Alanine; Amino Acids; Ammonia; Animals; Brain; Brain Chemistry; Central Nervous System Stimulants; D | 1965 |
Alcoholism-related phenotypes and genetic variants of the CB1 receptor.
Topics: Adult; Alanine; Alcoholism; Analysis of Variance; Case-Control Studies; Chitinases; Delirium; Drosop | 2003 |
Pregnenolone sulfate potentiates the effects of NMDA on hippocampal alanine and dopamine.
Topics: Alanine; Amino Acids; Animals; Bicuculline; Convulsants; Dopamine; Dose-Response Relationship, Drug; | 2004 |
Absence of convulsive liability of doripenem, a new carbapenem antibiotic, in comparison with beta-lactam antibiotics.
Topics: Alanine; Animals; Anti-Bacterial Agents; Anticonvulsants; Carbapenems; Convulsants; Dogs; Doripenem; | 2006 |
Total synthesis and biological evaluation of neodysiherbaine A and analogues.
Topics: Alanine; Animals; Binding, Competitive; Biological Assay; Bridged Bicyclo Compounds, Heterocyclic; C | 2006 |
Rapid and efficient synthesis of dysiherbaine and analogues to explore structure-activity relationships.
Topics: Alanine; Animals; Bridged Bicyclo Compounds, Heterocyclic; Convulsants; Drug Evaluation, Preclinical | 2008 |
Free amino acids and glutamate decarboxylase activity in brain of mice during drug-induced convulsions.
Topics: Alanine; Aminobutyrates; Animals; Aspartic Acid; Brain Chemistry; Carboxy-Lyases; Glutamates; Glutam | 1967 |
Delay or inhibition of convulsions by intraperitoneal injections of diverse substances.
Topics: Alanine; Aminobutyrates; Animals; Atmospheric Pressure; Brain Chemistry; Hypertonic Solutions; Injec | 1967 |
Metabolism of beta-cyanoalanine.
Topics: Alanine; Aldehydes; Amino Acids; Animals; Body Weight; Brain Chemistry; Chromatography, Ion Exchange | 1967 |
Amino acid metabolism in the brain with convulsive disorders. Part I: Free amino acid patterns in the brain of E1 mouse with convulsive seizure.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Brain; Cystathionine; gamma-Aminobutyric Acid; Glutami | 1984 |
gamma-Aminobutyric acid uptake inhibition and anticonvulsant activity of nipecotic acid esters.
Topics: Alanine; Animals; Anticonvulsants; Bicuculline; Chemical Phenomena; Chemistry, Physical; GABA Antago | 1984 |
Modulation of the kynurenine pathway in search for new neuroprotective agents. Synthesis and preliminary evaluation of (m-nitrobenzoyl)alanine, a potent inhibitor of kynurenine-3-hydroxylase.
Topics: Alanine; Animals; Anticonvulsants; Binding, Competitive; Brain; Hippocampus; Hydrolases; Kynurenic A | 1994 |
Synthesis and anticonvulsant activity of some amino acid derivatives. Part 1: alanine derivatives.
Topics: Acetylation; Alanine; Animals; Anticonvulsants; Chemical Phenomena; Chemistry, Physical; Convulsants | 1996 |
NMDA receptor-mediated increase in cyclic GMP in the rat cerebellum in vivo is blocked by alaproclate and GEA-857.
Topics: 4-Aminopyridine; Alanine; Animals; Behavior, Animal; Cerebellum; Convulsants; Cyclic GMP; Drug Inter | 1997 |
Regional excitatory and inhibitory amino acid concentrations in pentylenetetrazol kindling and kindled rat brain.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Brain Chemistry; Convulsants; gamma-Aminobutyric Acid; | 1997 |
Synthesis and anticonvulsant activity of a new class of 2-[(arylalky)amino]alkanamide derivatives.
Topics: Alanine; Animals; Anticonvulsants; Benzylamines; Bicuculline; Drug Design; Electroshock; Indicators | 1998 |
Acute behavioral and EEG effects of NW-1015 on electrically-induced afterdischarge in conscious monkeys.
Topics: Alanine; Animals; Anticonvulsants; Behavior, Animal; Benzylamines; Electric Stimulation; Electroence | 2000 |
Pharmacological properties of the potent epileptogenic amino acid dysiherbaine, a novel glutamate receptor agonist isolated from the marine sponge Dysidea herbacea.
Topics: Alanine; Amino Acid Transport System X-AG; Animals; ATP-Binding Cassette Transporters; Bridged Bicyc | 2001 |
Anticonvulsant activity of a mGlu(4alpha) receptor selective agonist, (1S,3R,4S)-1-aminocyclopentane-1,2,4-tricarboxylic acid.
Topics: Acoustic Stimulation; Alanine; Aminobutyrates; Animals; Anticonvulsants; Behavior, Animal; Cyclopent | 2001 |
Effect of amino-oxyacetic acid (AOAA) on focal penicillin seizures.
Topics: Acetates; Alanine; Aminooxyacetic Acid; Animals; Aspartic Acid; Cerebral Cortex; Disease Models, Ani | 1978 |
Glycerol intolerance in a child with intermittent hypoglycemia.
Topics: Alanine; Carbon Radioisotopes; Child, Preschool; Consciousness; Fructose; Fructose-Bisphosphatase; G | 1975 |
Isolated ACTH deficiency. Metabolic and endocrine studies in a 7-year-old boy.
Topics: Adrenocorticotropic Hormone; Alanine; Child; Humans; Hypoglycemia; Hypothalamo-Hypophyseal System; M | 1978 |
Brain gamma-aminobutyric acid and acoustic priming in C57BL/6Bg mice.
Topics: Acoustic Stimulation; Alanine; Aminobutyrates; Aminooxyacetic Acid; Animals; Bicuculline; Brain Chem | 1977 |
The chemical synthesis and biological evaluation of [1-L-alanine-A]-and [1-D-alanine-A]insulins.
Topics: Adipose Tissue; Alanine; Animals; Glucose; In Vitro Techniques; Insulin; Male; Mice; Rats; Receptor, | 1978 |
Effects of the Areca nut constituents arecaidine and guvacine on the action of GABA in the cat central nervous system.
Topics: Action Potentials; Alanine; Aminobutyrates; Animals; Areca; Arecoline; Bicuculline; Cats; Cerebellum | 1977 |
Suceptibility of mice to audiogenic seizures is increased by handling their dams during gestation.
Topics: Alanine; Animals; Female; Mice; Pregnancy; Pregnancy, Animal; Seizures; Sound; Stress, Physiological | 1976 |
Amino acid uptake in vivo by the mouse brain and by various regions of the rabbit brain after drug-induced convulsions.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Biological Transport, Active; Blood-Brain Barrier; Bra | 1975 |
[Chronic hyperammonemia with orotic aciduria: evidence of pyrimidine pathway stimulation (author's transl)].
Topics: Alanine; Amino Acids; Ammonia; Child, Preschool; Dietary Proteins; Erythrocytes; Growth Disorders; H | 1975 |
Nicotinylalanine increases cerebral kynurenic acid content and has anticonvulsant activity.
Topics: Alanine; Animals; Anticonvulsants; Brain Chemistry; Electroshock; In Vitro Techniques; Kidney; Kynur | 1992 |
The influence of strychnine-insensitive glycine receptor agonists and antagonists on generalized seizure thresholds.
Topics: Alanine; Amygdala; Animals; Glycine; Kindling, Neurologic; Kynurenic Acid; Male; Pyrrolidinones; Rat | 1991 |
[Effect of excitant amino acid antagonists on glutamate receptors in the locust and on convulsions induced by glutamate, aspartate, kynurenine and quinolinic acid in mice].
Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Dose-Response Relationship, Drug; Drug | 1986 |
Prevention of the convulsant and hyperalgesic action of strychnine by intrathecal glycine and related amino acids.
Topics: Alanine; Amino Acids; Animals; Betaine; Glycine; Injections, Spinal; Pain; Rats; Rats, Inbred Strain | 1988 |
Effects of glycine and other inhibitory amino acid neurotransmitters on strychnine convulsive threshold in mice.
Topics: Alanine; Animals; beta-Alanine; Diazepam; Dose-Response Relationship, Drug; Glycine; Male; Mice; Mic | 1985 |
On the neurotoxic effects induced by alkylating agents.
Topics: Alanine; Animals; Anti-Bacterial Agents; Antimetabolites; Azaserine; Behavior, Animal; Central Nervo | 1966 |
[Amino acid metabolism pathology in the convulsive syndrome in young children].
Topics: Alanine; Amino Acids; Arginine; Asparagine; Child, Preschool; Cystine; Female; Glutamates; Glutamine | 1972 |
[Mechanism of intrahepatic accumulation of dicarboxylic amino acids during ammonia poisoning].
Topics: Alanine; Amino Acids; Ammonia; Animals; Arginine; Aspartic Acid; Citrates; Citrulline; Dicarboxylic | 1972 |
The effect of hexafluorodiethyl ether (flurothyl) on the metabolism of rat brain amino acids labelled by (U-14C)glucose.
Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Brain; Carbon Radioisotopes; Chromatog | 1973 |
Brain amino acids during convulsions.
Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Brain; Electric Stimulation; Glutamate | 1974 |
Action of phenobarbitone on neocortical amino acid changes induced by a spiking focus.
Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Brain Chemistry; Cats; Cerebral Cortex; Depression, C | 1968 |
Incorporation of carbon from glucose into cerebral amino acids, proteins and lipids, and alterations during recovery from hypoglycaemia.
Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Blood Glucose; Carbon Isotopes; Cerebr | 1972 |
Pyridoxine deficiency and brain amino acids.
Topics: Acetates; Alanine; Amino Acids; Aminobutyrates; Animals; Brain; Brain Chemistry; Diet; Glutamates; G | 1969 |
Effects of various conditions on the movement of carbon atoms derived from glucose into and out of protein in rat brain.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Autoanalysis; Brain; Carbon Isotopes; Cerebral Cortex; | 1970 |
Incorporation of carbon atoms from glucose into free amino acids in brain under normal and altered conditions.
Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Autoanalysis; Brain; Carbon Isotopes; | 1970 |
Preparation and characterization of diphenylthiocarbamyl-insulin and des-gly A1-des phe B1-insulin (bovine).
Topics: Alanine; Amines; Amino Acids; Animals; Buffers; Carbon Isotopes; Chemical Phenomena; Chemistry; Chro | 1970 |
The acute cerebellar syndrome in 5-fluorouracil chemotherapy: a manifestation of fluoroacetate intoxication.
Topics: Alanine; Animals; Brain Chemistry; Cats; Cerebellar Ataxia; Citrates; Citric Acid Cycle; Fluoroaceta | 1970 |
Evidence for separate systems for the transport of neutral and basic amino acids across the blood-brain barrier.
Topics: Alanine; Amino Acids; Animals; Arginine; Biological Transport; Blood-Brain Barrier; Carbon Isotopes; | 1971 |
Some neurochemical aspects of fluorocitrate intoxication.
Topics: Adenosine Triphosphate; Alanine; Amino Acids; Aminobutyrates; Ammonia; Animals; Aspartic Acid; Brain | 1971 |
Convulsions and the gamma-aminobutyric acid content of rat brain.
Topics: Alanine; Aminobutyrates; Animals; Brain Chemistry; Hyperbaric Oxygenation; Osmolar Concentration; Ox | 1968 |
[Argininosuccinic aciduria disease of the newborn with lethal course].
Topics: Adult; Alanine; Amino Acids; Aminobutyrates; Anticonvulsants; Aspartic Acid; Brain Diseases; Chromat | 1968 |
[Metabolic studies of epileptic seizures. The concentration of free amino acids in cerebral tissue prior to and during cerebral seizures].
Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Brain; Centrifugation; Chromatography, | 1969 |