alamethicin has been researched along with Hypercholesterolemia* in 1 studies
1 other study(ies) available for alamethicin and Hypercholesterolemia
Article | Year |
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[Modification of the functional properties of sarcoplasmic reticulum Ca-ATPase in hypercholesterolemia].
Using alamethicin, permitting the measurement of genuine catalytic enzyme activity, hypercholesterolemia was shown to cause a 10-30% reduction of specific Ca-ATPase activity registered at 37 degrees C and the shift of Arrhenius plot in 20-30 degrees C temperature range. Reconstruction of delipidated Ca-ATPase of sarcoplasmic reticulum membranes by egg lecithin in animals with hypercholesterolemia does not lead to the recovery of Arrhenius plot. The data obtained demonstrate that modification of temperature-dependent Ca-ATPase activity in hypercholesterolemia is associated with the changes in the polypeptide with a catalytic function and is not induced by the changes in phospholipid enzyme surroundings. Topics: Alamethicin; Animals; Calcium-Transporting ATPases; Catalysis; Cholesterol, Dietary; Hypercholesterolemia; Male; Membrane Lipids; Rabbits; Sarcoplasmic Reticulum; Temperature | 1986 |