alagebrium has been researched along with Alloxan Diabetes in 19 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 11 (57.89) | 29.6817 |
| 2010's | 6 (31.58) | 24.3611 |
| 2020's | 2 (10.53) | 2.80 |
| Authors | Studies |
|---|---|
| Barakat, W; El-Akabawy, N; Elbatreek, MH; Elkomy, NM; Elshahat, A; Harb, A | 1 |
| Ender Caylan, A; Gurbuz, N; Gurkan, R; Surmen Usta, S; Usta, MF | 1 |
| Gao, Z; Guan, R; Li, G; Li, H; Tian, W; Uwais, Z; Wang, L; Xin, Z | 1 |
| Chen, W; Cheng, X; Cui, H; He, K; Li, S; Wang, L; Zhang, B; Zhong, W | 1 |
| Chan, DC; Chiang, CK; Chiu, CY; Liu, SH; Sheu, ML; Tsai, KS; Yang, RS; Yang, TH | 1 |
| Andrikopoulos, S; Bierhaus, A; Cooper, ME; Coughlan, MT; Forbes, JM; Harcourt, BE; O'Brien, RC; Penfold, S; Sourris, KC; Tan, AL; Thallas-Bonke, V; Thomas, MC | 1 |
| Choi, WJ; Ha, H; Huh, JY; Jeong, LS; Kim, J; Kim, WY; Kwon, MK; Lee, GT; Lee, HB; Nagai, R; Park, J | 1 |
| Bierhaus, A; Cooper, ME; Gray, SP; Jandeleit-Dahm, KA; Jiaze, L; Pickering, R; Soro-Paavonen, A; Thomas, MC; Tikellis, C; Tsorotes, D; Watson, AM; Wong, B | 1 |
| Burns, WC; Burrell, LM; Candido, R; Cooper, ME; Dean, RG; Forbes, JM; Ritchie, RH; Thallas, V; Thomas, MC; Tikellis, C; Twigg, SM | 1 |
| Kass, DA | 1 |
| Jyothirmayi, GN; Liu, J; Malhotra, A; Masurekar, MR; Meggs, LG; Regan, TJ; Vatner, DE; Vatner, SF | 1 |
| Burns, WC; Cooper, ME; Forbes, JM; Founds, HW; Jerums, G; Thallas, V; Thomas, MC | 1 |
| Allen, TJ; Burns, WC; Candido, R; Cooper, ME; Deemer, EK; Forbes, JM; Jandeleit-Dahm, KA; Lassila, M; Thallas, V; Thomas, MC; Thorpe, SM; Thorpe, SR; Yee, LT | 1 |
| Bach, LA; Boner, G; Cooper, ME; Forbes, JM; Haller, H; Lindschau, C; Meier, M; Rizkalla, B; Thallas-Bonke, V | 1 |
| Bivalacqua, TJ; Cellek, S; Foxwell, NA; Gur, S; Hellstrom, WJ; Kendirci, M; Usta, MF | 1 |
| Cooper, ME; Soldatos, G | 1 |
| Arnstein, M; Cooper, ME; Coughlan, MT; Forbes, JM; Gasser, A; Long, DM; Pete, J; Thallas-Bonke, V; Thorpe, SR; Tong, DC | 1 |
| Gangula, PR; Jeyabal, PV; Kumar, R; Micci, MA; Pasricha, PJ | 1 |
| Grill, V; Hiramatsu, S; Inoue, K; Tajirl, Y | 1 |
1 review(s) available for alagebrium and Alloxan Diabetes
| Article | Year |
|---|---|
Advanced glycation end products and vascular structure and function.
Topics: Animals; Atherosclerosis; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Endothelium, Vascular; Glycation End Products, Advanced; Humans; Lymphocyte Activation; Receptor for Advanced Glycation End Products; Thiazoles | 2006 |
18 other study(ies) available for alagebrium and Alloxan Diabetes
| Article | Year |
|---|---|
Repurposing alagebrium for diabetic foot ulcer healing: Impact on AGEs/NFκB/NOX1 signaling.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Foot; Epidermal Growth Factor; Glycation End Products, Advanced; Humans; NADPH Oxidase 1; NF-kappa B; Quality of Life; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A; Wound Healing | 2023 |
The therapeutic effect of ALT-711 on erectile function in rats treated with high-level AGEs (advanced glycation end products) containing diet.
Topics: Animals; Diabetes Mellitus, Experimental; Diet; Erectile Dysfunction; Glycation End Products, Advanced; Male; Nitric Oxide Synthase Type III; Penile Erection; Penis; Rats; Rats, Sprague-Dawley; Thiazoles | 2022 |
AGE-breaker ALT-711 plus insulin could restore erectile function in streptozocin-induced type 1 diabetic rats.
Topics: Animals; Apoptosis; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Erectile Dysfunction; Hypoglycemic Agents; Insulin; Male; Malondialdehyde; Nitric Oxide Synthase Type I; Oxidative Stress; Penile Erection; Penis; Random Allocation; Rats; Rats, Sprague-Dawley; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Thiazoles | 2014 |
Alagebrium (ALT-711) improves the anti-hypertensive efficacy of nifedipine in diabetic-hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Diabetes Mellitus, Experimental; Drug Therapy, Combination; Endothelin-1; Epoprostenol; Heart Rate; Hypertension; Male; Nifedipine; Nitric Oxide; Rats; Rats, Wistar; Thiazoles | 2014 |
Advanced glycation end-products induce skeletal muscle atrophy and dysfunction in diabetic mice via a RAGE-mediated, AMPK-down-regulated, Akt pathway.
Topics: Aged; AMP-Activated Protein Kinases; Animals; Atrophy; Case-Control Studies; Diabetes Mellitus; Diabetes Mellitus, Experimental; Down-Regulation; Glycation End Products, Advanced; Humans; Male; MAP Kinase Signaling System; Mice; Muscle Fatigue; Muscle Fibers, Skeletal; Muscle Proteins; Muscle Weakness; Muscle, Skeletal; Muscular Diseases; Receptor for Advanced Glycation End Products; Regeneration; Signal Transduction; SKP Cullin F-Box Protein Ligases; Thiazoles | 2016 |
Disparate effects on renal and oxidative parameters following RAGE deletion, AGE accumulation inhibition, or dietary AGE control in experimental diabetic nephropathy.
Topics: Adenosine Triphosphate; Albuminuria; Animals; Creatinine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Diet; Disease Models, Animal; Disease Progression; Glycation End Products, Advanced; Glycolysis; Ion Channels; Kidney; Male; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; Mitochondrial Proteins; Oxidative Stress; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Superoxides; Thiazoles; Time Factors; Uncoupling Protein 2 | 2010 |
Renoprotective antioxidant effect of alagebrium in experimental diabetes.
Topics: Acute Kidney Injury; Albuminuria; Animals; Antioxidants; Blotting, Western; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Hydrogen Peroxide; Immunoenzyme Techniques; Male; Mesangial Cells; Mice; Mice, Inbred C57BL; NADPH Oxidases; Oxidative Stress; Protein Kinase C; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; RNA, Messenger; Thiazoles | 2011 |
Alagebrium reduces glomerular fibrogenesis and inflammation beyond preventing RAGE activation in diabetic apolipoprotein E knockout mice.
Topics: Albuminuria; Animals; Apolipoproteins E; Diabetes Mellitus, Experimental; Fibrosis; Glomerular Mesangium; Glomerulonephritis; Glycation End Products, Advanced; Male; Mice; Mice, Knockout; Nephritis; Oxidative Stress; Quinapril; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Tetrahydroisoquinolines; Thiazoles | 2012 |
A breaker of advanced glycation end products attenuates diabetes-induced myocardial structural changes.
Topics: Animals; Blood Pressure; Body Weight; Collagen; Cytokines; Diabetes Mellitus, Experimental; Gene Expression Regulation; Glycation End Products, Advanced; Heart Ventricles; Hypertrophy, Left Ventricular; Immunohistochemistry; Male; Myocardium; Natriuretic Peptide, Brain; Organ Size; Rats; Rats, Sprague-Dawley; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Thiazoles | 2003 |
Getting better without AGE: new insights into the diabetic heart.
Topics: Animals; Collagen; Cytokines; Diabetes Mellitus, Experimental; Gene Expression Regulation; Glycation End Products, Advanced; Heart Ventricles; Hypertrophy, Left Ventricular; Natriuretic Peptide, Brain; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Thiazoles | 2003 |
Glycation end-product cross-link breaker reduces collagen and improves cardiac function in aging diabetic heart.
Topics: Aging; Animals; Blood Glucose; Collagen Type I; Collagen Type III; Cross-Linking Reagents; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Dogs; Glycation End Products, Advanced; Hemodynamics; Male; Myocardium; Solubility; Thiazoles | 2003 |
The breakdown of preexisting advanced glycation end products is associated with reduced renal fibrosis in experimental diabetes.
Topics: Albuminuria; Animal Population Groups; Animals; Blood Pressure; Collagen; Connective Tissue Growth Factor; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Fibrosis; Glycation End Products, Advanced; Immediate-Early Proteins; Immunohistochemistry; Intercellular Signaling Peptides and Proteins; Kidney; Kinetics; Lysine; Models, Biological; Rats; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Solubility; Thiazoles; Transforming Growth Factor beta; Transforming Growth Factor beta1; Tyrosine | 2003 |
Advanced glycation end product interventions reduce diabetes-accelerated atherosclerosis.
Topics: Actins; Animals; Aorta; Arteriosclerosis; Collagen; Cytokines; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Glycation End Products, Advanced; Guanidines; Lipid Metabolism; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth; Oxidation-Reduction; Skin; Thiazoles | 2004 |
Attenuation of extracellular matrix accumulation in diabetic nephropathy by the advanced glycation end product cross-link breaker ALT-711 via a protein kinase C-alpha-dependent pathway.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Extracellular Matrix Proteins; Glycation End Products, Advanced; Guanidines; Kidney Cortex; Male; Protein Kinase C; Protein Kinase C-alpha; Protein Transport; Rats; Rats, Sprague-Dawley; Thiazoles | 2004 |
The breakdown of preformed advanced glycation end products reverses erectile dysfunction in streptozotocin-induced diabetic rats: preventive versus curative treatment.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Dose-Response Relationship, Drug; Glycation End Products, Advanced; Guanidines; Immunohistochemistry; Impotence, Vasculogenic; Male; Rats; Rats, Sprague-Dawley; Streptozocin; Thiazoles | 2006 |
Combination therapy with the advanced glycation end product cross-link breaker, alagebrium, and angiotensin converting enzyme inhibitors in diabetes: synergy or redundancy?
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Cytosol; Diabetes Mellitus, Experimental; Drug Synergism; Drug Therapy, Combination; Enzyme Activation; Glycation End Products, Advanced; Kidney; Lysine; Male; Mitochondria; NF-kappa B; Oxidative Stress; Protein Kinase C; Ramipril; Rats; Rats, Sprague-Dawley; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Renin-Angiotensin System; Superoxide Dismutase; Thiazoles; Vascular Endothelial Growth Factor A | 2007 |
Inhibitors of advanced glycation end-products prevent loss of enteric neuronal nitric oxide synthase in diabetic rats.
Topics: Animals; Blood Glucose; Blotting, Western; Body Weight; Diabetes Mellitus, Experimental; Duodenum; Enteric Nervous System; Enzyme-Linked Immunosorbent Assay; Glycation End Products, Advanced; Guanidines; Immunohistochemistry; Male; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Thiazoles | 2008 |
Improvement by aminoguanidine of insulin secretion from pancreatic islets grafted to syngeneic diabetic rats.
Topics: Animals; B-Lymphocytes; Diabetes Mellitus, Experimental; Guanidines; Insulin; Insulin Secretion; Islets of Langerhans; Islets of Langerhans Transplantation; Male; Proinsulin; Protein Precursors; Rats; Rats, Wistar; RNA, Messenger; Thiazoles; Transplantation, Isogeneic | 2000 |