ajmaline has been researched along with Hyperthyroidism* in 3 studies
3 other study(ies) available for ajmaline and Hyperthyroidism
| Article | Year |
|---|---|
Pharmacokinetics and dromotropic activity of ajmaline in rats with hyperthyroidism.
1. The pharmacokinetics and the dromotropic action (increased PQ interval) of intravenously administered ajmaline (2 mg kg-1) were studied in hyperthyroid rats with sinus tachycardia. The hyperthyroidism was induced by intraperitoneal injection of 3,5,3'-triiodo-L-thyronine (0.5 mg kg-1) for 4 days. 2. The change in the ajmaline concentration in whole blood could be described by a biexponential equation. The steady state distribution volume of ajmaline decreased from 4.81 l kg-1 in control rats to 3.80 l kg-1 in hyperthyroid rats and the total body blood clearance was slightly higher in hyperthyroid rats than in control rats. 3. Ajmaline exhibited a saturable binding to rat plasma proteins, and one kind of binding site was found in the observed range of concentrations. The binding capacity was 2 fold higher in hyperthyroid rats than in control rats. 4. On the basis of the plasma unbound concentration, ajmaline exhibited an increased negative dromotropic activity in hyperthyroid rats compared with control rats. 5. A positive correlation was found between the pacing rate and the dromotropic action of ajmaline on atrioventricular conduction in isolated perfused hearts. There was no significant difference in the rate-dependence of the effect of ajmaline on the heart between control and hyperthyroid rats. 6. Our findings suggest that the increased dromotropic activity of ajmaline is mainly due to the increased heart rate in hyperthyroid rats. Topics: Ajmaline; Animals; Heart; Hyperthyroidism; In Vitro Techniques; Male; Protein Binding; Rats; Rats, Inbred Strains; Tachycardia; Triiodothyronine | 1989 |
[Therapy of paroxysmal supraventricular tachycardia].
Topics: Adult; Ajmaline; Cholecystitis; Deslanoside; Electric Countershock; Electric Stimulation; Female; Hernia, Hiatal; Humans; Hyperthyroidism; Male; Middle Aged; Pacemaker, Artificial; Tachycardia, Paroxysmal | 1976 |
[PRELIMINARY CLINICAL FINDINGS ON THE ANTI-ARRHYTHMIC ACTIVITY OF AN ACETYLATED DERIVATIVE OF AJMALINE: DICHLORO-ACETYL-AJMALINE].
Topics: Ajmaline; Anemia; Anti-Arrhythmia Agents; Arrhythmia, Sinus; Arrhythmias, Cardiac; Atrial Fibrillation; Cardiac Complexes, Premature; Heart Failure; Humans; Hypertension; Hyperthyroidism; Rauwolfia; Tachycardia | 1963 |