ajmaline and Chronic-Disease

Several class I antiarrhythmic drugs were used in an intraindividual comparative study in 15 patients with chronic stable ventricular extrasystole of various origins. In a randomised sequence lidocaine, ajmalin and, in a cross-over double blind study with placebo, the new antiarrhythmic Org 6001 were tested. Propafenon was given as a final preparation. Each substance was administered parentally in therapeutic doses. A significant placebo effect could be excluded, baseline control values before administration of individual substances correlated well. Comparing mean values obtained over one hour before and after administration of the substance it was shown that the effectiveness of drugs decreased as follows: ajmalin, propafenon, lidocaine, Org 6001. Whereas suppression of extrasystole was most marked after ajmalin, propafenon showed the longest period of activity. After Org 6001 divergent activity of arrhythmia could be observed; in some patients good antiarrhythmic effects could be demonstrated. For evaluation of effectiveness and validity of new antiarrhythmic substances intraindividual comparison with placebo and well established standard antiarrhythmic drugs is advisable.

Topics: 17-Ketosteroids; Adult; Aged; Ajmaline; Androstanols; Anti-Arrhythmia Agents; Cardiac Complexes, Premature; Chronic Disease; Double-Blind Method; Female; Humans; Lidocaine; Male; Middle Aged; Placebos; Propiophenones

The aetiology and evolution of chronic infranodal atrioventricular block (AVB) of young patients are not well known: are they the first sign of subclinical myocardial disease which can only be diagnosed by long term follow-up or do they represent isolated degenerative disease of the conduction tissue (Lenegre's disease)? Eighteen patients (15 men, 3 women) aged 25 to 49 years (average 41.5 years) were followed up for periods of 2 to 20 years (average 7.33 years) after pacemaker implantation for syncopal AVB. Follow-up was focused on the evolution of the conduction defects and the cardiovascular status. The patients were divided into two groups at the initial assessment: Group I: 15 patients with documented AVB; Group II: 3 patients in whom all basal recordings showed sinus rhythm (SR). Apart from one patient with an early non-ischaemic dilated cardiomyopathy, there was no previous cardiovascular disease. There was no history of ischaemic heart disease, drug effects, infection or inflammation in favour of an acute AVB. Three patients had permanent AVB, either 2nd degree with bundle branch block (N = 2) or 3rd degree block (N = 1). The other 15 patients were in sinus rhythm with bundle branch block: left bundle branch block (LBBB) in 5 cases, right bundle branch block (RBBB) in 3 cases; RBBB with left anterior hemiblock in 5 cases, RBBB and left posterior hemiblock in 2 cases. Paroxysmal AVB was recorded in 12 of these 15 patients on at least one occasion.(ABSTRACT TRUNCATED AT 250 WORDS)

Topics: Adams-Stokes Syndrome; Adult; Aging; Ajmaline; Atrioventricular Node; Bundle of His; Bundle-Branch Block; Chronic Disease; Electrocardiography; Female; Follow-Up Studies; Heart Block; Heart Conduction System; Humans; Male; Middle Aged; Retrospective Studies

Topics: Adult; Aged; Ajmaline; Anti-Arrhythmia Agents; Chronic Disease; Female; Humans; Lung Diseases, Obstructive; Male; Middle Aged; Quaternary Ammonium Compounds

Topics: Ajmaline; Cardiac Complexes, Premature; Chronic Disease; Electrocardiography; Heart; Heart Block; Humans; Methods; Pacemaker, Artificial; Pulse

Topics: Acute Disease; Ajmaline; Bile Ducts, Intrahepatic; Bilirubin; Cholestasis; Chronic Disease; Drug Synergism; Ethinyl Estradiol; Female; Humans; Liver; Liver Function Tests; Male; Methyltestosterone; Microscopy, Electron; Middle Aged; Mononuclear Phagocyte System; Plants, Medicinal; Rauwolfia