ajmaline and Angina-Pectoris

Topics: Adult; Ajmaline; Angina Pectoris; Clinical Trials as Topic; Diagnosis, Differential; Electric Countershock; Female; Heart Arrest; Humans; Intensive Care Units; Lidocaine; Male; Middle Aged; Monitoring, Physiologic; Myocardial Infarction; Pacemaker, Artificial; Prognosis; Propranolol; Resuscitation; Ventricular Fibrillation

Thirty patients undergoing cardiac catheterisation for coronary artery disease received parenteral ajmaline (15 patients) or prajmaline (15 patients). There were no statistically significant induced changes in left ventricular systolic or end diastolic pressures, indirect left atrial pressure, pulmonary artery mean pressure, cardiac output or left ventricular ejection fraction compared to control values. Intravenous prajmaline bitartrate in 15 patients with angina did not significantly alter work capacity, maximum exercise heart rate or systolic blood pressure compared to control values. Five patients developed transient minor conduction defects ( 2LBBB , 1 RBBB, 2 prolonged PR interval): all five were also receiving long-term treatment with beta blockers and nifedipine.

Topics: Adult; Ajmaline; Angina Pectoris; Blood Pressure; Cardiac Catheterization; Cardiac Output; Coronary Disease; Female; Heart Ventricles; Hemodynamics; Humans; Infusions, Parenteral; Male; Middle Aged; Physical Exertion; Prajmaline

Topics: Ajmaline; Angina Pectoris; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Heart Conduction System; Heart Ventricles; Humans; Lidocaine; Myocardial Infarction; Procainamide; Quinidine