alagebrium has been researched along with Aging in 20 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 14 (70.00) | 29.6817 |
| 2010's | 6 (30.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Abdullah, SM; Adams-Huet, B; Barkley, KW; Bhella, PS; Boyd, KN; Carrick-Ranson, G; Fujimoto, N; Hastings, JL; Levine, BD; Livingston, SA; Palmer, D; Shafer, KM; Shibata, S | 1 |
| Hopman, MT; Levine, BD; Olde Rikkert, MG; Oudegeest-Sander, MH; Smits, P; Thijssen, DH; van Dijk, AP | 1 |
| Kyriazis, M | 1 |
| Meyer, DM; Mills, LD; Mohammed, SF; Owan, TE; Redfield, MM; Schalkwijk, CG; Shapiro, BP | 1 |
| Cheng, YL; Guo, Y; Lu, M; Qian, J | 1 |
| Ferrucci, L; Nicklett, EJ; Semba, RD | 1 |
| Barodka, V; Benjo, AM; Berkowitz, DE; Daher, JP; Gupta, G; Levine, BD; Lussman, C; Nyhan, SM; Pellakuru, L; Ryoo, S; Shoukas, AA; Steppan, J; Tran, H; White, AR | 1 |
| Yamagishi, S | 1 |
| Jyothirmayi, GN; Liu, J; Malhotra, A; Masurekar, MR; Meggs, LG; Regan, TJ; Vatner, DE; Vatner, SF | 1 |
| Foiles, P; Founds, H; Vasan, S | 1 |
| Ahn, J; Frohlich, ED; Susic, D; Varagic, J | 1 |
| Bakris, GL; Bank, AJ; Kass, DA; Neutel, JM; Oparil, S; Preston, RA | 1 |
| Cui, H; Li, S; Wang, LL; Zhong, W | 1 |
| Scuteri, A | 1 |
| Capriotti, A; Clattenburg, L; Corretti, MC; Gerstenblith, G; Kass, DA; Melenovsky, V; Zieman, SJ | 1 |
| Asif, M; Brines, M; Cerami, A; Egan, J; Jyothirmayi, GN; Lopez, S; Masurekar, MR; Regan, TJ; Torres, RL; Ulrich, P; Vasan, S; Wagle, D; Williams, C | 1 |
| Melton, L | 1 |
| Brines, M; Cerami, A; Egan, JJ; Ingram, DK; Lakatta, EG; Lane, M; Roth, GS; Spurgeon, H; Ulrich, P; Vaitkevicius, PV; Vasan, S; Wagle, DR; Wuerth, JP | 1 |
| Cerami, A; Ulrich, P | 1 |
7 review(s) available for alagebrium and Aging
| Article | Year |
|---|---|
Does accumulation of advanced glycation end products contribute to the aging phenotype?
Topics: Aging; Bone and Bones; Brain; Diet; Enzyme Inhibitors; Erythrocytes; Eye; Food Analysis; Glycation End Products, Advanced; Guanidines; Humans; Inflammation; Kidney; Liver; Longevity; Muscle, Skeletal; Myocardium; Oxidative Stress; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Tendons; Thiazoles | 2010 |
Potential clinical utility of advanced glycation end product cross-link breakers in age- and diabetes-associated disorders.
Topics: Aging; Animals; Cross-Linking Reagents; Diabetes Complications; Glycation End Products, Advanced; Humans; Thiazoles | 2012 |
Therapeutic potential of breakers of advanced glycation end product-protein crosslinks.
Topics: Aging; Animals; Clinical Trials as Topic; Cross-Linking Reagents; Diabetes Mellitus; Diastole; Drug Evaluation, Preclinical; Elasticity; Glycation End Products, Advanced; Guanidines; Humans; Hypertrophy, Left Ventricular; Molecular Structure; Myocardium; Proteins; Skin; Thiazoles | 2003 |
Crosslink breakers: a new approach to cardiovascular therapy.
Topics: Aging; Animals; Blood Pressure; Cardiovascular Diseases; Collagen; Comorbidity; Cross-Linking Reagents; Diabetes Mellitus; Glycation End Products, Advanced; Humans; Hypertension; Kidney Failure, Chronic; Rats; Thiazoles; Treatment Outcome | 2004 |
Advanced glycation end-product cross-link breakers. A novel approach to cardiovascular pathologies related to the aging process.
Topics: Aging; Animals; Blood Pressure; Blood Vessels; Cardiovascular Agents; Cardiovascular Diseases; Controlled Clinical Trials as Topic; Glycation End Products, Advanced; Heart Failure; Humans; Hypertension; Thiazoles | 2004 |
[Targeted AGEes and AGEs cross-link in drug discovery: preventing and reversing arterial sclerosis in aging and diabetes].
Topics: Aging; Animals; Arteries; Arteriosclerosis; Blood Pressure; Diabetes Mellitus; Glycation End Products, Advanced; Guanidines; Humans; Thiazoles | 2005 |
Protein glycation, diabetes, and aging.
Topics: Aging; Animals; Diabetes Mellitus; Glycation End Products, Advanced; Humans; Models, Chemical; Thiazoles | 2001 |
3 trial(s) available for alagebrium and Aging
| Article | Year |
|---|---|
Cardiovascular effects of 1 year of alagebrium and endurance exercise training in healthy older individuals.
Topics: Aged; Aged, 80 and over; Aging; Cardiovascular System; Dose-Response Relationship, Drug; Double-Blind Method; Exercise Test; Exercise Tolerance; Female; Follow-Up Studies; Heart Ventricles; Humans; Male; Middle Aged; Prospective Studies; Reference Values; Thiazoles; Time Factors; Ventricular Function, Left | 2013 |
The effect of an advanced glycation end-product crosslink breaker and exercise training on vascular function in older individuals: a randomized factorial design trial.
Topics: Age Factors; Aged; Aging; Blood Flow Velocity; Cardiovascular Diseases; Endothelium, Vascular; Exercise Test; Exercise Therapy; Female; Glycation End Products, Advanced; Humans; Male; Oxygen Consumption; Physical Fitness; Plethysmography; Pulse Wave Analysis; Risk Assessment; Risk Factors; Sedentary Behavior; Thiazoles; Time Factors; Treatment Outcome; Vascular Stiffness; Vasoconstriction; Vasodilation | 2013 |
Advanced glycation endproduct crosslink breaker (alagebrium) improves endothelial function in patients with isolated systolic hypertension.
Topics: Aged; Aging; Blood Pressure; Carotid Arteries; Collagen; Elasticity; Endothelium, Vascular; Female; Glycation End Products, Advanced; Humans; Hypertension; Intercellular Adhesion Molecule-1; Male; Manometry; Matrix Metalloproteinase 9; Middle Aged; Peripheral Vascular Diseases; Single-Blind Method; Thiazoles; Transforming Growth Factor beta1; Vascular Cell Adhesion Molecule-1; Vasodilation | 2007 |
10 other study(ies) available for alagebrium and Aging
| Article | Year |
|---|---|
The impracticality of biomedical rejuvenation therapies: translational and pharmacological barriers.
Topics: Aging; Biotechnology; Glycation End Products, Advanced; Humans; Lysosomes; Medication Adherence; Pharmacology; Polypharmacy; Rejuvenation; Telomere; Thiazoles; Translational Research, Biomedical | 2014 |
Advanced glycation end products accumulate in vascular smooth muscle and modify vascular but not ventricular properties in elderly hypertensive canines.
Topics: Aging; Animals; Aorta; Collagen; Dogs; Drug Evaluation, Preclinical; Elastin; Glycation End Products, Advanced; Heart Ventricles; Hypertension; Lysine; Muscle, Smooth, Vascular; Thiazoles; Vasa Vasorum; Vascular Resistance; Ventricular Function, Left | 2008 |
Alagebrium chloride protects the heart against oxidative stress in aging rats.
Topics: Aging; Animals; DNA, Mitochondrial; Echocardiography; Female; Glutathione Peroxidase; Glycation End Products, Advanced; Heart; Myocardium; Oxidative Stress; Protective Agents; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Thiazoles | 2009 |
Alagebrium in combination with exercise ameliorates age-associated ventricular and vascular stiffness.
Topics: Aging; Animals; Diastole; Drug Evaluation, Preclinical; Glycation End Products, Advanced; Hemodynamics; Male; Physical Conditioning, Animal; Rats; Rats, Inbred F344; Systole; Thiazoles; Vascular Stiffness; Ventricular Function, Left | 2012 |
Glycation end-product cross-link breaker reduces collagen and improves cardiac function in aging diabetic heart.
Topics: Aging; Animals; Blood Glucose; Collagen Type I; Collagen Type III; Cross-Linking Reagents; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Dogs; Glycation End Products, Advanced; Hemodynamics; Male; Myocardium; Solubility; Thiazoles | 2003 |
Slowing arterial aging: how far have we progressed?
Topics: Aging; Blood Pressure; Glycation End Products, Advanced; Humans; Hypertension; Peripheral Vascular Diseases; Thiazoles | 2007 |
An advanced glycation endproduct cross-link breaker can reverse age-related increases in myocardial stiffness.
Topics: Aging; Animals; Diastole; Dogs; Elasticity; Glycation End Products, Advanced; Heart Rate; Hemodynamics; Male; Myocardium; Stroke Volume; Systole; Thiazoles; Ventricular Function | 2000 |
Age breakers. Rupturing the body's sugar-protein bonds might turn back the clock.
Topics: Aging; Carbohydrate Metabolism; Collagen; Elasticity; Glycation End Products, Advanced; Humans; Proteins; Thiazoles | 2000 |
A cross-link breaker has sustained effects on arterial and ventricular properties in older rhesus monkeys.
Topics: Aging; Animals; Arteries; Blood Pressure; Echocardiography; Glycation End Products, Advanced; Heart Rate; Hemodynamics; Injections, Intramuscular; Macaca mulatta; Male; Muscle, Smooth, Vascular; Pulse; Stroke Volume; Thiazoles; Time Factors; Ventricular Function, Left | 2001 |
Clinical trial to pharmacologically reverse the effects of ageing and diabetes.
Topics: Aging; Clinical Trials, Phase II as Topic; Diabetes Mellitus; Double-Blind Method; Female; Glycation End Products, Advanced; Humans; Male; Middle Aged; Multicenter Studies as Topic; Thiazoles | 2000 |