aica ribonucleotide has been researched along with Disease Models, Animal in 61 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (3.28) | 18.2507 |
| 2000's | 10 (16.39) | 29.6817 |
| 2010's | 44 (72.13) | 24.3611 |
| 2020's | 5 (8.20) | 2.80 |
| Authors | Studies |
|---|---|
| Dang, TN; Floyd, ZE; Kuhn, P; Pauli, GF; Poulev, A; Ribnicky, DM; Simmler, C; Vandanmagsar, B; Yu, Y | 1 |
| Iso, T; Kawakami, R; Koitabashi, N; Kurabayashi, M; Matsui, H; Murakami, M; Obokata, M; Sunaga, H; Yokoyama, T | 1 |
| Athineos, D; Blanco, GR; Blyth, K; Brunton, H; Dhayade, S; Fernandez-de-Cossio-Diaz, J; Lilla, S; Mackay, GM; Meiser, J; Oizel, K; Pietzke, M; Sumpton, D; Tait-Mulder, J; Vazquez, A; Zanivan, SR | 1 |
| Albuquerque, B; Andersen, NR; Birk, JB; Carling, D; Jørgensen, NO; Kjøbsted, R; Larsen, MR; Miller, R; Pehmøller, CK; Schjerling, P; Wojtaszewski, JFP | 1 |
| Fu, CN; Gao, WS; Qu, YJ; Song, SS; Wei, H; Yue, SW | 1 |
| Cao, L; Ji, L; Li, H; Mao, K; Sha, L; Tang, X; Wei, J; Wei, N; Wu, J; Xie, W; Yang, S; Yang, Z; Zhu, L | 1 |
| Choi, S; Samuvel, DJ; Saxena, N; Singh, AK; Singh, I; Won, J | 1 |
| Al-Rewashdy, A; Bélanger, G; Jasmin, BJ; Ravel-Chapuis, A | 1 |
| Hasko, G; Pacher, P; Ungvari, Z; Yabluchanskiy, A | 1 |
| Calo, N; Clavien, PA; Dufour, JF; Foti, M; Frick, L; Graf, R; Humar, B; Kachaylo, E; Kambakamba, P; Kron, P; Langiewicz, M; Limani, P; Linecker, M; Schneider, MA; Tian, Y; Tschuor, C; Ungethüm, U | 1 |
| Hughey, CC; Hunter, RW; Jessen, N; Lantier, L; Peggie, M; Sakamoto, K; Sicheri, F; Sundelin, EI; Wasserman, DH; Zeqiraj, E | 1 |
| Gao, J; Jiang, G; Xiong, D; Xiong, R; Yin, T; Yin, Z; Zhang, S; Zhang, X; Zhao, W | 1 |
| Cao, Y; Gu, C; Han, Y; Sun, G; Wang, Y; Wang, Z; Xu, M; Yin, Q; Zhu, H | 1 |
| Chai, Y; Dong, D; Hu, L; Liu, W; Lv, Y; Ma, T; Wu, R; Zhang, N; Zhu, H | 1 |
| Dong, Z; George, J; Hu, L; Lv, Y; Su, L; Wang, J; Wu, Y | 1 |
| Hu, L; Hu, XF; Li, HP; Li, M; Lin, LX; Liu, WT; Pan, HL; Shu, Y; Xiang, HC; Zhang, RY; Zhao, YL; Zhu, H | 1 |
| Lin, JR; Nakagawasai, O; Nemoto, W; Odaira, T; Sakuma, W; Takahashi, K; Tan-No, K | 1 |
| Banek, CT; Bauer, AJ; Dreyer, HC; Gilbert, JS; Needham, KM | 1 |
| Cieslik, KA; Crawford, JR; Entman, ML; Mejia Osuna, P; Taffet, GE; Trial, J | 1 |
| Chang, KH; Kim, YG; Lee, MY; Liu, Y; Oh, SJ | 1 |
| Komen, JC; Thorburn, DR | 1 |
| Ji, L; Li, H; Liu, W; Zhai, X | 1 |
| Horne, MK; Kemp, BE; Perera, ND; Scott, JW; Sheean, RK; Turner, BJ | 1 |
| Amrutkar, M; Cansby, E; Durán, EN; Mahlapuu, M; Nerstedt, A; Smith, U | 1 |
| Chai, DM; Du, LL; Li, XH; Liu, LB; Liu, R; Wang, JZ; Wu, K; Zhang, FC; Zhang, HB; Zhao, LN; Zhou, XW | 1 |
| Miyamoto, S; Sharma, K; You, YH; Zhao, J | 1 |
| Hu, XG; Liu, B; Ma, LJ; Qi, Y; Shang, JY; Sun, BB; Zhang, GJ | 1 |
| Ai, Q; Che, Q; Ge, P; Gong, X; Lin, L; Wan, J; Wen, A; Zhang, L; Zhou, D | 1 |
| Choi, JS; Choi, W; Cui, L; Li, Z; Park, MJ; Park, SH; Sung, MS; Yoon, KC | 1 |
| Chen, B; Li, J; Zhu, H | 1 |
| Ji, L; Li, H; Liu, W; Wang, Y | 1 |
| Calderó, J; Cerveró, C; Esquerda, JE; Montull, N; Piedrafita, L; Tarabal, O | 1 |
| Dong, M; Ren, J; Ren, SY; Wang, Q; Xu, X; Zhang, Y | 1 |
| Kim, DM; Leem, YH | 1 |
| Giri, S; Kumar, A | 1 |
| Arguello, T; Diaz, F; Garcia, S; Moraes, CT; Peralta, S; Yin, HY | 1 |
| Angelini, C; Brockhoff, M; Castets, P; Chojnowska, K; Eickhorst, C; Erne, B; Frank, S; Furling, D; Rion, N; Rüegg, MA; Sinnreich, M; Wiktorowicz, T | 1 |
| Hake, PW; Kim, P; Klingbeil, LR; O'Connor, M; Piraino, G; Wolfe, V; Zingarelli, B | 1 |
| Ma, A; Wang, J; Zhao, M; Zhu, H | 1 |
| Choi, A; Javadov, S; Karmazyn, M; Kilić, A; Rajapurohitam, V; Zeidan, A | 1 |
| Brown, S; Cheng, H; Ding, Y; Fan, X; McCrimmon, RJ; McNay, EC; Shaw, M; Sherwin, RS; Vella, MC; Zhou, L | 1 |
| Choi, JH; Lee, HK; Lee, W; Pak, YK; Park, KS; Park, SY; Ryu, HS | 1 |
| Li, D; Ling, W; Ma, J; Xia, M; Zhang, Y | 1 |
| Matsumoto, Y; Sekimizu, K; Sugita, T; Sumiya, E | 1 |
| Cai, X; Chen, B; Dong, Y; Liu, G; Mai, W; Meng, R; Pei, Z; Wei, J; Zhang, A; Zhou, Y | 1 |
| Bottani, E; Cerutti, R; Civiletto, G; Fagiolari, G; Lamperti, C; Moggio, M; Schon, EA; Viscomi, C; Zeviani, M | 1 |
| Kayama, M; Manola, A; Miller, JW; Morizane, Y; Murakami, Y; Sobrin, L; Suzuki, J; Takeuchi, K; Vavvas, DG | 1 |
| Jasmin, BJ; Khogali, S; Ljubicic, V; Renaud, JM | 1 |
| Loeken, MR; Thirumangalathu, S; Viana, M; Wu, Y | 1 |
| Miller, JW; Morizane, Y; Murakami, Y; Simeonova, M; Sobrin, L; Suzuki, J; Takeuchi, K; Vavvas, DG; Yoshimura, T | 1 |
| Chae, HJ; Jeon, MS; Kim, DI; Kim, SR; Lee, KS; Lee, YC; Park, SJ; Yoo, WH | 1 |
| Liang, B; Viollet, B; Wang, Q; Wang, S; Zhang, W; Zhu, Y; Zou, MH | 1 |
| Chavin, K; Lin, A; Orak, J; Sekhon, B; Sekhon, C; Singh, A; Singh, I; Smith, A | 1 |
| Landree, LE; Li, H; McCullough, LD; McFadden, J; Ronnett, GV; Zeng, Z | 1 |
| Bartrons, R; Carrasco-Chaumel, E; Casillas, A; Franco-Gou, R; Gelpí, E; Peralta, C; Rodés, J; Roselló-Catafau, J; Xaus, C | 1 |
| Giri, S; Nath, N; Prasad, R; Singh, AK; Singh, I | 1 |
| Chen, D; Dong, YG; Li, HL; Liu, D; Wang, D; Yang, Q; Yin, R | 1 |
| Cronstein, BN; Naime, D; Ostad, E | 1 |
| Buckley, MT; Carlin, G; Cronstein, BN; Gadangi, P; Levin, RI; Longaker, M; Montesinos, MC; Naime, D; Recht, PA | 1 |
| Croce, MA; Davis, KA; Fabian, TC; Proctor, KG; Ragsdale, DN; Trenthem, LL | 1 |
| Fiedler, M; Liang, Y; Sakariassen, KS; Selén, G; Wallberg-Henriksson, H; Zierath, JR | 1 |
1 review(s) available for aica ribonucleotide and Disease Models, Animal
| Article | Year |
|---|---|
Turn up the power - pharmacological activation of mitochondrial biogenesis in mouse models.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Bezafibrate; Disease Models, Animal; Energy Metabolism; Mitochondria; Mitochondrial Diseases; Mitochondrial Turnover; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Resveratrol; Ribonucleotides; Sirtuin 1; Stilbenes; Transcription Factors; Up-Regulation | 2014 |
60 other study(ies) available for aica ribonucleotide and Disease Models, Animal
| Article | Year |
|---|---|
Bioactive compounds from Artemisia dracunculus L. activate AMPK signaling in skeletal muscle.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Artemisia; Cell Line; Diet, High-Fat; Disease Models, Animal; Enzyme Activation; Enzyme Activators; Hypoglycemic Agents; Insulin Resistance; Male; Metformin; Mice, Inbred C57BL; Muscle, Skeletal; Myoblasts, Skeletal; Phosphorylation; Phytochemicals; Plant Extracts; Ribonucleotides; Signal Transduction | 2021 |
Activation of cardiac AMPK-FGF21 feed-forward loop in acute myocardial infarction: Role of adrenergic overdrive and lipolysis byproducts.
Topics: Adrenergic Agents; Aged; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Angina Pectoris; Animals; Catecholamines; Disease Models, Animal; Fatty Acid-Binding Proteins; Fatty Acids; Female; Fibroblast Growth Factors; Humans; Lipolysis; Male; Multivariate Analysis; Myocardial Infarction; Myocardium; Myocytes, Cardiac; Recombinant Proteins; Ribonucleotides; Time Factors; Troponin T | 2019 |
Formate induces a metabolic switch in nucleotide and energy metabolism.
Topics: Adenosine Triphosphate; Adenylate Kinase; Aminoimidazole Carboxamide; Animals; Cell Line, Tumor; Colorectal Neoplasms; Disease Models, Animal; Energy Metabolism; Female; Formates; Humans; Mice, Inbred C57BL; Models, Biological; Models, Genetic; Nucleotides; Orotic Acid; Pyrimidines; Ribonucleotides | 2020 |
Direct small molecule ADaM-site AMPK activators reveal an AMPKγ3-independent mechanism for blood glucose lowering.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Blood Glucose; Diet, High-Fat; Disease Models, Animal; Female; Humans; Mice; Mice, Knockout; Muscle, Skeletal; Obesity; Phosphorylation; Ribonucleotides; Signal Transduction | 2021 |
Obesity increases neuropathic pain via the AMPK-ERK-NOX4 pathway in rats.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Apoptosis; Butadienes; Diet, High-Fat; Disease Models, Animal; Enzyme Inhibitors; Ganglia, Spinal; Hypoglycemic Agents; Inflammation; Male; MAP Kinase Signaling System; Metformin; NADPH Oxidase 4; Neuralgia; Nitriles; Obesity; Oxidative Stress; Pain Threshold; Phosphorylation; Rats, Wistar; Ribonucleotides; Spinal Cord | 2021 |
Insulin degrading enzyme contributes to the pathology in a mixed model of Type 2 diabetes and Alzheimer's disease: possible mechanisms of IDE in T2D and AD.
Topics: Alzheimer Disease; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Amyloid beta-Peptides; Animals; Blood Glucose; Diabetes Mellitus, Type 2; Disease Models, Animal; Fasting; Gene Expression Regulation; Glucose Tolerance Test; Humans; Insulin; Insulysin; Learning; Mice; Mice, Transgenic; PPAR gamma; Ribonucleotides; Rosiglitazone; Streptozocin; Thiazolidinediones | 2018 |
Combination therapy of lovastatin and AMP-activated protein kinase activator improves mitochondrial and peroxisomal functions and clinical disease in experimental autoimmune encephalomyelitis model.
Topics: Adenosine Triphosphate; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Biomarkers; Cell Line; Cytokines; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Gene Expression; Humans; Lovastatin; Mice; Mitochondria; Peroxisomes; rho-Associated Kinases; rhoA GTP-Binding Protein; Ribonucleotides; Spinal Cord | 2018 |
Pharmacological and physiological activation of AMPK improves the spliceopathy in DM1 mouse muscles.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinase Kinases; Animals; Disease Models, Animal; Humans; Mice; Motor Activity; Muscle, Skeletal; Myoblasts; Myotonic Dystrophy; Protein Kinases; Resveratrol; Ribonucleotides; RNA-Binding Proteins; RNA, Messenger; Trinucleotide Repeat Expansion | 2018 |
Age-dependent cardiovascular effects of sepsis in a murine model of cecal ligation and puncture: implications for the design of interventional studies.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cecum; Disease Models, Animal; Ligation; Mice; Punctures; Ribonucleotides; Sepsis | 2018 |
Exercise Improves Outcomes of Surgery on Fatty Liver in Mice: A Novel Effect Mediated by the AMPK Pathway.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Disease Models, Animal; Fatty Liver; Glucose Tolerance Test; Hepatectomy; Insulin; Liver Regeneration; Male; Mice; Mice, Inbred C57BL; Physical Conditioning, Animal; Reperfusion Injury; Ribonucleotides | 2020 |
Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase.
Topics: Adenosine Monophosphate; Aminoimidazole Carboxamide; Animals; Base Sequence; Chickens; Disease Models, Animal; Fructose-Bisphosphatase; Glucose; Glucose Intolerance; Homeostasis; Humans; Hypoglycemia; Liver; Metformin; Mice, Inbred C57BL; Mutation; Obesity; Prodrugs; Ribonucleotides | 2018 |
The Adenosine Monophosphate (AMP) Analog, 5-Aminoimidazole-4-Carboxamide Ribonucleotide (AICAR) Inhibits Hepatosteatosis and Liver Tumorigenesis in a High-Fat Diet Murine Model Treated with Diethylnitrosamine (DEN).
Topics: Adenosine Monophosphate; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Carcinogenesis; Carcinoma, Hepatocellular; Diet, High-Fat; Diethylnitrosamine; Disease Models, Animal; Fatty Liver; Interleukin-6; Lipid Metabolism; Liver Neoplasms; Male; Mice; Mice, Inbred C57BL; Ribonucleotides; STAT3 Transcription Factor; Triglycerides | 2018 |
Activation of AMPK alleviates cardiopulmonary bypass-induced cardiac injury via ameliorating acute cardiac glucose metabolic disorder.
Topics: Adenosine Triphosphate; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Blood Glucose; Cardiopulmonary Bypass; Creatine Kinase, MB Form; Disease Models, Animal; Enzyme Activation; Enzyme Activators; Glucose Metabolism Disorders; Glucose Transporter Type 4; GTPase-Activating Proteins; Heart Diseases; Male; Myocardium; Phosphorylation; Rats, Sprague-Dawley; Ribonucleotides; Signal Transduction; Troponin I | 2018 |
AICAR-Induced AMPK Activation Inhibits the Noncanonical NF-κB Pathway to Attenuate Liver Injury and Fibrosis in BDL Rats.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Bile Ducts; Cholestasis; Chronic Disease; Disease Models, Animal; Kupffer Cells; Ligation; Liver; Liver Cirrhosis; NF-kappa B; Protective Agents; Rats; Ribonucleotides; Signal Transduction | 2018 |
AMPK agonist AICAR ameliorates portal hypertension and liver cirrhosis via NO pathway in the BDL rat model.
Topics: Actins; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Bile Ducts; Disease Models, Animal; Endothelial Cells; Hepatic Stellate Cells; Hypertension, Portal; Ligation; Liver Cirrhosis; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Rats, Sprague-Dawley; Ribonucleotides; Signal Transduction; Transforming Growth Factor beta | 2019 |
AMPK activation attenuates inflammatory pain through inhibiting NF-κB activation and IL-1β expression.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents; Antigens, CD; Antigens, Differentiation, Myelomonocytic; CX3C Chemokine Receptor 1; Disease Models, Animal; Enzyme Activation; Freund's Adjuvant; Gene Expression Regulation; Hypoglycemic Agents; Inflammation; Interleukin 1 Receptor Antagonist Protein; Interleukin-1beta; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; NF-kappa B; Pain; Pain Threshold; Ribonucleotides; RNA, Small Interfering; Skin | 2019 |
Mechanisms underpinning AMP-activated protein kinase-related effects on behavior and hippocampal neurogenesis in an animal model of depression.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Brain-Derived Neurotrophic Factor; Cyclic AMP Response Element-Binding Protein; Depression; Disease Models, Animal; Hindlimb Suspension; Hippocampus; Male; Mice; Neurogenesis; NF-kappa B; Phosphorylation; Ribonucleotides; Signal Transduction | 2019 |
AICAR administration ameliorates hypertension and angiogenic imbalance in a model of preeclampsia in the rat.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Blood Pressure; Disease Models, Animal; Female; Heart Rate; Hypertension; Ischemia; Kidney; Neovascularization, Physiologic; Oxidative Stress; Phosphorylation; Placenta; Pre-Eclampsia; Pregnancy; Rats; Rats, Sprague-Dawley; Ribonucleotides; Uterus; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1 | 2013 |
AICAR-dependent AMPK activation improves scar formation in the aged heart in a murine model of reperfused myocardial infarction.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cicatrix; Disease Models, Animal; Enzyme Activation; Fibroblasts; Male; Mice; Myocardial Infarction; Myocardial Reperfusion Injury; Myofibroblasts; Phosphorylation; Ribonucleotides; Ventricular Remodeling; Wound Healing | 2013 |
Antiplatelet effect of AMP-activated protein kinase activator and its potentiation by the phosphodiesterase inhibitor dipyridamole.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cyclic GMP; Dipyridamole; Disease Models, Animal; Enzyme Activation; Enzyme Activators; Male; Nitric Oxide Synthase Type III; Phosphodiesterase Inhibitors; Phosphorylation; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Ribonucleotides; Signal Transduction; Thrombosis | 2013 |
Depression-like behaviors in mice subjected to co-treatment of high-fat diet and corticosterone are ameliorated by AICAR and exercise.
Topics: Aminoimidazole Carboxamide; Animals; Corticosterone; Depression; Depressive Disorder; Diet, High-Fat; Disease Models, Animal; Glucocorticoids; Hypoglycemic Agents; Insulin Resistance; Male; Mice; Mice, Inbred C57BL; Physical Conditioning, Animal; Ribonucleotides | 2014 |
Mutant TDP-43 deregulates AMPK activation by PP2A in ALS models.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Amyotrophic Lateral Sclerosis; Animals; Brain; Cell Line; Disease Models, Animal; DNA-Binding Proteins; Enzyme Activation; Mice, Inbred C57BL; Mice, Transgenic; Motor Neurons; Mutant Proteins; Protein Phosphatase 2; Ribonucleotides; Spinal Cord; Superoxide Dismutase | 2014 |
Partial hepatic resistance to IL-6-induced inflammation develops in type 2 diabetic mice, while the anti-inflammatory effect of AMPK is maintained.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents; Blood Glucose; Blotting, Western; Diabetes Mellitus, Type 2; Diet, High-Fat; Disease Models, Animal; Inflammation; Interleukin-6; Liver; Male; Metformin; Mice; Mice, Inbred C57BL; Real-Time Polymerase Chain Reaction; Ribonucleotides | 2014 |
AMPK activation ameliorates Alzheimer's disease-like pathology and spatial memory impairment in a streptozotocin-induced Alzheimer's disease model in rats.
Topics: Adenylate Kinase; Alzheimer Disease; Aminoimidazole Carboxamide; Animals; Caspase 3; Disease Models, Animal; Hippocampus; Hypoglycemic Agents; Male; Memory Disorders; Phosphorylation; Rats; Rats, Sprague-Dawley; Ribonucleotides; Spatial Memory; Streptozocin; tau Proteins | 2015 |
AMP-activated protein kinase (AMPK) activation inhibits nuclear translocation of Smad4 in mesangial cells and diabetic kidneys.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Biological Transport; Cell Line; Cell Nucleus; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease Models, Animal; Glucose; Hypoglycemic Agents; In Vitro Techniques; Male; Mesangial Cells; Mice; Mice, Inbred C57BL; Ribonucleotides; Signal Transduction; Smad4 Protein; Streptozocin; Transforming Growth Factor beta | 2015 |
Inhibition of AMPK expression in skeletal muscle by systemic inflammation in COPD rats.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Down-Regulation; Gene Expression Regulation, Enzymologic; Male; Muscle Weakness; Muscle, Skeletal; Pulmonary Disease, Chronic Obstructive; Rats, Wistar; Resveratrol; Ribonucleotides; RNA, Messenger; Sirtuin 1; Stilbenes; Time Factors; Tumor Necrosis Factor-alpha | 2014 |
5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranoside-attenuates LPS/D-Gal-induced acute hepatitis in mice.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Apoptosis; Caspases; Disease Models, Animal; Galactose; Hepatitis, Animal; Humans; Hypoglycemic Agents; Lipopolysaccharides; Liver; Male; Mice; Molecular Targeted Therapy; Nitric Oxide; Ribonucleotides; Transaminases; Tumor Necrosis Factor-alpha | 2015 |
Effect of Topical 5-Aminoimidazole-4-carboxamide-1-β-d-Ribofuranoside in a Mouse Model of Experimental Dry Eye.
Topics: Administration, Topical; Aldehydes; Aminoimidazole Carboxamide; Animals; Blotting, Western; Chemokine CXCL9; Disease Models, Animal; Dry Eye Syndromes; Female; Flow Cytometry; Hypoglycemic Agents; Immunohistochemistry; Interferon-gamma; Interleukin-1beta; Mice; Mice, Inbred C57BL; Ophthalmic Solutions; Ribonucleotides; Tears; Tumor Necrosis Factor-alpha | 2015 |
AMP-activated protein kinase attenuates oxLDL uptake in macrophages through PP2A/NF-κB/LOX-1 pathway.
Topics: Adenosine; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Aorta; Apolipoproteins E; Atherosclerosis; Disease Models, Animal; Foam Cells; Lipoproteins, LDL; Macrophages; Mice; Mice, Knockout; NF-kappa B; Okadaic Acid; Protein Phosphatase 2; Ribonucleotides; Scavenger Receptors, Class E | 2016 |
The Role of Nitric Oxide in the Antidepressant Actions of 5-Aminoimidazole-4-Carboxamide-1-β-D-Ribofuranoside in Insulin-Resistant Mice.
Topics: Adenylate Kinase; Aminoimidazole Carboxamide; Animals; Antidepressive Agents; Combined Modality Therapy; Corticosterone; Depressive Disorder; Diet, High-Fat; Disease Models, Animal; Drug Evaluation, Preclinical; Enzyme Activation; Fluoxetine; Imipramine; Insulin Resistance; Ketamine; Male; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Physical Conditioning, Animal; Prefrontal Cortex; Ribonucleotides; Triazenes | 2016 |
Chronic Treatment with the AMPK Agonist AICAR Prevents Skeletal Muscle Pathology but Fails to Improve Clinical Outcome in a Mouse Model of Severe Spinal Muscular Atrophy.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Disease Models, Animal; Female; Male; Mice; Mice, Knockout; Muscle, Skeletal; Muscular Atrophy, Spinal; Ribonucleotides; Spinal Cord; Treatment Outcome | 2016 |
Permissive role of AMPK and autophagy in adiponectin deficiency-accentuated myocardial injury and inflammation in endotoxemia.
Topics: Adiponectin; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Autophagy; Autophagy-Related Protein-1 Homolog; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Kinase; Cell Death; Disease Models, Animal; Endotoxemia; Lipopolysaccharides; Male; Mice; Mice, Knockout; Myocarditis; Myocardium; Myocytes, Cardiac; Ribonucleotides; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Ventricular Dysfunction | 2016 |
Chronic stress-induced memory deficits are reversed by regular exercise via AMPK-mediated BDNF induction.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Brain-Derived Neurotrophic Factor; Cells, Cultured; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Exercise Therapy; Hippocampus; Male; Maze Learning; Memory Disorders; Mice, Inbred C57BL; Neurogenesis; Nootropic Agents; Restraint, Physical; Ribonucleotides; Running; Stress, Psychological | 2016 |
5-Aminoimidazole-4-carboxamide ribonucleoside-mediated adenosine monophosphate-activated protein kinase activation induces protective innate responses in bacterial endophthalmitis.
Topics: Acetyl-CoA Carboxylase; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bacterial Load; Disease Models, Animal; Endophthalmitis; Female; Gene Expression Regulation; Glycolysis; Host-Pathogen Interactions; Immunity, Innate; Intravitreal Injections; Macrophages; MAP Kinase Kinase 4; Mice; Mice, Inbred C57BL; Microglia; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phagocytosis; Retina; Ribonucleotides; Signal Transduction; Staphylococcal Infections; Staphylococcus aureus | 2016 |
Sustained AMPK activation improves muscle function in a mitochondrial myopathy mouse model by promoting muscle fiber regeneration.
Topics: Alkyl and Aryl Transferases; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Disease Models, Animal; Enzyme Activation; Membrane Proteins; Mice; Mice, Transgenic; Mitochondria, Muscle; Mitochondrial Myopathies; Muscle Fibers, Skeletal; Regeneration; Ribonucleotides | 2016 |
Targeting deregulated AMPK/mTORC1 pathways improves muscle function in myotonic dystrophy type I.
Topics: Adult; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Disease Models, Animal; Female; Humans; Male; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Mutant Strains; Middle Aged; Multiprotein Complexes; Muscle Fibers, Skeletal; Muscle Relaxation; Myotonic Dystrophy; Myotonin-Protein Kinase; Ribonucleotides; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2017 |
Age-Dependent Changes in AMPK Metabolic Pathways in the Lung in a Mouse Model of Hemorrhagic Shock.
Topics: Aging; Alveolar Epithelial Cells; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Autophagy; Blotting, Western; Bronchoalveolar Lavage Fluid; Cell Nucleus; Cytokines; Disease Models, Animal; Enzyme Activation; Hypotension; Lung; Male; Metabolic Networks and Pathways; Mice; Mice, Inbred C57BL; Mitochondria; Neutrophil Infiltration; NF-kappa B; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phosphorylation; Protein Transport; Pulmonary Edema; Ribonucleotides; Shock, Hemorrhagic; Sirtuin 1 | 2017 |
AMPK activation reduces the number of atheromata macrophages in ApoE deficient mice.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Antigens, Ly; Aorta; Aortic Diseases; Apolipoproteins E; Atherosclerosis; Biphenyl Compounds; Cell Line; Cell Migration Inhibition; Chemotaxis; Disease Models, Animal; Enzyme Activation; Enzyme Activators; Genetic Predisposition to Disease; Humans; Macrophages; Metformin; Mice, Knockout; Phenotype; Pyrones; Receptors, CCR2; Ribonucleotides; Signal Transduction; Thiophenes | 2017 |
Anti-hypertrophic effect of NHE-1 inhibition involves GSK-3beta-dependent attenuation of mitochondrial dysfunction.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Blotting, Western; Cardiomegaly; Cells, Cultured; Chromones; Disease Models, Animal; Electrophoresis, Polyacrylamide Gel; Endothelin-1; Flavonoids; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hypoglycemic Agents; Immunoprecipitation; Male; Membrane Potential, Mitochondrial; Microscopy, Confocal; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Morpholines; Myocytes, Cardiac; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Polymerase Chain Reaction; Protein Binding; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Ribonucleotides; Sodium-Hydrogen Exchangers; Voltage-Dependent Anion Channels | 2009 |
Hypothalamic AMP-activated protein kinase activation with AICAR amplifies counterregulatory responses to hypoglycemia in a rodent model of type 1 diabetes.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Blood Glucose; Diabetes Mellitus, Type 1; Disease Models, Animal; Enzyme Activation; Enzyme Activators; Epinephrine; Glucagon; Hypoglycemia; Hypoglycemic Agents; Insulin; Male; Microinjections; Rats; Rats, Inbred BB; Rats, Sprague-Dawley; Ribonucleotides; RNA Interference; RNA, Small Interfering; Time Factors; Ventromedial Hypothalamic Nucleus | 2009 |
C1q tumor necrosis factor alpha-related protein isoform 5 is increased in mitochondrial DNA-depleted myocytes and activates AMP-activated protein kinase.
Topics: Acetyl-CoA Carboxylase; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cell Line; Collagen; Diabetes Mellitus, Type 2; Disease Models, Animal; DNA, Mitochondrial; Enzyme Activation; Fatty Acids; Glucose; Glucose Transporter Type 4; Humans; Insulin Receptor Substrate Proteins; Intracellular Signaling Peptides and Proteins; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Obese; Mitochondria; Muscle Cells; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-akt; Rats; Rats, Inbred OLETF; Receptors, Adiponectin; Recombinant Fusion Proteins; Ribonucleotides; RNA, Small Interfering | 2009 |
Adenosine monophosphate activated protein kinase regulates ABCG1-mediated oxysterol efflux from endothelial cells and protects against hypercholesterolemia-induced endothelial dysfunction.
Topics: 3' Untranslated Regions; Acetylcholine; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; ATP Binding Cassette Transporter, Subfamily G, Member 1; ATP-Binding Cassette Transporters; Biological Transport; Cattle; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelial Cells; Endothelium, Vascular; Enzyme Activation; Enzyme Activators; Genes, Reporter; Humans; Hypercholesterolemia; Ketocholesterols; Male; Mice; Mice, Inbred C57BL; Nitric Oxide; Nitric Oxide Synthase Type III; Nitroprusside; Oxidative Stress; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; Reactive Oxygen Species; Ribonucleotides; RNA Interference; RNA Processing, Post-Transcriptional; RNA Stability; RNA, Messenger; Transfection; Up-Regulation; Vasodilation; Vasodilator Agents | 2010 |
An invertebrate hyperglycemic model for the identification of anti-diabetic drugs.
Topics: Aminoimidazole Carboxamide; Animals; Bombyx; Carbohydrates; Diet; Disease Models, Animal; Drug Evaluation, Preclinical; Feeding Behavior; Galactose; Glucose; Glycation End Products, Advanced; Hemolymph; Humans; Hyperglycemia; Hypoglycemic Agents; Insulin; Ribonucleotides | 2011 |
AMPK activation enhances PPARα activity to inhibit cardiac hypertrophy via ERK1/2 MAPK signaling pathway.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cardiomegaly; Cells, Cultured; Disease Models, Animal; Enzyme Activation; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocytes, Cardiac; p38 Mitogen-Activated Protein Kinases; Phosphorylation; PPAR alpha; Rats; Rats, Sprague-Dawley; Ribonucleotides | 2011 |
In vivo correction of COX deficiency by activation of the AMPK/PGC-1α axis.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Bezafibrate; Cytochrome-c Oxidase Deficiency; Disease Models, Animal; Electron Transport Complex IV; Gene Knock-In Techniques; Hypoglycemic Agents; Hypolipidemic Agents; Membrane Proteins; Mice; Mice, Knockout; Mice, Transgenic; Mitochondrial Proteins; Molecular Chaperones; Muscle, Skeletal; Oxidative Phosphorylation; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Ribonucleotides; Signal Transduction; Trans-Activators; Transcription Factors | 2011 |
Inhibitory effect of aminoimidazole carboxamide ribonucleotide (AICAR) on endotoxin-induced uveitis in rats.
Topics: Aminoimidazole Carboxamide; Animals; Anterior Chamber; Anti-Inflammatory Agents; Aqueous Humor; Blotting, Western; Chemokine CCL2; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Injections, Intraperitoneal; Intercellular Adhesion Molecule-1; Lipopolysaccharide Receptors; Lipopolysaccharides; Male; NF-kappa B; Rats; Rats, Inbred Lew; Retina; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleotides; RNA, Messenger; Salmonella typhimurium; Tumor Necrosis Factor-alpha; Uveitis, Anterior | 2011 |
Chronic AMPK stimulation attenuates adaptive signaling in dystrophic skeletal muscle.
Topics: Adaptation, Physiological; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Disease Models, Animal; Mice; Mice, Inbred C57BL; Mice, Inbred mdx; Mice, Transgenic; Muscle, Skeletal; Muscular Dystrophy, Duchenne; Physical Conditioning, Animal; Ribonucleotides; Signal Transduction | 2012 |
AMP-activated protein kinase mediates effects of oxidative stress on embryo gene expression in a mouse model of diabetic embryopathy.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Antioxidants; Cell Line; Disease Models, Animal; Embryo, Mammalian; Embryonic Stem Cells; Female; Gene Expression Regulation, Developmental; Hyperglycemia; Hypoxia; Mice; Mice, Inbred ICR; Neural Tube Defects; Oxidative Stress; Paired Box Transcription Factors; PAX3 Transcription Factor; Pregnancy; Pregnancy in Diabetics; Protein Kinase Inhibitors; Ribonucleotides; RNA, Messenger | 2012 |
Aminoimidazole carboxamide ribonucleotide ameliorates experimental autoimmune uveitis.
Topics: Aminoimidazole Carboxamide; Animals; Autoimmune Diseases; Blotting, Western; Cell Proliferation; Cytokines; Disease Models, Animal; Female; Flow Cytometry; Hypoglycemic Agents; Immunity, Cellular; Injections, Intraperitoneal; Mice; Mice, Inbred C57BL; Ribonucleotides; T-Lymphocytes; Treatment Outcome; Uvea; Uveitis | 2012 |
AMPK activation reduces vascular permeability and airway inflammation by regulating HIF/VEGFA pathway in a murine model of toluene diisocyanate-induced asthma.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Asthma; Basic Helix-Loop-Helix Transcription Factors; Bronchoalveolar Lavage Fluid; Capillary Permeability; Cytokines; Disease Models, Animal; Female; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Mice, Inbred BALB C; Pneumonia; Reactive Oxygen Species; Ribonucleotides; Signal Transduction; Toluene 2,4-Diisocyanate; Vascular Endothelial Growth Factor A | 2012 |
Aberrant endoplasmic reticulum stress in vascular smooth muscle increases vascular contractility and blood pressure in mice deficient of AMP-activated protein kinase-α2 in vivo.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Endoplasmic Reticulum Stress; Enzyme Activation; Enzyme Activators; Humans; Hypertension; Leupeptins; Mice; Mice, Knockout; Muscle, Smooth, Vascular; Myosin Light Chains; Nitric Oxide Synthase Type III; Phenylbutyrates; Phenylephrine; Phosphorylation; Ribonucleotides; Taurochenodeoxycholic Acid; Time Factors; Tunicamycin; Vasoconstriction; Vasoconstrictor Agents | 2013 |
Attenuation of ischemia-reperfusion injury in a canine model of autologous renal transplantation.
Topics: Acetylcysteine; Adenosine; Allopurinol; Aminoimidazole Carboxamide; Animals; Apoptosis; Creatinine; Disease Models, Animal; Dogs; Glutathione; Graft Survival; Immunohistochemistry; Insulin; Kidney; Kidney Transplantation; Male; Nephrectomy; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Organ Preservation; Organ Preservation Solutions; Raffinose; Reperfusion Injury; Ribonucleotides; Transplantation, Autologous; Tumor Necrosis Factor-alpha | 2004 |
Pharmacological inhibition of AMP-activated protein kinase provides neuroprotection in stroke.
Topics: 4-Butyrolactone; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Brain Ischemia; Cerebral Cortex; Constriction; Disease Models, Animal; Energy Metabolism; Enzyme Activation; Enzyme Inhibitors; Fatty Acid Synthases; Glucose; Hippocampus; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Cerebral Artery; Multienzyme Complexes; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxygen; Protein Serine-Threonine Kinases; Rats; Ribonucleotides; Stroke | 2005 |
Adenosine monophosphate-activated protein kinase and nitric oxide in rat steatotic liver transplantation.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Disease Models, Animal; Enzyme Activators; Enzyme Inhibitors; Fatty Liver; Ischemic Preconditioning; Liver; Liver Transplantation; Multienzyme Complexes; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Protein Serine-Threonine Kinases; Rats; Rats, Zucker; Reperfusion Injury; Ribonucleotides; Vidarabine | 2005 |
5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside attenuates experimental autoimmune encephalomyelitis via modulation of endothelial-monocyte interaction.
Topics: Aminoimidazole Carboxamide; Animals; Anti-Inflammatory Agents; Blood-Brain Barrier; Cell Adhesion; Cell Adhesion Molecules; Chemotaxis, Leukocyte; Disease Models, Animal; Down-Regulation; Encephalomyelitis, Autoimmune, Experimental; Endothelial Cells; Female; Inflammation Mediators; Mice; Monocytes; NF-kappa B; Rats; Rats, Inbred Lew; Ribonucleotides; Tumor Necrosis Factor-alpha | 2006 |
Long-term activation of adenosine monophosphate-activated protein kinase attenuates pressure-overload-induced cardiac hypertrophy.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Animals, Newborn; Calcineurin; Cardiomegaly; Cells, Cultured; Disease Models, Animal; Enzyme Activation; Gene Expression Regulation, Enzymologic; Hypoglycemic Agents; Male; Mitogen-Activated Protein Kinases; Multienzyme Complexes; Myocytes, Cardiac; NF-kappa B; Phosphorylation; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Ribonucleotides; Signal Transduction; Ventricular Pressure | 2007 |
The antiinflammatory mechanism of methotrexate. Increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation.
Topics: Adenosine; Adenosine Deaminase; Aminoimidazole Carboxamide; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Disease Models, Animal; Female; Inflammation; Kinetics; Leukocytes; Methotrexate; Mice; Mice, Inbred BALB C; Purinergic P1 Receptor Antagonists; Ribonucleotides; Spleen; Theobromine; Time Factors | 1993 |
The anti-inflammatory mechanism of sulfasalazine is related to adenosine release at inflamed sites.
Topics: Acyltransferases; Adenosine; Aminoimidazole Carboxamide; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Disease Models, Animal; Endothelium, Vascular; Female; Humans; Hydroxymethyl and Formyl Transferases; Mice; Mice, Inbred BALB C; Neutrophil Activation; Phosphoribosylaminoimidazolecarboxamide Formyltransferase; Ribonucleotides; Sulfasalazine | 1996 |
Combination therapy that targets secondary pulmonary changes after abdominal trauma.
Topics: Abdominal Abscess; Abdominal Injuries; Aminoimidazole Carboxamide; Animals; Anti-Inflammatory Agents; Blood Pressure; Capillaries; Disease Models, Animal; Hemodynamics; Inflammation; Lactates; Lung; Lung Injury; Neutrophils; Pulmonary Alveoli; Pulmonary Artery; Resuscitation; Ribonucleotides; Shock, Hemorrhagic; Steroids; Swine | 2001 |
5-aminoimidazole-4-carboxy-amide-1-beta-D-ribofuranoside treatment ameliorates hyperglycaemia and hyperinsulinaemia but not dyslipidaemia in KKAy-CETP mice.
Topics: Aminoimidazole Carboxamide; Animals; Carrier Proteins; Cholesterol Ester Transfer Proteins; Diabetes Mellitus, Type 2; Disease Models, Animal; Female; Glucose; Glycoproteins; Hyperglycemia; Hyperinsulinism; Hyperlipidemias; Hypoglycemic Agents; Mice; Mice, Transgenic; Muscle, Skeletal; Ribonucleotides | 2001 |