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alagebrium and Aging

alagebrium has been researched along with Aging in 20 studies

Research

Studies (20)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	14 (70.00)	29.6817
2010's	6 (30.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Abdullah, SM; Adams-Huet, B; Barkley, KW; Bhella, PS; Boyd, KN; Carrick-Ranson, G; Fujimoto, N; Hastings, JL; Levine, BD; Livingston, SA; Palmer, D; Shafer, KM; Shibata, S	1
Hopman, MT; Levine, BD; Olde Rikkert, MG; Oudegeest-Sander, MH; Smits, P; Thijssen, DH; van Dijk, AP	1
Kyriazis, M	1
Meyer, DM; Mills, LD; Mohammed, SF; Owan, TE; Redfield, MM; Schalkwijk, CG; Shapiro, BP	1
Cheng, YL; Guo, Y; Lu, M; Qian, J	1
Ferrucci, L; Nicklett, EJ; Semba, RD	1
Barodka, V; Benjo, AM; Berkowitz, DE; Daher, JP; Gupta, G; Levine, BD; Lussman, C; Nyhan, SM; Pellakuru, L; Ryoo, S; Shoukas, AA; Steppan, J; Tran, H; White, AR	1
Yamagishi, S	1
Jyothirmayi, GN; Liu, J; Malhotra, A; Masurekar, MR; Meggs, LG; Regan, TJ; Vatner, DE; Vatner, SF	1
Foiles, P; Founds, H; Vasan, S	1
Ahn, J; Frohlich, ED; Susic, D; Varagic, J	1
Bakris, GL; Bank, AJ; Kass, DA; Neutel, JM; Oparil, S; Preston, RA	1
Cui, H; Li, S; Wang, LL; Zhong, W	1
Scuteri, A	1
Capriotti, A; Clattenburg, L; Corretti, MC; Gerstenblith, G; Kass, DA; Melenovsky, V; Zieman, SJ	1
Asif, M; Brines, M; Cerami, A; Egan, J; Jyothirmayi, GN; Lopez, S; Masurekar, MR; Regan, TJ; Torres, RL; Ulrich, P; Vasan, S; Wagle, D; Williams, C	1
Melton, L	1
Brines, M; Cerami, A; Egan, JJ; Ingram, DK; Lakatta, EG; Lane, M; Roth, GS; Spurgeon, H; Ulrich, P; Vaitkevicius, PV; Vasan, S; Wagle, DR; Wuerth, JP	1
Cerami, A; Ulrich, P	1

Reviews

7 review(s) available for alagebrium and Aging

Article	Year
Does accumulation of advanced glycation end products contribute to the aging phenotype? The journals of gerontology. Series A, Biological sciences and medical sciences, 2010, Volume: 65, Issue:9 Topics: Aging; Bone and Bones; Brain; Diet; Enzyme Inhibitors; Erythrocytes; Eye; Food Analysis; Glycation End Products, Advanced; Guanidines; Humans; Inflammation; Kidney; Liver; Longevity; Muscle, Skeletal; Myocardium; Oxidative Stress; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Tendons; Thiazoles	2010
Potential clinical utility of advanced glycation end product cross-link breakers in age- and diabetes-associated disorders. Rejuvenation research, 2012, Volume: 15, Issue:6 Topics: Aging; Animals; Cross-Linking Reagents; Diabetes Complications; Glycation End Products, Advanced; Humans; Thiazoles	2012
Therapeutic potential of breakers of advanced glycation end product-protein crosslinks. Archives of biochemistry and biophysics, 2003, Nov-01, Volume: 419, Issue:1 Topics: Aging; Animals; Clinical Trials as Topic; Cross-Linking Reagents; Diabetes Mellitus; Diastole; Drug Evaluation, Preclinical; Elasticity; Glycation End Products, Advanced; Guanidines; Humans; Hypertrophy, Left Ventricular; Molecular Structure; Myocardium; Proteins; Skin; Thiazoles	2003
Crosslink breakers: a new approach to cardiovascular therapy. Current opinion in cardiology, 2004, Volume: 19, Issue:4 Topics: Aging; Animals; Blood Pressure; Cardiovascular Diseases; Collagen; Comorbidity; Cross-Linking Reagents; Diabetes Mellitus; Glycation End Products, Advanced; Humans; Hypertension; Kidney Failure, Chronic; Rats; Thiazoles; Treatment Outcome	2004
Advanced glycation end-product cross-link breakers. A novel approach to cardiovascular pathologies related to the aging process. American journal of hypertension, 2004, Volume: 17, Issue:12 Pt 2 Topics: Aging; Animals; Blood Pressure; Blood Vessels; Cardiovascular Agents; Cardiovascular Diseases; Controlled Clinical Trials as Topic; Glycation End Products, Advanced; Heart Failure; Humans; Hypertension; Thiazoles	2004
[Targeted AGEes and AGEs cross-link in drug discovery: preventing and reversing arterial sclerosis in aging and diabetes]. Yao xue xue bao = Acta pharmaceutica Sinica, 2005, Volume: 40, Issue:1 Topics: Aging; Animals; Arteries; Arteriosclerosis; Blood Pressure; Diabetes Mellitus; Glycation End Products, Advanced; Guanidines; Humans; Thiazoles	2005
Protein glycation, diabetes, and aging. Recent progress in hormone research, 2001, Volume: 56 Topics: Aging; Animals; Diabetes Mellitus; Glycation End Products, Advanced; Humans; Models, Chemical; Thiazoles	2001

Trials

3 trial(s) available for alagebrium and Aging

Article	Year
Cardiovascular effects of 1 year of alagebrium and endurance exercise training in healthy older individuals. Circulation. Heart failure, 2013, Volume: 6, Issue:6 Topics: Aged; Aged, 80 and over; Aging; Cardiovascular System; Dose-Response Relationship, Drug; Double-Blind Method; Exercise Test; Exercise Tolerance; Female; Follow-Up Studies; Heart Ventricles; Humans; Male; Middle Aged; Prospective Studies; Reference Values; Thiazoles; Time Factors; Ventricular Function, Left	2013
The effect of an advanced glycation end-product crosslink breaker and exercise training on vascular function in older individuals: a randomized factorial design trial. Experimental gerontology, 2013, Volume: 48, Issue:12 Topics: Age Factors; Aged; Aging; Blood Flow Velocity; Cardiovascular Diseases; Endothelium, Vascular; Exercise Test; Exercise Therapy; Female; Glycation End Products, Advanced; Humans; Male; Oxygen Consumption; Physical Fitness; Plethysmography; Pulse Wave Analysis; Risk Assessment; Risk Factors; Sedentary Behavior; Thiazoles; Time Factors; Treatment Outcome; Vascular Stiffness; Vasoconstriction; Vasodilation	2013
Advanced glycation endproduct crosslink breaker (alagebrium) improves endothelial function in patients with isolated systolic hypertension. Journal of hypertension, 2007, Volume: 25, Issue:3 Topics: Aged; Aging; Blood Pressure; Carotid Arteries; Collagen; Elasticity; Endothelium, Vascular; Female; Glycation End Products, Advanced; Humans; Hypertension; Intercellular Adhesion Molecule-1; Male; Manometry; Matrix Metalloproteinase 9; Middle Aged; Peripheral Vascular Diseases; Single-Blind Method; Thiazoles; Transforming Growth Factor beta1; Vascular Cell Adhesion Molecule-1; Vasodilation	2007

Other Studies

10 other study(ies) available for alagebrium and Aging

Article	Year
The impracticality of biomedical rejuvenation therapies: translational and pharmacological barriers. Rejuvenation research, 2014, Volume: 17, Issue:4 Topics: Aging; Biotechnology; Glycation End Products, Advanced; Humans; Lysosomes; Medication Adherence; Pharmacology; Polypharmacy; Rejuvenation; Telomere; Thiazoles; Translational Research, Biomedical	2014
Advanced glycation end products accumulate in vascular smooth muscle and modify vascular but not ventricular properties in elderly hypertensive canines. Circulation, 2008, Sep-02, Volume: 118, Issue:10 Topics: Aging; Animals; Aorta; Collagen; Dogs; Drug Evaluation, Preclinical; Elastin; Glycation End Products, Advanced; Heart Ventricles; Hypertension; Lysine; Muscle, Smooth, Vascular; Thiazoles; Vasa Vasorum; Vascular Resistance; Ventricular Function, Left	2008
Alagebrium chloride protects the heart against oxidative stress in aging rats. The journals of gerontology. Series A, Biological sciences and medical sciences, 2009, Volume: 64, Issue:6 Topics: Aging; Animals; DNA, Mitochondrial; Echocardiography; Female; Glutathione Peroxidase; Glycation End Products, Advanced; Heart; Myocardium; Oxidative Stress; Protective Agents; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Thiazoles	2009
Alagebrium in combination with exercise ameliorates age-associated ventricular and vascular stiffness. Experimental gerontology, 2012, Volume: 47, Issue:8 Topics: Aging; Animals; Diastole; Drug Evaluation, Preclinical; Glycation End Products, Advanced; Hemodynamics; Male; Physical Conditioning, Animal; Rats; Rats, Inbred F344; Systole; Thiazoles; Vascular Stiffness; Ventricular Function, Left	2012
Glycation end-product cross-link breaker reduces collagen and improves cardiac function in aging diabetic heart. American journal of physiology. Heart and circulatory physiology, 2003, Volume: 285, Issue:6 Topics: Aging; Animals; Blood Glucose; Collagen Type I; Collagen Type III; Cross-Linking Reagents; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Dogs; Glycation End Products, Advanced; Hemodynamics; Male; Myocardium; Solubility; Thiazoles	2003
Slowing arterial aging: how far have we progressed? Journal of hypertension, 2007, Volume: 25, Issue:3 Topics: Aging; Blood Pressure; Glycation End Products, Advanced; Humans; Hypertension; Peripheral Vascular Diseases; Thiazoles	2007
An advanced glycation endproduct cross-link breaker can reverse age-related increases in myocardial stiffness. Proceedings of the National Academy of Sciences of the United States of America, 2000, Mar-14, Volume: 97, Issue:6 Topics: Aging; Animals; Diastole; Dogs; Elasticity; Glycation End Products, Advanced; Heart Rate; Hemodynamics; Male; Myocardium; Stroke Volume; Systole; Thiazoles; Ventricular Function	2000
Age breakers. Rupturing the body's sugar-protein bonds might turn back the clock. Scientific American, 2000, Volume: 283, Issue:1 Topics: Aging; Carbohydrate Metabolism; Collagen; Elasticity; Glycation End Products, Advanced; Humans; Proteins; Thiazoles	2000
A cross-link breaker has sustained effects on arterial and ventricular properties in older rhesus monkeys. Proceedings of the National Academy of Sciences of the United States of America, 2001, Jan-30, Volume: 98, Issue:3 Topics: Aging; Animals; Arteries; Blood Pressure; Echocardiography; Glycation End Products, Advanced; Heart Rate; Hemodynamics; Injections, Intramuscular; Macaca mulatta; Male; Muscle, Smooth, Vascular; Pulse; Stroke Volume; Thiazoles; Time Factors; Ventricular Function, Left	2001
Clinical trial to pharmacologically reverse the effects of ageing and diabetes. Diabetes, obesity & metabolism, 2000, Volume: 2, Issue:4 Topics: Aging; Clinical Trials, Phase II as Topic; Diabetes Mellitus; Double-Blind Method; Female; Glycation End Products, Advanced; Humans; Male; Middle Aged; Multicenter Studies as Topic; Thiazoles	2000

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