ajudazol-b has been researched along with Brain-Neoplasms* in 1 studies
1 other study(ies) available for ajudazol-b and Brain-Neoplasms
| Article | Year |
|---|---|
Synthesis and biological evaluation of simplified ajudazol derivatives reveal potent 5-lipoxygenase inhibition and considerable apoptotic activity in neuroblastoma cells.
Simplified analogues of the myxobacterial polyketide ajudazol were obtained by synthesis and evaluated for their biological activities. Potent simplified 5-lipoxygenase inhibitors were identified. Moreover, strong antiproliferative and apoptotic activities were observed in brain cancer cell lines at low nano- to micromolar concentrations. Topics: Arachidonate 5-Lipoxygenase; Brain Neoplasms; Cell Line; Humans; Lipoxygenase Inhibitors; Neuroblastoma | 2023 |