ajmaline and Seizures

Topics: Ajmaline; Brugada Syndrome; Electrocardiography; Female; Humans; Pregnancy; Pregnancy Complications, Cardiovascular; Seizures

Topics: Ajmaline; Brugada Syndrome; Electrocardiography; Female; Humans; Pregnancy; Pregnancy Complications, Cardiovascular; Seizures

The role of hormonal changes during pregnancy in Brugada syndrome is unknown. Only rare case reports of Brugada syndrome during pregnancy have been published. In this article, we describe a patient with first clinical manifestation of Brugada syndrome during pregnancy. The definitive diagnosis could only be achieved by drug challenge with ajmaline after childbirth because the spontaneous typical Brugada-like pattern was absent. Elevated hormone levels during pregnancy may increase the risk for arrhythmias in particular cases.

Topics: Adult; Ajmaline; Anti-Arrhythmia Agents; Brugada Syndrome; Defibrillators, Implantable; Diagnosis, Differential; Electrocardiography; Female; Humans; Pregnancy; Pregnancy Complications, Cardiovascular; Seizures; Treatment Outcome

We present a case of overdosage of ajmaline in an infant. The appearance of atactic gait and clonic tonic seizures were followed by loss of consciousness, apnea, supraventricular tachycardia, left bundle-branch block, and a prolonged Q-T interval. Cardiopulmonary resuscitation, gastric lavage, and forced diuresis were followed by complete recovery. Continuous electrocardiographic monitoring is mandatory in these cases, and the use of a cardiac pacemaker, respirator, and therapy with antiarrhythmic agents should be considered.

Topics: Accidents, Home; Administration, Oral; Ajmaline; Apnea; Arrhythmias, Cardiac; Ataxia; Bundle-Branch Block; Consciousness Disorders; Diuresis; Electrocardiography; Female; Gastric Lavage; Humans; Infant; Monitoring, Physiologic; Resuscitation; Seizures; Sodium Chloride; Tablets; Tachycardia

Topics: Acute Disease; Adolescent; Adult; Ajmaline; Chloroquine; Coma; Digitalis Glycosides; Female; Humans; Male; Middle Aged; Myoclonus; Seizures; Vision Disorders

Topics: Adolescent; Ajmaline; Anesthetics, Local; Aniline Compounds; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Diethylamines; Drug Synergism; Heart Arrest; Humans; Indenes; Male; Seizures